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The map label for this gene is poxB [H]

Identifier: 158422979

GI number: 158422979

Start: 1526169

End: 1527905

Strand: Reverse

Name: poxB [H]

Synonym: AZC_1355

Alternate gene names: 158422979

Gene position: 1527905-1526169 (Counterclockwise)

Preceding gene: 158422980

Following gene: 158422978

Centisome position: 28.45

GC content: 67.18

Gene sequence:

>1737_bases
ATGTTCTCTCGTAACGTTGCGGAACTTATCGTAGACACGCTCGGCGAAGCGGGCGTCGAGCGCATCTATGGCGTGGTGGG
CGACAGCCTCAACGGCCTGACGGAGGCCCTGCGCACGACCGGGAAGATGCGGTGGGTGCATGTCAGGCACGAGGAAGTTG
CGGCCTTCGCGGCGGCCGGAGAGTCGCAGATCACCGGACAGCTCGCGGTGTGCGCCGGCTCCTGTGGTCCGGGCAATCTG
CACCTGATCAACGGCCTCTTCGATGCGCAGCGGAGCCGGACGCCGGTCCTCGCCATCGCCGCCCAGATCCCGTCCGCCGA
GATCGGGGGCGGCTATTTCCAGGAGACCCACCCGCAGAACCTCTTCCAGGAATGCAGCGTCTATTGCGAACTCGTCTCCG
ATCCCGCCCAGATGCCGTTCGTGCTGGAGAATGCCATCCGCGCCGCCGTCGGCCAACGCGGCGTGGCGGTGGTTGTCATT
CCCGGCGACGTCGCGCTGAAGCCGGCGCCGGACCGCCCGATCTCCGAGCGGCGGGGCCTCGTTCCCGCAGCGCCGGTGGT
GGTGCCCGCCGAGAGCGAACTCGATGCCCTCGCCGATCTGCTGAACGGCGCAGAGCGCGTCACGCTGTTCTGCGGCCGGG
GCTGCGCGGGTGCCCACCCCCAGCTCATGCAACTCGCGGAGGCGCTCAAGAGCCCCATGGTCCACGCGCTTGGCGGCAAG
GAGCACGTGGAATACGACAATCCCTATGATGTGGGCATGACGGGCTTCATCGGCTTCTCGTCCGGCTACGAAGCCATGCA
CGCCTGCGACGTGCTGCTGATGCTCGGCACCGACTTCCCCTACAAGCAGTTCCTGCCGACGGGCATCAAGATCGCCCAGG
TGGACATCCGGCCAGAGCATCTCGGGCGGCGCTGCAAGCTTGATCTCGGCGTGGTCGGTGATGTGGCCGCGACGATCACT
GCCCTCATGCCGCGCCTGACCGCCAAGGCCGACCGCCTGCACCTCGATGACAGCGTCACGCGTTACAAGCACGCCCGCAA
GGGCCTCGATGCGCTGGCGCAGGGCAAGCCCGGCAGCAAGCCGATCCATCCGCAGTATCTCACGCGGCTGATCAGCGAGC
GCGCCACCTCGGACGCAGCTTTCACCTTCGATGTGGGAACGCCCACCATCTGGGCCGCGCGTTATCTCGAAATGAACGGC
AAGCGCCGCCTCGTGGGGTCGCTGGCGCACGGCTCCATGGCGAATGCCCTGCCGCAGGCCATCGGCATCCAGGCCTCCCA
TCCCGATCGGCAGGTCATCTCGCTGTCGGGCGATGGCGGCTTCACCATGCTGATGGGCGATCTGGTCACGCTGGTGCAGG
AAAAGCTCCCGGTGAAGACGGTCATCTTCAACAATGGCGTGCTCGGCTTCGTGGCGCTGGAGATGAAGGCGGCAGGCTTC
GTGGAGCTGGGCACCGATCTCCAGAACCCGGATTTCGCGGCCATGGCCAATGCCATGGGCATCCTCGGCGTGCGGGTGGA
GGACCCCGGCGAGCTTCCCGCCGCCATCGACCAGGTGCTGGCCCACGACGGCCCGGCGGTGCTCGATGTGGTCACCGCGA
CGCAGGAACTGTCCATGCCGCCGACCATCGGGGTCGAGCAGGCGAAGGGCTTCGGCCTGTGGATGCTGCGTGCCGTCCTC
AGCGGGCACGGCACAGAGGTAATCGACCTCGCCAGCACCAACCTGCTGCCGCGCTGA

Upstream 100 bases:

>100_bases
CGTATGCCGCCGATAGCGCGATGTCTGGCAGCGCAGACGAACGACGCCTTCTATCTTTCCCGAGCCTCGTTTCTTGGCAT
TCACTTGGAAGGAGATGGCC

Downstream 100 bases:

>100_bases
GCCCGACCGCCTCCTCGCATCGCCCCTGCTCGTGCCGGTTCCTCAGAACGCGGGATACTCCCATGGAACTCACCCCCCTT
CTGCTGTCGCGAATCCAGTT

Product: pyruvate dehydrogenase

Products: NA

Alternate protein names: Pyruvate oxidase; POX [H]

