Click here to switch to the map view.

The map label for this gene is purK [H]

Identifier: 158424038

GI number: 158424038

Start: 2741003

End: 2742097

Strand: Direct

Name: purK [H]

Synonym: AZC_2414

Alternate gene names: 158424038

Gene position: 2741003-2742097 (Clockwise)

Preceding gene: 158424037

Following gene: 158424040

Centisome position: 51.05

GC content: 68.13

Gene sequence:

>1095_bases
ATGCTCAAGCCCGGTTCGACCATTGGCATCCTCGGCGGCGGTCAGCTGGGGCGCATGCTTGCCCTCGCCGCCGCGCCGCT
CGGTCTCAAGACGCACGTTCTGTGCCCCGATGCCGACAGCCCCGCCTTTCAGGTGTGCGACGCGCACGTCTGCGCCGCCT
ATGACGACTTCGACGCGCTCGACCGCTTCGCTGCCGGCGTCGATGTGGTGACATACGAATTCGAGAACGTGCCGCTCGCG
ACGGCCGAACGCCTGTCCATGCACGTGCCGGTCCTGCCCGGCGCCAAGGCGCTCGCCATCACGCAGGATCGCCTGCTGGA
AAAGAGCTTCGTGCGCGACCTTGGCATCGGCACCGCGCCCTTCGCCTCCGTCGATGATCTGCCGGGCCTCGAGGTTGCGG
TCGCCGCCATCGGACTGCCGGCGGTGCTGAAGACCCGGCGATTCGGCTATGACGGCAAGGGACAGGTGACGCTGCGGCCG
GGCGATGATGTTGCGGGCGCGTGGGAGGCCATCGGGCGCCAGCCGGCGATCCTTGAAGGCTTCGTGCCCTTCGTGCGCGA
GGTCTCCATCGTCGCCGCGCGGCGTGCGGACGATGCGTTCGCCGCCTTTGACGTGACCGAGAACGTCCATCGCGACCATA
TCCTGCACCGTTCCACGGTGCCGGCCACGTTGCAGGCGGACGCCATGCGCGATGCCCGGCGCATCGCCTGCCAGATTGCG
TCCGCCCTCGACTATGTGGGCGTGTTTGCCGTCGAGCTGTTCGTGGTCGCGAACCAGGGCGTCGAGAGCGTTCTGGTCAA
TGAGATCGCGCCCCGCGTCCATAACAGCGGACATTGGACGCAGGACGGCGCCGTGACTTCGCAGTTCGAGCAGCACGTGC
GGGCCATCGCCGGCTGGCCGCTGGGCGATGCCCGCCGGCTCGGTCGCGCCGAGATGGTCAATCTCATCGGCGACGATGTG
GAGCAGTGGCTGCCCCTGCTGGCCGAGCCCGGCACCCATCTGCACCTCTACGGCAAGGGCGAAGCCCGTCCCGGCCGCAA
GATGGGACACGTGAACCGGCTGTGGATCGACGAGAAAGCCGTTCCCGGCTGTTAG

Upstream 100 bases:

>100_bases
CGGCCGCGATCCTCGCGACGTCCGACGAGGCGCTCGCCGAGCGTCTCTCCGCATGGCGCGCCGCGCGCACGGATGCGGTG
GCGGAGCGTCCCTCCTGATC

Downstream 100 bases:

>100_bases
GCTGCGACCGGTACAGTCCCTCACGGAACGATCAAGGCCCGCCGGCGATCCGGCGGGCCTTTTCCTTCTGAGCTAGTCCG
GCCGCCGGGTCAGGCGGCGC

Product: phosphoribosylaminoimidazole carboxylase ATPase

Products: NA

Alternate protein names: N5-CAIR synthase; 5-(carboxyamino)imidazole ribonucleotide synthetase [H]

Number of amino acids: Translated: 364; Mature: 364

Protein sequence:

>364_residues
MLKPGSTIGILGGGQLGRMLALAAAPLGLKTHVLCPDADSPAFQVCDAHVCAAYDDFDALDRFAAGVDVVTYEFENVPLA
TAERLSMHVPVLPGAKALAITQDRLLEKSFVRDLGIGTAPFASVDDLPGLEVAVAAIGLPAVLKTRRFGYDGKGQVTLRP
GDDVAGAWEAIGRQPAILEGFVPFVREVSIVAARRADDAFAAFDVTENVHRDHILHRSTVPATLQADAMRDARRIACQIA
SALDYVGVFAVELFVVANQGVESVLVNEIAPRVHNSGHWTQDGAVTSQFEQHVRAIAGWPLGDARRLGRAEMVNLIGDDV
EQWLPLLAEPGTHLHLYGKGEARPGRKMGHVNRLWIDEKAVPGC

Sequences:

>Translated_364_residues
MLKPGSTIGILGGGQLGRMLALAAAPLGLKTHVLCPDADSPAFQVCDAHVCAAYDDFDALDRFAAGVDVVTYEFENVPLA
TAERLSMHVPVLPGAKALAITQDRLLEKSFVRDLGIGTAPFASVDDLPGLEVAVAAIGLPAVLKTRRFGYDGKGQVTLRP
GDDVAGAWEAIGRQPAILEGFVPFVREVSIVAARRADDAFAAFDVTENVHRDHILHRSTVPATLQADAMRDARRIACQIA
SALDYVGVFAVELFVVANQGVESVLVNEIAPRVHNSGHWTQDGAVTSQFEQHVRAIAGWPLGDARRLGRAEMVNLIGDDV
EQWLPLLAEPGTHLHLYGKGEARPGRKMGHVNRLWIDEKAVPGC
>Mature_364_residues
MLKPGSTIGILGGGQLGRMLALAAAPLGLKTHVLCPDADSPAFQVCDAHVCAAYDDFDALDRFAAGVDVVTYEFENVPLA
TAERLSMHVPVLPGAKALAITQDRLLEKSFVRDLGIGTAPFASVDDLPGLEVAVAAIGLPAVLKTRRFGYDGKGQVTLRP
GDDVAGAWEAIGRQPAILEGFVPFVREVSIVAARRADDAFAAFDVTENVHRDHILHRSTVPATLQADAMRDARRIACQIA
SALDYVGVFAVELFVVANQGVESVLVNEIAPRVHNSGHWTQDGAVTSQFEQHVRAIAGWPLGDARRLGRAEMVNLIGDDV
EQWLPLLAEPGTHLHLYGKGEARPGRKMGHVNRLWIDEKAVPGC

Specific function: Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) [H]

COG id: COG0026

COG function: function code F; Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Escherichia coli, GI1786733, Length=346, Percent_Identity=36.7052023121387, Blast_Score=179, Evalue=3e-46,
Organism=Escherichia coli, GI1788155, Length=369, Percent_Identity=28.4552845528455, Blast_Score=101, Evalue=6e-23,
Organism=Saccharomyces cerevisiae, GI6324702, Length=366, Percent_Identity=33.3333333333333, Blast_Score=201, Evalue=2e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005875
- InterPro:   IPR011761
- InterPro:   IPR003135
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02222 ATP-grasp [H]

EC number: =6.3.4.18 [H]

Molecular weight: Translated: 39019; Mature: 39019

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKPGSTIGILGGGQLGRMLALAAAPLGLKTHVLCPDADSPAFQVCDAHVCAAYDDFDAL
CCCCCCEEEEECCCHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHCCHHHCCCCCHHHH
DRFAAGVDVVTYEFENVPLATAERLSMHVPVLPGAKALAITQDRLLEKSFVRDLGIGTAP
HHHHCCCEEEEEEECCCCCHHHHHHEEECCCCCCCCEEEEHHHHHHHHHHHHHCCCCCCC
FASVDDLPGLEVAVAAIGLPAVLKTRRFGYDGKGQVTLRPGDDVAGAWEAIGRQPAILEG
CCCCCCCCCHHHHHHHHCCHHHHHHHHCCCCCCCEEEECCCCCCCHHHHHHCCCCHHHHH
FVPFVREVSIVAARRADDAFAAFDVTENVHRDHILHRSTVPATLQADAMRDARRIACQIA
HHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
SALDYVGVFAVELFVVANQGVESVLVNEIAPRVHNSGHWTQDGAVTSQFEQHVRAIAGWP
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCC
LGDARRLGRAEMVNLIGDDVEQWLPLLAEPGTHLHLYGKGEARPGRKMGHVNRLWIDEKA
CHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHCCCEEEEECCCC
VPGC
CCCC
>Mature Secondary Structure
MLKPGSTIGILGGGQLGRMLALAAAPLGLKTHVLCPDADSPAFQVCDAHVCAAYDDFDAL
CCCCCCEEEEECCCHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHCCHHHCCCCCHHHH
DRFAAGVDVVTYEFENVPLATAERLSMHVPVLPGAKALAITQDRLLEKSFVRDLGIGTAP
HHHHCCCEEEEEEECCCCCHHHHHHEEECCCCCCCCEEEEHHHHHHHHHHHHHCCCCCCC
FASVDDLPGLEVAVAAIGLPAVLKTRRFGYDGKGQVTLRPGDDVAGAWEAIGRQPAILEG
CCCCCCCCCHHHHHHHHCCHHHHHHHHCCCCCCCEEEECCCCCCCHHHHHHCCCCHHHHH
FVPFVREVSIVAARRADDAFAAFDVTENVHRDHILHRSTVPATLQADAMRDARRIACQIA
HHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
SALDYVGVFAVELFVVANQGVESVLVNEIAPRVHNSGHWTQDGAVTSQFEQHVRAIAGWP
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCC
LGDARRLGRAEMVNLIGDDVEQWLPLLAEPGTHLHLYGKGEARPGRKMGHVNRLWIDEKA
CHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHCCCEEEEECCCC
VPGC
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11756688 [H]