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The map label for this gene is bhbA [H]

Identifier: 159899897

GI number: 159899897

Start: 4260776

End: 4262455

Strand: Reverse

Name: bhbA [H]

Synonym: Haur_3380

Alternate gene names: 159899897

Gene position: 4262455-4260776 (Counterclockwise)

Preceding gene: 159899911

Following gene: 159899896

Centisome position: 67.16

GC content: 51.79

Gene sequence:

>1680_bases
ATGTTTAGTCCCGAGCAGTTAGCTCAGATGCGGGCGGCGCAGGAGCGCTGGAATGATGAAACGCTGGCTCCGACACTGCA
GAAAACTCCCGAACGTCCGGCGTTATTTAGCACAATTTCCAGCGAGCCGATTCAGCGCTTGTATACCCCGCTCGACATTG
CCGACACTGATTATCAGAAGGATATTAGCTTTCCTGGTGAGTTTCCCTATACCCGTGGGATTCACCCAACTGGCTATCGT
GGCAAGCTCTGGACGATGCGCATGTTTGCGGGGTTTGGCACTGCCGAAGAAACCAATGCTCGGTTTAAATATCTGCTGAG
CCAAGGCCAAACTGGGCTTTCGACGGCCTTCGATATGCCGACGCTCTATGGCCGTGACACCGATCATCCATTGGTCGAGG
GTGAGTTTGGCAAATGTGGCGTGGCCGTCACTTCGTTGGCCGATATGGATATTTTGTTCGATGGCATTCCACTCGATCAA
GTAACCACTTCGATGACGATTAACTCGCCAGCTGCAATTATTTGGGCGATGTATATTGCGGCGGCGGAAAAGCGCGGCAT
TTCACGCGCCAAGTTAGGTGGCACGCTCCAAAACGATATCCTTAAAGAATATGCCGCCCAGAACGAATATATCTTCCCGA
TTGCACCATCAATGCGCTTGGTGGTTGATACGATTGAATTTGCTGCCCAACATATGCCCAAGTGGAATCCAGTCTCGGTC
AGTGGCTATCATATTCGCGAAGCTGGATCTACGGCAGCCCAAGAGCTGGCATTTACGCTCGGCGACGGCATAGCGTATGT
CAAGGCTTGTCTCAAACGTGGCCTGAATATTGATGATTTTGCACCGCGCATTTCCTATTTCTTCAATGCTCACAACGATT
TCTTTGAAGAAATTGCCAAGTATCGCGCGGCGCGTCGGGTTTGGGCACGCCAGATGCGTGATGTGTATGGAGCGAAAAAT
CCTCGTTCGTGGTGGATGCGATTTCACACCCAGACGGCGGGCGTTTCGCTGACTGCCCAACAACCTGAGAACAACATCGT
GCGGGTGGCGATTCAAGCGTTGGCAGCGGTGATCGGCGGTACACAATCATTGCATACCGATGCGATGGATGAAGCCCTAG
CCTTGCCATCGGAAAAAGCTGTGACCATTGCCTTGCGTACCCAACAAATTATTGCTGAAGAAAGCGGCGTGACCAACACG
ATTGATCCGTTGGCTGGCTCGTATTTTGTCGAGGCTTTGACCAACCGCATGGAAGCCGAGTGTCTCGATTACTTCCGCCG
CATCGAGGAGCAAGGCGGCATGGAAGCGGCTTTGGAAAAAGGCTGGATTCAACAGCAAATCGCCGATTCATCCTATCGCT
TCCAACAAGAAGTTGATAGCGGCCAGCGCGGCTTTGTGGGAGTTAACAAATACACCGTCGATGATCCAATTGAAATTCCA
ATTTTGCAAATGGACCCCGATGGTGAGAACAAACACATGGCTCGCCTCAACAAAGTGCGCAACGAACGCGATCAAGTTCG
TTGGGCCGAAGCCATGGATAACCTACGCCAAGCAGCGCAAGGTGAGCACAATCTGATGGAGCCAATTCTGGCGGCGGTCA
ATGCCTATGCCACGTTGGGCGAAATGTGCGATGTATTGCGCGAGGTATTTGGGGTTTATCAAGAAGTGATGATCGTCTAA

Upstream 100 bases:

>100_bases
CCATTTTGACTTTTGACTTCTGCCTTCTGATTTTCTTTGCTACAATGGAAGCATACCGCGTGAAGGTTGAGAATTTTCAT
AACCCAAGGGGGAAACGACG

Downstream 100 bases:

