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The map label for this gene is dltE [H]

Identifier: 159898529

GI number: 159898529

Start: 2484225

End: 2485019

Strand: Direct

Name: dltE [H]

Synonym: Haur_2005

Alternate gene names: 159898529

Gene position: 2484225-2485019 (Clockwise)

Preceding gene: 159898528

Following gene: 159898530

Centisome position: 39.14

GC content: 51.19

Gene sequence:

>795_bases
ATGAAACTTTCAGCAAACACAATCCTCATCACGGGTGGAACAAGCGGTATCGGCTTGGAACTCGCCAAGCAACTCCACCA
ACGACAGAATACCATTCTCGTGACCGGACGAGATCCCAATAAACTCCGAGCCATCCACGAACATATCCCAAGGGTACAGA
CCTATCAAAGCGATGTCAGTGACCCGGCGGCAATTGCCGCACTCTACGAACGGGTAACGAACGAGTTTCCTGATCTAAAT
ATGCTGATCAATAACGCTGGCGTGATGCGGACGTTGCGGCTAAACGGGCGGATTGGCTTACAGGACATTGGCCGTGAGAT
TGAGGTCGATCTGCTTAGACCAGTGCGCATGATCGAGCAATTCTTGCCGTTTCTCAAAACAAAGCCCCATGCCACCATCA
TCAATACCTCATCATTGCTCGCGTTTGTCCCCCTCGCCAGTTCGCCTATTTACAGCGCAGCAAAGGCCGGCTTGCATTCC
TATACCCAATCTCTTCGCATCCAACTGCACGATACGAATGTCACAGTGATTGAACTGGCTCCGCCTGCCACCACCACCCC
ATTGCTGGAGAACTTGGGTTCCGACTCCCTCAATAGCAAGAATCCAATCGTGATGAATGTTGAAAAAATGGTACGGGTAG
CCCTGGAGCAACTTGAACACGACACCGCCGAAATTCGGCCAGGCATGAGCAACATCATGAAGCTGATGAGCCGTTTTGCA
CCAACCTTTATGCTGAAGCAGGTGAACAAGTCCATCACCAGTGACTTGGCAAAAGCCAACCTAGGCGAGGAATAG

Upstream 100 bases:

>100_bases
TATGCGTTCTCGACTCATTTTTTGAAGGTACGGCTGCATCTTTAACCATACATCACAGTGATTGCGCATGATCGCTGCAT
ATATAAAGGCAAAGGGTCTC

Downstream 100 bases:

>100_bases
TGACACGTATATCTTGAACGAACACGGCTTGATTCTGATAAATCTGTGGCAATGGATCAAGTGGATGGGCATCGTTTCGT
TTGGTCATCCGCTTGATCCA

Product: short-chain dehydrogenase/reductase SDR

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 264; Mature: 264

Protein sequence:

>264_residues
MKLSANTILITGGTSGIGLELAKQLHQRQNTILVTGRDPNKLRAIHEHIPRVQTYQSDVSDPAAIAALYERVTNEFPDLN
MLINNAGVMRTLRLNGRIGLQDIGREIEVDLLRPVRMIEQFLPFLKTKPHATIINTSSLLAFVPLASSPIYSAAKAGLHS
YTQSLRIQLHDTNVTVIELAPPATTTPLLENLGSDSLNSKNPIVMNVEKMVRVALEQLEHDTAEIRPGMSNIMKLMSRFA
PTFMLKQVNKSITSDLAKANLGEE

Sequences:

>Translated_264_residues
MKLSANTILITGGTSGIGLELAKQLHQRQNTILVTGRDPNKLRAIHEHIPRVQTYQSDVSDPAAIAALYERVTNEFPDLN
MLINNAGVMRTLRLNGRIGLQDIGREIEVDLLRPVRMIEQFLPFLKTKPHATIINTSSLLAFVPLASSPIYSAAKAGLHS
YTQSLRIQLHDTNVTVIELAPPATTTPLLENLGSDSLNSKNPIVMNVEKMVRVALEQLEHDTAEIRPGMSNIMKLMSRFA
PTFMLKQVNKSITSDLAKANLGEE
>Mature_264_residues
MKLSANTILITGGTSGIGLELAKQLHQRQNTILVTGRDPNKLRAIHEHIPRVQTYQSDVSDPAAIAALYERVTNEFPDLN
MLINNAGVMRTLRLNGRIGLQDIGREIEVDLLRPVRMIEQFLPFLKTKPHATIINTSSLLAFVPLASSPIYSAAKAGLHS
YTQSLRIQLHDTNVTVIELAPPATTTPLLENLGSDSLNSKNPIVMNVEKMVRVALEQLEHDTAEIRPGMSNIMKLMSRFA
PTFMLKQVNKSITSDLAKANLGEE

