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The map label for this gene is cpxR [H]

Identifier: 160873387

GI number: 160873387

Start: 300992

End: 301678

Strand: Reverse

Name: cpxR [H]

Synonym: Sbal195_0261

Alternate gene names: 160873387

Gene position: 301678-300992 (Counterclockwise)

Preceding gene: 160873392

Following gene: 160873386

Centisome position: 5.64

GC content: 48.18

Gene sequence:

>687_bases
ATGAGTCGGATATTATTAATCGATGACGATCTGGGTTTATCTGAGCTGCTAGGGCAACTGCTCGAGTTAGAAGGGTTTCA
GTTAACCTTGGCTTACGATGGTAAACAGGGTTTAGATCTGGCACTGAGTTCGGATTACGATCTGATCTTACTCGATGTCA
TGCTGCCTAAATTGAACGGCTTCGAAGTCCTGCGTGCACTGCGCCAACACAAGCAAACGCCTGTATTAATGCTGACCGCT
CGCGGCGATGAAATCGATCGCGTTGTTGGGCTTGAAATTGGCGCCGATGATTATCTGCCAAAGCCGTTTAATGACAGAGA
GTTAATCGCCCGTATCCGCGCCATTATTCGTCGTTCGAACTTAACAACCCAAGAAATCCATGCCGCACCAGCCCAAGAGT
TTGGCGATCTGCGCTTAGATCCATCGCGCCAAGAAGCTTACTGTAATGAGCAATTAATCATACTCACAGGCACAGAATTC
ACTCTGCTGCACACCCTTGCGCTGCACGCGGGAGAGTTGATGAATAAGGAAGAGTTAAACGAGAAAGTACTCGGCAAAAA
ACTCATGCCCTTCGATCGCAGCTTAGACATGCATTTATCGAATCTACGTAAAAAACTCCCCGAGCGTAGCGATGGGCGGC
CAAGGGTGAAAACCATCCGTGGCAAAGGTTATATTTGGCTCCCGTAA

Upstream 100 bases:

>100_bases
CACAGCAATTGACATCAAAACAGGTATACTCAGCCAAAGCGCTAAAAATGCCAGTATTACATGGGCGCATAAGGCCATAT
TACAGAGATTAAGGAACAGT

Downstream 100 bases:

>100_bases
TGGCGGTATCGACTGTGCCTAATCGTTTATTTATCAAATTATTGCTCGGATTCTGGCTCTGCAGCTCGCTGATCATTGCC
TTGGTCGGTCTGTTGCCATT

Product: two component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 228; Mature: 227

Protein sequence:

>228_residues
MSRILLIDDDLGLSELLGQLLELEGFQLTLAYDGKQGLDLALSSDYDLILLDVMLPKLNGFEVLRALRQHKQTPVLMLTA
RGDEIDRVVGLEIGADDYLPKPFNDRELIARIRAIIRRSNLTTQEIHAAPAQEFGDLRLDPSRQEAYCNEQLIILTGTEF
TLLHTLALHAGELMNKEELNEKVLGKKLMPFDRSLDMHLSNLRKKLPERSDGRPRVKTIRGKGYIWLP

Sequences:

>Translated_228_residues
MSRILLIDDDLGLSELLGQLLELEGFQLTLAYDGKQGLDLALSSDYDLILLDVMLPKLNGFEVLRALRQHKQTPVLMLTA
RGDEIDRVVGLEIGADDYLPKPFNDRELIARIRAIIRRSNLTTQEIHAAPAQEFGDLRLDPSRQEAYCNEQLIILTGTEF
TLLHTLALHAGELMNKEELNEKVLGKKLMPFDRSLDMHLSNLRKKLPERSDGRPRVKTIRGKGYIWLP
>Mature_227_residues
SRILLIDDDLGLSELLGQLLELEGFQLTLAYDGKQGLDLALSSDYDLILLDVMLPKLNGFEVLRALRQHKQTPVLMLTAR
GDEIDRVVGLEIGADDYLPKPFNDRELIARIRAIIRRSNLTTQEIHAAPAQEFGDLRLDPSRQEAYCNEQLIILTGTEFT
LLHTLALHAGELMNKEELNEKVLGKKLMPFDRSLDMHLSNLRKKLPERSDGRPRVKTIRGKGYIWLP