>100_bases
TAAGAACAACGAGCATAGAGCAAAGAACATCGCGCTTTGGAACTTGCTAAGTTTCGAGTATCATAGACATATGATGAACC
TATGCTTAATTATGTTCTAT

Product: methylmalonyl-CoA mutase large subunit

Products: NA

Alternate protein names: MCM [H]

Number of amino acids: Translated: 559; Mature: 559

Protein sequence:

>559_residues
MFSPEQLAQMRAAQERWNDETLAPTLQKTPERPALFSTISSEPIQRLYTPLDIADTDYQKDISFPGEFPYTRGIHPTGYR
GKLWTMRMFAGFGTAEETNARFKYLLSQGQTGLSTAFDMPTLYGRDTDHPLVEGEFGKCGVAVTSLADMDILFDGIPLDQ
VTTSMTINSPAAIIWAMYIAAAEKRGISRAKLGGTLQNDILKEYAAQNEYIFPIAPSMRLVVDTIEFAAQHMPKWNPVSV
SGYHIREAGSTAAQELAFTLGDGIAYVKACLKRGLNIDDFAPRISYFFNAHNDFFEEIAKYRAARRVWARQMRDVYGAKN
PRSWWMRFHTQTAGVSLTAQQPENNIVRVAIQALAAVIGGTQSLHTDAMDEALALPSEKAVTIALRTQQIIAEESGVTNT
IDPLAGSYFVEALTNRMEAECLDYFRRIEEQGGMEAALEKGWIQQQIADSSYRFQQEVDSGQRGFVGVNKYTVDDPIEIP
ILQMDPDGENKHMARLNKVRNERDQVRWAEAMDNLRQAAQGEHNLMEPILAAVNAYATLGEMCDVLREVFGVYQEVMIV

Sequences:

>Translated_559_residues
MFSPEQLAQMRAAQERWNDETLAPTLQKTPERPALFSTISSEPIQRLYTPLDIADTDYQKDISFPGEFPYTRGIHPTGYR
GKLWTMRMFAGFGTAEETNARFKYLLSQGQTGLSTAFDMPTLYGRDTDHPLVEGEFGKCGVAVTSLADMDILFDGIPLDQ
VTTSMTINSPAAIIWAMYIAAAEKRGISRAKLGGTLQNDILKEYAAQNEYIFPIAPSMRLVVDTIEFAAQHMPKWNPVSV
SGYHIREAGSTAAQELAFTLGDGIAYVKACLKRGLNIDDFAPRISYFFNAHNDFFEEIAKYRAARRVWARQMRDVYGAKN
PRSWWMRFHTQTAGVSLTAQQPENNIVRVAIQALAAVIGGTQSLHTDAMDEALALPSEKAVTIALRTQQIIAEESGVTNT
IDPLAGSYFVEALTNRMEAECLDYFRRIEEQGGMEAALEKGWIQQQIADSSYRFQQEVDSGQRGFVGVNKYTVDDPIEIP
ILQMDPDGENKHMARLNKVRNERDQVRWAEAMDNLRQAAQGEHNLMEPILAAVNAYATLGEMCDVLREVFGVYQEVMIV
>Mature_559_residues
MFSPEQLAQMRAAQERWNDETLAPTLQKTPERPALFSTISSEPIQRLYTPLDIADTDYQKDISFPGEFPYTRGIHPTGYR
GKLWTMRMFAGFGTAEETNARFKYLLSQGQTGLSTAFDMPTLYGRDTDHPLVEGEFGKCGVAVTSLADMDILFDGIPLDQ
VTTSMTINSPAAIIWAMYIAAAEKRGISRAKLGGTLQNDILKEYAAQNEYIFPIAPSMRLVVDTIEFAAQHMPKWNPVSV
SGYHIREAGSTAAQELAFTLGDGIAYVKACLKRGLNIDDFAPRISYFFNAHNDFFEEIAKYRAARRVWARQMRDVYGAKN
PRSWWMRFHTQTAGVSLTAQQPENNIVRVAIQALAAVIGGTQSLHTDAMDEALALPSEKAVTIALRTQQIIAEESGVTNT
IDPLAGSYFVEALTNRMEAECLDYFRRIEEQGGMEAALEKGWIQQQIADSSYRFQQEVDSGQRGFVGVNKYTVDDPIEIP
ILQMDPDGENKHMARLNKVRNERDQVRWAEAMDNLRQAAQGEHNLMEPILAAVNAYATLGEMCDVLREVFGVYQEVMIV

Specific function: Catalyzes the interconversion of succinyl-CoA and methylmalonyl-CoA during the polyhydroxyalkanoate degradation pathway [H]

