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The map label for this gene is patB [H]

Identifier: 159899323

GI number: 159899323

Start: 3563709

End: 3564884

Strand: Reverse

Name: patB [H]

Synonym: Haur_2804

Alternate gene names: 159899323

Gene position: 3564884-3563709 (Counterclockwise)

Preceding gene: 159899324

Following gene: 159899318

Centisome position: 56.17

GC content: 51.11

Gene sequence:

>1176_bases
ATGATCACTGCAGATTTCTTTGATCAGGTGATTGATCGAGTTAACACCAATTCGGTAAAGTGGGATATGCGCGAGCAATT
CCTTGGTGGCGCTGATGTGCTGCCTTTATGGGTTGCGGATATGGATTTTCGTTCGCCTCCAGCCGTGACAGAAGCACTGA
TCGAGCGAGCACAACACCCAATTTATGGCTATGCAGCGCGGCCTGAGCGCATGTTCAAAGCCATTCAAACGTGGAATCAA
ACCCGCCATGGTTGGGAAATTCCCCAAGAACAGATTGTGATAAATCCAGGGGTCGTGTTTGCATTAAATGTCGCTGTGCG
GGCGTTTACCCAAGCTGGCGATGGGATTGTCGTTCAGCCACCAGTGTATGCTCCGTTTTATGGTGTAATCAGCGACAATG
GTCGCACGCTGATTGAAAACCGCTTGCTCGAAGTCGATGGTCGCTACCAGATCGATTTTGCTGATCTTGAGGCTAAACTC
GCTCAAGCCAAAATGCTGGTTTTGTGTAGCCCGCACAATCCGGTTGGCCGAGTTTGGAACGCCGATGAGCTGAATCGGAT
TGCCGATTTGTGTTTGCAACATAATGTGATCGTGGTGAGTGACGAAATTCACTGCGATTTGGCTCTATTTGCTGAATTTA
CCCCGCTTGGCCGTTTGCGCCCCGATTTGGCCGACCAGCTAATTACCTTGGCCGCTCCTAGCAAAACCTTCAATTTACCT
GGCCTAACGACTTCGTATGGCGTGATTGCCAACGAGGAGCATCGTCAACGCTACGAAGCCGAAAAAGGCCGTAGCGGCTA
TCATGTTGGCACAGTTTTTGGCGATATTGGCCTAGCGGTGGCTTACGAATCGGGTGCTGAATGGCTCGATGCGCTGCACG
ACTATCTGCGTGAAAACTATCGCCTGATCGAACAAACTTTTGCTGATAATCCATTGGTGCGGCTAACCCCACTCGAAGGC
ACCTACTTGGCTTGGCTCGATTTTCGGGCAACTGGCTGGAGCGAAGAAGAACTAACTGAGCGTTTTCGCACCCATGCCAA
AGTTGGGCCAGAAAAAGGCGGCTTGTATGGCGAGGCTGGCTTGGGCTTTTGGCGGGTCAATTTTGCCACGCCACGCTCAT
TGCTTGCCGAAGGCTTGCGGCGCATGCAATTGGCATTAGCAGAACATAGAACATAG

Upstream 100 bases:

>100_bases
AGTACAATGAGTGCCAACAGAACCTGTGTGCGGCTCAGCGCCGAGTTGTTGCTAGGTTCTCTCGCTGTAGCAGCCAGTTT
GTGGCCGTGAGGGAGCATTC

Downstream 100 bases:

>100_bases
AACCCCCTCAGCCGCCGATCGACAAGAGGGGGAACCGCTCCAGGAGTGCTCCCCTCGCCCGCCGCAATGGGAGAGGGGTT
GGGGGTGAGGGCATGCTGAC

Product: class I and II aminotransferase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 391; Mature: 391

Protein sequence:

