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The map label for this gene is purE [H]

Identifier: 158424037

GI number: 158424037

Start: 2740518

End: 2741000

Strand: Direct

Name: purE [H]

Synonym: AZC_2413

Alternate gene names: 158424037

Gene position: 2740518-2741000 (Clockwise)

Preceding gene: 158424036

Following gene: 158424038

Centisome position: 51.04

GC content: 70.19

Gene sequence:

>483_bases
ATGGGGCAGCGGCCGGTGGCCGTCATCATGGGCAGCCAGTCCGATTGGGACACGATGCGCCATGCGGTGGAAATTCTCGA
GCAGCTCGGCGTCGGCCATGACGTGCGGATCGTATCGGCGCATCGCACGCCTGACCGCATGTATGCCTTCGCCAAGGACG
CGAAAGCCGAGGGGTTCAAGGTGATCATCGCCGGTGCCGGCGGCGCGGCGCACCTGCCCGGCATGGTCGCGGCCCTCACC
CCCCTGCCCGTCCTCGGCGTTCCCGTGGAATCGAAGGCGCTGCAAGGCGTCGACAGCCTGCATTCCATCGTGCAGATGCC
GGCCGGCATTCCCGTCGGCACGCTGGCCATCGGCAAGGCGGGCGCAACCAACGCCGGCCTTCTGGCGGCCGCGATCCTCG
CGACGTCCGACGAGGCGCTCGCCGAGCGTCTCTCCGCATGGCGCGCCGCGCGCACGGATGCGGTGGCGGAGCGTCCCTCC
TGA

Upstream 100 bases:

>100_bases
GCCAGCGCGCCGAGTAGGGGAGCGGACCGGGAGCGATTCCCCCTTGCCCCGGCAGTCCCGATCCGATAAAGCCGCGCTTT
CCTTTGCGGGGACGAACGCG

Downstream 100 bases:

>100_bases
TCATGCTCAAGCCCGGTTCGACCATTGGCATCCTCGGCGGCGGTCAGCTGGGGCGCATGCTTGCCCTCGCCGCCGCGCCG
CTCGGTCTCAAGACGCACGT

Product: phosphoribosylaminoimidazole carboxylase catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 160; Mature: 159

Protein sequence:

>160_residues
MGQRPVAVIMGSQSDWDTMRHAVEILEQLGVGHDVRIVSAHRTPDRMYAFAKDAKAEGFKVIIAGAGGAAHLPGMVAALT
PLPVLGVPVESKALQGVDSLHSIVQMPAGIPVGTLAIGKAGATNAGLLAAAILATSDEALAERLSAWRAARTDAVAERPS

Sequences:

>Translated_160_residues
MGQRPVAVIMGSQSDWDTMRHAVEILEQLGVGHDVRIVSAHRTPDRMYAFAKDAKAEGFKVIIAGAGGAAHLPGMVAALT
PLPVLGVPVESKALQGVDSLHSIVQMPAGIPVGTLAIGKAGATNAGLLAAAILATSDEALAERLSAWRAARTDAVAERPS
>Mature_159_residues
GQRPVAVIMGSQSDWDTMRHAVEILEQLGVGHDVRIVSAHRTPDRMYAFAKDAKAEGFKVIIAGAGGAAHLPGMVAALTP
LPVLGVPVESKALQGVDSLHSIVQMPAGIPVGTLAIGKAGATNAGLLAAAILATSDEALAERLSAWRAARTDAVAERPS

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=154, Percent_Identity=68.1818181818182, Blast_Score=180, Evalue=3e-47,
Organism=Saccharomyces cerevisiae, GI6324702, Length=150, Percent_Identity=54.6666666666667, Blast_Score=155, Evalue=3e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 16447; Mature: 16316

Theoretical pI: Translated: 7.09; Mature: 7.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGQRPVAVIMGSQSDWDTMRHAVEILEQLGVGHDVRIVSAHRTPDRMYAFAKDAKAEGFK
CCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHCCCCCCEE
VIIAGAGGAAHLPGMVAALTPLPVLGVPVESKALQGVDSLHSIVQMPAGIPVGTLAIGKA
EEEECCCCCHHHCHHHHHHCCCCEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEECCC
GATNAGLLAAAILATSDEALAERLSAWRAARTDAVAERPS
CCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
GQRPVAVIMGSQSDWDTMRHAVEILEQLGVGHDVRIVSAHRTPDRMYAFAKDAKAEGFK
CCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHCCCCCCEE
VIIAGAGGAAHLPGMVAALTPLPVLGVPVESKALQGVDSLHSIVQMPAGIPVGTLAIGKA
EEEECCCCCHHHCHHHHHHCCCCEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEECCC
GATNAGLLAAAILATSDEALAERLSAWRAARTDAVAERPS
CCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11756688 [H]