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The map label for this gene is hemD [H]

Identifier: 158337769

GI number: 158337769

Start: 4687446

End: 4689074

Strand: Direct

Name: hemD [H]

Synonym: AM1_4654

Alternate gene names: 158337769

Gene position: 4687446-4689074 (Clockwise)

Preceding gene: 158337764

Following gene: 158337771

Centisome position: 72.07

GC content: 50.09

Gene sequence:

>1629_bases
TTGAGCGAAAACAACTATTCAACAACTCAAACGCCTAAGTCACAGGGCAAGGTTTTTATCATTGGTGCTGGCCCTGGGGA
ACATAACTATCTTACGGTTATGGGACAAAACCTGCTTGCTCAGGCTGACGTCATCCTCTATGATGCCCTGATCAATCCTG
AATTATTAAACCTCGTAAAGAAAACTTGCTTAAAAATCCCAGTTGGTAAGCGAGGTAAGGGTCCTAGCACTCCCCAAACA
GAGATTGATCGCCGGTTAGTGGCGTATTGTTGCCAGGGATATCAAGTTGTCCGTCTTAAAAGTGGTGATCCCTTTGTGTT
TGGACGCACCACGTCTGAAGTCCTCGCCTTACACGCAGCAGGTTGTGCGGTTGAAGTGTTGCCGGGGATTTCTTCTGCCC
TAGCAGCACCTTTATTTGCTGGCATTCCCCTTACTGATGCCCAATTGGGCCAGCACTTTACGGTATTGAGTGCCCATGCC
CCAGAGCGTCTGGACTGGTCTGTTTTAGCCCAACTCGATACCTTGGTGATTCTGATGGGGGCGCGCCAGTTAGAAACCAT
CGTCCATCACCTGAGACACCATAGCCAGCCCGAACAACATCCGATTGCCATTATTCGTTGGGGAGGTCGGCGTCAGCAGC
AAGTTTGGACTGGCACGTTGGGGACGATTGTGGCCCAAACCCAAGGAGAGTCCCTATCGCCTTGTGTAATCGTGGTGGGC
AAAGTCGTTAATCTCCAACCAACCCTGGGACTTTCTTTCCCGACCAACAGTGAATATGCTCATAGAAGTGATTCTGCACA
ATGTTCCATGGGTGCTACTTCTCTTCAGTCAACTTTACCGTTAGCAGGTAAAACGATCTTGGTGACGCGAGCCGTTGCCC
AATCCAAGACCTTTAGTCAATCTCTTATGTCGATGGGGGCGACAGTCGTGGATATGCCGGCATTGGAAATTGGCCCGCCT
TCGTCTTGGAAGGCGTTAGATGGTGCGATCGCATCTTTAGATCGCTTTGACTGGCTGATCTTGACGTCTGCCAATGGCGT
TACTCGCTTCCTAGACCGTCTATTCCATGCCGGCTTAGATACGAGAGCACTCGCTTCCGTCAAGATTGCAGTGGTCGGTC
GAAAAACAGCCAAAACTTTAGAACAGCAAGGATTAAAGGCGGACTATATCCCACCTAACTTCGTTGCGGATGCTTTAGTA
GAGCATTTCCCAGGGGAAGCACTGACGGGGCAGACCCTGTTATTCCCCAGAGTTGAAAGTGGTGGACGAGACGTTTTGGT
CAAACAATTGACCCAAAAAGGGGCAACAGTGGTGGAGGTGGCTGCCTATCAATCACGATGTCCAGCAACCATTGCTCCCC
AGGCCCTCCATGCCTTGCGAACTCAAACCGTTGATATCGTCACCTTTGCCAGTTCTAAAACGGTTCGCTATTTTTATCAG
CTTCTGCAGCAAGCGGTTGGAGAGGGTAAACCCCAGGCATGGCTTACTCCCCTCAAGGTCGCCTCCATTGGTCCTCAGAC
TTCATTGACCTGCCAAGAGCTGCTGGGACGAGTCGATATTGAAGCGGAGGAATATACCTTAGACGGTTTAACGCAAAGTA
TTGTTGACCACTATCAGACTCAAGATTAG

Upstream 100 bases:

>100_bases
ATATGGAAGAGACTGCTTACCAAACCAACATGTGGCCGCAGGAGAATCATCTCTTGCTAGCAATACAAGCTAGGATCGAA
GCAGTTGAAATCCAATCGTT

Downstream 100 bases:

>100_bases
GCCTCATTCCATACCAACATTTCCGGGAAATTCCCAGAAATGGTAAACCCCACCCAATACCAAGGGTGACTAAACGGACA
AACATCTTGACCTGACTCCT

Product: uroporphyrinogen III synthase/methyltransferase

Products: NA

Alternate protein names: UROS; Hydroxymethylbilane hydrolyase [cyclizing]; Uroporphyrinogen-III cosynthase [H]

Number of amino acids: Translated: 542; Mature: 541

Protein sequence:

>542_residues
MSENNYSTTQTPKSQGKVFIIGAGPGEHNYLTVMGQNLLAQADVILYDALINPELLNLVKKTCLKIPVGKRGKGPSTPQT
EIDRRLVAYCCQGYQVVRLKSGDPFVFGRTTSEVLALHAAGCAVEVLPGISSALAAPLFAGIPLTDAQLGQHFTVLSAHA
PERLDWSVLAQLDTLVILMGARQLETIVHHLRHHSQPEQHPIAIIRWGGRRQQQVWTGTLGTIVAQTQGESLSPCVIVVG
KVVNLQPTLGLSFPTNSEYAHRSDSAQCSMGATSLQSTLPLAGKTILVTRAVAQSKTFSQSLMSMGATVVDMPALEIGPP
SSWKALDGAIASLDRFDWLILTSANGVTRFLDRLFHAGLDTRALASVKIAVVGRKTAKTLEQQGLKADYIPPNFVADALV
EHFPGEALTGQTLLFPRVESGGRDVLVKQLTQKGATVVEVAAYQSRCPATIAPQALHALRTQTVDIVTFASSKTVRYFYQ
LLQQAVGEGKPQAWLTPLKVASIGPQTSLTCQELLGRVDIEAEEYTLDGLTQSIVDHYQTQD

Sequences:

>Translated_542_residues
MSENNYSTTQTPKSQGKVFIIGAGPGEHNYLTVMGQNLLAQADVILYDALINPELLNLVKKTCLKIPVGKRGKGPSTPQT
EIDRRLVAYCCQGYQVVRLKSGDPFVFGRTTSEVLALHAAGCAVEVLPGISSALAAPLFAGIPLTDAQLGQHFTVLSAHA
PERLDWSVLAQLDTLVILMGARQLETIVHHLRHHSQPEQHPIAIIRWGGRRQQQVWTGTLGTIVAQTQGESLSPCVIVVG
KVVNLQPTLGLSFPTNSEYAHRSDSAQCSMGATSLQSTLPLAGKTILVTRAVAQSKTFSQSLMSMGATVVDMPALEIGPP
SSWKALDGAIASLDRFDWLILTSANGVTRFLDRLFHAGLDTRALASVKIAVVGRKTAKTLEQQGLKADYIPPNFVADALV
EHFPGEALTGQTLLFPRVESGGRDVLVKQLTQKGATVVEVAAYQSRCPATIAPQALHALRTQTVDIVTFASSKTVRYFYQ
LLQQAVGEGKPQAWLTPLKVASIGPQTSLTCQELLGRVDIEAEEYTLDGLTQSIVDHYQTQD
>Mature_541_residues
SENNYSTTQTPKSQGKVFIIGAGPGEHNYLTVMGQNLLAQADVILYDALINPELLNLVKKTCLKIPVGKRGKGPSTPQTE
IDRRLVAYCCQGYQVVRLKSGDPFVFGRTTSEVLALHAAGCAVEVLPGISSALAAPLFAGIPLTDAQLGQHFTVLSAHAP
ERLDWSVLAQLDTLVILMGARQLETIVHHLRHHSQPEQHPIAIIRWGGRRQQQVWTGTLGTIVAQTQGESLSPCVIVVGK
VVNLQPTLGLSFPTNSEYAHRSDSAQCSMGATSLQSTLPLAGKTILVTRAVAQSKTFSQSLMSMGATVVDMPALEIGPPS
SWKALDGAIASLDRFDWLILTSANGVTRFLDRLFHAGLDTRALASVKIAVVGRKTAKTLEQQGLKADYIPPNFVADALVE
HFPGEALTGQTLLFPRVESGGRDVLVKQLTQKGATVVEVAAYQSRCPATIAPQALHALRTQTVDIVTFASSKTVRYFYQL
LQQAVGEGKPQAWLTPLKVASIGPQTSLTCQELLGRVDIEAEEYTLDGLTQSIVDHYQTQD

Specific function: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III [H]

COG id: COG1587

COG function: function code H; Uroporphyrinogen-III synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen-III synthase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=238, Percent_Identity=38.655462184874, Blast_Score=161, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6322922, Length=245, Percent_Identity=31.0204081632653, Blast_Score=94, Evalue=6e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003754 [H]

Pfam domain/function: PF02602 HEM4 [H]

EC number: =4.2.1.75 [H]

Molecular weight: Translated: 58453; Mature: 58322

Theoretical pI: Translated: 7.83; Mature: 7.83

Prosite motif: PS00840 SUMT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSENNYSTTQTPKSQGKVFIIGAGPGEHNYLTVMGQNLLAQADVILYDALINPELLNLVK
CCCCCCCCCCCCCCCCCEEEEECCCCCCCEEEEECCHHHHHHHHHEEHHHCCHHHHHHHH
KTCLKIPVGKRGKGPSTPQTEIDRRLVAYCCQGYQVVRLKSGDPFVFGRTTSEVLALHAA
HHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCEEECCCHHHHHHHHHC
GCAVEVLPGISSALAAPLFAGIPLTDAQLGQHFTVLSAHAPERLDWSVLAQLDTLVILMG
CCCEEHHCCHHHHHHHHHHCCCCCCHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHH
ARQLETIVHHLRHHSQPEQHPIAIIRWGGRRQQQVWTGTLGTIVAQTQGESLSPCVIVVG
HHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCEEHHCHHHHEEEECCCCCCCCCEEEEC
KVVNLQPTLGLSFPTNSEYAHRSDSAQCSMGATSLQSTLPLAGKTILVTRAVAQSKTFSQ
CCEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCEEEEEHHHHHHHHHHH
SLMSMGATVVDMPALEIGPPSSWKALDGAIASLDRFDWLILTSANGVTRFLDRLFHAGLD
HHHHCCCEEEECCCEECCCCCCCHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCCCC
TRALASVKIAVVGRKTAKTLEQQGLKADYIPPNFVADALVEHFPGEALTGQTLLFPRVES
CHHHHEEEEEEECCHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEECCCC
GGRDVLVKQLTQKGATVVEVAAYQSRCPATIAPQALHALRTQTVDIVTFASSKTVRYFYQ
CCHHHHHHHHHHCCCEEEEEEHHHHCCCCCCCHHHHHHHHHCCEEEEEECCCHHHHHHHH
LLQQAVGEGKPQAWLTPLKVASIGPQTSLTCQELLGRVDIEAEEYTLDGLTQSIVDHYQT
HHHHHHCCCCCCCEECCEEEECCCCCCCCHHHHHHCCCCCCHHHEEHHHHHHHHHHHHCC
QD
CC
>Mature Secondary Structure 
SENNYSTTQTPKSQGKVFIIGAGPGEHNYLTVMGQNLLAQADVILYDALINPELLNLVK
CCCCCCCCCCCCCCCCEEEEECCCCCCCEEEEECCHHHHHHHHHEEHHHCCHHHHHHHH
KTCLKIPVGKRGKGPSTPQTEIDRRLVAYCCQGYQVVRLKSGDPFVFGRTTSEVLALHAA
HHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCEEECCCHHHHHHHHHC
GCAVEVLPGISSALAAPLFAGIPLTDAQLGQHFTVLSAHAPERLDWSVLAQLDTLVILMG
CCCEEHHCCHHHHHHHHHHCCCCCCHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHH
ARQLETIVHHLRHHSQPEQHPIAIIRWGGRRQQQVWTGTLGTIVAQTQGESLSPCVIVVG
HHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCEEHHCHHHHEEEECCCCCCCCCEEEEC
KVVNLQPTLGLSFPTNSEYAHRSDSAQCSMGATSLQSTLPLAGKTILVTRAVAQSKTFSQ
CCEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCEEEEEHHHHHHHHHHH
SLMSMGATVVDMPALEIGPPSSWKALDGAIASLDRFDWLILTSANGVTRFLDRLFHAGLD
HHHHCCCEEEECCCEECCCCCCCHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCCCC
TRALASVKIAVVGRKTAKTLEQQGLKADYIPPNFVADALVEHFPGEALTGQTLLFPRVES
CHHHHEEEEEEECCHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEECCCC
GGRDVLVKQLTQKGATVVEVAAYQSRCPATIAPQALHALRTQTVDIVTFASSKTVRYFYQ
CCHHHHHHHHHHCCCEEEEEEHHHHCCCCCCCHHHHHHHHHCCEEEEEECCCHHHHHHHH
LLQQAVGEGKPQAWLTPLKVASIGPQTSLTCQELLGRVDIEAEEYTLDGLTQSIVDHYQT
HHHHHHCCCCCCCEECCEEEECCCCCCCCHHHHHHCCCCCCHHHEEHHHHHHHHHHHHCC
QD
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8123787 [H]