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The map label for this gene is lysA [H]

Identifier: 159896546

GI number: 159896546

Start: 14745

End: 16076

Strand: Direct

Name: lysA [H]

Synonym: Haur_0013

Alternate gene names: 159896546

Gene position: 14745-16076 (Clockwise)

Preceding gene: 159896539

Following gene: 159896547

Centisome position: 0.23

GC content: 54.65

Gene sequence:

>1332_bases
ATGGAACACGCCGAAGTTCGTCGCATGCCTAATGCCCATGTTTGGCCAATCAGTGCCAGTGTTGTTCATGAGCGCTTGCA
GATTGCTAGTTGCGATCTGGCGGCGCTAGCGGCTGAATATGGAACCCCGCTCTATCTGCTGGATGCTGAGACGATTCGCA
CGATTGCAATGCGCTATAGTGCCGCATTACGCCATGCCTATGGCAGCAATGTCAGCATTCACTATGCCAGCAAAGCCTTG
TTAAATGTAGGCGTGGCGCGATTAGTGCATTCCTTGGGCTTGGGGTTGGATGTGGTGTCAGGTGGCGAATTGGCAATTGC
CCAACGTGCTGGAATGCCGCTCGACCATGTTCATTTGCACGGCAATGGTACACCACCAGCCGAATTAGCTCAAGCGGTCG
AGGCGGGAATTGGCCGAATTGTGGTCGATAATCTTGATCAGCTTAAATGGTTGGCCGATTATTGCGCCAAACGCCCAACA
CCCCAAACGATTCTCTTGCGCATCGCTCCCGATGTAACGGCGGGAGCACACGCCCATATTCGCACTGGAGCCGCCAGCGC
TAAGTTTGGCATGCCGCTTGATGATGGCACTGCTGCCGAGGCTGTGCGCTTAGCATTACAAGCACCAGGCTTGAATTTGG
TTGGTTTACACGCCCATATTGGCTCGCAAATGCGCGATTGGGCCGCCCTGCGCGAGATGATTGGGCGTTTGTTGGCCTTT
GCCGATCAGCAACGCCGTGAGCGAAGTTGGCTTTTAACTGAATTCAGCCCGGGTGGTGGTTTGGCGGTGGCTTACATGCC
CAACGAGCAAGCTGGCGATATCGAAACCTACGCCAATACGATTGCCAATGCTGTGCGTTTAGGCTGCGAACGCTACCAAA
TTCCGCTGCCACGCTTGATTATTGAGCCTGGCCGATCATTGGTGGCGCGGGCTGGCGTGGCTCTGTATAGCGTAACTGGG
CACAAAACGGTGGTCGGTGGTAGCGATTATTTGCATATTGATGGTGGAATGGGCGATAATTTGCGGCCTTCGTTGTACAA
TGCTCAGTATACCGCTGCGTTAGTTGCTCGTCCCTGTGCTCCGCCGATTGCGCCCGTTCAATTGGCCGGAAGGTTTTGTG
AGTCAGGCGATGTCTTAATTCGTGAAGTAGCGTTGCCTGCTGCCGAAGTTGGTGAGCTTGTGGCAGTGCCTGTCGCGGGA
GCCTATACACTCAGTATGGCCAGCGCGTATAATGGCGTGCCACGCCCAGCCTTGGTTCTGTTAGATCGAGGTCAGGCGAT
GCTCATTCAACGCCGCGAAACCTACGCCGATTTGATGGCGCGGGATATTTAG

Upstream 100 bases:

>100_bases
TGGTGCAAACCATATTGTACAGATCTGAGATATCTGTCATAAAAGCTTGTTAAACCTGATAAACCTATTTTTCATCTAGC
CAAGCCACGAGGATGAGCCA

Downstream 100 bases:

>100_bases
CGTAAAGGGATCAGGGGCTAGGGGTCAGGGATCAGGGACTAGCTTTAAATGCTGGTTTTGTGCTCTTCGTGGTTAAAAAA
GGAGCCAATGATAGGTATAG

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 443; Mature: 443

Protein sequence:

>443_residues
MEHAEVRRMPNAHVWPISASVVHERLQIASCDLAALAAEYGTPLYLLDAETIRTIAMRYSAALRHAYGSNVSIHYASKAL
LNVGVARLVHSLGLGLDVVSGGELAIAQRAGMPLDHVHLHGNGTPPAELAQAVEAGIGRIVVDNLDQLKWLADYCAKRPT
PQTILLRIAPDVTAGAHAHIRTGAASAKFGMPLDDGTAAEAVRLALQAPGLNLVGLHAHIGSQMRDWAALREMIGRLLAF
ADQQRRERSWLLTEFSPGGGLAVAYMPNEQAGDIETYANTIANAVRLGCERYQIPLPRLIIEPGRSLVARAGVALYSVTG
HKTVVGGSDYLHIDGGMGDNLRPSLYNAQYTAALVARPCAPPIAPVQLAGRFCESGDVLIREVALPAAEVGELVAVPVAG
AYTLSMASAYNGVPRPALVLLDRGQAMLIQRRETYADLMARDI

Sequences:

>Translated_443_residues
MEHAEVRRMPNAHVWPISASVVHERLQIASCDLAALAAEYGTPLYLLDAETIRTIAMRYSAALRHAYGSNVSIHYASKAL
LNVGVARLVHSLGLGLDVVSGGELAIAQRAGMPLDHVHLHGNGTPPAELAQAVEAGIGRIVVDNLDQLKWLADYCAKRPT
PQTILLRIAPDVTAGAHAHIRTGAASAKFGMPLDDGTAAEAVRLALQAPGLNLVGLHAHIGSQMRDWAALREMIGRLLAF
ADQQRRERSWLLTEFSPGGGLAVAYMPNEQAGDIETYANTIANAVRLGCERYQIPLPRLIIEPGRSLVARAGVALYSVTG
HKTVVGGSDYLHIDGGMGDNLRPSLYNAQYTAALVARPCAPPIAPVQLAGRFCESGDVLIREVALPAAEVGELVAVPVAG
AYTLSMASAYNGVPRPALVLLDRGQAMLIQRRETYADLMARDI
>Mature_443_residues
MEHAEVRRMPNAHVWPISASVVHERLQIASCDLAALAAEYGTPLYLLDAETIRTIAMRYSAALRHAYGSNVSIHYASKAL
LNVGVARLVHSLGLGLDVVSGGELAIAQRAGMPLDHVHLHGNGTPPAELAQAVEAGIGRIVVDNLDQLKWLADYCAKRPT
PQTILLRIAPDVTAGAHAHIRTGAASAKFGMPLDDGTAAEAVRLALQAPGLNLVGLHAHIGSQMRDWAALREMIGRLLAF
ADQQRRERSWLLTEFSPGGGLAVAYMPNEQAGDIETYANTIANAVRLGCERYQIPLPRLIIEPGRSLVARAGVALYSVTG
HKTVVGGSDYLHIDGGMGDNLRPSLYNAQYTAALVARPCAPPIAPVQLAGRFCESGDVLIREVALPAAEVGELVAVPVAG
AYTLSMASAYNGVPRPALVLLDRGQAMLIQRRETYADLMARDI

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Escherichia coli, GI1789203, Length=421, Percent_Identity=34.2042755344418, Blast_Score=156, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17562780, Length=366, Percent_Identity=25.1366120218579, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 47269; Mature: 47269

Theoretical pI: Translated: 7.07; Mature: 7.07

Prosite motif: PS00878 ODR_DC_2_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEHAEVRRMPNAHVWPISASVVHERLQIASCDLAALAAEYGTPLYLLDAETIRTIAMRYS
CCCCHHHCCCCCEEECCHHHHHHHHHHHHCCHHHHHHHHHCCCEEEECHHHHHHHHHHHH
AALRHAYGSNVSIHYASKALLNVGVARLVHSLGLGLDVVSGGELAIAQRAGMPLDHVHLH
HHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHCCCEEEECCCCEEEHHHCCCCEEEEEEE
GNGTPPAELAQAVEAGIGRIVVDNLDQLKWLADYCAKRPTPQTILLRIAPDVTAGAHAHI
CCCCCHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCEEE
RTGAASAKFGMPLDDGTAAEAVRLALQAPGLNLVGLHAHIGSQMRDWAALREMIGRLLAF
ECCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHH
ADQQRRERSWLLTEFSPGGGLAVAYMPNEQAGDIETYANTIANAVRLGCERYQIPLPRLI
HHHHHHHHCEEEEEECCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCHHHHCCCCCCEE
IEPGRSLVARAGVALYSVTGHKTVVGGSDYLHIDGGMGDNLRPSLYNAQYTAALVARPCA
ECCCHHHHHHCCEEEEEECCCEEEECCCCEEEECCCCCCCCCCCCCCCHHHHHHHCCCCC
PPIAPVQLAGRFCESGDVLIREVALPAAEVGELVAVPVAGAYTLSMASAYNGVPRPALVL
CCCCHHHHHHHHCCCCCEEEHHHHCCHHHHCCEEEECCCCHHHHHHHHHHCCCCCCEEEE
LDRGQAMLIQRRETYADLMARDI
EECCCEEEHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEHAEVRRMPNAHVWPISASVVHERLQIASCDLAALAAEYGTPLYLLDAETIRTIAMRYS
CCCCHHHCCCCCEEECCHHHHHHHHHHHHCCHHHHHHHHHCCCEEEECHHHHHHHHHHHH
AALRHAYGSNVSIHYASKALLNVGVARLVHSLGLGLDVVSGGELAIAQRAGMPLDHVHLH
HHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHCCCEEEECCCCEEEHHHCCCCEEEEEEE
GNGTPPAELAQAVEAGIGRIVVDNLDQLKWLADYCAKRPTPQTILLRIAPDVTAGAHAHI
CCCCCHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCEEE
RTGAASAKFGMPLDDGTAAEAVRLALQAPGLNLVGLHAHIGSQMRDWAALREMIGRLLAF
ECCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHH
ADQQRRERSWLLTEFSPGGGLAVAYMPNEQAGDIETYANTIANAVRLGCERYQIPLPRLI
HHHHHHHHCEEEEEECCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCHHHHCCCCCCEE
IEPGRSLVARAGVALYSVTGHKTVVGGSDYLHIDGGMGDNLRPSLYNAQYTAALVARPCA
ECCCHHHHHHCCEEEEEECCCEEEECCCCEEEECCCCCCCCCCCCCCCHHHHHHHCCCCC
PPIAPVQLAGRFCESGDVLIREVALPAAEVGELVAVPVAGAYTLSMASAYNGVPRPALVL
CCCCHHHHHHHHCCCCCEEEHHHHCCHHHHCCEEEECCCCHHHHHHHHHHCCCCCCEEEE
LDRGQAMLIQRRETYADLMARDI
EECCCEEEHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2513554; 7934829; 1368705; 8969508; 9384377 [H]