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The map label for this gene is moaC

Identifier: 158423827

GI number: 158423827

Start: 2518461

End: 2518937

Strand: Reverse

Name: moaC

Synonym: AZC_2203

Alternate gene names: 158423827

Gene position: 2518937-2518461 (Counterclockwise)

Preceding gene: 158423828

Following gene: 158423826

Centisome position: 46.91

GC content: 67.3

Gene sequence:

>477_bases
ATGACGCGCCTCACCCACCTCGATTCCACCGGCGCCGCGCGCATGGTGGACGTGTCCGACAAGCCTTCCACCACGCGCGA
GGCGCTGGCGGAAGGACAGGTGGTGATGGCCCCCGAGACCCTCGCGCTCATCCAGTCCGGCAATGCCAAGAAGGGCGACG
TGCTCGGCGTCGCCCGCATCGCCGGCATCATGGCTTCCAAGCGCACCCATGAGCTCATCCCCCTCTGCCATCCCCTCATG
CTGAGCAAGGTGGAAGTGGAAGTGACCCCAGACGAAGCCCTGCCCGGTCTTCATGTGGTGGCGCGAGTGAAGACCGCCGG
CCAGACCGGCGTCGAGATGGAGGCGCTGACGGCCGTCTCCGTCGCCTGCCTCACCATCTATGACATGGCCAAGGCCGCCG
ATCGCGGCATGCGCATCGAGAACATCCGCCTGCTTGAAAAATCCGGCGGCCGCTCGGGCGACTGGCGCGCGGCGTGA

Upstream 100 bases:

>100_bases
ACAGCGCCTCGCTGACGCTGGATGGTGACAACACGCTCAAGGTGCGCGGCTGCATCGTCGTGCCCTTGTGCCAGACCCAG
ACCTGGACCAGGGTCCGCTG

Downstream 100 bases:

>100_bases
ACATGACCGGCACGCCCAAGAAGGCCCCGCTCATGCCGGTGGCCGACGCCCTCGCGCTCATCACGCGCGATCTCGATGTT
CTGGCAACCGAGATGGTGCC

Product: molybdopterin cofactor biosynthesis protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 158; Mature: 157

Protein sequence:

>158_residues
MTRLTHLDSTGAARMVDVSDKPSTTREALAEGQVVMAPETLALIQSGNAKKGDVLGVARIAGIMASKRTHELIPLCHPLM
LSKVEVEVTPDEALPGLHVVARVKTAGQTGVEMEALTAVSVACLTIYDMAKAADRGMRIENIRLLEKSGGRSGDWRAA

Sequences:

>Translated_158_residues
MTRLTHLDSTGAARMVDVSDKPSTTREALAEGQVVMAPETLALIQSGNAKKGDVLGVARIAGIMASKRTHELIPLCHPLM
LSKVEVEVTPDEALPGLHVVARVKTAGQTGVEMEALTAVSVACLTIYDMAKAADRGMRIENIRLLEKSGGRSGDWRAA
>Mature_157_residues
TRLTHLDSTGAARMVDVSDKPSTTREALAEGQVVMAPETLALIQSGNAKKGDVLGVARIAGIMASKRTHELIPLCHPLML
SKVEVEVTPDEALPGLHVVARVKTAGQTGVEMEALTAVSVACLTIYDMAKAADRGMRIENIRLLEKSGGRSGDWRAA

Specific function: Together with moaA, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z

COG id: COG0315

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moaC family

Homologues:

Organism=Escherichia coli, GI1787001, Length=156, Percent_Identity=57.0512820512821, Blast_Score=168, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI32566331, Length=149, Percent_Identity=46.3087248322148, Blast_Score=139, Evalue=7e-34,
Organism=Drosophila melanogaster, GI28574490, Length=151, Percent_Identity=54.9668874172185, Blast_Score=151, Evalue=1e-37,
Organism=Drosophila melanogaster, GI28574492, Length=142, Percent_Identity=54.9295774647887, Blast_Score=140, Evalue=3e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MOAC_AZOC5 (A8I831)

Other databases:

- EMBL:   AP009384
- RefSeq:   YP_001525119.1
- ProteinModelPortal:   A8I831
- SMR:   A8I831
- GeneID:   5689544
- GenomeReviews:   AP009384_GR
- KEGG:   azc:AZC_2203
- HOGENOM:   HBG605231
- OMA:   PMCHPLM
- ProtClustDB:   CLSK980266
- BioCyc:   ACAU438753:AZC_2203-MONOMER
- HAMAP:   MF_01224_B
- InterPro:   IPR023045
- InterPro:   IPR023046
- InterPro:   IPR002820
- Gene3D:   G3DSA:3.30.70.640
- TIGRFAMs:   TIGR00581

Pfam domain/function: PF01967 MoaC; SSF55040 MoaC

EC number: NA

Molecular weight: Translated: 16773; Mature: 16642

Theoretical pI: Translated: 7.58; Mature: 7.58

Prosite motif: NA

Important sites: ACT_SITE 128-128

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRLTHLDSTGAARMVDVSDKPSTTREALAEGQVVMAPETLALIQSGNAKKGDVLGVARI
CCCCCCCCCCCCEEEEECCCCCCHHHHHHHCCCEEECCHHEEEEECCCCCCCCHHHHHHH
AGIMASKRTHELIPLCHPLMLSKVEVEVTPDEALPGLHVVARVKTAGQTGVEMEALTAVS
HHHHHCCCCHHHHHHHHHHHHCEEEEEECCCCCCCCCEEEEEEECCCCCCCHHHHHHHHH
VACLTIYDMAKAADRGMRIENIRLLEKSGGRSGDWRAA
HHHHHHHHHHHHHHCCCEEHHEEEEECCCCCCCCCCCC
>Mature Secondary Structure 
TRLTHLDSTGAARMVDVSDKPSTTREALAEGQVVMAPETLALIQSGNAKKGDVLGVARI
CCCCCCCCCCCEEEEECCCCCCHHHHHHHCCCEEECCHHEEEEECCCCCCCCHHHHHHH
AGIMASKRTHELIPLCHPLMLSKVEVEVTPDEALPGLHVVARVKTAGQTGVEMEALTAVS
HHHHHCCCCHHHHHHHHHHHHCEEEEEECCCCCCCCCEEEEEEECCCCCCCHHHHHHHHH
VACLTIYDMAKAADRGMRIENIRLLEKSGGRSGDWRAA
HHHHHHHHHHHHHHCCCEEHHEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Involved in molybdopterin biosynthesis [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA