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The map label for this gene is ethA [H]

Identifier: 159898492

GI number: 159898492

Start: 2412152

End: 2413609

Strand: Direct

Name: ethA [H]

Synonym: Haur_1968

Alternate gene names: 159898492

Gene position: 2412152-2413609 (Clockwise)

Preceding gene: 159898490

Following gene: 159898495

Centisome position: 38.01

GC content: 51.85

Gene sequence:

>1458_bases
ATGCAAGCGATCGATCTTGATGTGCTGATTGTGGGCGCTGGTTTGTCGGGCATTAGTGCAGCCTATTATCTGCAAACCCG
CTGCCCACACAAACGCTATACGATTCTCGAAGGCCGCAAGGCGATTGGCGGTACATGGGATCTGTTTCGCTACCCCGGCA
TTCGCTCGGATTCGGATATGTACACGCTGGGCTATGCTTTTCGCCCGTGGCATAGCTCGCAGGCAATCGCCGATGGTGCG
TCAATTTTGCAGTATATTCATGAAACGGCCCAAATCTATGGCATCGATCAACAAATTAACTTTGAACATATGGTTCGCCG
GATCAGTTGGTCATCGAAGCAGGCGCTCTGGACGGTTGAAGTTGAGCGCTTGGCCGAGGGCGATTGGGTGCAATATCGCT
GTAATTTTTTGTATATGTGCGGCGGCTATTACGATTACGCCCAAGGCTACACCCCTGAATGGCCGAGCTTGAGCCAATTT
CAAGGGCGGGTGGTGCATCCCCAAGCTTGGCCGCAAAATCTCGATTATCGCGATCAACGGGTGGTAGTGATTGGTAGCGG
TGCGACGGCAATTACCTTAGTGCCAGCCATGGCTGAGCAAGCGCACCATGTGACGATGTTGCAACGTTCGCCAACCTATG
TCGTGGCCCAACCTGCCAGTGATGCTCGTGCCGAGCAGTTGCGGCGTTGGTTGCCTGCCAAATTGGCCTTTCACGTGATC
CGCTGGCGAGCAATTATTCAAGGTATTATCTATTATTTATTGATGCGAACGCTGCCCAAAGTTGCCAAACGCGCCTTGGT
GAACATGGCGCAGCAAGAACTTGGCGATAGCTATGATGCCAACATCCACTTTAGCCCAAGCTATAACCCGTGGGATCAGC
GACTCTGTTTAGCGCCCGATGGTGATTTTTTCAAGGCGCTCAAATCGGGCCAAGCCAGCGTTATAACTGACCAAATTGCT
CAATTCACCGCTACAGGTATTCAACTGCAATCGGGCCAGCATTTGGCGGCTGATCTGATTGTCACGGCAACGGGCTTGAA
TTTGCGCTTGCTCAGCGGAATTGAAATTGTGGTTGATGGGCGCACGGTTGAATTGGGCACAACTCTGAATTACAAAGGCA
TGATGCTCAGCGATGTGCCTAATCTGGCCTTGGCGTTTGGCTATACCAACGCTTCGTGGACGCTCAAATGCGAACTAACC
TCGATGTATGTCTGCCGCTTGCTGAATTATATGGATCGCCATGGCTATGTCAGTTGTATGCCCAAGAATTTTAACCCCAC
CATGGCGACCGAGCCAGCGCTTAGTTTCACCTCAAGCTATGTTCAACGGGTGATCAAGCATTTGCCCCGTCAAGGTCGCC
AACGCCCATGGCGGCTCTACCAAAACTACCTGCTCGATTTGCTGATGTTGCGGCTTGGCTCGCTCGATGATGGCAATATG
GAGTTTTTTCGCGCTTGA

Upstream 100 bases:

>100_bases
CATGGACGATTATACCGATCTTTCATAATTGTGCAACTTAACCATTAACACTCTTATACACTTGCTATAATGAGCCATTG
ACTTGGTTATGAGGTGAGCG

Downstream 100 bases:

>100_bases
CCTAGCCAACGCCAAGTTGAGTAACCTAATCATTGGTTTGCAGGGCTGTGCGATAGGCTGCCAAGGCGCGTTCACGGGCA
AAACTATGCTCAACTAGCGG

Product: FAD dependent oxidoreductase

Products: NA

Alternate protein names: Baeyer-Villiger monooxygenase; BVMO [H]

Number of amino acids: Translated: 485; Mature: 485

Protein sequence:

>485_residues
MQAIDLDVLIVGAGLSGISAAYYLQTRCPHKRYTILEGRKAIGGTWDLFRYPGIRSDSDMYTLGYAFRPWHSSQAIADGA
SILQYIHETAQIYGIDQQINFEHMVRRISWSSKQALWTVEVERLAEGDWVQYRCNFLYMCGGYYDYAQGYTPEWPSLSQF
QGRVVHPQAWPQNLDYRDQRVVVIGSGATAITLVPAMAEQAHHVTMLQRSPTYVVAQPASDARAEQLRRWLPAKLAFHVI
RWRAIIQGIIYYLLMRTLPKVAKRALVNMAQQELGDSYDANIHFSPSYNPWDQRLCLAPDGDFFKALKSGQASVITDQIA
QFTATGIQLQSGQHLAADLIVTATGLNLRLLSGIEIVVDGRTVELGTTLNYKGMMLSDVPNLALAFGYTNASWTLKCELT
SMYVCRLLNYMDRHGYVSCMPKNFNPTMATEPALSFTSSYVQRVIKHLPRQGRQRPWRLYQNYLLDLLMLRLGSLDDGNM
EFFRA

Sequences:

>Translated_485_residues
MQAIDLDVLIVGAGLSGISAAYYLQTRCPHKRYTILEGRKAIGGTWDLFRYPGIRSDSDMYTLGYAFRPWHSSQAIADGA
SILQYIHETAQIYGIDQQINFEHMVRRISWSSKQALWTVEVERLAEGDWVQYRCNFLYMCGGYYDYAQGYTPEWPSLSQF
QGRVVHPQAWPQNLDYRDQRVVVIGSGATAITLVPAMAEQAHHVTMLQRSPTYVVAQPASDARAEQLRRWLPAKLAFHVI
RWRAIIQGIIYYLLMRTLPKVAKRALVNMAQQELGDSYDANIHFSPSYNPWDQRLCLAPDGDFFKALKSGQASVITDQIA
QFTATGIQLQSGQHLAADLIVTATGLNLRLLSGIEIVVDGRTVELGTTLNYKGMMLSDVPNLALAFGYTNASWTLKCELT
SMYVCRLLNYMDRHGYVSCMPKNFNPTMATEPALSFTSSYVQRVIKHLPRQGRQRPWRLYQNYLLDLLMLRLGSLDDGNM
EFFRA
>Mature_485_residues
MQAIDLDVLIVGAGLSGISAAYYLQTRCPHKRYTILEGRKAIGGTWDLFRYPGIRSDSDMYTLGYAFRPWHSSQAIADGA
SILQYIHETAQIYGIDQQINFEHMVRRISWSSKQALWTVEVERLAEGDWVQYRCNFLYMCGGYYDYAQGYTPEWPSLSQF
QGRVVHPQAWPQNLDYRDQRVVVIGSGATAITLVPAMAEQAHHVTMLQRSPTYVVAQPASDARAEQLRRWLPAKLAFHVI
RWRAIIQGIIYYLLMRTLPKVAKRALVNMAQQELGDSYDANIHFSPSYNPWDQRLCLAPDGDFFKALKSGQASVITDQIA
QFTATGIQLQSGQHLAADLIVTATGLNLRLLSGIEIVVDGRTVELGTTLNYKGMMLSDVPNLALAFGYTNASWTLKCELT
SMYVCRLLNYMDRHGYVSCMPKNFNPTMATEPALSFTSSYVQRVIKHLPRQGRQRPWRLYQNYLLDLLMLRLGSLDDGNM
EFFRA

Specific function: Catalyzes the activation of thiocarbamide-containing drugs such as ethionamide (ETH), isoxyl (ISO) and thiacetazone (TAC) into reactive species [H]

COG id: COG2072

COG function: function code P; Predicted flavoprotein involved in K+ transport

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-binding monooxygenase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006076
- InterPro:   IPR020946 [H]

Pfam domain/function: PF01266 DAO; PF00743 FMO-like [H]

EC number: NA

Molecular weight: Translated: 55062; Mature: 55062

Theoretical pI: Translated: 8.56; Mature: 8.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQAIDLDVLIVGAGLSGISAAYYLQTRCPHKRYTILEGRKAIGGTWDLFRYPGIRSDSDM
CCEEEEEEEEEECCCCHHHHEEEEECCCCCCCEEEECCCCCCCCCCHHHCCCCCCCCCCE
YTLGYAFRPWHSSQAIADGASILQYIHETAQIYGIDQQINFEHMVRRISWSSKQALWTVE
EEEEEEECCCCCCCHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHCCCCCCEEEEEE
VERLAEGDWVQYRCNFLYMCGGYYDYAQGYTPEWPSLSQFQGRVVHPQAWPQNLDYRDQR
HHHHCCCCEEEEEEEEEEEECCEEHHHCCCCCCCCCHHHHCCEEECCCCCCCCCCCCCCE
VVVIGSGATAITLVPAMAEQAHHVTMLQRSPTYVVAQPASDARAEQLRRWLPAKLAFHVI
EEEEECCCCEEEEEHHHHHHHHHEEEEECCCCEEEECCCCHHHHHHHHHHCCHHHHHHHH
RWRAIIQGIIYYLLMRTLPKVAKRALVNMAQQELGDSYDANIHFSPSYNPWDQRLCLAPD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCHHHCEEEECCC
GDFFKALKSGQASVITDQIAQFTATGIQLQSGQHLAADLIVTATGLNLRLLSGIEIVVDG
CHHHHHHHCCCCHHHHHHHHHHHHCCEEEECCCCEEEEEEEEECCCCEEEECCEEEEECC
RTVELGTTLNYKGMMLSDVPNLALAFGYTNASWTLKCELTSMYVCRLLNYMDRHGYVSCM
EEEEECCEECCCCEEECCCCCEEEEEECCCCCEEEEEEHHHHHHHHHHHHHHCCCEEEEE
PKNFNPTMATEPALSFTSSYVQRVIKHLPRQGRQRPWRLYQNYLLDLLMLRLGSLDDGNM
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCE
EFFRA
EEEEC
>Mature Secondary Structure
MQAIDLDVLIVGAGLSGISAAYYLQTRCPHKRYTILEGRKAIGGTWDLFRYPGIRSDSDM
CCEEEEEEEEEECCCCHHHHEEEEECCCCCCCEEEECCCCCCCCCCHHHCCCCCCCCCCE
YTLGYAFRPWHSSQAIADGASILQYIHETAQIYGIDQQINFEHMVRRISWSSKQALWTVE
EEEEEEECCCCCCCHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHCCCCCCEEEEEE
VERLAEGDWVQYRCNFLYMCGGYYDYAQGYTPEWPSLSQFQGRVVHPQAWPQNLDYRDQR
HHHHCCCCEEEEEEEEEEEECCEEHHHCCCCCCCCCHHHHCCEEECCCCCCCCCCCCCCE
VVVIGSGATAITLVPAMAEQAHHVTMLQRSPTYVVAQPASDARAEQLRRWLPAKLAFHVI
EEEEECCCCEEEEEHHHHHHHHHEEEEECCCCEEEECCCCHHHHHHHHHHCCHHHHHHHH
RWRAIIQGIIYYLLMRTLPKVAKRALVNMAQQELGDSYDANIHFSPSYNPWDQRLCLAPD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCHHHCEEEECCC
GDFFKALKSGQASVITDQIAQFTATGIQLQSGQHLAADLIVTATGLNLRLLSGIEIVVDG
CHHHHHHHCCCCHHHHHHHHHHHHCCEEEECCCCEEEEEEEEECCCCEEEECCEEEEECC
RTVELGTTLNYKGMMLSDVPNLALAFGYTNASWTLKCELTSMYVCRLLNYMDRHGYVSCM
EEEEECCEECCCCEEECCCCCEEEEEECCCCCEEEEEEHHHHHHHHHHHHHHCCCEEEEE
PKNFNPTMATEPALSFTSSYVQRVIKHLPRQGRQRPWRLYQNYLLDLLMLRLGSLDDGNM
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCE
EFFRA
EEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]