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG3967

COG function: function code M; Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI7657478, Length=194, Percent_Identity=28.8659793814433, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI223718074, Length=191, Percent_Identity=28.2722513089005, Blast_Score=68, Evalue=7e-12,
Organism=Escherichia coli, GI1787335, Length=196, Percent_Identity=28.0612244897959, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1787820, Length=175, Percent_Identity=27.4285714285714, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI87082100, Length=207, Percent_Identity=26.0869565217391, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17559964, Length=212, Percent_Identity=27.8301886792453, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI72001658, Length=223, Percent_Identity=26.457399103139, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17563726, Length=203, Percent_Identity=25.615763546798, Blast_Score=64, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6323882, Length=189, Percent_Identity=28.042328042328, Blast_Score=80, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6322067, Length=265, Percent_Identity=27.1698113207547, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI221331218, Length=202, Percent_Identity=24.7524752475248, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24665243, Length=202, Percent_Identity=24.7524752475248, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24643142, Length=197, Percent_Identity=30.4568527918782, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21355631, Length=183, Percent_Identity=26.2295081967213, Blast_Score=71, Evalue=8e-13,
Organism=Drosophila melanogaster, GI23397609, Length=201, Percent_Identity=27.363184079602, Blast_Score=71, Evalue=8e-13,
Organism=Drosophila melanogaster, GI221331216, Length=203, Percent_Identity=24.6305418719212, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24665247, Length=203, Percent_Identity=24.6305418719212, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI281364892, Length=196, Percent_Identity=26.530612244898, Blast_Score=68, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24651139, Length=192, Percent_Identity=27.0833333333333, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 29135; Mature: 29135

Theoretical pI: Translated: 9.40; Mature: 9.40

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLSANTILITGGTSGIGLELAKQLHQRQNTILVTGRDPNKLRAIHEHIPRVQTYQSDVS
CCCCCCEEEEECCCCCCHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHCCHHHHHHHCCC
DPAAIAALYERVTNEFPDLNMLINNAGVMRTLRLNGRIGLQDIGREIEVDLLRPVRMIEQ
CHHHHHHHHHHHHHCCCCHHEEECCCCEEEEEEECCCCCHHHHCCHHHHHHHHHHHHHHH
FLPFLKTKPHATIINTSSLLAFVPLASSPIYSAAKAGLHSYTQSLRIQLHDTNVTVIELA
HHHHHHCCCCEEEEECHHHHHHHCCCCCCHHHHHHHHHHHHHHHEEEEEECCCEEEEEEC
PPATTTPLLENLGSDSLNSKNPIVMNVEKMVRVALEQLEHDTAEIRPGMSNIMKLMSRFA
CCCCCHHHHHHCCCCCCCCCCCEEEEHHHHHHHHHHHHHCHHHHHCCCHHHHHHHHHHHH
PTFMLKQVNKSITSDLAKANLGEE
HHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKLSANTILITGGTSGIGLELAKQLHQRQNTILVTGRDPNKLRAIHEHIPRVQTYQSDVS
CCCCCCEEEEECCCCCCHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHCCHHHHHHHCCC
DPAAIAALYERVTNEFPDLNMLINNAGVMRTLRLNGRIGLQDIGREIEVDLLRPVRMIEQ
CHHHHHHHHHHHHHCCCCHHEEECCCCEEEEEEECCCCCHHHHCCHHHHHHHHHHHHHHH
FLPFLKTKPHATIINTSSLLAFVPLASSPIYSAAKAGLHSYTQSLRIQLHDTNVTVIELA
HHHHHHCCCCEEEEECHHHHHHHCCCCCCHHHHHHHHHHHHHHHEEEEEECCCEEEEEEC
PPATTTPLLENLGSDSLNSKNPIVMNVEKMVRVALEQLEHDTAEIRPGMSNIMKLMSRFA
CCCCCHHHHHHCCCCCCCCCCCEEEEHHHHHHHHHHHHHCHHHHHCCCHHHHHHHHHHHH
PTFMLKQVNKSITSDLAKANLGEE
HHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7934828; 9384377; 7797557 [H]