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The map label for this gene is hisI [H]

Identifier: 159899264

GI number: 159899264

Start: 3499957

End: 3500595

Strand: Reverse

Name: hisI [H]

Synonym: Haur_2745

Alternate gene names: 159899264

Gene position: 3500595-3499957 (Counterclockwise)

Preceding gene: 159899265

Following gene: 159899263

Centisome position: 55.16

GC content: 49.77

Gene sequence:

>639_bases
ATGGTCGAATTAACCTACGATAGCCAAGGCCTGATTCCCGCTGTAGTGCAACATGCCCGCAGTGGTGAGGTATTGATGGT
TGGATATATGAACGCCGAAGCGCTGGCCAAAACCCAAACCAGCGGCTTAGTGACCTTTTGGAGCCGTTCGCGCCAACAGT
TATGGACAAAAGGCGAAACCAGCGGCAATGTGCTGAAATTTATCGCTGCTCGCACCGATTGCGACAATGATGCGTTGTTG
ATTTTGGCTGAGCCAACTGGCCCAACCTGCCATACTGGTTCACGCTCGTGTTTTCATACGACGCTTGATGGCACCAAACG
CGAAGGTAGCGCTGTGCCATTGGCCTTTGTTAGCCAATTGTTTGAATTTTTGCGCGAACGCGAACAAACCCGCCCGATTG
GCTCCTACACCACCTACTTGCTGGAAAAAGGGGTCGATAAAATTGGCAAGAAAATTGGCGAAGAATCAGCTGAAGTAATT
ATTGCCGCCAAAAATGGCAACGCCGACGAATTGCGCAACGAAGCCAGCGATTTAATTTATCACTTGTTTGTATTGTTGCT
CAATCAGGGCGTTTCGCCCGAGGATGTTTGGTTTACCTTGCGCGAACGCCATGGCCGCCAACGTGAGGAAAAACAATAA

Upstream 100 bases:

>100_bases
CACTGCTACTCGCCACTTCAAACACTAAATCTATCTACTGGCCAGCGTTGGTCGATGGTCGGCCACGCTGGTCGCTTTTT
AGTCGAAAGAATGTGATGTT

Downstream 100 bases:

>100_bases
CTATGACTTTTCAACGTCCAGCCAATCTGGCTTCGCTCGAAATTCTGCGGGTGCGCGTCGATGATGTGACCATGGATGAA
ACGATTGAGCTGATTGCGGC

Product: phosphoribosyl-AMP cyclohydrolase

Products: NA

Alternate protein names: Phosphoribosyl-AMP cyclohydrolase; PRA-CH; Phosphoribosyl-ATP pyrophosphatase; PRA-PH [H]

Number of amino acids: Translated: 212; Mature: 212

Protein sequence:

>212_residues
MVELTYDSQGLIPAVVQHARSGEVLMVGYMNAEALAKTQTSGLVTFWSRSRQQLWTKGETSGNVLKFIAARTDCDNDALL
ILAEPTGPTCHTGSRSCFHTTLDGTKREGSAVPLAFVSQLFEFLREREQTRPIGSYTTYLLEKGVDKIGKKIGEESAEVI
IAAKNGNADELRNEASDLIYHLFVLLLNQGVSPEDVWFTLRERHGRQREEKQ

Sequences:

>Translated_212_residues
MVELTYDSQGLIPAVVQHARSGEVLMVGYMNAEALAKTQTSGLVTFWSRSRQQLWTKGETSGNVLKFIAARTDCDNDALL
ILAEPTGPTCHTGSRSCFHTTLDGTKREGSAVPLAFVSQLFEFLREREQTRPIGSYTTYLLEKGVDKIGKKIGEESAEVI
IAAKNGNADELRNEASDLIYHLFVLLLNQGVSPEDVWFTLRERHGRQREEKQ
>Mature_212_residues
MVELTYDSQGLIPAVVQHARSGEVLMVGYMNAEALAKTQTSGLVTFWSRSRQQLWTKGETSGNVLKFIAARTDCDNDALL
ILAEPTGPTCHTGSRSCFHTTLDGTKREGSAVPLAFVSQLFEFLREREQTRPIGSYTTYLLEKGVDKIGKKIGEESAEVI
IAAKNGNADELRNEASDLIYHLFVLLLNQGVSPEDVWFTLRERHGRQREEKQ

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PRA-PH family [H]

Homologues:

Organism=Escherichia coli, GI2367128, Length=197, Percent_Identity=52.2842639593909, Blast_Score=199, Evalue=1e-52,
Organism=Saccharomyces cerevisiae, GI6319819, Length=177, Percent_Identity=34.4632768361582, Blast_Score=80, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023019
- InterPro:   IPR008179
- InterPro:   IPR021130
- InterPro:   IPR002496
- ProDom:   PD002610 [H]

Pfam domain/function: PF01502 PRA-CH; PF01503 PRA-PH [H]

EC number: =3.5.4.19; =3.6.1.31 [H]

Molecular weight: Translated: 23633; Mature: 23633

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVELTYDSQGLIPAVVQHARSGEVLMVGYMNAEALAKTQTSGLVTFWSRSRQQLWTKGET
CEEEEECCCCCHHHHHHHCCCCCEEEEEECCHHHHHHHCCCCCHHHHHHHHHHHHCCCCC
SGNVLKFIAARTDCDNDALLILAEPTGPTCHTGSRSCFHTTLDGTKREGSAVPLAFVSQL
CCHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCHHHHHHH
FEFLREREQTRPIGSYTTYLLEKGVDKIGKKIGEESAEVIIAAKNGNADELRNEASDLIY
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHH
HLFVLLLNQGVSPEDVWFTLRERHGRQREEKQ
HHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MVELTYDSQGLIPAVVQHARSGEVLMVGYMNAEALAKTQTSGLVTFWSRSRQQLWTKGET
CEEEEECCCCCHHHHHHHCCCCCEEEEEECCHHHHHHHCCCCCHHHHHHHHHHHHCCCCC
SGNVLKFIAARTDCDNDALLILAEPTGPTCHTGSRSCFHTTLDGTKREGSAVPLAFVSQL
CCHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCHHHHHHH
FEFLREREQTRPIGSYTTYLLEKGVDKIGKKIGEESAEVIIAAKNGNADELRNEASDLIY
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHH
HLFVLLLNQGVSPEDVWFTLRERHGRQREEKQ
HHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9370271 [H]