Click here to switch to the map view.

The map label for this gene is prs [H]

Identifier: 159899140

GI number: 159899140

Start: 3363276

End: 3364250

Strand: Direct

Name: prs [H]

Synonym: Haur_2621

Alternate gene names: 159899140

Gene position: 3363276-3364250 (Clockwise)

Preceding gene: 159899139

Following gene: 159899141

Centisome position: 52.99

GC content: 52.21

Gene sequence:

>975_bases
GTGAGCCGTTTTGATGAAATGCGCATTTTTAGTGGAACGGGCAACCCAACCCTAGCGCAGGCGATCAGCTCGTACATTGG
CATTCGCCACGGTGAACTGAGTATCCATACGTTTCCGAATGAAAATATTTTTGTCAAAATCGAAGAAAGCGTCCGCGAAC
AAGATGTGTTCGTGGTGCAATCATTAGGTGCTCCGCTTAACCATTTGATTATGGAAATGTTGATTATGCTCGATGCCTTC
AAACGGGCTTCGGCTGGTCGCATTACCGCTGTGATTCCTTACCTCGCCTATAGCCGCACCGATAAAAAAGACCAACCACG
CGTGCCAATTACTGCCCGTTTGCTGGCCGACCTGATCGTCGCTGCTGGAGCTCAACGGGTGCTGACCCTCGATTTGCATG
CTGGTCAAGTTCAAGGCTTTTTTAGCGTCCCCGTCGATGAAATGAGCACCATGCACCTGCTGACCAACGAGGTCAAATCG
TGGGGCTTGGAAAATGGCATCATCGTCTCACCTGGCTTGGGTTTTGCCAAAAAAGCCCGTAACTTCGCCGAAGCTGTCAA
TATGCCCTTGGCCTTGGTCGAAAAACGTCGAATCAATCACCACGATGGCACGGTTGGTCATTTGGCAATTTTGGGCGATG
TGGCTGATCACGATTGTGTAATCGTCGATGATGAAGTTGCAACTGGCCATACCATGGTGCGGGTTTCCGAGTTGTTGATG
GAACGCGGCGCACGCTCGGTTCGCGCTTGCTGTATCCATCCTTTGCTCTACGGCGATTCAGTTGAGCGGATCAAGCGCAG
CCCAATCGAGCGCTTTGTCACCACAGATACGATCACCTTGCCACCGGAAAAACGCTGGCCAGCCTTGGTGGTCAAGTCAG
TTGCTCCGCTCTTGGGCGAGGTCATTCAGCGTATCCACACTGGGATTTCGGTCGGCGCAATGTTTCCCGCTGGCCCACAA
ATTGGCCGCTGGTAA

Upstream 100 bases:

>100_bases
TGAATTTGAACAAGCTATCACGTTATAGCCATTCGCCGCGAGATGCTGGTTGGCAACGCAGCCAACCAGCCGCATATTGC
AAGCATAAGGAGAACACCGC

Downstream 100 bases:

>100_bases
ATTAATACCCAAATAAGCACCATAACCCGAAGATTTAGCTAAACAGTGCGATCTTCGGGTTGTTTAATCTGGCATAAGGA
TGTTTGGCGATGCTTGATTC

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 324; Mature: 323

Protein sequence:

>324_residues
MSRFDEMRIFSGTGNPTLAQAISSYIGIRHGELSIHTFPNENIFVKIEESVREQDVFVVQSLGAPLNHLIMEMLIMLDAF
KRASAGRITAVIPYLAYSRTDKKDQPRVPITARLLADLIVAAGAQRVLTLDLHAGQVQGFFSVPVDEMSTMHLLTNEVKS
WGLENGIIVSPGLGFAKKARNFAEAVNMPLALVEKRRINHHDGTVGHLAILGDVADHDCVIVDDEVATGHTMVRVSELLM
ERGARSVRACCIHPLLYGDSVERIKRSPIERFVTTDTITLPPEKRWPALVVKSVAPLLGEVIQRIHTGISVGAMFPAGPQ
IGRW

