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The map label for this gene is hisI [H]

Identifier: 159041968

GI number: 159041968

Start: 1480947

End: 1481333

Strand: Reverse

Name: hisI [H]

Synonym: Cmaq_1404

Alternate gene names: 159041968

Gene position: 1481333-1480947 (Counterclockwise)

Preceding gene: 159041969

Following gene: 159041963

Centisome position: 71.3

GC content: 45.22

Gene sequence:

>387_bases
ATGCTGCCTAATGGTGTTAATGTACTTAAGTTAAGCCCAGAGGAGGCTTCTAAGATTGCTGAATCCCTACTGTATAGGCA
TACTGATGGAACCGTCGTGGCCGTGGCCCAGGATTACTTAACTAAGGATGTGTTAATGGTTGCGAACATGAATAAGGAAG
CCGTTTTCAAAACATTAACCACAGGAATGGTTCACTACTGGTCCCTAAGCCGTAGGAGGCTTTGGTTAAAGGGGGAGACA
AGCGGCCACTACCAGTATTTAATTGATTACAGGATTGACTGCGATGGTGATGCATTACTGCTTAAGGTTTACCAAGTGGG
TAACGCATGCCACCTAGGTACTAGGTCCTGTTTCGACGCCAGGTACGTGAATAGGATTCATTTATAG

Upstream 100 bases:

>100_bases
GAAATTAGGCTTAAGTATTCTGAATGGCTTAGTTAATTTAGCTAGGAGGTGAATCATGGTTTCAATAATGTTTTAAAGCA
GCCTTAATTAGGCTTCATTA

Downstream 100 bases:

>100_bases
GCTAAATGCGTACCCTAATGCCTAACTCTGATAAGTAGGCTTTGAGTATCGAGATGTTTATTACACCCATGTGAAACACG
CTTGCAGCCAATGCAGCATC

Product: phosphoribosyl-AMP cyclohydrolase

Products: NA

Alternate protein names: PRA-CH [H]

Number of amino acids: Translated: 128; Mature: 128

Protein sequence:

>128_residues
MLPNGVNVLKLSPEEASKIAESLLYRHTDGTVVAVAQDYLTKDVLMVANMNKEAVFKTLTTGMVHYWSLSRRRLWLKGET
SGHYQYLIDYRIDCDGDALLLKVYQVGNACHLGTRSCFDARYVNRIHL

Sequences:

>Translated_128_residues
MLPNGVNVLKLSPEEASKIAESLLYRHTDGTVVAVAQDYLTKDVLMVANMNKEAVFKTLTTGMVHYWSLSRRRLWLKGET
SGHYQYLIDYRIDCDGDALLLKVYQVGNACHLGTRSCFDARYVNRIHL
>Mature_128_residues
MLPNGVNVLKLSPEEASKIAESLLYRHTDGTVVAVAQDYLTKDVLMVANMNKEAVFKTLTTGMVHYWSLSRRRLWLKGET
SGHYQYLIDYRIDCDGDALLLKVYQVGNACHLGTRSCFDARYVNRIHL

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-CH family [H]

Homologues:

Organism=Escherichia coli, GI2367128, Length=97, Percent_Identity=42.2680412371134, Blast_Score=89, Evalue=7e-20,
Organism=Saccharomyces cerevisiae, GI6319819, Length=116, Percent_Identity=36.2068965517241, Blast_Score=61, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002496
- ProDom:   PD002610 [H]

Pfam domain/function: PF01502 PRA-CH [H]

EC number: =3.5.4.19 [H]

Molecular weight: Translated: 14567; Mature: 14567

Theoretical pI: Translated: 8.46; Mature: 8.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPNGVNVLKLSPEEASKIAESLLYRHTDGTVVAVAQDYLTKDVLMVANMNKEAVFKTLT
CCCCCCEEEEECHHHHHHHHHHHHEECCCCCEEEEEHHHHHHHEEEEECCCHHHHHHHHH
TGMVHYWSLSRRRLWLKGETSGHYQYLIDYRIDCDGDALLLKVYQVGNACHLGTRSCFDA
HHHHHEEECCCCEEEEECCCCCCEEEEEEEEECCCCCEEEEEEECCCCEEECCCCCHHHH
RYVNRIHL
HHHHEECC
>Mature Secondary Structure
MLPNGVNVLKLSPEEASKIAESLLYRHTDGTVVAVAQDYLTKDVLMVANMNKEAVFKTLT
CCCCCCEEEEECHHHHHHHHHHHHEECCCCCEEEEEHHHHHHHEEEEECCCHHHHHHHHH
TGMVHYWSLSRRRLWLKGETSGHYQYLIDYRIDCDGDALLLKVYQVGNACHLGTRSCFDA
HHHHHEEECCCCEEEEECCCCCCEEEEEEEEECCCCCEEEEEEECCCCEEECCCCCHHHH
RYVNRIHL
HHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11572479 [H]