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The map label for this gene is purH [H]

Identifier: 159899265

GI number: 159899265

Start: 3500668

End: 3502188

Strand: Reverse

Name: purH [H]

Synonym: Haur_2746

Alternate gene names: 159899265

Gene position: 3502188-3500668 (Counterclockwise)

Preceding gene: 159899268

Following gene: 159899264

Centisome position: 55.18

GC content: 52.66

Gene sequence:

>1521_bases
ATGCGAGCTATTGTCAGTGTTTCAGACAAATCGGGGTTGGCGGATTTTGCTCAGGGCTTGAGCGATTTGGGCATTGAATT
ATTTTCAACTGGCGGTACCAAAGCCGCGTTGGTTGGGGCTGGTGTGCCAGTCCGCAGTGTCAGCGATTTGACGGGCTTTC
CTGAAATTTTGGAAGGTCGGGTCAAAACCTTGCATCCTGGTGTGCATGCTGGCATTTTGGCCCGCCGTGATAAGCCAGCC
CATCTGGCCCAATTGGCTGAGCACCACATCGGCCAGATCGATTTGGTAGTTGTCAATTTGTATCCGTTTGCTCAAACCAT
CGCCAAACCTGATGTTACTTTAGAAGAAGCAGTTGAACAGATTGATATTGGTGGCCCAACGATGGTGCGAGCTTCGGCCA
AAAATCATGCCCATGTCTTGATTGTGATCGATCCTGCTGATTATCCACGGGTTTTGGAAGCCTTGCGGACTGAGCAAATT
ACGCCTGAATTGCGCCGCCAACTTGCTGCCAAAGCCTTTGCCCATACCGCAGCCTACGATAGCGCGATTGCCGCCTACTT
AACCGACGAAACGTTCCCGCAGCAATTGCCCTTGGCCTGGGAATTAGCCCAATCGCTGCGTTATGGCGAGAATCCGCATC
AAGCAGCGGCGTTTTATCGCGCTCCCAATGCTGCCGCCAACACCTTGGCAAAAGCAGTGCAACATCAAGGCAAAGAGCTT
TCCTACAACAACTTGCTTGATGCTGATGCTACCTTGCAAGTAATTCAAAATTTTGATCAGCCAACCGTGGCGATTATCAA
GCACACTAATCCTTGTGGCCTGGCTTCGGCTGAGGATTTGGTGGCGGCCCACAAAGCGGCGCGGGCGGGTGATCCGCTTT
CGGCGTTTGGTGGCATCGTCGGGGTCAATCGCCCCGTCGATCGGGCTTTAGCCAATGTGCTGAAAAAATATTTTTACGAA
GTGATTATTGCCCCATCCTTTAGCCCTGAAGCCTTGACAATTTTGGCCGAAAAGCCCAATTTACGCTTGTTGAGCGTCGA
TACCAGCCGCTCAAGCAGCAACGATTGGGAATATCGCAGTATTGGCGGCGGCATTTTGGCCCAACATGTTGATCGCGTTG
GTAATGATCGCTGGGATGCTTGGCAGGTTGTTACTGAAACTGTGCCCAGCGATGAGCAACTGGCAGCCTTGCAATTTGCT
TGGAAAGCTTGTGCCAGCGTGAAATCGAATGCGATTGTCTTGGTGCAAGGCGAGGAATTGGTGGGGATGGGCGCTGGTCA
GCCTTCACGGGTTGATTCGGTATTGACGGCGATTCGCAAGGCGGGCGAACGGGCCAAGGGTAGCGTGCTAGCTTCCGATG
CCTTCTTCCCCAAAGCCGATGGAATTCAGGCCGCGATTGAAGCTGGCGTGAGCGCAATTGTTCAGCCTGGTGGCTCGCAA
GGTGATGATGAAGTGATTGCTGCTGCTAACGCCGCAGGCATCGCGATGATCTTCACTGCTACTCGCCACTTCAAACACTA
A

Upstream 100 bases:

>100_bases
CAAACGTGGGCAACCACGGGGGAGCCGATTTGCGCAGATGCCGCTCGCCTGGGCAAAGGGCTGTTTAGCCCTATGTACAC
CGCGAATGGAGCTTTGGTTC

Downstream 100 bases:

>100_bases
ATCTATCTACTGGCCAGCGTTGGTCGATGGTCGGCCACGCTGGTCGCTTTTTAGTCGAAAGAATGTGATGTTATGGTCGA
ATTAACCTACGATAGCCAAG

Product: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase

Products: NA

Alternate protein names: Phosphoribosylaminoimidazolecarboxamide formyltransferase; AICAR transformylase; IMP cyclohydrolase; ATIC; IMP synthase; Inosinicase [H]

