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The map label for this gene is cpxA [H]

Identifier: 160873386

GI number: 160873386

Start: 299628

End: 300992

Strand: Reverse

Name: cpxA [H]

Synonym: Sbal195_0260

Alternate gene names: 160873386

Gene position: 300992-299628 (Counterclockwise)

Preceding gene: 160873387

Following gene: 160873384

Centisome position: 5.63

GC content: 48.57

Gene sequence:

>1365_bases
ATGGCGGTATCGACTGTGCCTAATCGTTTATTTATCAAATTATTGCTCGGATTCTGGCTCTGCAGCTCGCTGATCATTGC
CTTGGTCGGTCTGTTGCCATTGCTGCAACAGAGCCACGATCGTGCACCACTGCCACCTCACCTTGAAAAAGTCCTATCGA
CTATAGCTAAGCGCATTCAAGAAAACCCCGCCTTACTGGAGTCTGATTTTCTTCGCCGCTGGGAAAGACACAGAGACATG
GAAGGCAAACCTCTGCGGGTTTATCTCGTCAACAGCCAAGGCCAAGTCGTCAACACCCATAGGGTGAGTCGCGGTGTGCG
TAGCTTTATGTTGATGGCAGATGAAGAAAAACAACCTATTAGCCATCAGTTTAAAGATGAGTTGGTGTTTGGTCCCTTTC
AATTCAATCTGGGCGCCGAGACGTATTCACTCTACGGCCGTCTGCCGGATAACCATCCGCGGCCTTGGTTCTTCTTCTTC
GCCGAAAATAAGTTATTAACTTTAAGCCTAGCGATTTTCCTGTCGGGACTATTATGTGGCCTGCTCGCTTGGCATCTAGG
TAAGGCATTAAATTCACTTAAAAAGAGTGCCAATGCCCTCGCTGAAGGTGACTTAAGTAACCGTGTCGATAAGTCCACCA
CTCAGCGCAACGACGAAATTGGTCAGCTCGCCACGGCTTTTAACAGCATGGCCGACTCCATCGAAGCTATGGTGAATAAT
CAGCAACGACTCATGGGGGATATTTCCCATGAACTGCGTACCCCATTGACGCGACTGCAATTATCCCTCGCCCTCGCCCG
TAAAAAAGGTCAACAAACCGCCGAAACTGAACGCATAGGTTATGAAGCCGAGCAACTCGAAAAGCTTATCAGTGAATTGT
TAGAACTCTCGCGGGTCAAGCTCAGCACTAACGAAACCAAAGTGCATTTAGGCTTGGCAGAATCCCTGAGCCAAGTTTTA
GACGATGCGGAATTTGAAGCAGAACAGCAAGGTAAAAGCATTACTATCGATATCGATGAAGAAATTGAGTTAGCGCATTT
TCCTAAATCACTTTCCCGCGCGATTGAAAATCTGCTGCGTAATGCAATTCGCTATGCCGCAAGCGACATTCAGTTACAGG
CAAGTGCAACAGCTGATCAAGTAAAAATCACGATAAAAGACGATGGACCAGGCATAGATGCCGCCGAACTCGATGCCATT
TTCAAACCCTTCTATCGCCCTGACTCTGCACGGCAAAGAGAAAGCGGTGGCTGGGGACTTGGGCTGGCAATCACTGAAGC
GGCGATTACCGCCCACAAGGGTAAGATTAAAGCCGAGAACCGTATCCCAACTGGACTTGAAGTGACGATCACGCTGCCGA
GGTAG

Upstream 100 bases:

>100_bases
ACATGCATTTATCGAATCTACGTAAAAAACTCCCCGAGCGTAGCGATGGGCGGCCAAGGGTGAAAACCATCCGTGGCAAA
GGTTATATTTGGCTCCCGTA

Downstream 100 bases:

>100_bases
CAGCTTGACCATGTAGCTGTAATAGCCAATCGGTAAATTTTTGTTTGGTGGGAATTCGCTTATCCGAATGTCCCATCAGC
TGACCCATCGCATAGCTAAA

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 454; Mature: 453

Protein sequence:

