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The map label for this gene is moeA [H]

Identifier: 158423826

GI number: 158423826

Start: 2517226

End: 2518464

Strand: Reverse

Name: moeA [H]

Synonym: AZC_2202

Alternate gene names: 158423826

Gene position: 2518464-2517226 (Counterclockwise)

Preceding gene: 158423827

Following gene: 158423825

Centisome position: 46.9

GC content: 70.38

Gene sequence:

>1239_bases
GTGAACATGACCGGCACGCCCAAGAAGGCCCCGCTCATGCCGGTGGCCGACGCCCTCGCGCTCATCACGCGCGATCTCGA
TGTTCTGGCAACCGAGATGGTGCCGGTGGCCGAAGCCGTGGGCCGCGTGCTCGCGGCCCCGCTCGCCGCCCGCCGCAGCC
AGCCGGGTGCCGACATGTCGGCCATGGACGGCTATGCCTTCGCCTATCCCGACACGCTGGACATCCCGCTGACCCTGAAG
GTGGTGGGCGAATCGGCCGCTGGCCGCGCCTTCGACGGCGCCGTGCGGCCGGGAGAAGCCACGCGTATCTTCACCGGCGG
CGTCGTGCCGCCCGGCGCAGACACCGTGGTCATCCAGGAGAACACCACGCGGGAGGGTGACAGCGTCACCATCACCGTGC
CGCTCGCCAAGGGCCGCAATGTGCGCAAGGCCGGCTTTGACTTCGCCGCCGGCACCGCTCTCTTGCCGGCCGGCCGGCGG
CTGAATGCCCGCGACGTGATGCTCGCTGCCGCCGCCGATCACGCGTCCCTACCGGTGGTGCGCCGGCCGCGGGTGGGAAT
CATCCAGACGGGCGATGAGTTGGTCTATCCGGGACAGGCCACGGGCCTCCTCTCGGAAGTGGTGGTCTCCAACGTCTATG
GCCTTGCGGCGCTGGCGCGCGAAGCGGGCGCGGAGGTGATCGACCTCGGCCTCGTGCGCGACGGCATGGACGAGACCCGC
GCCGCCATAAGCCGCGCCCGTGACCTCGGCATCGACGTGCTCGTCTCCTCTGGCGGCGCTTCCGTGGGCGAGCATGATCT
GATGGCCCCGGCGCTGAAGGCCGAGGGCATCGCGCTCGCCGTGCACAAGATCGCCTTGCGCCCCGGCAAGCCGCTGATGT
TCGGCGCGGGCGGCAACATGCGGGCCCTCGGCCTGCCGGGCAATCCGGTCTCGGCCTATGTGTGCGCCGTGCTCTTCCTC
CTGCCCATCCTGAGCCGCCTTCAGGGCGAGGACGCCCCGCTCATGGCGACGCGCCCGGCGCGGCTCGGCACCGCCATGCC
GGCCAATGACACGCGCATGGATTTCGTGCGGGCCCGGCTGTCTTTCGAGGACGGGAAAGCCATTGCCCATCCTCTGACCA
ATCAGGACAGCAGCATGCTTTCGGCTCTCGCCAGCGCCGACTGCCTGCTGATTCGCCCCGCTCATGCGCCCGAGGCGAAG
GTGGGCGACCCGTGCGAGATCATCCCGCTCAACGCCTGA

Upstream 100 bases:

>100_bases
CCATCTATGACATGGCCAAGGCCGCCGATCGCGGCATGCGCATCGAGAACATCCGCCTGCTTGAAAAATCCGGCGGCCGC
TCGGGCGACTGGCGCGCGGC

Downstream 100 bases:

>100_bases
GACCGGCGTTTACCCGATGTTGAGGCTTGTGGAACAAACAAGAAACAGGTACATGATGTTCCTGATTTGTTTCGCAGGGC
GCGGAGCGGATCGTCTCCCG

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 412; Mature: 412

Protein sequence:

>412_residues
MNMTGTPKKAPLMPVADALALITRDLDVLATEMVPVAEAVGRVLAAPLAARRSQPGADMSAMDGYAFAYPDTLDIPLTLK
VVGESAAGRAFDGAVRPGEATRIFTGGVVPPGADTVVIQENTTREGDSVTITVPLAKGRNVRKAGFDFAAGTALLPAGRR
LNARDVMLAAAADHASLPVVRRPRVGIIQTGDELVYPGQATGLLSEVVVSNVYGLAALAREAGAEVIDLGLVRDGMDETR
AAISRARDLGIDVLVSSGGASVGEHDLMAPALKAEGIALAVHKIALRPGKPLMFGAGGNMRALGLPGNPVSAYVCAVLFL
LPILSRLQGEDAPLMATRPARLGTAMPANDTRMDFVRARLSFEDGKAIAHPLTNQDSSMLSALASADCLLIRPAHAPEAK
VGDPCEIIPLNA

Sequences:

>Translated_412_residues
MNMTGTPKKAPLMPVADALALITRDLDVLATEMVPVAEAVGRVLAAPLAARRSQPGADMSAMDGYAFAYPDTLDIPLTLK
VVGESAAGRAFDGAVRPGEATRIFTGGVVPPGADTVVIQENTTREGDSVTITVPLAKGRNVRKAGFDFAAGTALLPAGRR
LNARDVMLAAAADHASLPVVRRPRVGIIQTGDELVYPGQATGLLSEVVVSNVYGLAALAREAGAEVIDLGLVRDGMDETR
AAISRARDLGIDVLVSSGGASVGEHDLMAPALKAEGIALAVHKIALRPGKPLMFGAGGNMRALGLPGNPVSAYVCAVLFL
LPILSRLQGEDAPLMATRPARLGTAMPANDTRMDFVRARLSFEDGKAIAHPLTNQDSSMLSALASADCLLIRPAHAPEAK
VGDPCEIIPLNA
>Mature_412_residues
MNMTGTPKKAPLMPVADALALITRDLDVLATEMVPVAEAVGRVLAAPLAARRSQPGADMSAMDGYAFAYPDTLDIPLTLK
VVGESAAGRAFDGAVRPGEATRIFTGGVVPPGADTVVIQENTTREGDSVTITVPLAKGRNVRKAGFDFAAGTALLPAGRR
LNARDVMLAAAADHASLPVVRRPRVGIIQTGDELVYPGQATGLLSEVVVSNVYGLAALAREAGAEVIDLGLVRDGMDETR
AAISRARDLGIDVLVSSGGASVGEHDLMAPALKAEGIALAVHKIALRPGKPLMFGAGGNMRALGLPGNPVSAYVCAVLFL
LPILSRLQGEDAPLMATRPARLGTAMPANDTRMDFVRARLSFEDGKAIAHPLTNQDSSMLSALASADCLLIRPAHAPEAK
VGDPCEIIPLNA

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=403, Percent_Identity=32.5062034739454, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI66932975, Length=403, Percent_Identity=32.5062034739454, Blast_Score=150, Evalue=3e-36,
Organism=Escherichia coli, GI1787049, Length=383, Percent_Identity=36.0313315926893, Blast_Score=209, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI25147659, Length=369, Percent_Identity=32.2493224932249, Blast_Score=155, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI17562606, Length=342, Percent_Identity=27.1929824561404, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI17136978, Length=411, Percent_Identity=27.7372262773723, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI24638841, Length=411, Percent_Identity=27.7372262773723, Blast_Score=115, Evalue=5e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 42662; Mature: 42662

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNMTGTPKKAPLMPVADALALITRDLDVLATEMVPVAEAVGRVLAAPLAARRSQPGADMS
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCH
AMDGYAFAYPDTLDIPLTLKVVGESAAGRAFDGAVRPGEATRIFTGGVVPPGADTVVIQE
HCCCEEEECCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCEEEECC
NTTREGDSVTITVPLAKGRNVRKAGFDFAAGTALLPAGRRLNARDVMLAAAADHASLPVV
CCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCEECCCCCCCCCCCEEEEECCCCCCCCEE
RRPRVGIIQTGDELVYPGQATGLLSEVVVSNVYGLAALAREAGAEVIDLGLVRDGMDETR
ECCCCCEEECCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHCCHHHHH
AAISRARDLGIDVLVSSGGASVGEHDLMAPALKAEGIALAVHKIALRPGKPLMFGAGGNM
HHHHHHHHCCEEEEEECCCCCCCCCHHHCHHHHCCCEEEEEEEEHCCCCCCEEEECCCCE
RALGLPGNPVSAYVCAVLFLLPILSRLQGEDAPLMATRPARLGTAMPANDTRMDFVRARL
EEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCHHHCCCCCCCCCHHHHHHHHH
SFEDGKAIAHPLTNQDSSMLSALASADCLLIRPAHAPEAKVGDPCEIIPLNA
CCCCCCEEECCCCCCHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCEEECCC
>Mature Secondary Structure
MNMTGTPKKAPLMPVADALALITRDLDVLATEMVPVAEAVGRVLAAPLAARRSQPGADMS
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCH
AMDGYAFAYPDTLDIPLTLKVVGESAAGRAFDGAVRPGEATRIFTGGVVPPGADTVVIQE
HCCCEEEECCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCEEEECC
NTTREGDSVTITVPLAKGRNVRKAGFDFAAGTALLPAGRRLNARDVMLAAAADHASLPVV
CCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCEECCCCCCCCCCCEEEEECCCCCCCCEE
RRPRVGIIQTGDELVYPGQATGLLSEVVVSNVYGLAALAREAGAEVIDLGLVRDGMDETR
ECCCCCEEECCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHCCHHHHH
AAISRARDLGIDVLVSSGGASVGEHDLMAPALKAEGIALAVHKIALRPGKPLMFGAGGNM
HHHHHHHHCCEEEEEECCCCCCCCCHHHCHHHHCCCEEEEEEEEHCCCCCCEEEECCCCE
RALGLPGNPVSAYVCAVLFLLPILSRLQGEDAPLMATRPARLGTAMPANDTRMDFVRARL
EEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCHHHCCCCCCCCCHHHHHHHHH
SFEDGKAIAHPLTNQDSSMLSALASADCLLIRPAHAPEAKVGDPCEIIPLNA
CCCCCCEEECCCCCCHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3045084; 8905232; 9278503; 9515915 [H]