Click here to switch to the map view.

The map label for this gene is oac1 [C]

Identifier: 158423457

GI number: 158423457

Start: 2097794

End: 2098858

Strand: Reverse

Name: oac1 [C]

Synonym: AZC_1833

Alternate gene names: 158423457

Gene position: 2098858-2097794 (Counterclockwise)

Preceding gene: 158423458

Following gene: 158423456

Centisome position: 39.09

GC content: 66.38

Gene sequence:

>1065_bases
GTGGACAACATGGCCAAGCGTGTTCTCGTCACCGGCGGCGCCGGCTTCATCGGATCGGCCGTGGTGCGCCATCTCGTCGC
CACCGGCGCCACGGTCCTCAACTTCGACAAGCTGACCTATGCGGGCAATCTCGCCTCCGTCGGCCCGGTCGCGGATCATC
CCAACTATCAGTTCGTACAGGCCGACATCTGCGATGCCGAGGCGGTGCGCGGTGCGCTGGAGGGCTTCAAGCCGGACACG
GTGATGCACCTCGCCGCCGAGTCCCATGTGGACCGCTCCATCGACGGGCCGGGCGCCTTCATCACCACCAACATCAACGG
CACTTACGTGATGCTGCAGGAGGCGCTGCGCTACTGGCGCACGCTCGGCAGCGCCGCGCAGGAGGGCTTCCGCTTCCACC
ACATCTCCACCGACGAGGTGTTCGGAAGCCTCGGGGCCGAGGGCCTGTTCCGCGAGGACACGCCGTATCAGCCCAATTCG
CCCTATTCCGCCTCCAAGGCGGCGTCCGATCATCTGGTGCGGGCCTGGCACCACACCTACGGCCTGCCCACGGTGATGTC
GAACTGCTCGAACAATTACGGGCCGTACCATTTCCCCGAGAAGCTGATCCCGCTCACCATCCTCAACGCGCTCGACGGCC
TCAAGCTGCCCGTCTACGGCACCGGCGAGAACATCCGCGACTGGCTCTATGTGGAAGACCATGCGGAGGCCCTCGCCCTG
ATTGCCGCCACCGGCACGCCGGGCGAGAGCTACAATGTGGGCGGCCTCAACGAGCGCCGGAACATCGACGTGGTGCGCAC
CATCTGCGCCATCCTCGACGAGATCCGCCCCGACGCGAAGATCGGCCCGCGCGAAAACCTCATCACCTTCGTGACCGATC
GGCCGGGGCATGATGCGCGCTATGCCATCGATGCCACCAAGCTCACCACCGAGCTCGGCTGGAAGGCGCGCGAGACCTTC
GAGACCGGCCTGCGCAAGACGGTGCACTGGTATCTCGACAACCGCGCCTGGTGGGAGCCGCTGCGCAACCGCTATGCCGG
CCAGCGTCTGGGGCTCGCCTCCTGA

Upstream 100 bases:

>100_bases
CTGGCCATCGACTGGCCCGTGTCGAACGCGCTCGTCTCCGAGAAGGACGAGATCCTGCCGCGTTTCAAGGATCTCGACAG
CCCCTTCATCTACGCCTGAG

Downstream 100 bases:

>100_bases
TGCGCGTCCTCCTGCTCGGCGCTGACGGTCAGCTCGGCCGGGAACTCACGGCTCTTGCGGTCGAGCGGGGCCTTGCGCTC
GCGGCGCTCAACCGCGCCGC

Product: dTDP-D-glucose-4,6-dehydratase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 354; Mature: 354

Protein sequence:

>354_residues
MDNMAKRVLVTGGAGFIGSAVVRHLVATGATVLNFDKLTYAGNLASVGPVADHPNYQFVQADICDAEAVRGALEGFKPDT
VMHLAAESHVDRSIDGPGAFITTNINGTYVMLQEALRYWRTLGSAAQEGFRFHHISTDEVFGSLGAEGLFREDTPYQPNS
PYSASKAASDHLVRAWHHTYGLPTVMSNCSNNYGPYHFPEKLIPLTILNALDGLKLPVYGTGENIRDWLYVEDHAEALAL
IAATGTPGESYNVGGLNERRNIDVVRTICAILDEIRPDAKIGPRENLITFVTDRPGHDARYAIDATKLTTELGWKARETF
ETGLRKTVHWYLDNRAWWEPLRNRYAGQRLGLAS

Sequences:

>Translated_354_residues
MDNMAKRVLVTGGAGFIGSAVVRHLVATGATVLNFDKLTYAGNLASVGPVADHPNYQFVQADICDAEAVRGALEGFKPDT
VMHLAAESHVDRSIDGPGAFITTNINGTYVMLQEALRYWRTLGSAAQEGFRFHHISTDEVFGSLGAEGLFREDTPYQPNS
PYSASKAASDHLVRAWHHTYGLPTVMSNCSNNYGPYHFPEKLIPLTILNALDGLKLPVYGTGENIRDWLYVEDHAEALAL
IAATGTPGESYNVGGLNERRNIDVVRTICAILDEIRPDAKIGPRENLITFVTDRPGHDARYAIDATKLTTELGWKARETF
ETGLRKTVHWYLDNRAWWEPLRNRYAGQRLGLAS
>Mature_354_residues
MDNMAKRVLVTGGAGFIGSAVVRHLVATGATVLNFDKLTYAGNLASVGPVADHPNYQFVQADICDAEAVRGALEGFKPDT
VMHLAAESHVDRSIDGPGAFITTNINGTYVMLQEALRYWRTLGSAAQEGFRFHHISTDEVFGSLGAEGLFREDTPYQPNS
PYSASKAASDHLVRAWHHTYGLPTVMSNCSNNYGPYHFPEKLIPLTILNALDGLKLPVYGTGENIRDWLYVEDHAEALAL
IAATGTPGESYNVGGLNERRNIDVVRTICAILDEIRPDAKIGPRENLITFVTDRPGHDARYAIDATKLTTELGWKARETF
ETGLRKTVHWYLDNRAWWEPLRNRYAGQRLGLAS