Specific function: Member of the two-component regulatory system CpxA/CpxR. This system combats a variety of extracytoplasmic protein-mediated toxicities. It performs this function by increasing the synthesis of the periplasmic protease, DegP as well as that of CpxP protein

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=58.3333333333333, Blast_Score=254, Evalue=4e-69,
Organism=Escherichia coli, GI1789809, Length=233, Percent_Identity=39.0557939914163, Blast_Score=165, Evalue=2e-42,
Organism=Escherichia coli, GI1786599, Length=226, Percent_Identity=39.3805309734513, Blast_Score=147, Evalue=4e-37,
Organism=Escherichia coli, GI1788394, Length=224, Percent_Identity=36.1607142857143, Blast_Score=141, Evalue=3e-35,
Organism=Escherichia coli, GI87082012, Length=226, Percent_Identity=38.4955752212389, Blast_Score=139, Evalue=1e-34,
Organism=Escherichia coli, GI1790860, Length=223, Percent_Identity=37.219730941704, Blast_Score=135, Evalue=2e-33,
Organism=Escherichia coli, GI1786784, Length=225, Percent_Identity=37.3333333333333, Blast_Score=133, Evalue=1e-32,
Organism=Escherichia coli, GI1790863, Length=225, Percent_Identity=33.3333333333333, Blast_Score=126, Evalue=1e-30,
Organism=Escherichia coli, GI1786911, Length=225, Percent_Identity=35.5555555555556, Blast_Score=123, Evalue=8e-30,
Organism=Escherichia coli, GI1790552, Length=227, Percent_Identity=36.5638766519824, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1789402, Length=223, Percent_Identity=34.9775784753363, Blast_Score=121, Evalue=5e-29,
Organism=Escherichia coli, GI145693140, Length=235, Percent_Identity=32.3404255319149, Blast_Score=117, Evalue=7e-28,
Organism=Escherichia coli, GI1787375, Length=227, Percent_Identity=32.15859030837, Blast_Score=104, Evalue=4e-24,
Organism=Escherichia coli, GI1787229, Length=209, Percent_Identity=31.5789473684211, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1788550, Length=109, Percent_Identity=33.9449541284404, Blast_Score=74, Evalue=6e-15,
Organism=Escherichia coli, GI1790437, Length=161, Percent_Identity=29.1925465838509, Blast_Score=71, Evalue=5e-14,
Organism=Escherichia coli, GI1790299, Length=114, Percent_Identity=33.3333333333333, Blast_Score=65, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25908; Mature: 25776

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRILLIDDDLGLSELLGQLLELEGFQLTLAYDGKQGLDLALSSDYDLILLDVMLPKLNG
CCEEEEEECCCCHHHHHHHHHHCCCCEEEEEECCCCCCEEEECCCCCEEEEEEHHCCCCH
FEVLRALRQHKQTPVLMLTARGDEIDRVVGLEIGADDYLPKPFNDRELIARIRAIIRRSN
HHHHHHHHHCCCCCEEEEEECCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCC
LTTQEIHAAPAQEFGDLRLDPSRQEAYCNEQLIILTGTEFTLLHTLALHAGELMNKEELN
CCHHHHHCCCHHHHCCCCCCCCHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHCCHHHHH
EKVLGKKLMPFDRSLDMHLSNLRKKLPERSDGRPRVKTIRGKGYIWLP
HHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEEECCEEEECC
>Mature Secondary Structure 
SRILLIDDDLGLSELLGQLLELEGFQLTLAYDGKQGLDLALSSDYDLILLDVMLPKLNG
CEEEEEECCCCHHHHHHHHHHCCCCEEEEEECCCCCCEEEECCCCCEEEEEEHHCCCCH
FEVLRALRQHKQTPVLMLTARGDEIDRVVGLEIGADDYLPKPFNDRELIARIRAIIRRSN
HHHHHHHHHCCCCCEEEEEECCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCC
LTTQEIHAAPAQEFGDLRLDPSRQEAYCNEQLIILTGTEFTLLHTLALHAGELMNKEELN
CCHHHHHCCCHHHHCCCCCCCCHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHCCHHHHH
EKVLGKKLMPFDRSLDMHLSNLRKKLPERSDGRPRVKTIRGKGYIWLP
HHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEEECCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]