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The map label for this gene is galE [H]

Identifier: 158338673

GI number: 158338673

Start: 5633346

End: 5634338

Strand: Direct

Name: galE [H]

Synonym: AM1_5577

Alternate gene names: 158338673

Gene position: 5633346-5634338 (Clockwise)

Preceding gene: 158338672

Following gene: 158338675

Centisome position: 86.62

GC content: 48.64

Gene sequence:

>993_bases
ATGAACAAACCCACTGTATTGGTAACTGGTGGTGCCGGTTACATCGGTTCTCACACTGTTCTGGCACTGCAACAAGCAGG
CTACTCTGTGGTCGTGTTAGATAATTTAGTCTATGGTCATCGCGATATTGTTGAGTCCGTCTTGCAAGTTGAGTTTATTT
GTGGCGATATTTGCGATCGCACTCTCCTAGACCAGATCTTTTCCCAACATGACATTGCTGCAGTCATTCATTTTGCCGCC
TATGCCTACGTTGGTGAATCCGTTGAAGATCCAGCGAAGTATTACCGAAATAATGTCTTGGGCACCTTGACATTGCTAGA
AGCGATGCTAGCAGCCAAAGTATCAAACGTTGTCTTTTCTTCTACCTGTGCATCCTACGGCCACCCTAATCAAATTCCCA
TCCCCGAAGAGCATCCCCAGGATCCCATTAACCCCTATGGCATGACTAAGTTTATGGTGGAGAAGATTCTCACGGACTTT
GATCAAGCCTACAGCCTGAGATCAGTGCGGTTCCGCTATTTTAACGCCGCAGGGGCCGATCCAGAAGGTCGCCTTGGAGA
AGATCACAACCCAGAGACCCATTTAATTCCTCTGGTGCTAATGACAGCTCTGGGAAAACGGGAAAGCATCACCATCTTTG
GCACCGACTACAAAACTTCAGATGGCACCTGTGTCCGTGACTATATCCATGTCACCGATCTAGCCCAGGCCCATGTTTTG
GGATTGGAATATCTCTTATCCGGTGGCGAAACCAGCGTCTTTAACCTAGGCAATGGCGATGGTTTCTCCGTGCGAGAAGT
CATCGATATGGCCAAAAAGGTTACCGGGTTGCCCATCCCTGTTGTTGAAGGCTATCGACGAGCAGGCGACCCTGCCCTAC
TCATAGGTAGTGCCGCCAAGGCTCGCAAAATTTTGAACTGGCAACCCCAATATGCCGATTTAGAAAAAATCATCAGCCAT
GCGTGGCAATGGCATCAAAAGCGCCATGCCTAA

Upstream 100 bases:

>100_bases
ATTCGGGAAATTGATCGCTTAGATAATACGTCTCTAGGCGAAAAGGTGATGCATTGGTTGGTTACTGCTAAACAAGGTCT
CTTACATTAGTCTGCAATAA

Downstream 100 bases:

>100_bases
CTATTCTTGGGTCTGTACCGTTAATACCTGCGGTGGCGTGGAATCCGGTGGATAGAGGAAATCAACTTGAACCAGGCGAA
TATCCTGGGGCGCGATTTCC

Product: UDP-glucose 4-epimerase

Products: NA

Alternate protein names: Galactowaldenase; UDP-galactose 4-epimerase [H]

Number of amino acids: Translated: 330; Mature: 330

Protein sequence:

>330_residues
MNKPTVLVTGGAGYIGSHTVLALQQAGYSVVVLDNLVYGHRDIVESVLQVEFICGDICDRTLLDQIFSQHDIAAVIHFAA
YAYVGESVEDPAKYYRNNVLGTLTLLEAMLAAKVSNVVFSSTCASYGHPNQIPIPEEHPQDPINPYGMTKFMVEKILTDF
DQAYSLRSVRFRYFNAAGADPEGRLGEDHNPETHLIPLVLMTALGKRESITIFGTDYKTSDGTCVRDYIHVTDLAQAHVL
GLEYLLSGGETSVFNLGNGDGFSVREVIDMAKKVTGLPIPVVEGYRRAGDPALLIGSAAKARKILNWQPQYADLEKIISH
AWQWHQKRHA

Sequences:

>Translated_330_residues
MNKPTVLVTGGAGYIGSHTVLALQQAGYSVVVLDNLVYGHRDIVESVLQVEFICGDICDRTLLDQIFSQHDIAAVIHFAA
YAYVGESVEDPAKYYRNNVLGTLTLLEAMLAAKVSNVVFSSTCASYGHPNQIPIPEEHPQDPINPYGMTKFMVEKILTDF
DQAYSLRSVRFRYFNAAGADPEGRLGEDHNPETHLIPLVLMTALGKRESITIFGTDYKTSDGTCVRDYIHVTDLAQAHVL
GLEYLLSGGETSVFNLGNGDGFSVREVIDMAKKVTGLPIPVVEGYRRAGDPALLIGSAAKARKILNWQPQYADLEKIISH
AWQWHQKRHA
>Mature_330_residues
MNKPTVLVTGGAGYIGSHTVLALQQAGYSVVVLDNLVYGHRDIVESVLQVEFICGDICDRTLLDQIFSQHDIAAVIHFAA
YAYVGESVEDPAKYYRNNVLGTLTLLEAMLAAKVSNVVFSSTCASYGHPNQIPIPEEHPQDPINPYGMTKFMVEKILTDF
DQAYSLRSVRFRYFNAAGADPEGRLGEDHNPETHLIPLVLMTALGKRESITIFGTDYKTSDGTCVRDYIHVTDLAQAHVL
GLEYLLSGGETSVFNLGNGDGFSVREVIDMAKKVTGLPIPVVEGYRRAGDPALLIGSAAKARKILNWQPQYADLEKIISH
AWQWHQKRHA

Specific function: Galactose metabolism; third step. [C]

COG id: COG1087

COG function: function code M; UDP-glucose 4-epimerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family [H]

Homologues:

Organism=Homo sapiens, GI56237023, Length=336, Percent_Identity=41.9642857142857, Blast_Score=253, Evalue=2e-67,
Organism=Homo sapiens, GI56118217, Length=336, Percent_Identity=41.9642857142857, Blast_Score=253, Evalue=2e-67,
Organism=Homo sapiens, GI189083684, Length=336, Percent_Identity=41.9642857142857, Blast_Score=253, Evalue=2e-67,
Organism=Homo sapiens, GI7657641, Length=281, Percent_Identity=28.1138790035587, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI42516563, Length=343, Percent_Identity=26.530612244898, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI4504031, Length=363, Percent_Identity=26.9972451790634, Blast_Score=76, Evalue=5e-14,
Organism=Escherichia coli, GI1786974, Length=332, Percent_Identity=43.9759036144578, Blast_Score=259, Evalue=2e-70,
Organism=Escherichia coli, GI1788353, Length=356, Percent_Identity=29.7752808988764, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI48994969, Length=352, Percent_Identity=29.5454545454545, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1790049, Length=270, Percent_Identity=29.2592592592593, Blast_Score=85, Evalue=6e-18,
Organism=Escherichia coli, GI1788366, Length=347, Percent_Identity=23.6311239193084, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71982035, Length=340, Percent_Identity=40.8823529411765, Blast_Score=244, Evalue=4e-65,
Organism=Caenorhabditis elegans, GI71982038, Length=342, Percent_Identity=40.6432748538012, Blast_Score=243, Evalue=7e-65,
Organism=Caenorhabditis elegans, GI17539532, Length=320, Percent_Identity=26.875, Blast_Score=85, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17539422, Length=347, Percent_Identity=24.7838616714697, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI133901786, Length=347, Percent_Identity=24.7838616714697, Blast_Score=78, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI133901788, Length=347, Percent_Identity=24.7838616714697, Blast_Score=78, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI133901790, Length=347, Percent_Identity=24.7838616714697, Blast_Score=78, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17539424, Length=347, Percent_Identity=24.7838616714697, Blast_Score=78, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17507723, Length=344, Percent_Identity=24.4186046511628, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17568069, Length=284, Percent_Identity=26.4084507042254, Blast_Score=74, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI115532424, Length=283, Percent_Identity=26.8551236749117, Blast_Score=65, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6319493, Length=335, Percent_Identity=43.5820895522388, Blast_Score=256, Evalue=5e-69,
Organism=Drosophila melanogaster, GI19923002, Length=345, Percent_Identity=41.7391304347826, Blast_Score=254, Evalue=5e-68,
Organism=Drosophila melanogaster, GI21356223, Length=331, Percent_Identity=28.0966767371601, Blast_Score=104, Evalue=7e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR005886
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.2 [H]

Molecular weight: Translated: 36379; Mature: 36379

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKPTVLVTGGAGYIGSHTVLALQQAGYSVVVLDNLVYGHRDIVESVLQVEFICGDICDR
CCCCEEEEECCCCCCCCHHHEEHHHCCCEEEEECCHHHCCHHHHHHHHHHHHHHHHHHHH
TLLDQIFSQHDIAAVIHFAAYAYVGESVEDPAKYYRNNVLGTLTLLEAMLAAKVSNVVFS
HHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHH
STCASYGHPNQIPIPEEHPQDPINPYGMTKFMVEKILTDFDQAYSLRSVRFRYFNAAGAD
HHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCC
PEGRLGEDHNPETHLIPLVLMTALGKRESITIFGTDYKTSDGTCVRDYIHVTDLAQAHVL
CCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHH
GLEYLLSGGETSVFNLGNGDGFSVREVIDMAKKVTGLPIPVVEGYRRAGDPALLIGSAAK
HHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCCCEEEECCHHH
ARKILNWQPQYADLEKIISHAWQWHQKRHA
HHHHHCCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNKPTVLVTGGAGYIGSHTVLALQQAGYSVVVLDNLVYGHRDIVESVLQVEFICGDICDR
CCCCEEEEECCCCCCCCHHHEEHHHCCCEEEEECCHHHCCHHHHHHHHHHHHHHHHHHHH
TLLDQIFSQHDIAAVIHFAAYAYVGESVEDPAKYYRNNVLGTLTLLEAMLAAKVSNVVFS
HHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHH
STCASYGHPNQIPIPEEHPQDPINPYGMTKFMVEKILTDFDQAYSLRSVRFRYFNAAGAD
HHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCC
PEGRLGEDHNPETHLIPLVLMTALGKRESITIFGTDYKTSDGTCVRDYIHVTDLAQAHVL
CCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHH
GLEYLLSGGETSVFNLGNGDGFSVREVIDMAKKVTGLPIPVVEGYRRAGDPALLIGSAAK
HHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCCCEEEECCHHH
ARKILNWQPQYADLEKIISHAWQWHQKRHA
HHHHHCCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]