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The map label for this gene is oac2 [C]

Identifier: 158423456

GI number: 158423456

Start: 2096901

End: 2097794

Strand: Reverse

Name: oac2 [C]

Synonym: AZC_1832

Alternate gene names: 158423456

Gene position: 2097794-2096901 (Counterclockwise)

Preceding gene: 158423457

Following gene: 158423455

Centisome position: 39.07

GC content: 70.81

Gene sequence:

>894_bases
ATGCGCGTCCTCCTGCTCGGCGCTGACGGTCAGCTCGGCCGGGAACTCACGGCTCTTGCGGTCGAGCGGGGCCTTGCGCT
CGCGGCGCTCAACCGCGCCGCCACAGACATCACCGATCCGGTGGCGGTGGCAAAGGCGCTGGAGGCGCATAAGCCGGACG
TGGTGGTGAATGCCGCCGCCTATACGGCCGTGGACAAGGCCGAGAGCGAGCCGGATCTCGCCGCGAAGGTGAATGCGGTG
GCGCCCGGCCTCATCGCCGAGCGCTGCGCCAGCGCGGGCGTGCCGCTGATCCACGTCTCGACGGATTACGTCTTCGACGG
CACCAAGACCGGCGCCTATGTGGAGAGCGATCCGCTCGCGCCGCTCGGCGTCTACGGGCGCACCAAGGCGGCGGGCGAGG
CGGCCATCCGCGCCGCCGGCGAGAAGCACCTCATCCTGCGCACCGCCTGGGTCTATGGCATCTACGGCAACAATTTCCTC
AAGACAATGCTGCGGCTCGCCAAGGACCGGGACCGGCTGACCATCGTCGCCGACCAGCGCGGCTGCCCGACCGCCACCCG
CGACATCGCCGAGGGCATCCTCGCGGCGGCAGCGCCCGCCGTGGCGGGAAGTGCCCGCTGGGGCACCTATCATCTGGGCG
GCACGGGCGTCACCACGTGGCACGGCTTCGCGCAGGCGATCATCGACCGGGCGGCGACCTACACCGGCCGCAGGCCGGAG
GTGGCGGCCATCACCACCGCCGAGTATCCCACCCCGGCCCGACGGCCGGCCAATTCCGAACTTGATTCCAGCCTGTTCGA
GCGGACATTCCACTTCCGCGCCGCGCCCTGGCAGCAGCGCACGGTCGAGGTGGTGGACACGCTGCTCGCCAAGAGCCCCG
TGGAGGCATCGTGA

Upstream 100 bases:

>100_bases
CCGGCCTGCGCAAGACGGTGCACTGGTATCTCGACAACCGCGCCTGGTGGGAGCCGCTGCGCAACCGCTATGCCGGCCAG
CGTCTGGGGCTCGCCTCCTG

Downstream 100 bases:

>100_bases
AAGGCATCATACTCGCCGGAGGTTCCGGCACCCGTCTCCACCCCATCACGCTCGTCGTGTCCAAGCAGCTGCTGCCGGTC
TACGACAAGCCGATGATCTA

Product: dTDP-4-dehydrorhamnose reductase

Products: NA

Alternate protein names: dTDP-4-keto-L-rhamnose reductase; dTDP-6-deoxy-L-lyxo-4-hexulose reductase; dTDP-6-deoxy-L-mannose dehydrogenase; dTDP-L-rhamnose synthase [H]

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
MRVLLLGADGQLGRELTALAVERGLALAALNRAATDITDPVAVAKALEAHKPDVVVNAAAYTAVDKAESEPDLAAKVNAV
APGLIAERCASAGVPLIHVSTDYVFDGTKTGAYVESDPLAPLGVYGRTKAAGEAAIRAAGEKHLILRTAWVYGIYGNNFL
KTMLRLAKDRDRLTIVADQRGCPTATRDIAEGILAAAAPAVAGSARWGTYHLGGTGVTTWHGFAQAIIDRAATYTGRRPE
VAAITTAEYPTPARRPANSELDSSLFERTFHFRAAPWQQRTVEVVDTLLAKSPVEAS

Sequences:

>Translated_297_residues
MRVLLLGADGQLGRELTALAVERGLALAALNRAATDITDPVAVAKALEAHKPDVVVNAAAYTAVDKAESEPDLAAKVNAV
APGLIAERCASAGVPLIHVSTDYVFDGTKTGAYVESDPLAPLGVYGRTKAAGEAAIRAAGEKHLILRTAWVYGIYGNNFL
KTMLRLAKDRDRLTIVADQRGCPTATRDIAEGILAAAAPAVAGSARWGTYHLGGTGVTTWHGFAQAIIDRAATYTGRRPE
VAAITTAEYPTPARRPANSELDSSLFERTFHFRAAPWQQRTVEVVDTLLAKSPVEAS
>Mature_297_residues
MRVLLLGADGQLGRELTALAVERGLALAALNRAATDITDPVAVAKALEAHKPDVVVNAAAYTAVDKAESEPDLAAKVNAV
APGLIAERCASAGVPLIHVSTDYVFDGTKTGAYVESDPLAPLGVYGRTKAAGEAAIRAAGEKHLILRTAWVYGIYGNNFL
KTMLRLAKDRDRLTIVADQRGCPTATRDIAEGILAAAAPAVAGSARWGTYHLGGTGVTTWHGFAQAIIDRAATYTGRRPE
VAAITTAEYPTPARRPANSELDSSLFERTFHFRAAPWQQRTVEVVDTLLAKSPVEAS

Specific function: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose. RmlD uses NADH and NADPH nearly equally well [H]

COG id: COG1091

COG function: function code M; dTDP-4-dehydrorhamnose reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dTDP-4-dehydrorhamnose reductase family [H]

Homologues:

Organism=Homo sapiens, GI11034825, Length=278, Percent_Identity=30.5755395683453, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI33519455, Length=278, Percent_Identity=30.5755395683453, Blast_Score=99, Evalue=6e-21,
Organism=Escherichia coli, GI1788352, Length=304, Percent_Identity=41.1184210526316, Blast_Score=217, Evalue=7e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005913
- InterPro:   IPR016040 [H]

Pfam domain/function: PF04321 RmlD_sub_bind [H]

EC number: =1.1.1.133 [H]

Molecular weight: Translated: 31368; Mature: 31368

Theoretical pI: Translated: 7.66; Mature: 7.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVLLLGADGQLGRELTALAVERGLALAALNRAATDITDPVAVAKALEAHKPDVVVNAAA
CEEEEECCCCCCHHHHHHHHHHHCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEHHH
YTAVDKAESEPDLAAKVNAVAPGLIAERCASAGVPLIHVSTDYVFDGTKTGAYVESDPLA
HHHHHHCCCCCCHHHHHHHCCCHHHHHHHHHCCCCEEEEECCEEECCCCCCCEEECCCCC
PLGVYGRTKAAGEAAIRAAGEKHLILRTAWVYGIYGNNFLKTMLRLAKDRDRLTIVADQR
CCCCCCCCCHHHHHHHHHCCCCEEEEEEEEEEEECCCHHHHHHHHHHCCCCCEEEEECCC
GCPTATRDIAEGILAAAAPAVAGSARWGTYHLGGTGVTTWHGFAQAIIDRAATYTGRRPE
CCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCC
VAAITTAEYPTPARRPANSELDSSLFERTFHFRAAPWQQRTVEVVDTLLAKSPVEAS
EEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MRVLLLGADGQLGRELTALAVERGLALAALNRAATDITDPVAVAKALEAHKPDVVVNAAA
CEEEEECCCCCCHHHHHHHHHHHCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEHHH
YTAVDKAESEPDLAAKVNAVAPGLIAERCASAGVPLIHVSTDYVFDGTKTGAYVESDPLA
HHHHHHCCCCCCHHHHHHHCCCHHHHHHHHHCCCCEEEEECCEEECCCCCCCEEECCCCC
PLGVYGRTKAAGEAAIRAAGEKHLILRTAWVYGIYGNNFLKTMLRLAKDRDRLTIVADQR
CCCCCCCCCHHHHHHHHHCCCCEEEEEEEEEEEECCCHHHHHHHHHHCCCCCEEEEECCC
GCPTATRDIAEGILAAAAPAVAGSARWGTYHLGGTGVTTWHGFAQAIIDRAATYTGRRPE
CCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCC
VAAITTAEYPTPARRPANSELDSSLFERTFHFRAAPWQQRTVEVVDTLLAKSPVEAS
EEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]