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The map label for this gene is mrdA [H]

Identifier: 159901286

GI number: 159901286

Start: 6089737

End: 6091989

Strand: Reverse

Name: mrdA [H]

Synonym: Haur_4774

Alternate gene names: 159901286

Gene position: 6091989-6089737 (Counterclockwise)

Preceding gene: 159901287

Following gene: 159901285

Centisome position: 95.99

GC content: 51.44

Gene sequence:

>2253_bases
ATGCGCGGTCGCTTGATCGGCTTACGGGTCGTGAGCTTAATTATTTTTGTGGTCTTGCTCGCGCGATTGCAGCAATTGCA
ATTTGGCAGTAGCGCCGCAACTTCACGCGCTTCAATTGAGCAAAATATTACCCGCCGCGATTATGTTGCTCCCCAACGTG
GCGAGATTTTTGCCAGCGATGGCACAACCCTGCTAGCAGCCTCGGTTCCCACCTCGATCTTGGGAATTCAAGCCGAATCG
CTGCCGCGCAAACGCGCTGAGCGCAATGCGGTGTATATGCGGCTGAGTATGTTATTGCCTTTCAGCGATACCTTCACGCT
CTCGCCAACCACTAAATTACAAGAAGATCCAGCTTTGGCCGCAGCAATTTATGGCATCTCGCCAATTTTGCCTGCCGATA
CCAACTTCGCGCCAGCGCAATCGATCACGGTGACCGTGCCCATGGGCAAGGCCTTGACCGCGCTGCAATTAAGCCAAGCC
TATACCGATGTGATCACCCTGCAACCTGGGGTTGAAAAGGTACTAGCCAAAGCCAACCTGCCTGGCTATTTGGTTGTGCC
AGTCGCCAAAAATATTCCTGATGATGTCGCCTTGGCGATTCGCGAAAATGCGCTGGCCTTGCCCGGCGTGCGGGTGGTCG
ATGGCTTCCAGCGCGATTACCCACTGAGTGCCGAAGTCCAATCGCTCTCGCATTTATTGGGCTATATGATTCGGATTAAC
GACAAGCAACTGGCTCGTTATAACCCCACCAATGATGCTGACGGCCCGCGCCAATATCTCGAAAGTGATTTGATTGGGGT
CGATGGAATCGAAAATTATTACGAATCAACCTTGCGCGGCAAGTTGGGCACCAATCAAATTTCGGTTGATGTCTCGGATC
GGATTGTCGGCGAGCCAACGGTGTTGCAGCCAATGGAAGATGGCAAAAATCTGATTTTGAATATTGATATGGATTTGCAG
CGAGCCAGCGAAGCAATTTTACAAAAATGGCTCGATGTTGCCGATCAACGCCGCGTGCGCTTAGCCAACACGCCAGGCAA
AGATCAAGCTAAATATGCCTCATACGACCCGATTAACAAAGGCGTGATTATGGTGATGGATGTCAACACAGGGGCGGTTT
TAGCCTCGGTCAGCTTGCCAGCCTACGATAACAACGCCTTTAATCGCGGTGAGGTCGAGGAAATTACCGATTTATTTACC
GATGAAGAAAACACGCCGTTGCTGCATCGGGCAATTGCTGGTAAATATCCACCTGGCTCGACCTTCAAGCAATTTACGGC
TGCCGCTGCCTTAGATAGCGATATCATCAATCCTGGCACGCAGATTCAAGACCCTGGCTTTTTGATTGTGCGCAACGAAT
ATAACGAAGCTTTGACCAACCAATATCCTAACTCCAACCGCCGCGCCAATGGCCTGATCAACGTTTCCGATGCTTTGAAA
GTTTCATCGAACGTCTTTTTCAACACGGTTGCTGGCGGTACCGATTATGTTACCAATCTCAAACCAACCGATCCACAAAT
CAAAGGTGGCTTGGGGATTGATCGCTTGTATGAGACGGTTTCGGGCGAGTTTGGCTTCGATAAACTGACCGGGATCGATT
TGCCAGGCGAAGATTCAGGGATTATTCCGAATAAAGAGTGGAAGAAACAGCGCCGCGAACGTTGGGGCGTTGGCGATACC
TATATCGCCGCAATTGGTCAGGGCGATGTGCAAGTTACGCCATTGCAATTGCTACGGGCTACCGTCGCTACCGCCAATCG
TGGTTCAGTCTATCAACCACAAGTTGTCAAAGCGATCACCGATTTGAACCGCACCGACACGATTACGCTGACCCCAGTGA
TTGAACACACGATTGAACTTGCACCTGAGCATTGGGCGATTATTCGTGAAGGCATGCGGCGCTCTGTCCGTGATCCCGAT
GCCTACAATCGGATCGCCAATGGCAATAACAAACCTGCAGGCGCAATTTTGACCGATCTTGATCGGCTGGATTTGGCGGG
CAAAACTGGAACCGCCGAGTATGCCGAAGGGCCATATTTGCGTTCGCACTCGTGGTTTGTTGGCTTTGCGCCGTTCGATA
ATCCCAAAGTAGCAATTTTAGCGATGCTCGAAGGCACTGGCGATTTGGGCGACGGATCGGGGACACTGGCCTTGCCAGCG
GTAGTTGATGTGCTACGAGCCTATAATGGCGAGGCCTTCCCCGATATTAATGGTAATTTGCCTGCGCCTGCTGCTGGCAG
CACTGGCCAATAG