>391_residues
MITADFFDQVIDRVNTNSVKWDMREQFLGGADVLPLWVADMDFRSPPAVTEALIERAQHPIYGYAARPERMFKAIQTWNQ
TRHGWEIPQEQIVINPGVVFALNVAVRAFTQAGDGIVVQPPVYAPFYGVISDNGRTLIENRLLEVDGRYQIDFADLEAKL
AQAKMLVLCSPHNPVGRVWNADELNRIADLCLQHNVIVVSDEIHCDLALFAEFTPLGRLRPDLADQLITLAAPSKTFNLP
GLTTSYGVIANEEHRQRYEAEKGRSGYHVGTVFGDIGLAVAYESGAEWLDALHDYLRENYRLIEQTFADNPLVRLTPLEG
TYLAWLDFRATGWSEEELTERFRTHAKVGPEKGGLYGEAGLGFWRVNFATPRSLLAEGLRRMQLALAEHRT

Sequences:

>Translated_391_residues
MITADFFDQVIDRVNTNSVKWDMREQFLGGADVLPLWVADMDFRSPPAVTEALIERAQHPIYGYAARPERMFKAIQTWNQ
TRHGWEIPQEQIVINPGVVFALNVAVRAFTQAGDGIVVQPPVYAPFYGVISDNGRTLIENRLLEVDGRYQIDFADLEAKL
AQAKMLVLCSPHNPVGRVWNADELNRIADLCLQHNVIVVSDEIHCDLALFAEFTPLGRLRPDLADQLITLAAPSKTFNLP
GLTTSYGVIANEEHRQRYEAEKGRSGYHVGTVFGDIGLAVAYESGAEWLDALHDYLRENYRLIEQTFADNPLVRLTPLEG
TYLAWLDFRATGWSEEELTERFRTHAKVGPEKGGLYGEAGLGFWRVNFATPRSLLAEGLRRMQLALAEHRT
>Mature_391_residues
MITADFFDQVIDRVNTNSVKWDMREQFLGGADVLPLWVADMDFRSPPAVTEALIERAQHPIYGYAARPERMFKAIQTWNQ
TRHGWEIPQEQIVINPGVVFALNVAVRAFTQAGDGIVVQPPVYAPFYGVISDNGRTLIENRLLEVDGRYQIDFADLEAKL
AQAKMLVLCSPHNPVGRVWNADELNRIADLCLQHNVIVVSDEIHCDLALFAEFTPLGRLRPDLADQLITLAAPSKTFNLP
GLTTSYGVIANEEHRQRYEAEKGRSGYHVGTVFGDIGLAVAYESGAEWLDALHDYLRENYRLIEQTFADNPLVRLTPLEG
TYLAWLDFRATGWSEEELTERFRTHAKVGPEKGGLYGEAGLGFWRVNFATPRSLLAEGLRRMQLALAEHRT

Specific function: Catalyzes the transformation of cystathionine to homocysteine. Also exhibits cysteine desulfhydrase activity in vitro, producing sulfide from cysteine [H]

COG id: COG1168

COG function: function code E; Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. MalY/PatB cystathionine beta-lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI56713256, Length=182, Percent_Identity=26.3736263736264, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI56713254, Length=182, Percent_Identity=26.3736263736264, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI95147551, Length=172, Percent_Identity=28.4883720930233, Blast_Score=65, Evalue=9e-11,
Organism=Homo sapiens, GI169881279, Length=172, Percent_Identity=28.4883720930233, Blast_Score=65, Evalue=9e-11,
Organism=Escherichia coli, GI1787909, Length=380, Percent_Identity=37.3684210526316, Blast_Score=244, Evalue=8e-66,
Organism=Escherichia coli, GI1788627, Length=200, Percent_Identity=29.5, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1788332, Length=168, Percent_Identity=31.547619047619, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1786816, Length=245, Percent_Identity=22.4489795918367, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1788722, Length=224, Percent_Identity=24.5535714285714, Blast_Score=62, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI71994472, Length=220, Percent_Identity=25, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71994476, Length=174, Percent_Identity=25.8620689655172, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17567369, Length=162, Percent_Identity=26.5432098765432, Blast_Score=66, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6322401, Length=186, Percent_Identity=24.7311827956989, Blast_Score=80, Evalue=6e-16,
Organism=Drosophila melanogaster, GI28573069, Length=219, Percent_Identity=29.6803652968037, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24646114, Length=219, Percent_Identity=29.6803652968037, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI28573067, Length=219, Percent_Identity=29.6803652968037, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI28573065, Length=219, Percent_Identity=29.6803652968037, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 44053; Mature: 44053

