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The map label for this gene is cusR [H]

Identifier: 159900821

GI number: 159900821

Start: 5500513

End: 5502171

Strand: Reverse

Name: cusR [H]

Synonym: Haur_4308

Alternate gene names: 159900821

Gene position: 5502171-5500513 (Counterclockwise)

Preceding gene: 159900822

Following gene: 159900820

Centisome position: 86.69

GC content: 52.2

Gene sequence:

>1659_bases
ATGGATAGCTACGAACGCCGTTCTCGTTTTGTTCACCGCTTTGCAACACCCCTGACCACGCTGAATGCGGGGTTGGCGTT
GCTTGAGCGTTATTTAGCTGAAAGTAATGCCAACTCGGCCCAAATTGCTGAGGTGATGGGCTTGCTCAATCGCTCGGCAA
CCCGTTTGGGCAGTGCGATTGATGTGCTGCAAGAATATATGTTTGATCACCCAACTGGCATTCAGGTGATTATTCCCGAT
GAGGTGCTGGCGCAGCGCCCACAGCATCCAGTTCAAACGCCTACCGAACAGCCCAATTTGGCCTTACCCAAATATCCGCC
CGATATCGACACCAGCAAACCGTGTGTCTTGCTGATCGAAGATTCGCAAACCTATCGCGCAGTGGTTTCCGCACGTTTGA
CCCAATCGGGCTATAACGTGGTAACCGCTCCCGATGGCATGGCTGGCTTAGATTTGGCGCGGGCTTATCAACCAGTGGCG
ATTATTCTCGACCTGATGTTGCCCCACCTCAATGGCGAACAAGTGGCCTTTGTGCTGGGTGAAGACCCTGAAACCAAGCA
TATTCCAATTATTATTTACACTGGCTTAGAGGCCAAGCAAACCGAAAAACTTGAGCTTGACCCACGCCTGCAAATCATCC
GCAAAGACGAAGCCTTGGATCGTTTGCCAATCATGGTCAGCGAGTTGGTGATCAAAAGCCGCAAAAAAACCATCGCCGAG
CTTTTGGTAATCGAAGATGATCAAGAGATTCAGCAAGTGGTCAGCCAAGGCTTATCCAACGCTGGTTATTCGATTACGGT
CACGACCAGCGGCGAGGAAGGCTTGCGTTTAGCCATGCGCCAGCCTTTCGATTTGATTATGCTCGATTTGATGTTGCCCG
ATATTGATGGCTGGACGGTGTTGCGCCAGTTGCGCGAACGCACGCAAACTGCGACCACGCCGCTGATGCTGGTTTCGGCG
CTGGGCAAGCCCGAAGAAAAAGTACGCGGCTTTCAGCTTGGTGCAGACGATTATATTACCAAGCCCTTTGATTGGAACGA
ATTGCTAGCACGAATCAGTGCCTCGCTGCGCCGCCGCGAAGTCGAAGGCAACGCCAACCCATCGACGATGTTGCCTGGCA
ATCGGGCGATTGAACGGGCGATTGCTGCTCGTTTAGATCGCAAACAGCCATTTGTGGTTGGCTACTGCGACCTTGATCAC
TTCAAAGCCTACAACGATCAATATGGCTTTCTCAAAGGCGATGCGATTATCCACCAAACCGCGCGAATTATCACTGGCGC
GGTGGAACGTTCGGGAGCGGCTGGCGATTTTGTCGGCCACATTGGTGGCGACGATTTTGTGTTTCTAGCCCATCCCGACA
ACGTTGTAGCGATCTGCGAATCAATCATTCGCGAGTTTGATCAGCTTGCGCCCTTGTATTACGACATCGAATCGCGCCAA
CGCGGTTTTATTCGCCAAAACGACCGCGAGGGTAATCCCAAGCAATTTCCGTTTGTCAGCATCTCGATTGGCGTAGTTTC
GAGTCTCAACCACCAAATTACCCACTTTGCCGAGTTTGGCGATTTGGCCGCCGATGTGAAAAAGCGGGCCAAAGCCCATA
AAGGCAGCGTTTATCTGATTGAAACTGGCGACAAGGCCACTGTCAACGCCGCAGGCTAG

Upstream 100 bases:

>100_bases
GTGGCCCGTCAGTTGGCGCTGATGGAAGACCAAGGCGATCGCCCTTCCGGCTCGGTTGAGCGACAACGTCCCTAAGCGCG
AGGCATCTGGAGATACCTGT

Downstream 100 bases:

>100_bases
ATTCGCCCACCGCAACCCCTCTCCCAATTGTTGGGAGAGGGGCTTTTTTGTATTATTTGAGATTAATAGGGCTAGCGACT
GATATTAATAATTAAGCTAA

Product: response regulator receiver modulated diguanylate cyclase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 552; Mature: 552