Sequences:

>Translated_324_residues
MSRFDEMRIFSGTGNPTLAQAISSYIGIRHGELSIHTFPNENIFVKIEESVREQDVFVVQSLGAPLNHLIMEMLIMLDAF
KRASAGRITAVIPYLAYSRTDKKDQPRVPITARLLADLIVAAGAQRVLTLDLHAGQVQGFFSVPVDEMSTMHLLTNEVKS
WGLENGIIVSPGLGFAKKARNFAEAVNMPLALVEKRRINHHDGTVGHLAILGDVADHDCVIVDDEVATGHTMVRVSELLM
ERGARSVRACCIHPLLYGDSVERIKRSPIERFVTTDTITLPPEKRWPALVVKSVAPLLGEVIQRIHTGISVGAMFPAGPQ
IGRW
>Mature_323_residues
SRFDEMRIFSGTGNPTLAQAISSYIGIRHGELSIHTFPNENIFVKIEESVREQDVFVVQSLGAPLNHLIMEMLIMLDAFK
RASAGRITAVIPYLAYSRTDKKDQPRVPITARLLADLIVAAGAQRVLTLDLHAGQVQGFFSVPVDEMSTMHLLTNEVKSW
GLENGIIVSPGLGFAKKARNFAEAVNMPLALVEKRRINHHDGTVGHLAILGDVADHDCVIVDDEVATGHTMVRVSELLME
RGARSVRACCIHPLLYGDSVERIKRSPIERFVTTDTITLPPEKRWPALVVKSVAPLLGEVIQRIHTGISVGAMFPAGPQI
GRW

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506127, Length=321, Percent_Identity=37.3831775700935, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI28557709, Length=319, Percent_Identity=37.3040752351097, Blast_Score=215, Evalue=3e-56,
Organism=Homo sapiens, GI4506129, Length=318, Percent_Identity=36.7924528301887, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI84875539, Length=321, Percent_Identity=36.4485981308411, Blast_Score=208, Evalue=5e-54,
Organism=Homo sapiens, GI4506133, Length=342, Percent_Identity=30.1169590643275, Blast_Score=153, Evalue=2e-37,
Organism=Homo sapiens, GI194018537, Length=342, Percent_Identity=29.8245614035088, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI310128524, Length=140, Percent_Identity=27.8571428571429, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI310115209, Length=140, Percent_Identity=27.8571428571429, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI310118259, Length=140, Percent_Identity=27.8571428571429, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI310119946, Length=140, Percent_Identity=27.8571428571429, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1787458, Length=313, Percent_Identity=41.85303514377, Blast_Score=248, Evalue=4e-67,
Organism=Caenorhabditis elegans, GI17554702, Length=324, Percent_Identity=35.1851851851852, Blast_Score=206, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI25149168, Length=320, Percent_Identity=35, Blast_Score=206, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI71989924, Length=324, Percent_Identity=35.1851851851852, Blast_Score=205, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI17554704, Length=318, Percent_Identity=35.2201257861635, Blast_Score=204, Evalue=4e-53,
Organism=Caenorhabditis elegans, GI17570245, Length=337, Percent_Identity=27.893175074184, Blast_Score=149, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6319403, Length=320, Percent_Identity=35.9375, Blast_Score=220, Evalue=3e-58,
Organism=Saccharomyces cerevisiae, GI6321776, Length=305, Percent_Identity=37.7049180327869, Blast_Score=219, Evalue=4e-58,
Organism=Saccharomyces cerevisiae, GI6320946, Length=318, Percent_Identity=35.8490566037736, Blast_Score=216, Evalue=6e-57,
Organism=Saccharomyces cerevisiae, GI6322667, Length=201, Percent_Identity=36.318407960199, Blast_Score=130, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6324511, Length=105, Percent_Identity=39.0476190476191, Blast_Score=83, Evalue=5e-17,
Organism=Drosophila melanogaster, GI21355239, Length=323, Percent_Identity=39.0092879256966, Blast_Score=226, Evalue=2e-59,
Organism=Drosophila melanogaster, GI45551540, Length=346, Percent_Identity=36.4161849710983, Blast_Score=213, Evalue=2e-55,
Organism=Drosophila melanogaster, GI24651458, Length=351, Percent_Identity=29.6296296296296, Blast_Score=154, Evalue=9e-38,
Organism=Drosophila melanogaster, GI24651456, Length=351, Percent_Identity=29.6296296296296, Blast_Score=154, Evalue=9e-38,
Organism=Drosophila melanogaster, GI281362873, Length=351, Percent_Identity=29.6296296296296, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI24651454, Length=351, Percent_Identity=29.6296296296296, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI45552010, Length=187, Percent_Identity=35.8288770053476, Blast_Score=125, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24651462, Length=187, Percent_Identity=35.8288770053476, Blast_Score=125, Evalue=4e-29,
Organism=Drosophila melanogaster, GI24651464, Length=187, Percent_Identity=35.8288770053476, Blast_Score=125, Evalue=4e-29,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 35665; Mature: 35534