>454_residues
MAVSTVPNRLFIKLLLGFWLCSSLIIALVGLLPLLQQSHDRAPLPPHLEKVLSTIAKRIQENPALLESDFLRRWERHRDM
EGKPLRVYLVNSQGQVVNTHRVSRGVRSFMLMADEEKQPISHQFKDELVFGPFQFNLGAETYSLYGRLPDNHPRPWFFFF
AENKLLTLSLAIFLSGLLCGLLAWHLGKALNSLKKSANALAEGDLSNRVDKSTTQRNDEIGQLATAFNSMADSIEAMVNN
QQRLMGDISHELRTPLTRLQLSLALARKKGQQTAETERIGYEAEQLEKLISELLELSRVKLSTNETKVHLGLAESLSQVL
DDAEFEAEQQGKSITIDIDEEIELAHFPKSLSRAIENLLRNAIRYAASDIQLQASATADQVKITIKDDGPGIDAAELDAI
FKPFYRPDSARQRESGGWGLGLAITEAAITAHKGKIKAENRIPTGLEVTITLPR

Sequences:

>Translated_454_residues
MAVSTVPNRLFIKLLLGFWLCSSLIIALVGLLPLLQQSHDRAPLPPHLEKVLSTIAKRIQENPALLESDFLRRWERHRDM
EGKPLRVYLVNSQGQVVNTHRVSRGVRSFMLMADEEKQPISHQFKDELVFGPFQFNLGAETYSLYGRLPDNHPRPWFFFF
AENKLLTLSLAIFLSGLLCGLLAWHLGKALNSLKKSANALAEGDLSNRVDKSTTQRNDEIGQLATAFNSMADSIEAMVNN
QQRLMGDISHELRTPLTRLQLSLALARKKGQQTAETERIGYEAEQLEKLISELLELSRVKLSTNETKVHLGLAESLSQVL
DDAEFEAEQQGKSITIDIDEEIELAHFPKSLSRAIENLLRNAIRYAASDIQLQASATADQVKITIKDDGPGIDAAELDAI
FKPFYRPDSARQRESGGWGLGLAITEAAITAHKGKIKAENRIPTGLEVTITLPR
>Mature_453_residues
AVSTVPNRLFIKLLLGFWLCSSLIIALVGLLPLLQQSHDRAPLPPHLEKVLSTIAKRIQENPALLESDFLRRWERHRDME
GKPLRVYLVNSQGQVVNTHRVSRGVRSFMLMADEEKQPISHQFKDELVFGPFQFNLGAETYSLYGRLPDNHPRPWFFFFA
ENKLLTLSLAIFLSGLLCGLLAWHLGKALNSLKKSANALAEGDLSNRVDKSTTQRNDEIGQLATAFNSMADSIEAMVNNQ
QRLMGDISHELRTPLTRLQLSLALARKKGQQTAETERIGYEAEQLEKLISELLELSRVKLSTNETKVHLGLAESLSQVLD
DAEFEAEQQGKSITIDIDEEIELAHFPKSLSRAIENLLRNAIRYAASDIQLQASATADQVKITIKDDGPGIDAAELDAIF
KPFYRPDSARQRESGGWGLGLAITEAAITAHKGKIKAENRIPTGLEVTITLPR

Specific function: This protein is involved in several diverse cellular processes, such as the functioning of acetohydroxyacid synthetase I, in the biosynthesis of isoleucine and valine, the TraJ protein activation activity for tra gene expression in F plasmid, and the synt

