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The map label for this gene is icd [H]

Identifier: 159896666

GI number: 159896666

Start: 164250

End: 165329

Strand: Direct

Name: icd [H]

Synonym: Haur_0133

Alternate gene names: 159896666

Gene position: 164250-165329 (Clockwise)

Preceding gene: 159896665

Following gene: 159896667

Centisome position: 2.59

GC content: 52.41

Gene sequence:

>1080_bases
ATGAGTAAGCCAACGATTGTTGTCCTTGAGGGCGATCAAACGGGGCAAGAACTGCTTGAAGAAAGTCTGCGCGTCCTTGA
TCCTGCGGTGACGGGCGTTGATATAGAGCTAAAGCGCTACGATTTGAGCCTCGAATCGCGCCGAGCGACCAATAATCAAA
TTGTGTTGGAAGCAGCTCAAGCCATGAAGGAAGCTGGTTTTGGCTTGAAAGCCGCTACAATCACTCCTGAAAAAGCTGGC
GATGTTGGTAGCCCTAACGCTATTCTGCGCGAACAAATCAATGGTACGGTGATTGTACGAACGGGCCGCCGGATTCCAGG
CGTGCGCCCAGTTGGTGGTGCGTATGCGCCAATCTCGGTCATTCGCATGGCGGTTGACGATGCCTATGGTGCCAAAGAAT
GGCGCGAAGGCGAAGGCGATAATGAAGTTGCTTATCGCACCGAGAAAATCACCCGTGGCACGTGCCGCGCCGTTTCAGAA
TATGCCTTTATGCATGCTCGTCGCATGAAAGCCAAAGTTTTCGGTGGCCCCAAATATACGGTTAGCCCAATTTATGAAGG
CATGCTTAAGGAAGAAATGGATGCAGCCGCCAAGCGCTATGCCGATGTACGCTACGAACCACAGTTGATCGATGCGACCT
ATGCTTTGCTCTTGACCAACTCGGGCGATCCAATGGTGATTCCTGCGCTCAACCGCGACGGCGACTGCTTGAGCGACTTG
GTATTGCAAATGTTCGGCACGATTGCTGGCGCAGAATCATTGCTCTTGGCCTTCGACAAAGATTTCAAAGTTAATGTTGT
GATGGCTGAAGCACCCCACGGCACGGCTCCCAGCTTGGAAGGCAAGAATGTTGCTAATCCAATGGCGATGATTTTGGCTT
CGGCAGCCTTGCTTGATTATATTGATACACCGCAAGCCAACATGGCAGCCCGCGCGATCAGCGAAGCTACCTTGGAAGCT
GTCTACGACGGCGTGCGTACTGCCGATTTGGGTGGCCACACCACCACCAGCGATTTCACCGACGAAGTGATTCGCCGCGT
AAAAACCAAAATGGAAGTTTGGCCATCGCTCGGTAACTAA

Upstream 100 bases:

>100_bases
CAATTCCTATGTTCTATGGAGCTTTTGACAGTAGTGGCACAGACTTGTATCCTTAGGTGAAACAAAGTTTTGCACCAAAA
CCTATAAGGAGTTAAGTTAA

Downstream 100 bases:

>100_bases
ATCTAAACCGCTCGCTGCAAGAAATTGTGGCCAACTTGCACATTAGAAAGCACACTGCAACGGCGGAGTGTGCTTTTGTA
TTATTCGGGAATCAGGTGTT

Product: isocitrate/isopropylmalate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 359; Mature: 358

Protein sequence:

>359_residues
MSKPTIVVLEGDQTGQELLEESLRVLDPAVTGVDIELKRYDLSLESRRATNNQIVLEAAQAMKEAGFGLKAATITPEKAG
DVGSPNAILREQINGTVIVRTGRRIPGVRPVGGAYAPISVIRMAVDDAYGAKEWREGEGDNEVAYRTEKITRGTCRAVSE
YAFMHARRMKAKVFGGPKYTVSPIYEGMLKEEMDAAAKRYADVRYEPQLIDATYALLLTNSGDPMVIPALNRDGDCLSDL
VLQMFGTIAGAESLLLAFDKDFKVNVVMAEAPHGTAPSLEGKNVANPMAMILASAALLDYIDTPQANMAARAISEATLEA
VYDGVRTADLGGHTTTSDFTDEVIRRVKTKMEVWPSLGN

Sequences:

>Translated_359_residues
MSKPTIVVLEGDQTGQELLEESLRVLDPAVTGVDIELKRYDLSLESRRATNNQIVLEAAQAMKEAGFGLKAATITPEKAG
DVGSPNAILREQINGTVIVRTGRRIPGVRPVGGAYAPISVIRMAVDDAYGAKEWREGEGDNEVAYRTEKITRGTCRAVSE
YAFMHARRMKAKVFGGPKYTVSPIYEGMLKEEMDAAAKRYADVRYEPQLIDATYALLLTNSGDPMVIPALNRDGDCLSDL
VLQMFGTIAGAESLLLAFDKDFKVNVVMAEAPHGTAPSLEGKNVANPMAMILASAALLDYIDTPQANMAARAISEATLEA
VYDGVRTADLGGHTTTSDFTDEVIRRVKTKMEVWPSLGN
>Mature_358_residues
SKPTIVVLEGDQTGQELLEESLRVLDPAVTGVDIELKRYDLSLESRRATNNQIVLEAAQAMKEAGFGLKAATITPEKAGD
VGSPNAILREQINGTVIVRTGRRIPGVRPVGGAYAPISVIRMAVDDAYGAKEWREGEGDNEVAYRTEKITRGTCRAVSEY
AFMHARRMKAKVFGGPKYTVSPIYEGMLKEEMDAAAKRYADVRYEPQLIDATYALLLTNSGDPMVIPALNRDGDCLSDLV
LQMFGTIAGAESLLLAFDKDFKVNVVMAEAPHGTAPSLEGKNVANPMAMILASAALLDYIDTPQANMAARAISEATLEAV
YDGVRTADLGGHTTTSDFTDEVIRRVKTKMEVWPSLGN

Specific function: Unknown

COG id: COG0473

COG function: function code CE; Isocitrate/isopropylmalate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI28178825, Length=419, Percent_Identity=27.9236276849642, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI5031777, Length=357, Percent_Identity=27.7310924369748, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI28178832, Length=389, Percent_Identity=27.7634961439589, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI28178821, Length=352, Percent_Identity=24.7159090909091, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI28178816, Length=346, Percent_Identity=24.5664739884393, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI4758582, Length=354, Percent_Identity=25.4237288135593, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI28178819, Length=207, Percent_Identity=26.5700483091787, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1788101, Length=360, Percent_Identity=27.5, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI87081683, Length=368, Percent_Identity=27.7173913043478, Blast_Score=79, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17550822, Length=379, Percent_Identity=29.023746701847, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI71986051, Length=347, Percent_Identity=27.0893371757925, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI25144293, Length=357, Percent_Identity=24.6498599439776, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17550882, Length=355, Percent_Identity=23.943661971831, Blast_Score=78, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17505779, Length=358, Percent_Identity=24.0223463687151, Blast_Score=72, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6320137, Length=412, Percent_Identity=30.0970873786408, Blast_Score=107, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6323203, Length=383, Percent_Identity=29.5039164490862, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6324319, Length=412, Percent_Identity=27.1844660194175, Blast_Score=94, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6324709, Length=352, Percent_Identity=29.2613636363636, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6324291, Length=356, Percent_Identity=24.7191011235955, Blast_Score=87, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6322097, Length=361, Percent_Identity=24.6537396121884, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6319830, Length=374, Percent_Identity=26.4705882352941, Blast_Score=73, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24661184, Length=353, Percent_Identity=28.6118980169972, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24643270, Length=346, Percent_Identity=26.3005780346821, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24643268, Length=346, Percent_Identity=26.3005780346821, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24660856, Length=349, Percent_Identity=29.2263610315186, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24660868, Length=349, Percent_Identity=29.2263610315186, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24660860, Length=349, Percent_Identity=29.2263610315186, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI221330987, Length=349, Percent_Identity=29.2263610315186, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI221330985, Length=349, Percent_Identity=29.2263610315186, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI28574947, Length=349, Percent_Identity=29.2263610315186, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24660849, Length=349, Percent_Identity=29.2263610315186, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI221330983, Length=349, Percent_Identity=29.2263610315186, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI21356561, Length=349, Percent_Identity=29.2263610315186, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI161078633, Length=356, Percent_Identity=24.1573033707865, Blast_Score=81, Evalue=9e-16,
Organism=Drosophila melanogaster, GI24650122, Length=356, Percent_Identity=24.1573033707865, Blast_Score=81, Evalue=9e-16,
Organism=Drosophila melanogaster, GI161078639, Length=351, Percent_Identity=24.5014245014245, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI281362242, Length=350, Percent_Identity=26.5714285714286, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24648872, Length=350, Percent_Identity=26.5714285714286, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI161078637, Length=355, Percent_Identity=23.943661971831, Blast_Score=78, Evalue=7e-15,
Organism=Drosophila melanogaster, GI161078635, Length=351, Percent_Identity=23.9316239316239, Blast_Score=76, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004790 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 38876; Mature: 38745

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKPTIVVLEGDQTGQELLEESLRVLDPAVTGVDIELKRYDLSLESRRATNNQIVLEAAQ
CCCCEEEEEECCCCHHHHHHHHHHHHCHHHCCCEEEEEEECCCHHHHCCCCCCEEHHHHH
AMKEAGFGLKAATITPEKAGDVGSPNAILREQINGTVIVRTGRRIPGVRPVGGAYAPISV
HHHHCCCCEEEEEECCHHCCCCCCCHHHHHHHCCCEEEEEECCCCCCCCCCCCCHHHHHH
IRMAVDDAYGAKEWREGEGDNEVAYRTEKITRGTCRAVSEYAFMHARRMKAKVFGGPKYT
HHHHHHHHCCCHHHHCCCCCCHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
VSPIYEGMLKEEMDAAAKRYADVRYEPQLIDATYALLLTNSGDPMVIPALNRDGDCLSDL
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCEEEEEEECCCCCEEEECCCCCCHHHHHH
VLQMFGTIAGAESLLLAFDKDFKVNVVMAEAPHGTAPSLEGKNVANPMAMILASAALLDY
HHHHHHHHHCCCCEEEEECCCCEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
IDTPQANMAARAISEATLEAVYDGVRTADLGGHTTTSDFTDEVIRRVKTKMEVWPSLGN
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SKPTIVVLEGDQTGQELLEESLRVLDPAVTGVDIELKRYDLSLESRRATNNQIVLEAAQ
CCCEEEEEECCCCHHHHHHHHHHHHCHHHCCCEEEEEEECCCHHHHCCCCCCEEHHHHH
AMKEAGFGLKAATITPEKAGDVGSPNAILREQINGTVIVRTGRRIPGVRPVGGAYAPISV
HHHHCCCCEEEEEECCHHCCCCCCCHHHHHHHCCCEEEEEECCCCCCCCCCCCCHHHHHH
IRMAVDDAYGAKEWREGEGDNEVAYRTEKITRGTCRAVSEYAFMHARRMKAKVFGGPKYT
HHHHHHHHCCCHHHHCCCCCCHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
VSPIYEGMLKEEMDAAAKRYADVRYEPQLIDATYALLLTNSGDPMVIPALNRDGDCLSDL
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCEEEEEEECCCCCEEEECCCCCCHHHHHH
VLQMFGTIAGAESLLLAFDKDFKVNVVMAEAPHGTAPSLEGKNVANPMAMILASAALLDY
HHHHHHHHHCCCCEEEEECCCCEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
IDTPQANMAARAISEATLEAVYDGVRTADLGGHTTTSDFTDEVIRRVKTKMEVWPSLGN
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8626059 [H]