Number of amino acids: Translated: 506; Mature: 506

Protein sequence:

>506_residues
MRAIVSVSDKSGLADFAQGLSDLGIELFSTGGTKAALVGAGVPVRSVSDLTGFPEILEGRVKTLHPGVHAGILARRDKPA
HLAQLAEHHIGQIDLVVVNLYPFAQTIAKPDVTLEEAVEQIDIGGPTMVRASAKNHAHVLIVIDPADYPRVLEALRTEQI
TPELRRQLAAKAFAHTAAYDSAIAAYLTDETFPQQLPLAWELAQSLRYGENPHQAAAFYRAPNAAANTLAKAVQHQGKEL
SYNNLLDADATLQVIQNFDQPTVAIIKHTNPCGLASAEDLVAAHKAARAGDPLSAFGGIVGVNRPVDRALANVLKKYFYE
VIIAPSFSPEALTILAEKPNLRLLSVDTSRSSSNDWEYRSIGGGILAQHVDRVGNDRWDAWQVVTETVPSDEQLAALQFA
WKACASVKSNAIVLVQGEELVGMGAGQPSRVDSVLTAIRKAGERAKGSVLASDAFFPKADGIQAAIEAGVSAIVQPGGSQ
GDDEVIAAANAAGIAMIFTATRHFKH

Sequences:

>Translated_506_residues
MRAIVSVSDKSGLADFAQGLSDLGIELFSTGGTKAALVGAGVPVRSVSDLTGFPEILEGRVKTLHPGVHAGILARRDKPA
HLAQLAEHHIGQIDLVVVNLYPFAQTIAKPDVTLEEAVEQIDIGGPTMVRASAKNHAHVLIVIDPADYPRVLEALRTEQI
TPELRRQLAAKAFAHTAAYDSAIAAYLTDETFPQQLPLAWELAQSLRYGENPHQAAAFYRAPNAAANTLAKAVQHQGKEL
SYNNLLDADATLQVIQNFDQPTVAIIKHTNPCGLASAEDLVAAHKAARAGDPLSAFGGIVGVNRPVDRALANVLKKYFYE
VIIAPSFSPEALTILAEKPNLRLLSVDTSRSSSNDWEYRSIGGGILAQHVDRVGNDRWDAWQVVTETVPSDEQLAALQFA
WKACASVKSNAIVLVQGEELVGMGAGQPSRVDSVLTAIRKAGERAKGSVLASDAFFPKADGIQAAIEAGVSAIVQPGGSQ
GDDEVIAAANAAGIAMIFTATRHFKH
>Mature_506_residues
MRAIVSVSDKSGLADFAQGLSDLGIELFSTGGTKAALVGAGVPVRSVSDLTGFPEILEGRVKTLHPGVHAGILARRDKPA
HLAQLAEHHIGQIDLVVVNLYPFAQTIAKPDVTLEEAVEQIDIGGPTMVRASAKNHAHVLIVIDPADYPRVLEALRTEQI
TPELRRQLAAKAFAHTAAYDSAIAAYLTDETFPQQLPLAWELAQSLRYGENPHQAAAFYRAPNAAANTLAKAVQHQGKEL
SYNNLLDADATLQVIQNFDQPTVAIIKHTNPCGLASAEDLVAAHKAARAGDPLSAFGGIVGVNRPVDRALANVLKKYFYE
VIIAPSFSPEALTILAEKPNLRLLSVDTSRSSSNDWEYRSIGGGILAQHVDRVGNDRWDAWQVVTETVPSDEQLAALQFA
WKACASVKSNAIVLVQGEELVGMGAGQPSRVDSVLTAIRKAGERAKGSVLASDAFFPKADGIQAAIEAGVSAIVQPGGSQ
GDDEVIAAANAAGIAMIFTATRHFKH

Specific function: De novo purine biosynthesis; ninth step. De novo purine biosynthesis; tenth step. [C]

COG id: COG0138

COG function: function code F; AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purH family [H]

Homologues:

Organism=Homo sapiens, GI20127454, Length=477, Percent_Identity=38.9937106918239, Blast_Score=268, Evalue=1e-71,
Organism=Escherichia coli, GI1790439, Length=524, Percent_Identity=48.8549618320611, Blast_Score=460, Evalue=1e-131,
Organism=Caenorhabditis elegans, GI71985564, Length=474, Percent_Identity=34.5991561181435, Blast_Score=234, Evalue=9e-62,
Organism=Caenorhabditis elegans, GI71985574, Length=306, Percent_Identity=26.1437908496732, Blast_Score=70, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6323056, Length=480, Percent_Identity=36.6666666666667, Blast_Score=250, Evalue=4e-67,
Organism=Saccharomyces cerevisiae, GI6323768, Length=470, Percent_Identity=36.5957446808511, Blast_Score=247, Evalue=3e-66,
Organism=Drosophila melanogaster, GI24649832, Length=474, Percent_Identity=38.6075949367089, Blast_Score=255, Evalue=5e-68,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 640 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002695
- InterPro:   IPR013982
- InterPro:   IPR016193
- InterPro:   IPR011607 [H]