Protein sequence:

>552_residues
MDSYERRSRFVHRFATPLTTLNAGLALLERYLAESNANSAQIAEVMGLLNRSATRLGSAIDVLQEYMFDHPTGIQVIIPD
EVLAQRPQHPVQTPTEQPNLALPKYPPDIDTSKPCVLLIEDSQTYRAVVSARLTQSGYNVVTAPDGMAGLDLARAYQPVA
IILDLMLPHLNGEQVAFVLGEDPETKHIPIIIYTGLEAKQTEKLELDPRLQIIRKDEALDRLPIMVSELVIKSRKKTIAE
LLVIEDDQEIQQVVSQGLSNAGYSITVTTSGEEGLRLAMRQPFDLIMLDLMLPDIDGWTVLRQLRERTQTATTPLMLVSA
LGKPEEKVRGFQLGADDYITKPFDWNELLARISASLRRREVEGNANPSTMLPGNRAIERAIAARLDRKQPFVVGYCDLDH
FKAYNDQYGFLKGDAIIHQTARIITGAVERSGAAGDFVGHIGGDDFVFLAHPDNVVAICESIIREFDQLAPLYYDIESRQ
RGFIRQNDREGNPKQFPFVSISIGVVSSLNHQITHFAEFGDLAADVKKRAKAHKGSVYLIETGDKATVNAAG

Sequences:

>Translated_552_residues
MDSYERRSRFVHRFATPLTTLNAGLALLERYLAESNANSAQIAEVMGLLNRSATRLGSAIDVLQEYMFDHPTGIQVIIPD
EVLAQRPQHPVQTPTEQPNLALPKYPPDIDTSKPCVLLIEDSQTYRAVVSARLTQSGYNVVTAPDGMAGLDLARAYQPVA
IILDLMLPHLNGEQVAFVLGEDPETKHIPIIIYTGLEAKQTEKLELDPRLQIIRKDEALDRLPIMVSELVIKSRKKTIAE
LLVIEDDQEIQQVVSQGLSNAGYSITVTTSGEEGLRLAMRQPFDLIMLDLMLPDIDGWTVLRQLRERTQTATTPLMLVSA
LGKPEEKVRGFQLGADDYITKPFDWNELLARISASLRRREVEGNANPSTMLPGNRAIERAIAARLDRKQPFVVGYCDLDH
FKAYNDQYGFLKGDAIIHQTARIITGAVERSGAAGDFVGHIGGDDFVFLAHPDNVVAICESIIREFDQLAPLYYDIESRQ
RGFIRQNDREGNPKQFPFVSISIGVVSSLNHQITHFAEFGDLAADVKKRAKAHKGSVYLIETGDKATVNAAG
>Mature_552_residues
MDSYERRSRFVHRFATPLTTLNAGLALLERYLAESNANSAQIAEVMGLLNRSATRLGSAIDVLQEYMFDHPTGIQVIIPD
EVLAQRPQHPVQTPTEQPNLALPKYPPDIDTSKPCVLLIEDSQTYRAVVSARLTQSGYNVVTAPDGMAGLDLARAYQPVA
IILDLMLPHLNGEQVAFVLGEDPETKHIPIIIYTGLEAKQTEKLELDPRLQIIRKDEALDRLPIMVSELVIKSRKKTIAE
LLVIEDDQEIQQVVSQGLSNAGYSITVTTSGEEGLRLAMRQPFDLIMLDLMLPDIDGWTVLRQLRERTQTATTPLMLVSA
LGKPEEKVRGFQLGADDYITKPFDWNELLARISASLRRREVEGNANPSTMLPGNRAIERAIAARLDRKQPFVVGYCDLDH
FKAYNDQYGFLKGDAIIHQTARIITGAVERSGAAGDFVGHIGGDDFVFLAHPDNVVAICESIIREFDQLAPLYYDIESRQ
RGFIRQNDREGNPKQFPFVSISIGVVSSLNHQITHFAEFGDLAADVKKRAKAHKGSVYLIETGDKATVNAAG

Specific function: Member of the two-component regulatory system CusS/CusR. Activates the expression of cusCFBA in response to increasing levels of copper ions, and probably silver ions [H]