Number of amino acids: Translated: 578; Mature: 578

Protein sequence:

>578_residues
MFSRNVAELIVDTLGEAGVERIYGVVGDSLNGLTEALRTTGKMRWVHVRHEEVAAFAAAGESQITGQLAVCAGSCGPGNL
HLINGLFDAQRSRTPVLAIAAQIPSAEIGGGYFQETHPQNLFQECSVYCELVSDPAQMPFVLENAIRAAVGQRGVAVVVI
PGDVALKPAPDRPISERRGLVPAAPVVVPAESELDALADLLNGAERVTLFCGRGCAGAHPQLMQLAEALKSPMVHALGGK
EHVEYDNPYDVGMTGFIGFSSGYEAMHACDVLLMLGTDFPYKQFLPTGIKIAQVDIRPEHLGRRCKLDLGVVGDVAATIT
ALMPRLTAKADRLHLDDSVTRYKHARKGLDALAQGKPGSKPIHPQYLTRLISERATSDAAFTFDVGTPTIWAARYLEMNG
KRRLVGSLAHGSMANALPQAIGIQASHPDRQVISLSGDGGFTMLMGDLVTLVQEKLPVKTVIFNNGVLGFVALEMKAAGF
VELGTDLQNPDFAAMANAMGILGVRVEDPGELPAAIDQVLAHDGPAVLDVVTATQELSMPPTIGVEQAKGFGLWMLRAVL
SGHGTEVIDLASTNLLPR

Sequences:

>Translated_578_residues
MFSRNVAELIVDTLGEAGVERIYGVVGDSLNGLTEALRTTGKMRWVHVRHEEVAAFAAAGESQITGQLAVCAGSCGPGNL
HLINGLFDAQRSRTPVLAIAAQIPSAEIGGGYFQETHPQNLFQECSVYCELVSDPAQMPFVLENAIRAAVGQRGVAVVVI
PGDVALKPAPDRPISERRGLVPAAPVVVPAESELDALADLLNGAERVTLFCGRGCAGAHPQLMQLAEALKSPMVHALGGK
EHVEYDNPYDVGMTGFIGFSSGYEAMHACDVLLMLGTDFPYKQFLPTGIKIAQVDIRPEHLGRRCKLDLGVVGDVAATIT
ALMPRLTAKADRLHLDDSVTRYKHARKGLDALAQGKPGSKPIHPQYLTRLISERATSDAAFTFDVGTPTIWAARYLEMNG
KRRLVGSLAHGSMANALPQAIGIQASHPDRQVISLSGDGGFTMLMGDLVTLVQEKLPVKTVIFNNGVLGFVALEMKAAGF
VELGTDLQNPDFAAMANAMGILGVRVEDPGELPAAIDQVLAHDGPAVLDVVTATQELSMPPTIGVEQAKGFGLWMLRAVL
SGHGTEVIDLASTNLLPR
>Mature_578_residues
MFSRNVAELIVDTLGEAGVERIYGVVGDSLNGLTEALRTTGKMRWVHVRHEEVAAFAAAGESQITGQLAVCAGSCGPGNL
HLINGLFDAQRSRTPVLAIAAQIPSAEIGGGYFQETHPQNLFQECSVYCELVSDPAQMPFVLENAIRAAVGQRGVAVVVI
PGDVALKPAPDRPISERRGLVPAAPVVVPAESELDALADLLNGAERVTLFCGRGCAGAHPQLMQLAEALKSPMVHALGGK
EHVEYDNPYDVGMTGFIGFSSGYEAMHACDVLLMLGTDFPYKQFLPTGIKIAQVDIRPEHLGRRCKLDLGVVGDVAATIT
ALMPRLTAKADRLHLDDSVTRYKHARKGLDALAQGKPGSKPIHPQYLTRLISERATSDAAFTFDVGTPTIWAARYLEMNG
KRRLVGSLAHGSMANALPQAIGIQASHPDRQVISLSGDGGFTMLMGDLVTLVQEKLPVKTVIFNNGVLGFVALEMKAAGF
VELGTDLQNPDFAAMANAMGILGVRVEDPGELPAAIDQVLAHDGPAVLDVVTATQELSMPPTIGVEQAKGFGLWMLRAVL
SGHGTEVIDLASTNLLPR