Upstream 100 bases:

>100_bases
TGATTATCAATGCGATTGCGGTTTTGCCAACCTTCCTCGTTTTGCAATGGTGGAACGAGCGCAAAATCCGCCACTAAACT
TTATCATCAAGGAGAACCCT

Downstream 100 bases:

>100_bases
AGGAAAAAACCAATGCAGTTAACCGTGGCACTTGCTCAAATCGATTTAGTGTTGGGCGATCGCGAAGCCAATTTAGCGAC
GGTGCGTCAACTTGCTGCGC

Product: penicillin-binding protein transpeptidase

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 750; Mature: 750

Protein sequence:

>750_residues
MRGRLIGLRVVSLIIFVVLLARLQQLQFGSSAATSRASIEQNITRRDYVAPQRGEIFASDGTTLLAASVPTSILGIQAES
LPRKRAERNAVYMRLSMLLPFSDTFTLSPTTKLQEDPALAAAIYGISPILPADTNFAPAQSITVTVPMGKALTALQLSQA
YTDVITLQPGVEKVLAKANLPGYLVVPVAKNIPDDVALAIRENALALPGVRVVDGFQRDYPLSAEVQSLSHLLGYMIRIN
DKQLARYNPTNDADGPRQYLESDLIGVDGIENYYESTLRGKLGTNQISVDVSDRIVGEPTVLQPMEDGKNLILNIDMDLQ
RASEAILQKWLDVADQRRVRLANTPGKDQAKYASYDPINKGVIMVMDVNTGAVLASVSLPAYDNNAFNRGEVEEITDLFT
DEENTPLLHRAIAGKYPPGSTFKQFTAAAALDSDIINPGTQIQDPGFLIVRNEYNEALTNQYPNSNRRANGLINVSDALK
VSSNVFFNTVAGGTDYVTNLKPTDPQIKGGLGIDRLYETVSGEFGFDKLTGIDLPGEDSGIIPNKEWKKQRRERWGVGDT
YIAAIGQGDVQVTPLQLLRATVATANRGSVYQPQVVKAITDLNRTDTITLTPVIEHTIELAPEHWAIIREGMRRSVRDPD
AYNRIANGNNKPAGAILTDLDRLDLAGKTGTAEYAEGPYLRSHSWFVGFAPFDNPKVAILAMLEGTGDLGDGSGTLALPA
VVDVLRAYNGEAFPDINGNLPAPAAGSTGQ

Sequences:

>Translated_750_residues
MRGRLIGLRVVSLIIFVVLLARLQQLQFGSSAATSRASIEQNITRRDYVAPQRGEIFASDGTTLLAASVPTSILGIQAES
LPRKRAERNAVYMRLSMLLPFSDTFTLSPTTKLQEDPALAAAIYGISPILPADTNFAPAQSITVTVPMGKALTALQLSQA
YTDVITLQPGVEKVLAKANLPGYLVVPVAKNIPDDVALAIRENALALPGVRVVDGFQRDYPLSAEVQSLSHLLGYMIRIN
DKQLARYNPTNDADGPRQYLESDLIGVDGIENYYESTLRGKLGTNQISVDVSDRIVGEPTVLQPMEDGKNLILNIDMDLQ
RASEAILQKWLDVADQRRVRLANTPGKDQAKYASYDPINKGVIMVMDVNTGAVLASVSLPAYDNNAFNRGEVEEITDLFT
DEENTPLLHRAIAGKYPPGSTFKQFTAAAALDSDIINPGTQIQDPGFLIVRNEYNEALTNQYPNSNRRANGLINVSDALK
VSSNVFFNTVAGGTDYVTNLKPTDPQIKGGLGIDRLYETVSGEFGFDKLTGIDLPGEDSGIIPNKEWKKQRRERWGVGDT
YIAAIGQGDVQVTPLQLLRATVATANRGSVYQPQVVKAITDLNRTDTITLTPVIEHTIELAPEHWAIIREGMRRSVRDPD
AYNRIANGNNKPAGAILTDLDRLDLAGKTGTAEYAEGPYLRSHSWFVGFAPFDNPKVAILAMLEGTGDLGDGSGTLALPA
VVDVLRAYNGEAFPDINGNLPAPAAGSTGQ
>Mature_750_residues
MRGRLIGLRVVSLIIFVVLLARLQQLQFGSSAATSRASIEQNITRRDYVAPQRGEIFASDGTTLLAASVPTSILGIQAES
LPRKRAERNAVYMRLSMLLPFSDTFTLSPTTKLQEDPALAAAIYGISPILPADTNFAPAQSITVTVPMGKALTALQLSQA
YTDVITLQPGVEKVLAKANLPGYLVVPVAKNIPDDVALAIRENALALPGVRVVDGFQRDYPLSAEVQSLSHLLGYMIRIN
DKQLARYNPTNDADGPRQYLESDLIGVDGIENYYESTLRGKLGTNQISVDVSDRIVGEPTVLQPMEDGKNLILNIDMDLQ
RASEAILQKWLDVADQRRVRLANTPGKDQAKYASYDPINKGVIMVMDVNTGAVLASVSLPAYDNNAFNRGEVEEITDLFT
DEENTPLLHRAIAGKYPPGSTFKQFTAAAALDSDIINPGTQIQDPGFLIVRNEYNEALTNQYPNSNRRANGLINVSDALK
VSSNVFFNTVAGGTDYVTNLKPTDPQIKGGLGIDRLYETVSGEFGFDKLTGIDLPGEDSGIIPNKEWKKQRRERWGVGDT
YIAAIGQGDVQVTPLQLLRATVATANRGSVYQPQVVKAITDLNRTDTITLTPVIEHTIELAPEHWAIIREGMRRSVRDPD
AYNRIANGNNKPAGAILTDLDRLDLAGKTGTAEYAEGPYLRSHSWFVGFAPFDNPKVAILAMLEGTGDLGDGSGTLALPA
VVDVLRAYNGEAFPDINGNLPAPAAGSTGQ

Specific function: Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross- linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=581, Percent_Identity=28.9156626506024, Blast_Score=203, Evalue=3e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460
- InterPro:   IPR017790 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 81257; Mature: 81257