COG id: COG3706

COG function: function code T; Response regulator containing a CheY-like receiver domain and a GGDEF domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=119, Percent_Identity=43.6974789915966, Blast_Score=116, Evalue=5e-27,
Organism=Escherichia coli, GI87082012, Length=119, Percent_Identity=46.218487394958, Blast_Score=115, Evalue=8e-27,
Organism=Escherichia coli, GI1789809, Length=144, Percent_Identity=38.1944444444444, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1789402, Length=118, Percent_Identity=40.6779661016949, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI1787229, Length=130, Percent_Identity=36.9230769230769, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1786599, Length=119, Percent_Identity=37.8151260504202, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1788394, Length=118, Percent_Identity=36.4406779661017, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1786911, Length=130, Percent_Identity=34.6153846153846, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI1790552, Length=158, Percent_Identity=32.2784810126582, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI2367329, Length=121, Percent_Identity=36.3636363636364, Blast_Score=73, Evalue=6e-14,
Organism=Escherichia coli, GI1790860, Length=131, Percent_Identity=32.0610687022901, Blast_Score=70, Evalue=5e-13,
Organism=Escherichia coli, GI1787375, Length=132, Percent_Identity=31.0606060606061, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1788550, Length=111, Percent_Identity=27.9279279279279, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790863, Length=118, Percent_Identity=31.3559322033898, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI1790437, Length=117, Percent_Identity=27.3504273504274, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1790299, Length=117, Percent_Identity=31.6239316239316, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 61264; Mature: 61264

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50887 GGDEF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSYERRSRFVHRFATPLTTLNAGLALLERYLAESNANSAQIAEVMGLLNRSATRLGSAI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
DVLQEYMFDHPTGIQVIIPDEVLAQRPQHPVQTPTEQPNLALPKYPPDIDTSKPCVLLIE
HHHHHHHCCCCCCCEEEECCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEE
DSQTYRAVVSARLTQSGYNVVTAPDGMAGLDLARAYQPVAIILDLMLPHLNGEQVAFVLG
CCCHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEC
EDPETKHIPIIIYTGLEAKQTEKLELDPRLQIIRKDEALDRLPIMVSELVIKSRKKTIAE
CCCCCCEEEEEEEECCCCCCCCCCCCCCHHHEEECHHHHHHHHHHHHHHHHHHHHHHHHH
LLVIEDDQEIQQVVSQGLSNAGYSITVTTSGEEGLRLAMRQPFDLIMLDLMLPDIDGWTV
HEEECCCHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHCCHHHHHHHHHCCCCCHHHH
LRQLRERTQTATTPLMLVSALGKPEEKVRGFQLGADDYITKPFDWNELLARISASLRRRE
HHHHHHHHHHHHHHHHHHHHCCCCHHHHCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHH
VEGNANPSTMLPGNRAIERAIAARLDRKQPFVVGYCDLDHFKAYNDQYGFLKGDAIIHQT
CCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECHHHHHCCCCCCCEEECCHHHHHH
ARIITGAVERSGAAGDFVGHIGGDDFVFLAHPDNVVAICESIIREFDQLAPLYYDIESRQ
HHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCEEEHHHHC
RGFIRQNDREGNPKQFPFVSISIGVVSSLNHQITHFAEFGDLAADVKKRAKAHKGSVYLI
CCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
ETGDKATVNAAG
ECCCCCEEECCC
>Mature Secondary Structure
MDSYERRSRFVHRFATPLTTLNAGLALLERYLAESNANSAQIAEVMGLLNRSATRLGSAI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
DVLQEYMFDHPTGIQVIIPDEVLAQRPQHPVQTPTEQPNLALPKYPPDIDTSKPCVLLIE
HHHHHHHCCCCCCCEEEECCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEE
DSQTYRAVVSARLTQSGYNVVTAPDGMAGLDLARAYQPVAIILDLMLPHLNGEQVAFVLG
CCCHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEC
EDPETKHIPIIIYTGLEAKQTEKLELDPRLQIIRKDEALDRLPIMVSELVIKSRKKTIAE
CCCCCCEEEEEEEECCCCCCCCCCCCCCHHHEEECHHHHHHHHHHHHHHHHHHHHHHHHH
LLVIEDDQEIQQVVSQGLSNAGYSITVTTSGEEGLRLAMRQPFDLIMLDLMLPDIDGWTV
HEEECCCHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHCCHHHHHHHHHCCCCCHHHH
LRQLRERTQTATTPLMLVSALGKPEEKVRGFQLGADDYITKPFDWNELLARISASLRRRE
HHHHHHHHHHHHHHHHHHHHCCCCHHHHCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHH
VEGNANPSTMLPGNRAIERAIAARLDRKQPFVVGYCDLDHFKAYNDQYGFLKGDAIIHQT
CCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECHHHHHCCCCCCCEEECCHHHHHH
ARIITGAVERSGAAGDFVGHIGGDDFVFLAHPDNVVAICESIIREFDQLAPLYYDIESRQ
HHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCEEEHHHHC
RGFIRQNDREGNPKQFPFVSISIGVVSSLNHQITHFAEFGDLAADVKKRAKAHKGSVYLI
CCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
ETGDKATVNAAG
ECCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]