Pfam domain/function: PF01808 AICARFT_IMPCHas; PF02142 MGS [H]

EC number: =2.1.2.3; =3.5.4.10 [H]

Molecular weight: Translated: 53757; Mature: 53757

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAIVSVSDKSGLADFAQGLSDLGIELFSTGGTKAALVGAGVPVRSVSDLTGFPEILEGR
CCEEEEECCCCCHHHHHHHHHHCCCEEECCCCCEEEEEECCCCCCCHHHHCCCHHHHHCH
VKTLHPGVHAGILARRDKPAHLAQLAEHHIGQIDLVVVNLYPFAQTIAKPDVTLEEAVEQ
HHHCCCCHHHHHHCCCCCCHHHHHHHHHCCCEEEEEEEEEHHHHHHHCCCCCCHHHHHHH
IDIGGPTMVRASAKNHAHVLIVIDPADYPRVLEALRTEQITPELRRQLAAKAFAHTAAYD
HCCCCCCEEEECCCCCEEEEEEECCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
SAIAAYLTDETFPQQLPLAWELAQSLRYGENPHQAAAFYRAPNAAANTLAKAVQHQGKEL
HHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCC
SYNNLLDADATLQVIQNFDQPTVAIIKHTNPCGLASAEDLVAAHKAARAGDPLSAFGGIV
CCCCCCCCHHHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHCCCCCHHHHCCCC
GVNRPVDRALANVLKKYFYEVIIAPSFSPEALTILAEKPNLRLLSVDTSRSSSNDWEYRS
CCCCCHHHHHHHHHHHHHHHEEECCCCCCCEEEEEECCCCEEEEEEECCCCCCCCCCHHH
IGGGILAQHVDRVGNDRWDAWQVVTETVPSDEQLAALQFAWKACASVKSNAIVLVQGEEL
CCCHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCE
VGMGAGQPSRVDSVLTAIRKAGERAKGSVLASDAFFPKADGIQAAIEAGVSAIVQPGGSQ
EECCCCCCHHHHHHHHHHHHHCCHHCCCEEECCCCCCCCCCHHHHHHHCHHHEECCCCCC
GDDEVIAAANAAGIAMIFTATRHFKH
CCCCEEEECCCCCEEEEEEHHHHCCC
>Mature Secondary Structure
MRAIVSVSDKSGLADFAQGLSDLGIELFSTGGTKAALVGAGVPVRSVSDLTGFPEILEGR
CCEEEEECCCCCHHHHHHHHHHCCCEEECCCCCEEEEEECCCCCCCHHHHCCCHHHHHCH
VKTLHPGVHAGILARRDKPAHLAQLAEHHIGQIDLVVVNLYPFAQTIAKPDVTLEEAVEQ
HHHCCCCHHHHHHCCCCCCHHHHHHHHHCCCEEEEEEEEEHHHHHHHCCCCCCHHHHHHH
IDIGGPTMVRASAKNHAHVLIVIDPADYPRVLEALRTEQITPELRRQLAAKAFAHTAAYD
HCCCCCCEEEECCCCCEEEEEEECCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
SAIAAYLTDETFPQQLPLAWELAQSLRYGENPHQAAAFYRAPNAAANTLAKAVQHQGKEL
HHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCC
SYNNLLDADATLQVIQNFDQPTVAIIKHTNPCGLASAEDLVAAHKAARAGDPLSAFGGIV
CCCCCCCCHHHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHCCCCCHHHHCCCC
GVNRPVDRALANVLKKYFYEVIIAPSFSPEALTILAEKPNLRLLSVDTSRSSSNDWEYRS
CCCCCHHHHHHHHHHHHHHHEEECCCCCCCEEEEEECCCCEEEEEEECCCCCCCCCCHHH
IGGGILAQHVDRVGNDRWDAWQVVTETVPSDEQLAALQFAWKACASVKSNAIVLVQGEEL
CCCHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCE
VGMGAGQPSRVDSVLTAIRKAGERAKGSVLASDAFFPKADGIQAAIEAGVSAIVQPGGSQ
EECCCCCCHHHHHHHHHHHHHCCHHCCCEEECCCCCCCCCCHHHHHHHCHHHEECCCCCC
GDDEVIAAANAAGIAMIFTATRHFKH
CCCCEEEECCCCCEEEEEEHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA