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The map label for this gene is lysC [C]

Identifier: 159040601

GI number: 159040601

Start: 22269

End: 23402

Strand: Reverse

Name: lysC [C]

Synonym: Cmaq_0009

Alternate gene names: 159040601

Gene position: 23402-22269 (Counterclockwise)

Preceding gene: 159040602

Following gene: 159040600

Centisome position: 1.13

GC content: 44.18

Gene sequence:

>1134_bases
ATGCCAAGGACATTAAACGTCACCGTGGCTAAGGTGGGTGGCTCCCTACTTAAGCCAGGTGACGTTGAGAAGGTTTTAAG
TAAGGTCATTGAGAGGCACATGGTTGATGATGGTAAGTTAATCCTCGTTGTATCTGCAATGAAGGGTGTCACCGACCTCT
TAATTAAGGCTTATGATGAAGGTAAGCCTCATTTAATAAAGGATGCGATTCAACCTTACTTAAATGAAGCATATAGGTTC
GGCTTAAGTAAACTGGGTTCATTAATTGAGGGTGTGGGTGAGAGACTGGAGACTTTAATTAACGTTAGGGAACCGTGGGT
TAGGGATAATGTTGTTGTTCACGGTGAATTACTCTCAGTGATGTTGATTGAGTCAATACTCTATAATGAGCTTGGTGTCG
ATGCAGGTGCAGTGTATGACCCAGGAATAACAACTAATGAGGATTGGGGGAAGGCATCAGTGCTGGGTGTTAGCTCCCAT
TACGTTAAGCATAGGTTAACCTGGGCATTATCCAGGAGGAGTATTGTGGTTGTTCCAGGTTTCCTGGGAATCAGCCTAAA
CGGTAGGTTAACATCACTGGGTAGGGGTGGTAGTGATTACACTGCCTCATTAATAGCAGCTTACATTAATGCCCCAAGGT
TAATCTTCTACACTGACGTTGAGGGTATAATGACTGGGGATCCTAGGATAATAGGTGATGCTAAGGTGATACCAAGCCTA
ACCCATGAGGAGGCCTACGTAGCATCATTAACCGGCGCTAAGAAATTCCACCCAGGTACATTTAAGCCGTTAATAGATAG
TAACGTTAACGTCATGGTGACTAACCCATGGTCAAGTAGCGGTACATCAATAATATCAAGGTGCGTTAACACGCCTAAAT
TAGTCTCAGTATCTGATGTAGGTTCAATAGGCTTAATCAACCTCAAGAGTGGGTACGCCGTAACGGTTGTAGGCTGTGTA
ATGGGGCTTGATGAATATAGGAGGGAGGTTTACTTAATCATGAGTAGTTACGACCCAGTGGACGTGGTAAATGATACTGA
GGGTAACGCAGTCTCATCAATAGTTAAGGATCAGGATGAAGCGGTTAAGTTGGCTAAGGACCTGCACAAGTGGGTGGTGT
CATGGATAAGGTGA

Upstream 100 bases:

>100_bases
ATAATCACTAAGGTGATAGAATATAGTTTAATTAGGGGGGTAATGTTTAAAAGAGGGCTAATATGGGGCTATATATGATG
TGGTGGGAAATGCGGGAAAC

Downstream 100 bases:

>100_bases
GGGTTTCAATACTTGGGGCAACGGGCCTAGTGGGGCAGTGGATGGTTAAGCTACTTGAGAATCACCCATACATTGAAGTG
ACCGCCCTATCAGCCTCACC

Product: aspartate kinase

Products: NA

Alternate protein names: Aspartate kinase [H]

Number of amino acids: Translated: 377; Mature: 376

Protein sequence:

>377_residues
MPRTLNVTVAKVGGSLLKPGDVEKVLSKVIERHMVDDGKLILVVSAMKGVTDLLIKAYDEGKPHLIKDAIQPYLNEAYRF
GLSKLGSLIEGVGERLETLINVREPWVRDNVVVHGELLSVMLIESILYNELGVDAGAVYDPGITTNEDWGKASVLGVSSH
YVKHRLTWALSRRSIVVVPGFLGISLNGRLTSLGRGGSDYTASLIAAYINAPRLIFYTDVEGIMTGDPRIIGDAKVIPSL
THEEAYVASLTGAKKFHPGTFKPLIDSNVNVMVTNPWSSSGTSIISRCVNTPKLVSVSDVGSIGLINLKSGYAVTVVGCV
MGLDEYRREVYLIMSSYDPVDVVNDTEGNAVSSIVKDQDEAVKLAKDLHKWVVSWIR

Sequences:

>Translated_377_residues
MPRTLNVTVAKVGGSLLKPGDVEKVLSKVIERHMVDDGKLILVVSAMKGVTDLLIKAYDEGKPHLIKDAIQPYLNEAYRF
GLSKLGSLIEGVGERLETLINVREPWVRDNVVVHGELLSVMLIESILYNELGVDAGAVYDPGITTNEDWGKASVLGVSSH
YVKHRLTWALSRRSIVVVPGFLGISLNGRLTSLGRGGSDYTASLIAAYINAPRLIFYTDVEGIMTGDPRIIGDAKVIPSL
THEEAYVASLTGAKKFHPGTFKPLIDSNVNVMVTNPWSSSGTSIISRCVNTPKLVSVSDVGSIGLINLKSGYAVTVVGCV
MGLDEYRREVYLIMSSYDPVDVVNDTEGNAVSSIVKDQDEAVKLAKDLHKWVVSWIR
>Mature_376_residues
PRTLNVTVAKVGGSLLKPGDVEKVLSKVIERHMVDDGKLILVVSAMKGVTDLLIKAYDEGKPHLIKDAIQPYLNEAYRFG
LSKLGSLIEGVGERLETLINVREPWVRDNVVVHGELLSVMLIESILYNELGVDAGAVYDPGITTNEDWGKASVLGVSSHY
VKHRLTWALSRRSIVVVPGFLGISLNGRLTSLGRGGSDYTASLIAAYINAPRLIFYTDVEGIMTGDPRIIGDAKVIPSLT
HEEAYVASLTGAKKFHPGTFKPLIDSNVNVMVTNPWSSSGTSIISRCVNTPKLVSVSDVGSIGLINLKSGYAVTVVGCVM
GLDEYRREVYLIMSSYDPVDVVNDTEGNAVSSIVKDQDEAVKLAKDLHKWVVSWIR

Specific function: Lysine biosynthesis; first step. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1790455, Length=355, Percent_Identity=28.4507042253521, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1786183, Length=126, Percent_Identity=34.9206349206349, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1790376, Length=298, Percent_Identity=27.8523489932886, Blast_Score=77, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6320893, Length=312, Percent_Identity=27.5641025641026, Blast_Score=77, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 40963; Mature: 40832

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRTLNVTVAKVGGSLLKPGDVEKVLSKVIERHMVDDGKLILVVSAMKGVTDLLIKAYDE
CCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHCC
GKPHLIKDAIQPYLNEAYRFGLSKLGSLIEGVGERLETLINVREPWVRDNVVVHGELLSV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEHHHHHHH
MLIESILYNELGVDAGAVYDPGITTNEDWGKASVLGVSSHYVKHRLTWALSRRSIVVVPG
HHHHHHHHHHHCCCCCCEECCCCCCCCCCCCEEEEECHHHHHHHHHHHEECCCEEEEECC
FLGISLNGRLTSLGRGGSDYTASLIAAYINAPRLIFYTDVEGIMTGDPRIIGDAKVIPSL
EEEEEECCEEEECCCCCCHHHHHHHHHHHCCCEEEEEECCCCEECCCCEEEECCHHCCCC
THEEAYVASLTGAKKFHPGTFKPLIDSNVNVMVTNPWSSSGTSIISRCVNTPKLVSVSDV
CCCCHHHEECCCCCCCCCCCCCHHHCCCCEEEEECCCCCCCHHHHHHHCCCCCEEEECCC
GSIGLINLKSGYAVTVVGCVMGLDEYRREVYLIMSSYDPVDVVNDTEGNAVSSIVKDQDE
CCEEEEEECCCCHHHHHHHHHCHHHHCCEEEEEEECCCCCCCCCCCCCHHHHHHHHCHHH
AVKLAKDLHKWVVSWIR
HHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PRTLNVTVAKVGGSLLKPGDVEKVLSKVIERHMVDDGKLILVVSAMKGVTDLLIKAYDE
CCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHCC
GKPHLIKDAIQPYLNEAYRFGLSKLGSLIEGVGERLETLINVREPWVRDNVVVHGELLSV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEHHHHHHH
MLIESILYNELGVDAGAVYDPGITTNEDWGKASVLGVSSHYVKHRLTWALSRRSIVVVPG
HHHHHHHHHHHCCCCCCEECCCCCCCCCCCCEEEEECHHHHHHHHHHHEECCCEEEEECC
FLGISLNGRLTSLGRGGSDYTASLIAAYINAPRLIFYTDVEGIMTGDPRIIGDAKVIPSL
EEEEEECCEEEECCCCCCHHHHHHHHHHHCCCEEEEEECCCCEECCCCEEEECCHHCCCC
THEEAYVASLTGAKKFHPGTFKPLIDSNVNVMVTNPWSSSGTSIISRCVNTPKLVSVSDV
CCCCHHHEECCCCCCCCCCCCCHHHCCCCEEEEECCCCCCCHHHHHHHCCCCCEEEECCC
GSIGLINLKSGYAVTVVGCVMGLDEYRREVYLIMSSYDPVDVVNDTEGNAVSSIVKDQDE
CCEEEEEECCCCHHHHHHHHHCHHHHCCEEEEEEECCCCCCCCCCCCCHHHHHHHHCHHH
AVKLAKDLHKWVVSWIR
HHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]