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITADFFDQVIDRVNTNSVKWDMREQFLGGADVLPLWVADMDFRSPPAVTEALIERAQHP
CCCHHHHHHHHHHCCCCCEEECHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHCCC
IYGYAARPERMFKAIQTWNQTRHGWEIPQEQIVINPGVVFALNVAVRAFTQAGDGIVVQP
CEEECCCHHHHHHHHHHHHCCCCCCCCCCCCEEECCCEEEEHHHHHHHHHHCCCCEEECC
PVYAPFYGVISDNGRTLIENRLLEVDGRYQIDFADLEAKLAQAKMLVLCSPHNPVGRVWN
CCCCCEEEEEECCCCEEECCCEEEECCCEEEEHHHHHHHHHHCEEEEEECCCCCCCCCCC
ADELNRIADLCLQHNVIVVSDEIHCDLALFAEFTPLGRLRPDLADQLITLAAPSKTFNLP
HHHHHHHHHHHHHCCEEEEECCCCCCHHHHHCCCCCCCCCHHHHHHHEEEECCCCCCCCC
GLTTSYGVIANEEHRQRYEAEKGRSGYHVGTVFGDIGLAVAYESGAEWLDALHDYLRENY
CCCCCCCEEECHHHHHHHHHHCCCCCCEEEEEHHCCCEEEEECCCHHHHHHHHHHHHHHH
RLIEQTFADNPLVRLTPLEGTYLAWLDFRATGWSEEELTERFRTHAKVGPEKGGLYGEAG
HHHHHHHCCCCEEEEECCCCCEEEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCEEECCC
LGFWRVNFATPRSLLAEGLRRMQLALAEHRT
CCEEEEECCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MITADFFDQVIDRVNTNSVKWDMREQFLGGADVLPLWVADMDFRSPPAVTEALIERAQHP
CCCHHHHHHHHHHCCCCCEEECHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHCCC
IYGYAARPERMFKAIQTWNQTRHGWEIPQEQIVINPGVVFALNVAVRAFTQAGDGIVVQP
CEEECCCHHHHHHHHHHHHCCCCCCCCCCCCEEECCCEEEEHHHHHHHHHHCCCCEEECC
PVYAPFYGVISDNGRTLIENRLLEVDGRYQIDFADLEAKLAQAKMLVLCSPHNPVGRVWN
CCCCCEEEEEECCCCEEECCCEEEECCCEEEEHHHHHHHHHHCEEEEEECCCCCCCCCCC
ADELNRIADLCLQHNVIVVSDEIHCDLALFAEFTPLGRLRPDLADQLITLAAPSKTFNLP
HHHHHHHHHHHHHCCEEEEECCCCCCHHHHHCCCCCCCCCHHHHHHHEEEECCCCCCCCC
GLTTSYGVIANEEHRQRYEAEKGRSGYHVGTVFGDIGLAVAYESGAEWLDALHDYLRENY
CCCCCCCEEECHHHHHHHHHHCCCCCCEEEEEHHCCCEEEEECCCHHHHHHHHHHHHHHH
RLIEQTFADNPLVRLTPLEGTYLAWLDFRATGWSEEELTERFRTHAKVGPEKGGLYGEAG
HHHHHHHCCCCEEEEECCCCCEEEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCEEECCC
LGFWRVNFATPRSLLAEGLRRMQLALAEHRT
CCEEEEECCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8497199; 9274030; 9384377 [H]