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The map label for this gene is lysR [H]

Identifier: 158424089

GI number: 158424089

Start: 2799679

End: 2800584

Strand: Direct

Name: lysR [H]

Synonym: AZC_2465

Alternate gene names: 158424089

Gene position: 2799679-2800584 (Clockwise)

Preceding gene: 158424077

Following gene: 158424097

Centisome position: 52.14

GC content: 67.55

Gene sequence:

>906_bases
ATGCGTTTCGACCTGCGCCACATCCGGAGCTTCATCGTCCTCGCCGAGACCTTGCATTTCGGCCGGGCGGCGGAACGGCT
GAACATGACCCAGCCCGGCATGAGCCGGCTGATCGGCGAGCTCGAGCGGGAGGTGGGCGTTCCCCTCTTCCGCCGAACCA
CGCGTACCGTGGAGCTGACGGAAGCCGGCAAGGCCTTCCTTGGGGAATGCGCGCTCGCCATGGACCGGCTCGACCGCGCG
GTGTCCATCGCCCGGCGTACCGCCAAGGGCGAGACCGGCATCCTGCGCATCGCCTACATGGATTTCGCCATCAACGGGCG
CCTGCCCGAACTGTTGCGCAGCTTCAGCCGCATGCGGCCGGACATCCGGCTCGAACTGTCCTTCATCGCGACCCTGAAGC
AGTATGAGGCGCTGCTGGCGGACCGTATCGACATCGGCTTCCTCATCGGCCCCGTGGACCAGCCGGGGCTCGCCAGCTAC
ACCTTCGACCGCGACCGCTACGTGGTCCTTCTGCCGACCACCCACCCGCTCTCGAACGTGCGCAACCTGCGCCTGTCGGA
TCTCGCCCGCGAGCCCTTCGTGCTCGGGTCCGGCGAGAACTGGGGCGCCTTCCGCAACCAGCTCTTCGCACTCTGCCACC
GGGCCGGCTTCGTGCCGGACATCGTGCAGGAAGCCTCATCCTCCGAAGGCATCTTCGGCCTCGTGGCCGCAGGGGCGGGC
ATCAGCCTCTATGCGAGCTGCGTGCGCAACCTCCAGCGCCGGGGCATCGTCATCCGCGAGATCGAGGACACGCCGGACCA
GCTTCTCACCTGCGCCGCCTGGATCAGCCCGACGCAGTCGCCTGGCGTTCAAGTGTTCGTGGATTTCCTCTCGCAGGTCT
GGGGCGGTCAGATCGCCAGCGCCTGA

Upstream 100 bases:

>100_bases
CTGTTGTTGCTGCGCTTGACCGCAACGATGGGGCCGTTCGATCGAGAATTGGAAATTCTAATTTCTTCGCTATTGATACG
GTTTTTGGTATGAATTCCGG

Downstream 100 bases:

>100_bases
ACGTGCCTCCAAACGCAGACGGGCGGCCGAAGCCGCCCGCTGCGTGTCTCTTGCGGGGCGATGCGACTCAGGCGGCCCGG
ACCGTCTGGAGGAAGCGCGC

Product: transcriptional regulatory protein

Products: NA

Alternate protein names: Als operon regulatory protein [H]

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MRFDLRHIRSFIVLAETLHFGRAAERLNMTQPGMSRLIGELEREVGVPLFRRTTRTVELTEAGKAFLGECALAMDRLDRA
VSIARRTAKGETGILRIAYMDFAINGRLPELLRSFSRMRPDIRLELSFIATLKQYEALLADRIDIGFLIGPVDQPGLASY
TFDRDRYVVLLPTTHPLSNVRNLRLSDLAREPFVLGSGENWGAFRNQLFALCHRAGFVPDIVQEASSSEGIFGLVAAGAG
ISLYASCVRNLQRRGIVIREIEDTPDQLLTCAAWISPTQSPGVQVFVDFLSQVWGGQIASA

Sequences:

>Translated_301_residues
MRFDLRHIRSFIVLAETLHFGRAAERLNMTQPGMSRLIGELEREVGVPLFRRTTRTVELTEAGKAFLGECALAMDRLDRA
VSIARRTAKGETGILRIAYMDFAINGRLPELLRSFSRMRPDIRLELSFIATLKQYEALLADRIDIGFLIGPVDQPGLASY
TFDRDRYVVLLPTTHPLSNVRNLRLSDLAREPFVLGSGENWGAFRNQLFALCHRAGFVPDIVQEASSSEGIFGLVAAGAG
ISLYASCVRNLQRRGIVIREIEDTPDQLLTCAAWISPTQSPGVQVFVDFLSQVWGGQIASA
>Mature_301_residues
MRFDLRHIRSFIVLAETLHFGRAAERLNMTQPGMSRLIGELEREVGVPLFRRTTRTVELTEAGKAFLGECALAMDRLDRA
VSIARRTAKGETGILRIAYMDFAINGRLPELLRSFSRMRPDIRLELSFIATLKQYEALLADRIDIGFLIGPVDQPGLASY
TFDRDRYVVLLPTTHPLSNVRNLRLSDLAREPFVLGSGENWGAFRNQLFALCHRAGFVPDIVQEASSSEGIFGLVAAGAG
ISLYASCVRNLQRRGIVIREIEDTPDQLLTCAAWISPTQSPGVQVFVDFLSQVWGGQIASA

Specific function: Regulates the expression of the alsSD operon for acetoin biosynthesis [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787879, Length=253, Percent_Identity=35.5731225296443, Blast_Score=154, Evalue=9e-39,
Organism=Escherichia coli, GI1788887, Length=290, Percent_Identity=29.6551724137931, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI2367136, Length=267, Percent_Identity=29.5880149812734, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI157672245, Length=230, Percent_Identity=32.6086956521739, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI145693105, Length=244, Percent_Identity=27.4590163934426, Blast_Score=91, Evalue=7e-20,
Organism=Escherichia coli, GI1788296, Length=235, Percent_Identity=32.7659574468085, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1790208, Length=283, Percent_Identity=27.5618374558304, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1790399, Length=270, Percent_Identity=24.8148148148148, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI87081904, Length=199, Percent_Identity=29.1457286432161, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1788748, Length=248, Percent_Identity=26.6129032258064, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1787806, Length=242, Percent_Identity=22.7272727272727, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1789204, Length=244, Percent_Identity=27.8688524590164, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1789173, Length=209, Percent_Identity=31.1004784688995, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1787589, Length=149, Percent_Identity=29.5302013422819, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1788481, Length=241, Percent_Identity=30.2904564315353, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1787530, Length=251, Percent_Identity=25.0996015936255, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI1786713, Length=199, Percent_Identity=30.6532663316583, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI87082132, Length=147, Percent_Identity=31.2925170068027, Blast_Score=65, Evalue=6e-12,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33482; Mature: 33482

Theoretical pI: Translated: 8.33; Mature: 8.33

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFDLRHIRSFIVLAETLHFGRAAERLNMTQPGMSRLIGELEREVGVPLFRRTTRTVELT
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCHHHHCCCEEEHH
EAGKAFLGECALAMDRLDRAVSIARRTAKGETGILRIAYMDFAINGRLPELLRSFSRMRP
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEEECCCHHHHHHHHHHCCC
DIRLELSFIATLKQYEALLADRIDIGFLIGPVDQPGLASYTFDRDRYVVLLPTTHPLSNV
CEEEHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCEEEECCCCEEEEEECCCCHHHH
RNLRLSDLAREPFVLGSGENWGAFRNQLFALCHRAGFVPDIVQEASSSEGIFGLVAAGAG
HCCHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHCCCCHHHHHHCCCCCCEEEEEECCCC
ISLYASCVRNLQRRGIVIREIEDTPDQLLTCAAWISPTQSPGVQVFVDFLSQVWGGQIAS
HHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCC
A
C
>Mature Secondary Structure
MRFDLRHIRSFIVLAETLHFGRAAERLNMTQPGMSRLIGELEREVGVPLFRRTTRTVELT
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCHHHHCCCEEEHH
EAGKAFLGECALAMDRLDRAVSIARRTAKGETGILRIAYMDFAINGRLPELLRSFSRMRP
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEEECCCHHHHHHHHHHCCC
DIRLELSFIATLKQYEALLADRIDIGFLIGPVDQPGLASYTFDRDRYVVLLPTTHPLSNV
CEEEHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCEEEECCCCEEEEEECCCCHHHH
RNLRLSDLAREPFVLGSGENWGAFRNQLFALCHRAGFVPDIVQEASSSEGIFGLVAAGAG
HCCHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHCCCCHHHHHHCCCCCCEEEEEECCCC
ISLYASCVRNLQRRGIVIREIEDTPDQLLTCAAWISPTQSPGVQVFVDFLSQVWGGQIAS
HHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCC
A
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7685336; 9353933; 9384377 [H]