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGRLIGLRVVSLIIFVVLLARLQQLQFGSSAATSRASIEQNITRRDYVAPQRGEIFASD
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHCCCCCCCCEEECC
GTTLLAASVPTSILGIQAESLPRKRAERNAVYMRLSMLLPFSDTFTLSPTTKLQEDPALA
CCEEEEECCCCHHEECCHHHCCHHHHHCCEEEEEEEEECCCCCCEEECCCCCCCCCCCHH
AAIYGISPILPADTNFAPAQSITVTVPMGKALTALQLSQAYTDVITLQPGVEKVLAKANL
HHHHCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHEEEEECCCHHHHHHHCCC
PGYLVVPVAKNIPDDVALAIRENALALPGVRVVDGFQRDYPLSAEVQSLSHLLGYMIRIN
CCEEEEECCCCCCHHHHHHHHCCCCCCCCCHHHCCCCCCCCCCHHHHHHHHHHHEEEEEC
DKQLARYNPTNDADGPRQYLESDLIGVDGIENYYESTLRGKLGTNQISVDVSDRIVGEPT
CCHHEECCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCEEEEEECCCCCCCCC
VLQPMEDGKNLILNIDMDLQRASEAILQKWLDVADQRRVRLANTPGKDQAKYASYDPINK
EECCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCC
GVIMVMDVNTGAVLASVSLPAYDNNAFNRGEVEEITDLFTDEENTPLLHRAIAGKYPPGS
CEEEEEECCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHCCCCCCCC
TFKQFTAAAALDSDIINPGTQIQDPGFLIVRNEYNEALTNQYPNSNRRANGLINVSDALK
HHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCHHHHHCCCCCCCCCCCEEEEHHHHH
VSSNVFFNTVAGGTDYVTNLKPTDPQIKGGLGIDRLYETVSGEFGFDKLTGIDLPGEDSG
HCCCEEEEEECCCCCEECCCCCCCCCCCCCCCHHHHHHHHCCCCCCCHHCCCCCCCCCCC
IIPNKEWKKQRRERWGVGDTYIAAIGQGDVQVTPLQLLRATVATANRGSVYQPQVVKAIT
CCCCHHHHHHHHHHCCCCCEEEEEECCCCEEECHHHHHHHHHHCCCCCCCCCHHHHHHHH
DLNRTDTITLTPVIEHTIELAPEHWAIIREGMRRSVRDPDAYNRIANGNNKPAGAILTDL
CCCCCCEEEECHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCHHHHHH
DRLDLAGKTGTAEYAEGPYLRSHSWFVGFAPFDNPKVAILAMLEGTGDLGDGSGTLALPA
HHHHCCCCCCCCCCCCCCEEECCCEEEEECCCCCCCEEEEEEEECCCCCCCCCCCEEHHH
VVDVLRAYNGEAFPDINGNLPAPAAGSTGQ
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRGRLIGLRVVSLIIFVVLLARLQQLQFGSSAATSRASIEQNITRRDYVAPQRGEIFASD
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHCCCCCCCCEEECC
GTTLLAASVPTSILGIQAESLPRKRAERNAVYMRLSMLLPFSDTFTLSPTTKLQEDPALA
CCEEEEECCCCHHEECCHHHCCHHHHHCCEEEEEEEEECCCCCCEEECCCCCCCCCCCHH
AAIYGISPILPADTNFAPAQSITVTVPMGKALTALQLSQAYTDVITLQPGVEKVLAKANL
HHHHCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHEEEEECCCHHHHHHHCCC
PGYLVVPVAKNIPDDVALAIRENALALPGVRVVDGFQRDYPLSAEVQSLSHLLGYMIRIN
CCEEEEECCCCCCHHHHHHHHCCCCCCCCCHHHCCCCCCCCCCHHHHHHHHHHHEEEEEC
DKQLARYNPTNDADGPRQYLESDLIGVDGIENYYESTLRGKLGTNQISVDVSDRIVGEPT
CCHHEECCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCEEEEEECCCCCCCCC
VLQPMEDGKNLILNIDMDLQRASEAILQKWLDVADQRRVRLANTPGKDQAKYASYDPINK
EECCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCC
GVIMVMDVNTGAVLASVSLPAYDNNAFNRGEVEEITDLFTDEENTPLLHRAIAGKYPPGS
CEEEEEECCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHCCCCCCCC
TFKQFTAAAALDSDIINPGTQIQDPGFLIVRNEYNEALTNQYPNSNRRANGLINVSDALK
HHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCHHHHHCCCCCCCCCCCEEEEHHHHH
VSSNVFFNTVAGGTDYVTNLKPTDPQIKGGLGIDRLYETVSGEFGFDKLTGIDLPGEDSG
HCCCEEEEEECCCCCEECCCCCCCCCCCCCCCHHHHHHHHCCCCCCCHHCCCCCCCCCCC
IIPNKEWKKQRRERWGVGDTYIAAIGQGDVQVTPLQLLRATVATANRGSVYQPQVVKAIT
CCCCHHHHHHHHHHCCCCCEEEEEECCCCEEECHHHHHHHHHHCCCCCCCCCHHHHHHHH
DLNRTDTITLTPVIEHTIELAPEHWAIIREGMRRSVRDPDAYNRIANGNNKPAGAILTDL
CCCCCCEEEECHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCHHHHHH
DRLDLAGKTGTAEYAEGPYLRSHSWFVGFAPFDNPKVAILAMLEGTGDLGDGSGTLALPA
HHHHCCCCCCCCCCCCCCEEECCCEEEEECCCCCCCEEEEEEEECCCCCCCCCCCEEHHH
VVDVLRAYNGEAFPDINGNLPAPAAGSTGQ
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]