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The map label for this gene is pyrF [H]

Identifier: 158337488

GI number: 158337488

Start: 4396986

End: 4397708

Strand: Direct

Name: pyrF [H]

Synonym: AM1_4367

Alternate gene names: 158337488

Gene position: 4396986-4397708 (Clockwise)

Preceding gene: 158337487

Following gene: 158337489

Centisome position: 67.61

GC content: 50.21

Gene sequence:

>723_bases
GTGACGACTGAGATTGCTCAACGAATTATTGTGCCGTTAGATGTGCCTTCAGAGGCAGATGCGATCGCATTGATCGATCA
GATTCCCCAAGTTCAATTTTGGAAAGTCGGTTTAGAGCTGTTTGTGAGCTGTGGCCCCAGTATCTTAGAGCAGCTTAAAC
AGCGCCAAAAAAAGGTTTTTCTCGATCTAAAATTTCACGATATTCCCAATACTGTGGCTGGTGCTTGCCGGTCTGCTGCC
ACTTATGGCGTGGATCTACTCACGATTCATGCCACAGCAGGTCGTCCTGCCCTCTCTGCTGCGCAACAGGCTTTACAAGA
AGGCGCTCAATCGGCTCAAACGGCTCCTCCGAAGTTGATTGCGATTACAGTATTGACCAGTCTCTCTCTCCGCGAGCTGG
CCTTGGACTTAAAAATACCCCTGGAACTTCCCGAGTATGCCTTGCAAATGGGTCTGTTGGCTCAAGAGTCAGGTCTAAAT
GGGATCGTCTGTTCGCCTCACGAAGCAGAACAAATGCGTCAGGTATGCGGGGATGAATTTCTCATCGTTTGTCCAGGCGT
GCGCCCTCCAGGATCAGTGACAGGTGATCAAAAACGGGCTATGACACCCACTGCAGCCATGCAAGCAGGGGCCAACTATT
TGGTCATTGGTCGCCCGATCACGACTGCTACTGATCCTCAACAGGCCTTTCAACAGATCTGTACCGATTTAGTTAGCGCT
TGA

Upstream 100 bases:

>100_bases
TGGAAATGTGGTCAATCTTCATCCCCTATTGGCCGAGAGTCGCCCAAAGGTAATTCCTAGGCAGTAGAGTATTAAACGAC
CGCTATTGCAGGCTGGTGTC

Downstream 100 bases:

>100_bases
TAGCAAAAACGGCTGGCTTCTATCGTGTTTTAGCTGTCAAGCGTCGTCATTACCGATCGGAATTGACTGATGGATGTTAG
ATGCTCTGTTTGAGTGTGGG

Product: orotidine 5'-phosphate decarboxylase

Products: NA

Alternate protein names: OMP decarboxylase; OMPDCase; OMPdecase [H]

Number of amino acids: Translated: 240; Mature: 239

Protein sequence:

>240_residues
MTTEIAQRIIVPLDVPSEADAIALIDQIPQVQFWKVGLELFVSCGPSILEQLKQRQKKVFLDLKFHDIPNTVAGACRSAA
TYGVDLLTIHATAGRPALSAAQQALQEGAQSAQTAPPKLIAITVLTSLSLRELALDLKIPLELPEYALQMGLLAQESGLN
GIVCSPHEAEQMRQVCGDEFLIVCPGVRPPGSVTGDQKRAMTPTAAMQAGANYLVIGRPITTATDPQQAFQQICTDLVSA

Sequences:

>Translated_240_residues
MTTEIAQRIIVPLDVPSEADAIALIDQIPQVQFWKVGLELFVSCGPSILEQLKQRQKKVFLDLKFHDIPNTVAGACRSAA
TYGVDLLTIHATAGRPALSAAQQALQEGAQSAQTAPPKLIAITVLTSLSLRELALDLKIPLELPEYALQMGLLAQESGLN
GIVCSPHEAEQMRQVCGDEFLIVCPGVRPPGSVTGDQKRAMTPTAAMQAGANYLVIGRPITTATDPQQAFQQICTDLVSA
>Mature_239_residues
TTEIAQRIIVPLDVPSEADAIALIDQIPQVQFWKVGLELFVSCGPSILEQLKQRQKKVFLDLKFHDIPNTVAGACRSAAT
YGVDLLTIHATAGRPALSAAQQALQEGAQSAQTAPPKLIAITVLTSLSLRELALDLKIPLELPEYALQMGLLAQESGLNG
IVCSPHEAEQMRQVCGDEFLIVCPGVRPPGSVTGDQKRAMTPTAAMQAGANYLVIGRPITTATDPQQAFQQICTDLVSA

Specific function: Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) [H]

COG id: COG0284

COG function: function code F; Orotidine-5'-phosphate decarboxylase

Gene ontology:
GO:0003824: Orotidine 5'-phosphate decarboxylase
GO:0004590: Orotidine 5'-phosphate decarboxylase
GO:0006207: Orotidine 5'-phosphate decarboxylase
GO:0006221: Orotidine 5'-phosphate decarboxylase
GO:0008152: Orotidine 5'-phosphate decarboxylase
GO:0016829: Orotidine 5'-phosphate decarboxylase
GO:0016831: Orotidine 5'-phosphate decarboxylase
GO:0044205: Orotidine 5'-phosphate decarboxylase

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the OMP decarboxylase family. Type 1 subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787537, Length=230, Percent_Identity=45.2173913043478, Blast_Score=189, Evalue=1e-49,

Paralogues:

None

Copy number: 6,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR014732
- InterPro:   IPR018089
- InterPro:   IPR001754
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00215 OMPdecase [H]

EC number: =4.1.1.23 [H]

Molecular weight: Translated: 25651; Mature: 25520

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: PS00156 OMPDECASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTEIAQRIIVPLDVPSEADAIALIDQIPQVQFWKVGLELFVSCGPSILEQLKQRQKKVF
CCHHHHHHEEEECCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHEE
LDLKFHDIPNTVAGACRSAATYGVDLLTIHATAGRPALSAAQQALQEGAQSAQTAPPKLI
EEEEECCCCHHHHHHHHHHHHCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCEE
AITVLTSLSLRELALDLKIPLELPEYALQMGLLAQESGLNGIVCSPHEAEQMRQVCGDEF
EHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHCCCCE
LIVCPGVRPPGSVTGDQKRAMTPTAAMQAGANYLVIGRPITTATDPQQAFQQICTDLVSA
EEEECCCCCCCCCCCCCHHCCCHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TTEIAQRIIVPLDVPSEADAIALIDQIPQVQFWKVGLELFVSCGPSILEQLKQRQKKVF
CHHHHHHEEEECCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHEE
LDLKFHDIPNTVAGACRSAATYGVDLLTIHATAGRPALSAAQQALQEGAQSAQTAPPKLI
EEEEECCCCHHHHHHHHHHHHCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCEE
AITVLTSLSLRELALDLKIPLELPEYALQMGLLAQESGLNGIVCSPHEAEQMRQVCGDEF
EHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHCCCCE
LIVCPGVRPPGSVTGDQKRAMTPTAAMQAGANYLVIGRPITTATDPQQAFQQICTDLVSA
EEEECCCCCCCCCCCCCHHCCCHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA