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The map label for this gene is mprA [H]

Identifier: 159899318

GI number: 159899318

Start: 3558772

End: 3559482

Strand: Reverse

Name: mprA [H]

Synonym: Haur_2799

Alternate gene names: 159899318

Gene position: 3559482-3558772 (Counterclockwise)

Preceding gene: 159899323

Following gene: 159899317

Centisome position: 56.08

GC content: 52.32

Gene sequence:

>711_bases
ATGAGCCAACCGCAAGCTGCTGCACGAATTTTGGTTGTTGAAGATGAAAAAGAAATTGCTGGCTATTTGCGGCGTGGTTT
GGCCTTCGAAGGTTTTACAGTTGAGGTCGCCCATGACGGGCCAACTGGGATTGCCGCCGCTCGTGAACGCCCCGCCGATC
TGGTGATTCTCGATATTATGTTGCCAGGCATGGATGGCTTTGAGGTTTGTCGGCGATTACGGGCTGGCAGCGATGTGCCA
ATTATTATGTTGACCGCCAAAGAAACGGTGCCCGACCGCGTGATGGGCTTAGAAAGTGGCGCAGATGATTATTTGATCAA
GCCGTTTGCCTTTGAAGAATTGTTAGCGCGAATTCGGGCCTTGCTGCGTCGCCATGTAGCCCGCACCGAAGGCCCAGTTG
TCTTGCAAGTCAATGGCTTGGAGATGAACACGGCTTCGCGCGAGGTCACAATTGCAGGCCGCGCTGTCCAACTTACTGCC
AAAGAATACGAATTGCTCGAATTATTTATGCGCCATCCAGGTCAAGTGCTAACCCGCGATGTCATTTATGATCGGGTTTG
GGGCTATGATTTCGGCGGCGAATCGAATATCATTGAGGTCTATGTGCGCTATCTGCGCCAAAAACTCGAAGAATCGGGCG
AAGGCCGCATGCTGCACACCGTGCGTGGAGCTGGCTACATTTTACGTGAACAACCCTACGGTGAACGATGA

Upstream 100 bases:

>100_bases
TCTTGCCAGATTTTCAGCAGAATGTGCTATGCTAGGGGGAATAATTCCGAATCTCACACCCTAGCGGTGTTGTTTATTAT
TCAAAGAAGGAGTGTGCTGC

Downstream 100 bases:

>100_bases
CCCTACGCTATCGGCTAACCTTCATTTCTGTGGCCTTTATGACCCTTGGATTGTTAATTCTAGGGTTGACACTCTATTCG
GCGGAACGGGCGATTTTGCT

Product: two component transcriptional regulator

Products: NA

Alternate protein names: Mycobacterial persistence regulator A [H]

Number of amino acids: Translated: 236; Mature: 235

Protein sequence:

>236_residues
MSQPQAAARILVVEDEKEIAGYLRRGLAFEGFTVEVAHDGPTGIAAARERPADLVILDIMLPGMDGFEVCRRLRAGSDVP
IIMLTAKETVPDRVMGLESGADDYLIKPFAFEELLARIRALLRRHVARTEGPVVLQVNGLEMNTASREVTIAGRAVQLTA
KEYELLELFMRHPGQVLTRDVIYDRVWGYDFGGESNIIEVYVRYLRQKLEESGEGRMLHTVRGAGYILREQPYGER

Sequences:

>Translated_236_residues
MSQPQAAARILVVEDEKEIAGYLRRGLAFEGFTVEVAHDGPTGIAAARERPADLVILDIMLPGMDGFEVCRRLRAGSDVP
IIMLTAKETVPDRVMGLESGADDYLIKPFAFEELLARIRALLRRHVARTEGPVVLQVNGLEMNTASREVTIAGRAVQLTA
KEYELLELFMRHPGQVLTRDVIYDRVWGYDFGGESNIIEVYVRYLRQKLEESGEGRMLHTVRGAGYILREQPYGER
>Mature_235_residues
SQPQAAARILVVEDEKEIAGYLRRGLAFEGFTVEVAHDGPTGIAAARERPADLVILDIMLPGMDGFEVCRRLRAGSDVPI
IMLTAKETVPDRVMGLESGADDYLIKPFAFEELLARIRALLRRHVARTEGPVVLQVNGLEMNTASREVTIAGRAVQLTAK
EYELLELFMRHPGQVLTRDVIYDRVWGYDFGGESNIIEVYVRYLRQKLEESGEGRMLHTVRGAGYILREQPYGER

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a tr

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=232, Percent_Identity=46.9827586206897, Blast_Score=198, Evalue=2e-52,
Organism=Escherichia coli, GI87082012, Length=218, Percent_Identity=40.3669724770642, Blast_Score=187, Evalue=6e-49,
Organism=Escherichia coli, GI1786599, Length=223, Percent_Identity=39.4618834080717, Blast_Score=157, Evalue=8e-40,
Organism=Escherichia coli, GI1789402, Length=224, Percent_Identity=40.1785714285714, Blast_Score=151, Evalue=5e-38,
Organism=Escherichia coli, GI1786911, Length=218, Percent_Identity=38.5321100917431, Blast_Score=142, Evalue=2e-35,
Organism=Escherichia coli, GI2367329, Length=227, Percent_Identity=37.4449339207048, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI1790552, Length=221, Percent_Identity=38.0090497737557, Blast_Score=141, Evalue=4e-35,
Organism=Escherichia coli, GI1789809, Length=231, Percent_Identity=36.7965367965368, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI1790860, Length=222, Percent_Identity=36.4864864864865, Blast_Score=137, Evalue=8e-34,
Organism=Escherichia coli, GI1788394, Length=223, Percent_Identity=33.1838565022422, Blast_Score=131, Evalue=3e-32,
Organism=Escherichia coli, GI1787375, Length=221, Percent_Identity=33.4841628959276, Blast_Score=127, Evalue=4e-31,
Organism=Escherichia coli, GI1787229, Length=229, Percent_Identity=34.061135371179, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI145693140, Length=239, Percent_Identity=32.2175732217573, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI1790863, Length=225, Percent_Identity=31.5555555555556, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1788550, Length=110, Percent_Identity=36.3636363636364, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1790437, Length=127, Percent_Identity=34.6456692913386, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1790299, Length=132, Percent_Identity=31.8181818181818, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1787487, Length=109, Percent_Identity=32.1100917431193, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26488; Mature: 26357

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQPQAAARILVVEDEKEIAGYLRRGLAFEGFTVEVAHDGPTGIAAARERPADLVILDIM
CCCCCHHEEEEEEECCHHHHHHHHHCCEECCEEEEEECCCCCCCHHHCCCCCCEEEEEEE
LPGMDGFEVCRRLRAGSDVPIIMLTAKETVPDRVMGLESGADDYLIKPFAFEELLARIRA
CCCCCHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHCCCCCCCCEECCHHHHHHHHHHHH
LLRRHVARTEGPVVLQVNGLEMNTASREVTIAGRAVQLTAKEYELLELFMRHPGQVLTRD
HHHHHHHCCCCCEEEEECCEEECCCCCEEEEECCEEEEEHHHHHHHHHHHHCCCHHHHHH
VIYDRVWGYDFGGESNIIEVYVRYLRQKLEESGEGRMLHTVRGAGYILREQPYGER
HHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEECCCCCCC
>Mature Secondary Structure 
SQPQAAARILVVEDEKEIAGYLRRGLAFEGFTVEVAHDGPTGIAAARERPADLVILDIM
CCCCHHEEEEEEECCHHHHHHHHHCCEECCEEEEEECCCCCCCHHHCCCCCCEEEEEEE
LPGMDGFEVCRRLRAGSDVPIIMLTAKETVPDRVMGLESGADDYLIKPFAFEELLARIRA
CCCCCHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHCCCCCCCCEECCHHHHHHHHHHHH
LLRRHVARTEGPVVLQVNGLEMNTASREVTIAGRAVQLTAKEYELLELFMRHPGQVLTRD
HHHHHHHCCCCCEEEEECCEEECCCCCEEEEECCEEEEEHHHHHHHHHHHHCCCHHHHHH
VIYDRVWGYDFGGESNIIEVYVRYLRQKLEESGEGRMLHTVRGAGYILREQPYGER
HHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA