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The map label for this gene is folE [H]

Identifier: 159896664

GI number: 159896664

Start: 162124

End: 162744

Strand: Direct

Name: folE [H]

Synonym: Haur_0131

Alternate gene names: 159896664

Gene position: 162124-162744 (Clockwise)

Preceding gene: 159896663

Following gene: 159896665

Centisome position: 2.55

GC content: 49.6

Gene sequence:

>621_bases
ATGACGCTTATTTACTCTGGCAATGGACTCAATGGCAACTCAGCACCAGCAGTGCGCGAAGATATGGAAGCCGCCGTGCG
AACCATTCTCGAAGGTCTCGGCGAGGATGTTGATCGTGAGGGCTTGCAACGCACCCCGCATCGGGTTGCCAAAATGTTTG
GCGAGCTGACCGCTGGTTATCATACTGATCCGGTGGCGTTGATTAACGATGCCATTTTTACGGTCGAATATAACGAAATG
GTCTTGGTGCGTGATATTGAATTTTCGTCGCTGTGCGAACATCATATGTTGCCATTTTGGGGCAAAGCCCACGTTGCCTA
TGTGCCAAATGGCAAAGTGCTTGGGCTTTCGAAAATTCCACGGATTGTTGATATGTTTGCCAAACGTTTGCAAGTGCAAG
AACGCCTAACCCGCGAAATCGCCGATTTTGTGGCGCAAACGATCGATGCAAGCGGCGTAGCAGTGGTGGTACAGGGTGCG
CATATGTGCTCAATGATTCGTGGCGTTAAAAAGGCCAACGCTCGCATGGTCACGCAATCGTTGCAAGGTGTGTTTAAAAC
CGATCCGCAAATTCGCGCTGAATTTATGGGTCATATCACGGCGAATTTTTCCGATGACTAA

Upstream 100 bases:

>100_bases
GCCAATAATGTGTTTGATTACCCGCTCAGCCAGCATTGAGCAGCGGCAACCCTGAATCGTGGATGAGGTTCTGGAACTAC
TAATGCAAAGGATGGATCAG

Downstream 100 bases:

>100_bases
AACAATGGTGATTACTGGAGCTGGCCGTGGGATTGGCCGGGCAATTGCCTTGGCCTGTGCCGCCAACAACCAACTGGTTT
TGCTCGCTCGCAGCGCAGCT

Product: GTP cyclohydrolase I

Products: NA

Alternate protein names: GTP cyclohydrolase I; GTP-CH-I [H]

Number of amino acids: Translated: 206; Mature: 205

Protein sequence:

>206_residues
MTLIYSGNGLNGNSAPAVREDMEAAVRTILEGLGEDVDREGLQRTPHRVAKMFGELTAGYHTDPVALINDAIFTVEYNEM
VLVRDIEFSSLCEHHMLPFWGKAHVAYVPNGKVLGLSKIPRIVDMFAKRLQVQERLTREIADFVAQTIDASGVAVVVQGA
HMCSMIRGVKKANARMVTQSLQGVFKTDPQIRAEFMGHITANFSDD

Sequences:

>Translated_206_residues
MTLIYSGNGLNGNSAPAVREDMEAAVRTILEGLGEDVDREGLQRTPHRVAKMFGELTAGYHTDPVALINDAIFTVEYNEM
VLVRDIEFSSLCEHHMLPFWGKAHVAYVPNGKVLGLSKIPRIVDMFAKRLQVQERLTREIADFVAQTIDASGVAVVVQGA
HMCSMIRGVKKANARMVTQSLQGVFKTDPQIRAEFMGHITANFSDD
>Mature_205_residues
TLIYSGNGLNGNSAPAVREDMEAAVRTILEGLGEDVDREGLQRTPHRVAKMFGELTAGYHTDPVALINDAIFTVEYNEMV
LVRDIEFSSLCEHHMLPFWGKAHVAYVPNGKVLGLSKIPRIVDMFAKRLQVQERLTREIADFVAQTIDASGVAVVVQGAH
MCSMIRGVKKANARMVTQSLQGVFKTDPQIRAEFMGHITANFSDD

Specific function: Tetrahydrofolate biosynthesis; first step. [C]

COG id: COG0302

COG function: function code H; GTP cyclohydrolase I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase I family [H]

Homologues:

Organism=Homo sapiens, GI66932968, Length=181, Percent_Identity=46.9613259668508, Blast_Score=187, Evalue=4e-48,
Organism=Homo sapiens, GI4503949, Length=181, Percent_Identity=46.9613259668508, Blast_Score=187, Evalue=4e-48,
Organism=Homo sapiens, GI66932970, Length=149, Percent_Identity=44.9664429530201, Blast_Score=145, Evalue=3e-35,
Organism=Homo sapiens, GI66932972, Length=139, Percent_Identity=47.4820143884892, Blast_Score=144, Evalue=7e-35,
Organism=Escherichia coli, GI1788476, Length=172, Percent_Identity=42.4418604651163, Blast_Score=123, Evalue=9e-30,
Organism=Caenorhabditis elegans, GI17560486, Length=181, Percent_Identity=50.2762430939227, Blast_Score=203, Evalue=5e-53,
Organism=Saccharomyces cerevisiae, GI6321706, Length=178, Percent_Identity=47.752808988764, Blast_Score=178, Evalue=6e-46,
Organism=Drosophila melanogaster, GI24656782, Length=190, Percent_Identity=48.4210526315789, Blast_Score=182, Evalue=1e-46,
Organism=Drosophila melanogaster, GI24656791, Length=190, Percent_Identity=48.4210526315789, Blast_Score=181, Evalue=2e-46,
Organism=Drosophila melanogaster, GI24656796, Length=190, Percent_Identity=48.4210526315789, Blast_Score=181, Evalue=2e-46,

Paralogues:

None

Copy number: 420 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001474
- InterPro:   IPR020602
- InterPro:   IPR018234 [H]

Pfam domain/function: PF01227 GTP_cyclohydroI [H]

EC number: =3.5.4.16 [H]

Molecular weight: Translated: 22761; Mature: 22629

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS00859 GTP_CYCLOHYDROL_1_1 ; PS00860 GTP_CYCLOHYDROL_1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLIYSGNGLNGNSAPAVREDMEAAVRTILEGLGEDVDREGLQRTPHRVAKMFGELTAGY
CEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHCCHHHHHHHHHHHHCCC
HTDPVALINDAIFTVEYNEMVLVRDIEFSSLCEHHMLPFWGKAHVAYVPNGKVLGLSKIP
CCCCHHHHCCEEEEEEECCEEEEECCCHHHHHHHCCCCCCCCCEEEECCCCCEECHHHHH
RIVDMFAKRLQVQERLTREIADFVAQTIDASGVAVVVQGAHMCSMIRGVKKANARMVTQS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHH
LQGVFKTDPQIRAEFMGHITANFSDD
HHHHHCCCHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TLIYSGNGLNGNSAPAVREDMEAAVRTILEGLGEDVDREGLQRTPHRVAKMFGELTAGY
EEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHCCHHHHHHHHHHHHCCC
HTDPVALINDAIFTVEYNEMVLVRDIEFSSLCEHHMLPFWGKAHVAYVPNGKVLGLSKIP
CCCCHHHHCCEEEEEEECCEEEEECCCHHHHHHHCCCCCCCCCEEEECCCCCEECHHHHH
RIVDMFAKRLQVQERLTREIADFVAQTIDASGVAVVVQGAHMCSMIRGVKKANARMVTQS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHH
LQGVFKTDPQIRAEFMGHITANFSDD
HHHHHCCCHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA