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The map label for this gene is pqqL [C]

Identifier: 159899139

GI number: 159899139

Start: 3361935

End: 3363203

Strand: Direct

Name: pqqL [C]

Synonym: Haur_2620

Alternate gene names: 159899139

Gene position: 3361935-3363203 (Clockwise)

Preceding gene: 159899137

Following gene: 159899140

Centisome position: 52.97

GC content: 48.62

Gene sequence:

>1269_bases
ATGGCCCCTGTAAAAGTTGTCTTACCAAATGGCCTGCGAATTTATACCGATGAAATGCCCCATACCCATTCAGTTTCGAT
GGGTATTTTTACCCAAGTTGGCTCGCGCTATGAAAATGCTCGCCTGACGGGAATTTCACATTTTTTGGAGCATATGTTTT
TTAAGGGTACTGCCAAATACCCCACTGCCAAAGACCTTAGCGAGGCAATTGAGGGCATTGGTGGCTATATCAACGCTACT
ACCTCGTATGATACAACCTGTTATTATTGTAAAGTTGCCAATATTCATACCGAACGCGGCATCGATGTGTTAACTGATAT
GCTCAACGCTGCCCTATTCGACCCTAAAGAAATTGAAAAAGAACGCGGCGTGATTCAAGAAGAAATTAAAATGTCGCTCG
ATGTACCCGCTCAATGGGTGCATCAATTGCTCGACGAATTAATGTGGGGCGATCAGCCACTTGGCCGTGATATCGCTGGC
ACGCTCGAAAGTGTTGGAGCCTTTAGCCGCGAAGATTTGTTGAATTACCGCGATCAGCATTATGTTGCAGGTAATACGGT
CATTTCGTTGGCTGGCAACTTTAATAGCACCGAAATTGTTGATCGTCTGACGAGCTTATTTAGCCATTATCGGGTGCTTG
ACGTGCCCAAACCAATTACCACCAATAGTTTTGGCACAGCTCCAGTTGTGCATCTTTTAAATAAACCAACCGAACAAACC
AATTTTGTGTTGGGCCTCAAATCGTTTGGCTATGGCGATAGCGATCGCTGGGCGCTCAGCGTGCTCGATAGCATCCTTGG
TGGCGGTATGTCTTCGCGCTTGTTCCAAGAAATTCGCGAAGAACGCGGCTTGGCCTATAGCGTCGGCTCCTACACCGCCG
AATACGATGACGCTGGCAAATGGATTGTGTATGGCGGGGTTGAAGTCAGCAAGGCAGTCGATGCAATTGCCGCAATTATC
GAAGAACTGCGCAAATTGCGCGATCATGGGGTGACTGCCGCCGAGTTACACCGCATCAAGGAGCAAGTTAAGGGCGGAAT
GCTGCTTGGGCTGGAAGATACTTGGTCGGTGGCCAATCGCAATGCTCGCCACGAACTGCGCTACGGCGAGGTGATTCCGG
TTGAGCAAATTGTGGCTTGGATCGAAGCGGTCACGCTCGAAGATATTCAGCGCGTGGCTCAACGCCTAATTCGCCCAGAT
AACTTATACTTAGCAATCATCGGCCCGCATGCCGAGGCTGCTGAATTTGAACAAGCTATCACGTTATAG

Upstream 100 bases:

>100_bases
AACCCACCAAAATAGCTGTTCCTTGGCACAAAATGCCGTGTTATGATTAACCTAAACCATTGCGAAATGTGATGATTTAA
TCAGGTTTTAGGAGTGTACC

Downstream 100 bases:

>100_bases
CCATTCGCCGCGAGATGCTGGTTGGCAACGCAGCCAACCAGCCGCATATTGCAAGCATAAGGAGAACACCGCGTGAGCCG
TTTTGATGAAATGCGCATTT

Product: peptidase M16 domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 422; Mature: 421

Protein sequence:

>422_residues
MAPVKVVLPNGLRIYTDEMPHTHSVSMGIFTQVGSRYENARLTGISHFLEHMFFKGTAKYPTAKDLSEAIEGIGGYINAT
TSYDTTCYYCKVANIHTERGIDVLTDMLNAALFDPKEIEKERGVIQEEIKMSLDVPAQWVHQLLDELMWGDQPLGRDIAG
TLESVGAFSREDLLNYRDQHYVAGNTVISLAGNFNSTEIVDRLTSLFSHYRVLDVPKPITTNSFGTAPVVHLLNKPTEQT
NFVLGLKSFGYGDSDRWALSVLDSILGGGMSSRLFQEIREERGLAYSVGSYTAEYDDAGKWIVYGGVEVSKAVDAIAAII
EELRKLRDHGVTAAELHRIKEQVKGGMLLGLEDTWSVANRNARHELRYGEVIPVEQIVAWIEAVTLEDIQRVAQRLIRPD
NLYLAIIGPHAEAAEFEQAITL

Sequences:

>Translated_422_residues
MAPVKVVLPNGLRIYTDEMPHTHSVSMGIFTQVGSRYENARLTGISHFLEHMFFKGTAKYPTAKDLSEAIEGIGGYINAT
TSYDTTCYYCKVANIHTERGIDVLTDMLNAALFDPKEIEKERGVIQEEIKMSLDVPAQWVHQLLDELMWGDQPLGRDIAG
TLESVGAFSREDLLNYRDQHYVAGNTVISLAGNFNSTEIVDRLTSLFSHYRVLDVPKPITTNSFGTAPVVHLLNKPTEQT
NFVLGLKSFGYGDSDRWALSVLDSILGGGMSSRLFQEIREERGLAYSVGSYTAEYDDAGKWIVYGGVEVSKAVDAIAAII
EELRKLRDHGVTAAELHRIKEQVKGGMLLGLEDTWSVANRNARHELRYGEVIPVEQIVAWIEAVTLEDIQRVAQRLIRPD
NLYLAIIGPHAEAAEFEQAITL
>Mature_421_residues
APVKVVLPNGLRIYTDEMPHTHSVSMGIFTQVGSRYENARLTGISHFLEHMFFKGTAKYPTAKDLSEAIEGIGGYINATT
SYDTTCYYCKVANIHTERGIDVLTDMLNAALFDPKEIEKERGVIQEEIKMSLDVPAQWVHQLLDELMWGDQPLGRDIAGT
LESVGAFSREDLLNYRDQHYVAGNTVISLAGNFNSTEIVDRLTSLFSHYRVLDVPKPITTNSFGTAPVVHLLNKPTEQTN
FVLGLKSFGYGDSDRWALSVLDSILGGGMSSRLFQEIREERGLAYSVGSYTAEYDDAGKWIVYGGVEVSKAVDAIAAIIE
ELRKLRDHGVTAAELHRIKEQVKGGMLLGLEDTWSVANRNARHELRYGEVIPVEQIVAWIEAVTLEDIQRVAQRLIRPDN
LYLAIIGPHAEAAEFEQAITL

Specific function: Unknown

COG id: COG0612

COG function: function code R; Predicted Zn-dependent peptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M16 family [H]

Homologues:

Organism=Homo sapiens, GI94538354, Length=426, Percent_Identity=29.3427230046948, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI46593007, Length=416, Percent_Identity=25, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI24308013, Length=429, Percent_Identity=23.7762237762238, Blast_Score=109, Evalue=5e-24,
Organism=Homo sapiens, GI155969707, Length=218, Percent_Identity=27.0642201834862, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI1787770, Length=215, Percent_Identity=29.7674418604651, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI2367164, Length=183, Percent_Identity=27.3224043715847, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71999683, Length=415, Percent_Identity=26.5060240963855, Blast_Score=147, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17553678, Length=417, Percent_Identity=23.9808153477218, Blast_Score=112, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI17510601, Length=427, Percent_Identity=23.4192037470726, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17557500, Length=127, Percent_Identity=29.9212598425197, Blast_Score=65, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6323192, Length=398, Percent_Identity=28.643216080402, Blast_Score=170, Evalue=4e-43,
Organism=Saccharomyces cerevisiae, GI6321813, Length=416, Percent_Identity=23.5576923076923, Blast_Score=113, Evalue=5e-26,
Organism=Saccharomyces cerevisiae, GI6323421, Length=174, Percent_Identity=26.4367816091954, Blast_Score=83, Evalue=9e-17,
Organism=Drosophila melanogaster, GI21357875, Length=410, Percent_Identity=27.3170731707317, Blast_Score=161, Evalue=6e-40,
Organism=Drosophila melanogaster, GI24646943, Length=410, Percent_Identity=27.3170731707317, Blast_Score=161, Evalue=6e-40,
Organism=Drosophila melanogaster, GI19921772, Length=429, Percent_Identity=26.3403263403263, Blast_Score=118, Evalue=8e-27,
Organism=Drosophila melanogaster, GI24667786, Length=150, Percent_Identity=29.3333333333333, Blast_Score=82, Evalue=9e-16,
Organism=Drosophila melanogaster, GI24641429, Length=188, Percent_Identity=27.6595744680851, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI221513245, Length=218, Percent_Identity=25.6880733944954, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011249
- InterPro:   IPR011237
- InterPro:   IPR011765
- InterPro:   IPR001431
- InterPro:   IPR007863 [H]