Specific function: Unknown

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI93004078, Length=566, Percent_Identity=25.0883392226148, Blast_Score=125, Evalue=9e-29,
Organism=Escherichia coli, GI1787096, Length=575, Percent_Identity=59.8260869565217, Blast_Score=692, Evalue=0.0,
Organism=Escherichia coli, GI87081685, Length=532, Percent_Identity=28.0075187969925, Blast_Score=189, Evalue=3e-49,
Organism=Escherichia coli, GI1790104, Length=547, Percent_Identity=27.6051188299817, Blast_Score=177, Evalue=1e-45,
Organism=Escherichia coli, GI1786717, Length=549, Percent_Identity=26.775956284153, Blast_Score=158, Evalue=7e-40,
Organism=Escherichia coli, GI1788716, Length=545, Percent_Identity=22.7522935779817, Blast_Score=95, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17531299, Length=569, Percent_Identity=26.1862917398945, Blast_Score=118, Evalue=9e-27,
Organism=Caenorhabditis elegans, GI17531301, Length=569, Percent_Identity=26.5377855887522, Blast_Score=117, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6323755, Length=554, Percent_Identity=25.0902527075812, Blast_Score=170, Evalue=5e-43,
Organism=Saccharomyces cerevisiae, GI6320816, Length=482, Percent_Identity=22.1991701244813, Blast_Score=95, Evalue=3e-20,
Organism=Drosophila melanogaster, GI19922626, Length=489, Percent_Identity=26.3803680981595, Blast_Score=124, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =1.2.5.1 [H]

Molecular weight: Translated: 61387; Mature: 61387

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: PS00187 TPP_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSRNVAELIVDTLGEAGVERIYGVVGDSLNGLTEALRTTGKMRWVHVRHEEVAAFAAAG
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCEEEEEEEHHHHHHHHHCC
ESQITGQLAVCAGSCGPGNLHLINGLFDAQRSRTPVLAIAAQIPSAEIGGGYFQETHPQN
CCCCCCEEEEEECCCCCCCEEEEHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCHHH
LFQECSVYCELVSDPAQMPFVLENAIRAAVGQRGVAVVVIPGDVALKPAPDRPISERRGL
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCEEECCCCCCCHHHHCCC
VPAAPVVVPAESELDALADLLNGAERVTLFCGRGCAGAHPQLMQLAEALKSPMVHALGGK
CCCCCEEECCCHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCEECCCCC
EHVEYDNPYDVGMTGFIGFSSGYEAMHACDVLLMLGTDFPYKQFLPTGIKIAQVDIRPEH
CCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCCHHHHCCCCCEEEEEECCHHH
LGRRCKLDLGVVGDVAATITALMPRLTAKADRLHLDDSVTRYKHARKGLDALAQGKPGSK
CCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHHHHHHHHCCCCCCC
PIHPQYLTRLISERATSDAAFTFDVGTPTIWAARYLEMNGKRRLVGSLAHGSMANALPQA
CCCHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHH
IGIQASHPDRQVISLSGDGGFTMLMGDLVTLVQEKLPVKTVIFNNGVLGFVALEMKAAGF
HCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCEEEEEECCCCEEEEEEEHHHCCC
VELGTDLQNPDFAAMANAMGILGVRVEDPGELPAAIDQVLAHDGPAVLDVVTATQELSMP
EEECCCCCCCCHHHHHHHHCEEEEEECCCCCCHHHHHHHHHCCCCCEEHHHHHHHHCCCC
PTIGVEQAKGFGLWMLRAVLSGHGTEVIDLASTNLLPR
CCCCHHHCCCCHHHHHHHHHCCCCCEEEEECCCCCCCC
>Mature Secondary Structure
MFSRNVAELIVDTLGEAGVERIYGVVGDSLNGLTEALRTTGKMRWVHVRHEEVAAFAAAG
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCEEEEEEEHHHHHHHHHCC
ESQITGQLAVCAGSCGPGNLHLINGLFDAQRSRTPVLAIAAQIPSAEIGGGYFQETHPQN
CCCCCCEEEEEECCCCCCCEEEEHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCHHH
LFQECSVYCELVSDPAQMPFVLENAIRAAVGQRGVAVVVIPGDVALKPAPDRPISERRGL
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCEEECCCCCCCHHHHCCC
VPAAPVVVPAESELDALADLLNGAERVTLFCGRGCAGAHPQLMQLAEALKSPMVHALGGK
CCCCCEEECCCHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCEECCCCC
EHVEYDNPYDVGMTGFIGFSSGYEAMHACDVLLMLGTDFPYKQFLPTGIKIAQVDIRPEH
CCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCCHHHHCCCCCEEEEEECCHHH
LGRRCKLDLGVVGDVAATITALMPRLTAKADRLHLDDSVTRYKHARKGLDALAQGKPGSK
CCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHHHHHHHHCCCCCCC
PIHPQYLTRLISERATSDAAFTFDVGTPTIWAARYLEMNGKRRLVGSLAHGSMANALPQA
CCCHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHH
IGIQASHPDRQVISLSGDGGFTMLMGDLVTLVQEKLPVKTVIFNNGVLGFVALEMKAAGF
HCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCEEEEEECCCCEEEEEEEHHHCCC
VELGTDLQNPDFAAMANAMGILGVRVEDPGELPAAIDQVLAHDGPAVLDVVTATQELSMP
EEECCCCCCCCHHHHHHHHCEEEEEECCCCCCHHHHHHHHHCCCCCEEHHHHHHHHCCCC
PTIGVEQAKGFGLWMLRAVLSGHGTEVIDLASTNLLPR
CCCCHHHCCCCHHHHHHHHHCCCCCEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3016647; 8905232; 9278503; 2663858; 3902830; 8022274 [H]