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The map label for this gene is pgsA2 [H]

Identifier: 158422561

GI number: 158422561

Start: 1048594

End: 1049124

Strand: Direct

Name: pgsA2 [H]

Synonym: AZC_0937

Alternate gene names: 158422561

Gene position: 1048594-1049124 (Clockwise)

Preceding gene: 158422560

Following gene: 158422562

Centisome position: 19.53

GC content: 66.85

Gene sequence:

>531_bases
ATGAACCTGCCCAACCTCATCACGATCGGCCGGCTCATCATCGTGCCCGTGGTGATCTGGGCCATCTCCGCAGACCTGCC
GCAACTGGCCCTCGGCCTGTTCCTGCTGGCGGGCCTGTCGGATGCGGTGGACGGCTTCATCGCCCGCCGCTTCAACATGC
GCACCGAACTCGGCGCCTATCTCGACCCCCTGGCCGACAAGGCGCTGCTGGTCTCCATCTATGTCACGCTGGCGATCTCC
GGCGACATCCCGCGCTGGGTCGCCATCGCGGTGGTGTCGCGCGACCTGATGATCGTGGGCGCCATCGTGCTCTCCTCCGT
GCTCGCCAAGCCCGTGGTGATCCGGCCGCTGGCCGTTTCCAAGGTGAATACGGCCGTGCAGATTGCCTTTGCGGCACTCG
TGCTGTCGCGGGAGAGTTTTGACTTCGCCTGGACCCGGCCGTACCAGCTCGGGCTCGTGGCCGTCGGGGGCTTGACGGCC
CTTTCCGCGGCTGCCTATCTCGCCGCATGGATGCGCCACATGGCGCGGTGA

Upstream 100 bases:

>100_bases
ATGTGGTGGTGCTCCGCATCCAGGCCATGGCCAACCAGCAGAGCTTCAGCCCCTTCTCCATCAAGCGCTGACGGCAGCCG
CCGGGCGCAGGGAGCGCGCC

Downstream 100 bases:

>100_bases
GCCGCCTTCCGCCTTCCGCTTGCGACCGGGCCGGGGAAGCGCCGTCGCCATGCGGGGAAGGGGACAGGCCGGCCATGAAG
CTGCAGCTGCAGTTCCGCTT

Product: CDP-alcohol phosphatidyltransferase

Products: NA

Alternate protein names: Phosphatidylglycerophosphate synthase; PGP synthase [H]

Number of amino acids: Translated: 176; Mature: 176

Protein sequence:

>176_residues
MNLPNLITIGRLIIVPVVIWAISADLPQLALGLFLLAGLSDAVDGFIARRFNMRTELGAYLDPLADKALLVSIYVTLAIS
GDIPRWVAIAVVSRDLMIVGAIVLSSVLAKPVVIRPLAVSKVNTAVQIAFAALVLSRESFDFAWTRPYQLGLVAVGGLTA
LSAAAYLAAWMRHMAR

Sequences:

>Translated_176_residues
MNLPNLITIGRLIIVPVVIWAISADLPQLALGLFLLAGLSDAVDGFIARRFNMRTELGAYLDPLADKALLVSIYVTLAIS
GDIPRWVAIAVVSRDLMIVGAIVLSSVLAKPVVIRPLAVSKVNTAVQIAFAALVLSRESFDFAWTRPYQLGLVAVGGLTA
LSAAAYLAAWMRHMAR
>Mature_176_residues
MNLPNLITIGRLIIVPVVIWAISADLPQLALGLFLLAGLSDAVDGFIARRFNMRTELGAYLDPLADKALLVSIYVTLAIS
GDIPRWVAIAVVSRDLMIVGAIVLSSVLAKPVVIRPLAVSKVNTAVQIAFAALVLSRESFDFAWTRPYQLGLVAVGGLTA
LSAAAYLAAWMRHMAR

Specific function: This Protein Catalyzes The Committed Step To The Synthesis Of The Acidic Phospholipids. [C]

COG id: COG0558

COG function: function code I; Phosphatidylglycerophosphate synthase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CDP-alcohol phosphatidyltransferase class-I family [H]

Homologues:

Organism=Homo sapiens, GI188536108, Length=181, Percent_Identity=36.4640883977901, Blast_Score=95, Evalue=4e-20,
Organism=Homo sapiens, GI10092647, Length=181, Percent_Identity=35.9116022099448, Blast_Score=93, Evalue=1e-19,
Organism=Escherichia coli, GI1788220, Length=176, Percent_Identity=31.8181818181818, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71984834, Length=185, Percent_Identity=29.7297297297297, Blast_Score=77, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI71984838, Length=158, Percent_Identity=31.6455696202532, Blast_Score=77, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6320059, Length=102, Percent_Identity=36.2745098039216, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24650130, Length=180, Percent_Identity=30.5555555555556, Blast_Score=80, Evalue=9e-16,
Organism=Drosophila melanogaster, GI24650126, Length=180, Percent_Identity=30.5555555555556, Blast_Score=80, Evalue=9e-16,
Organism=Drosophila melanogaster, GI24650128, Length=180, Percent_Identity=30.5555555555556, Blast_Score=80, Evalue=9e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000462
- InterPro:   IPR004570 [H]

Pfam domain/function: PF01066 CDP-OH_P_transf [H]

EC number: =2.7.8.5 [H]

Molecular weight: Translated: 18852; Mature: 18852

Theoretical pI: Translated: 10.24; Mature: 10.24

Prosite motif: PS00379 CDP_ALCOHOL_P_TRANSF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLPNLITIGRLIIVPVVIWAISADLPQLALGLFLLAGLSDAVDGFIARRFNMRTELGAY
CCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
LDPLADKALLVSIYVTLAISGDIPRWVAIAVVSRDLMIVGAIVLSSVLAKPVVIRPLAVS
HHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCHHHH
KVNTAVQIAFAALVLSRESFDFAWTRPYQLGLVAVGGLTALSAAAYLAAWMRHMAR
HHHHHHHHHHHHHHHHCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNLPNLITIGRLIIVPVVIWAISADLPQLALGLFLLAGLSDAVDGFIARRFNMRTELGAY
CCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
LDPLADKALLVSIYVTLAISGDIPRWVAIAVVSRDLMIVGAIVLSSVLAKPVVIRPLAVS
HHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCHHHH
KVNTAVQIAFAALVLSRESFDFAWTRPYQLGLVAVGGLTALSAAAYLAAWMRHMAR
HHHHHHHHHHHHHHHHCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9634230; 12368430; 12218036; 10889206 [H]