Theoretical pI: Translated: 7.42; Mature: 7.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRFDEMRIFSGTGNPTLAQAISSYIGIRHGELSIHTFPNENIFVKIEESVREQDVFVVQ
CCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCEEEEECCCCCEEEEEHHHHCHHHHHHHH
SLGAPLNHLIMEMLIMLDAFKRASAGRITAVIPYLAYSRTDKKDQPRVPITARLLADLIV
HCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHCCCCCCCCCCCCHHHHHHHHHHH
AAGAQRVLTLDLHAGQVQGFFSVPVDEMSTMHLLTNEVKSWGLENGIIVSPGLGFAKKAR
HCCCCEEEEEEECCCCCCCEEECCHHHHHHHHHHHHHHHHCCCCCCEEECCCCCHHHHHH
NFAEAVNMPLALVEKRRINHHDGTVGHLAILGDVADHDCVIVDDEVATGHTMVRVSELLM
HHHHHHCCCHHHHHHHHCCCCCCCEEEEEEEECCCCCCEEEEECCCCCCHHHHHHHHHHH
ERGARSVRACCIHPLLYGDSVERIKRSPIERFVTTDTITLPPEKRWPALVVKSVAPLLGE
HHCCHHHHHHHHHHHHCCCHHHHHHHCHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHHH
VIQRIHTGISVGAMFPAGPQIGRW
HHHHHHCCCEECCCCCCCCCCCCC
>Mature Secondary Structure 
SRFDEMRIFSGTGNPTLAQAISSYIGIRHGELSIHTFPNENIFVKIEESVREQDVFVVQ
CCCCCEEEEECCCCHHHHHHHHHHHCCCCCCEEEEECCCCCEEEEEHHHHCHHHHHHHH
SLGAPLNHLIMEMLIMLDAFKRASAGRITAVIPYLAYSRTDKKDQPRVPITARLLADLIV
HCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHCCCCCCCCCCCCHHHHHHHHHHH
AAGAQRVLTLDLHAGQVQGFFSVPVDEMSTMHLLTNEVKSWGLENGIIVSPGLGFAKKAR
HCCCCEEEEEEECCCCCCCEEECCHHHHHHHHHHHHHHHHCCCCCCEEECCCCCHHHHHH
NFAEAVNMPLALVEKRRINHHDGTVGHLAILGDVADHDCVIVDDEVATGHTMVRVSELLM
HHHHHHCCCHHHHHHHHCCCCCCCEEEEEEEECCCCCCEEEEECCCCCCHHHHHHHHHHH
ERGARSVRACCIHPLLYGDSVERIKRSPIERFVTTDTITLPPEKRWPALVVKSVAPLLGE
HHCCHHHHHHHHHHHHCCCHHHHHHHCHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHHH
VIQRIHTGISVGAMFPAGPQIGRW
HHHHHHCCCEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]