Specific function: INVOLVED IN THE SYNTHESIS OF ENTEROBACTERIAL COMMON ANTIGEN (ECA) AND REQUIRED FOR SYNTHESIS OF LIPOPOLYSACCHARIDE O-SIDE CHAINS. [C]

COG id: COG1088

COG function: function code M; dTDP-D-glucose 4,6-dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family. dTDP-glucose dehydratase subfamily [H]

Homologues:

Organism=Homo sapiens, GI7657641, Length=341, Percent_Identity=36.6568914956012, Blast_Score=228, Evalue=6e-60,
Organism=Homo sapiens, GI42516563, Length=332, Percent_Identity=24.6987951807229, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI4504031, Length=342, Percent_Identity=24.5614035087719, Blast_Score=78, Evalue=1e-14,
Organism=Escherichia coli, GI48994969, Length=352, Percent_Identity=61.0795454545455, Blast_Score=449, Evalue=1e-127,
Organism=Escherichia coli, GI1788353, Length=347, Percent_Identity=61.9596541786743, Blast_Score=432, Evalue=1e-122,
Organism=Escherichia coli, GI1788366, Length=360, Percent_Identity=25.5555555555556, Blast_Score=78, Evalue=7e-16,
Organism=Escherichia coli, GI1786974, Length=351, Percent_Identity=27.0655270655271, Blast_Score=78, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17568069, Length=332, Percent_Identity=35.5421686746988, Blast_Score=189, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI115532424, Length=330, Percent_Identity=32.1212121212121, Blast_Score=152, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17539532, Length=349, Percent_Identity=24.3553008595989, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI133901788, Length=253, Percent_Identity=25.6916996047431, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI133901786, Length=253, Percent_Identity=25.6916996047431, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17539422, Length=253, Percent_Identity=25.6916996047431, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI133901790, Length=253, Percent_Identity=25.6916996047431, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17539424, Length=253, Percent_Identity=25.6916996047431, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6319493, Length=365, Percent_Identity=24.1095890410959, Blast_Score=67, Evalue=4e-12,
Organism=Drosophila melanogaster, GI21356223, Length=338, Percent_Identity=26.0355029585799, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI19923002, Length=360, Percent_Identity=27.7777777777778, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005888
- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =4.2.1.46 [H]

Molecular weight: Translated: 39030; Mature: 39030

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDNMAKRVLVTGGAGFIGSAVVRHLVATGATVLNFDKLTYAGNLASVGPVADHPNYQFVQ
CCCHHCEEEEECCCCHHHHHHHHHHHHCCCCEEEECHHEECCCCCCCCCCCCCCCCEEEE
ADICDAEAVRGALEGFKPDTVMHLAAESHVDRSIDGPGAFITTNINGTYVMLQEALRYWR
ECCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCEEEECCCCHHHHHHHHHHHHH
TLGSAAQEGFRFHHISTDEVFGSLGAEGLFREDTPYQPNSPYSASKAASDHLVRAWHHTY
HHHHHHHCCCEEEECCHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHC
GLPTVMSNCSNNYGPYHFPEKLIPLTILNALDGLKLPVYGTGENIRDWLYVEDHAEALAL
CCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCEEEEECCCCEEEE
IAATGTPGESYNVGGLNERRNIDVVRTICAILDEIRPDAKIGPRENLITFVTDRPGHDAR
EEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCE
YAIDATKLTTELGWKARETFETGLRKTVHWYLDNRAWWEPLRNRYAGQRLGLAS
EEEEHHHHHHHHCCHHHHHHHHHHHHEEHEEECCCHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MDNMAKRVLVTGGAGFIGSAVVRHLVATGATVLNFDKLTYAGNLASVGPVADHPNYQFVQ
CCCHHCEEEEECCCCHHHHHHHHHHHHCCCCEEEECHHEECCCCCCCCCCCCCCCCEEEE
ADICDAEAVRGALEGFKPDTVMHLAAESHVDRSIDGPGAFITTNINGTYVMLQEALRYWR
ECCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCEEEECCCCHHHHHHHHHHHHH
TLGSAAQEGFRFHHISTDEVFGSLGAEGLFREDTPYQPNSPYSASKAASDHLVRAWHHTY
HHHHHHHCCCEEEECCHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHC
GLPTVMSNCSNNYGPYHFPEKLIPLTILNALDGLKLPVYGTGENIRDWLYVEDHAEALAL
CCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCEEEEECCCCEEEE
IAATGTPGESYNVGGLNERRNIDVVRTICAILDEIRPDAKIGPRENLITFVTDRPGHDAR
EEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCE
YAIDATKLTTELGWKARETFETGLRKTVHWYLDNRAWWEPLRNRYAGQRLGLAS
EEEEHHHHHHHHCCHHHHHHHHHHHHEEHEEECCCHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]