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790346, Length=371, Percent_Identity=38.544474393531, Blast_Score=224, Evalue=9e-60,
Organism=Escherichia coli, GI1787894, Length=331, Percent_Identity=29.9093655589124, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI1786783, Length=303, Percent_Identity=32.013201320132, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1788393, Length=282, Percent_Identity=34.0425531914894, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1789808, Length=239, Percent_Identity=29.7071129707113, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI1786600, Length=222, Percent_Identity=27.9279279279279, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI145693157, Length=247, Percent_Identity=28.7449392712551, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1786912, Length=220, Percent_Identity=30.4545454545455, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1787374, Length=305, Percent_Identity=24.5901639344262, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1790551, Length=294, Percent_Identity=26.530612244898, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1790436, Length=217, Percent_Identity=30.4147465437788, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1788279, Length=286, Percent_Identity=26.5734265734266, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1788549, Length=221, Percent_Identity=27.6018099547511, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1789149, Length=282, Percent_Identity=25.531914893617, Blast_Score=73, Evalue=5e-14,
Organism=Escherichia coli, GI1789403, Length=272, Percent_Identity=26.4705882352941, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI87082128, Length=279, Percent_Identity=26.5232974910394, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1788713, Length=236, Percent_Identity=27.1186440677966, Blast_Score=65, Evalue=8e-12,
Organism=Escherichia coli, GI1790861, Length=303, Percent_Identity=25.0825082508251, Blast_Score=63, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 50702; Mature: 50571

Theoretical pI: Translated: 6.75; Mature: 6.75

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVSTVPNRLFIKLLLGFWLCSSLIIALVGLLPLLQQSHDRAPLPPHLEKVLSTIAKRIQ
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
ENPALLESDFLRRWERHRDMEGKPLRVYLVNSQGQVVNTHRVSRGVRSFMLMADEEKQPI
CCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCEEHHHHHHHHHHHHHHHCCCCCCCC
SHQFKDELVFGPFQFNLGAETYSLYGRLPDNHPRPWFFFFAENKLLTLSLAIFLSGLLCG
HHHHHHHHEECCEEECCCCHHHHHCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHH
LLAWHLGKALNSLKKSANALAEGDLSNRVDKSTTQRNDEIGQLATAFNSMADSIEAMVNN
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCC
QQRLMGDISHELRTPLTRLQLSLALARKKGQQTAETERIGYEAEQLEKLISELLELSRVK
HHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHE
LSTNETKVHLGLAESLSQVLDDAEFEAEQQGKSITIDIDEEIELAHFPKSLSRAIENLLR
ECCCCCEEEEEHHHHHHHHHCCHHHHHHHCCCEEEEEECCCCHHHHCCHHHHHHHHHHHH
NAIRYAASDIQLQASATADQVKITIKDDGPGIDAAELDAIFKPFYRPDSARQRESGGWGL
HHHHHHHHCCEEEECCCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCCCHHHHCCCCCEE
GLAITEAAITAHKGKIKAENRIPTGLEVTITLPR
HHHHHHHHHHHHCCCEEECCCCCCCCEEEEECCC
>Mature Secondary Structure 
AVSTVPNRLFIKLLLGFWLCSSLIIALVGLLPLLQQSHDRAPLPPHLEKVLSTIAKRIQ
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
ENPALLESDFLRRWERHRDMEGKPLRVYLVNSQGQVVNTHRVSRGVRSFMLMADEEKQPI
CCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCEEHHHHHHHHHHHHHHHCCCCCCCC
SHQFKDELVFGPFQFNLGAETYSLYGRLPDNHPRPWFFFFAENKLLTLSLAIFLSGLLCG
HHHHHHHHEECCEEECCCCHHHHHCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHH
LLAWHLGKALNSLKKSANALAEGDLSNRVDKSTTQRNDEIGQLATAFNSMADSIEAMVNN
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCC
QQRLMGDISHELRTPLTRLQLSLALARKKGQQTAETERIGYEAEQLEKLISELLELSRVK
HHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHE
LSTNETKVHLGLAESLSQVLDDAEFEAEQQGKSITIDIDEEIELAHFPKSLSRAIENLLR
ECCCCCEEEEEHHHHHHHHHCCHHHHHHHCCCEEEEEECCCCHHHHCCHHHHHHHHHHHH
NAIRYAASDIQLQASATADQVKITIKDDGPGIDAAELDAIFKPFYRPDSARQRESGGWGL
HHHHHHHHCCEEEECCCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCCCHHHHCCCCCEE
GLAITEAAITAHKGKIKAENRIPTGLEVTITLPR
HHHHHHHHHHHHCCCEEECCCCCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]