COG id: COG1884

COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 B12-binding domain [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=529, Percent_Identity=44.0453686200378, Blast_Score=453, Evalue=1e-127,
Organism=Escherichia coli, GI1789284, Length=511, Percent_Identity=45.7925636007828, Blast_Score=453, Evalue=1e-128,
Organism=Caenorhabditis elegans, GI25144500, Length=515, Percent_Identity=44.8543689320388, Blast_Score=468, Evalue=1e-132,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006159
- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR006098 [H]

Pfam domain/function: PF02310 B12-binding; PF01642 MM_CoA_mutase [H]

EC number: =5.4.99.2 [H]

Molecular weight: Translated: 62613; Mature: 62613

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSPEQLAQMRAAQERWNDETLAPTLQKTPERPALFSTISSEPIQRLYTPLDIADTDYQK
CCCHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHH
DISFPGEFPYTRGIHPTGYRGKLWTMRMFAGFGTAEETNARFKYLLSQGQTGLSTAFDMP
CCCCCCCCCCCCCCCCCCCCCCCEEHHHHHCCCCCCCCCHHHHHHHHCCCCCCHHHHCCC
TLYGRDTDHPLVEGEFGKCGVAVTSLADMDILFDGIPLDQVTTSMTINSPAAIIWAMYIA
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHCEECCCHHHHHHHHHHH
AAEKRGISRAKLGGTLQNDILKEYAAQNEYIFPIAPSMRLVVDTIEFAAQHMPKWNPVSV
HHHHCCCCHHHHCCHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHCCCCCCCCC
SGYHIREAGSTAAQELAFTLGDGIAYVKACLKRGLNIDDFAPRISYFFNAHNDFFEEIAK
CCEEECCCCCHHHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHH
YRAARRVWARQMRDVYGAKNPRSWWMRFHTQTAGVSLTAQQPENNIVRVAIQALAAVIGG
HHHHHHHHHHHHHHHHCCCCCHHHHHHEEEHHCCEEEEECCCCCHHHHHHHHHHHHHHCC
TQSLHTDAMDEALALPSEKAVTIALRTQQIIAEESGVTNTIDPLAGSYFVEALTNRMEAE
CHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
CLDYFRRIEEQGGMEAALEKGWIQQQIADSSYRFQQEVDSGQRGFVGVNKYTVDDPIEIP
HHHHHHHHHHCCCHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCEEECCCEECCCCCEEE
ILQMDPDGENKHMARLNKVRNERDQVRWAEAMDNLRQAAQGEHNLMEPILAAVNAYATLG
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
EMCDVLREVFGVYQEVMIV
HHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MFSPEQLAQMRAAQERWNDETLAPTLQKTPERPALFSTISSEPIQRLYTPLDIADTDYQK
CCCHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHH
DISFPGEFPYTRGIHPTGYRGKLWTMRMFAGFGTAEETNARFKYLLSQGQTGLSTAFDMP
CCCCCCCCCCCCCCCCCCCCCCCEEHHHHHCCCCCCCCCHHHHHHHHCCCCCCHHHHCCC
TLYGRDTDHPLVEGEFGKCGVAVTSLADMDILFDGIPLDQVTTSMTINSPAAIIWAMYIA
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHCEECCCHHHHHHHHHHH
AAEKRGISRAKLGGTLQNDILKEYAAQNEYIFPIAPSMRLVVDTIEFAAQHMPKWNPVSV
HHHHCCCCHHHHCCHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHCCCCCCCCC
SGYHIREAGSTAAQELAFTLGDGIAYVKACLKRGLNIDDFAPRISYFFNAHNDFFEEIAK
CCEEECCCCCHHHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHH
YRAARRVWARQMRDVYGAKNPRSWWMRFHTQTAGVSLTAQQPENNIVRVAIQALAAVIGG
HHHHHHHHHHHHHHHHCCCCCHHHHHHEEEHHCCEEEEECCCCCHHHHHHHHHHHHHHCC
TQSLHTDAMDEALALPSEKAVTIALRTQQIIAEESGVTNTIDPLAGSYFVEALTNRMEAE
CHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
CLDYFRRIEEQGGMEAALEKGWIQQQIADSSYRFQQEVDSGQRGFVGVNKYTVDDPIEIP
HHHHHHHHHHCCCHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCEEECCCEECCCCCEEE
ILQMDPDGENKHMARLNKVRNERDQVRWAEAMDNLRQAAQGEHNLMEPILAAVNAYATLG
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
EMCDVLREVFGVYQEVMIV
HHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9889346; 11481431 [H]