Pfam domain/function: PF00675 Peptidase_M16; PF05193 Peptidase_M16_C [H]

EC number: 3.4.99.- [C]

Molecular weight: Translated: 46977; Mature: 46846

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: PS00143 INSULINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPVKVVLPNGLRIYTDEMPHTHSVSMGIFTQVGSRYENARLTGISHFLEHMFFKGTAKY
CCCEEEECCCCCEEEECCCCCCCCCHHHHHHHHHCHHCCCHHHHHHHHHHHHHHCCCCCC
PTAKDLSEAIEGIGGYINATTSYDTTCYYCKVANIHTERGIDVLTDMLNAALFDPKEIEK
CCHHHHHHHHHHCCCEEECCCCCCCEEEEEEECCCCHHCCHHHHHHHHHHHCCCHHHHHH
ERGVIQEEIKMSLDVPAQWVHQLLDELMWGDQPLGRDIAGTLESVGAFSREDLLNYRDQH
HHCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCHHHHHHHCCCE
YVAGNTVISLAGNFNSTEIVDRLTSLFSHYRVLDVPKPITTNSFGTAPVVHLLNKPTEQT
EEECCEEEEEECCCCHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCHHHHHHHCCCCCCC
NFVLGLKSFGYGDSDRWALSVLDSILGGGMSSRLFQEIREERGLAYSVGSYTAEYDDAGK
EEEEEEHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEECCCCEECCCCCCC
WIVYGGVEVSKAVDAIAAIIEELRKLRDHGVTAAELHRIKEQVKGGMLLGLEDTWSVANR
EEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEECCHHHHHHCC
NARHELRYGEVIPVEQIVAWIEAVTLEDIQRVAQRLIRPDNLYLAIIGPHAEAAEFEQAI
CCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHH
TL
CC
>Mature Secondary Structure 
APVKVVLPNGLRIYTDEMPHTHSVSMGIFTQVGSRYENARLTGISHFLEHMFFKGTAKY
CCEEEECCCCCEEEECCCCCCCCCHHHHHHHHHCHHCCCHHHHHHHHHHHHHHCCCCCC
PTAKDLSEAIEGIGGYINATTSYDTTCYYCKVANIHTERGIDVLTDMLNAALFDPKEIEK
CCHHHHHHHHHHCCCEEECCCCCCCEEEEEEECCCCHHCCHHHHHHHHHHHCCCHHHHHH
ERGVIQEEIKMSLDVPAQWVHQLLDELMWGDQPLGRDIAGTLESVGAFSREDLLNYRDQH
HHCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCHHHHHHHCCCE
YVAGNTVISLAGNFNSTEIVDRLTSLFSHYRVLDVPKPITTNSFGTAPVVHLLNKPTEQT
EEECCEEEEEECCCCHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCHHHHHHHCCCCCCC
NFVLGLKSFGYGDSDRWALSVLDSILGGGMSSRLFQEIREERGLAYSVGSYTAEYDDAGK
EEEEEEHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEECCCCEECCCCCCC
WIVYGGVEVSKAVDAIAAIIEELRKLRDHGVTAAELHRIKEQVKGGMLLGLEDTWSVANR
EEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEECCHHHHHHCC
NARHELRYGEVIPVEQIVAWIEAVTLEDIQRVAQRLIRPDNLYLAIIGPHAEAAEFEQAI
CCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHH
TL
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Endopeptidases of unknown catalytic mechanism [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]