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The map label for this gene is cysG [H]

Identifier: 158337487

GI number: 158337487

Start: 4396155

End: 4396952

Strand: Direct

Name: cysG [H]

Synonym: AM1_4366

Alternate gene names: 158337487

Gene position: 4396155-4396952 (Clockwise)

Preceding gene: 158337486

Following gene: 158337488

Centisome position: 67.59

GC content: 52.01

Gene sequence:

>798_bases
ATGACCACTGATTTTCCCCAGCCGCCAGCCACTTGTTTTGGGAAAGTATATCTTGTGGGAGCGGGACCCGGTGACCCCGG
ATTACTCACGCTCAAAGGTAAGACACTTCTAGAATGTGCTGATGTGGTGATCTATGATGCCCTCGTTAGCCCAGAAATTC
TGGCTATGATTGGTGATCAAGCCGAGAAGATTCATGCCGGTAAACGTCGCGGGCAGCATTCTCTGTTACAAGCAGAAACT
ACCCAGTTGCTGATTGATAAAGCCCAAACCCATGCCGTCGTCGTCCGACTCAAGGGGGGAGACCCCTTTGTCTTTGGCCG
GGGAGGAGAAGAAATGGAAGATTTAATCCAAGCAGGGGTTTCTGTAGAAATTATTCCAGGGATTACAGCGGGTATTGCGG
CACCTGCCTATGCCGGTATTCCGGTCACCCATCGCAACTACAGTTCCTCCGTTACCTTTGTGACTGGCCATGAACCGATC
GACAAATATCGACCTCGGGTCAATTGGCGAGCCATGGCGGAGGCATCCGAAACCCTGGTGATTTATATGGGGGTGCATAA
TCTGTCCCATATTTTGTCTGAACTGGACGCGGCAGGAAAAGACCCAGATACCCCCATTGCATTAGTTCGTTGGGGGACTC
GCCCCGATCAAGAAGAACTCGTGGGGACCTTGGCCACCATTCTCAGCCAAATGGAAGCGGCTCAATTTGAGGCTCCGGCT
GTGGCCGTCATTGGAAATGTGGTCAATCTTCATCCCCTATTGGCCGAGAGTCGCCCAAAGGTAATTCCTAGGCAGTAG

Upstream 100 bases:

>100_bases
TTAACTTTTTCTTCACCTTTAGAACCCAGTGCTCCTCTCGTTCATTTAATTCAAGAGTTAATAACTGCCTGATTGTTTTA
CCCTCTTTTTCAGGTTGTCT

Downstream 100 bases:

>100_bases
AGTATTAAACGACCGCTATTGCAGGCTGGTGTCGTGACGACTGAGATTGCTCAACGAATTATTGTGCCGTTAGATGTGCC
TTCAGAGGCAGATGCGATCG

Product: uroporphyrin-III C-methyltransferase

Products: NA

Alternate protein names: Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM [H]

Number of amino acids: Translated: 265; Mature: 264

Protein sequence:

>265_residues
MTTDFPQPPATCFGKVYLVGAGPGDPGLLTLKGKTLLECADVVIYDALVSPEILAMIGDQAEKIHAGKRRGQHSLLQAET
TQLLIDKAQTHAVVVRLKGGDPFVFGRGGEEMEDLIQAGVSVEIIPGITAGIAAPAYAGIPVTHRNYSSSVTFVTGHEPI
DKYRPRVNWRAMAEASETLVIYMGVHNLSHILSELDAAGKDPDTPIALVRWGTRPDQEELVGTLATILSQMEAAQFEAPA
VAVIGNVVNLHPLLAESRPKVIPRQ

Sequences:

>Translated_265_residues
MTTDFPQPPATCFGKVYLVGAGPGDPGLLTLKGKTLLECADVVIYDALVSPEILAMIGDQAEKIHAGKRRGQHSLLQAET
TQLLIDKAQTHAVVVRLKGGDPFVFGRGGEEMEDLIQAGVSVEIIPGITAGIAAPAYAGIPVTHRNYSSSVTFVTGHEPI
DKYRPRVNWRAMAEASETLVIYMGVHNLSHILSELDAAGKDPDTPIALVRWGTRPDQEELVGTLATILSQMEAAQFEAPA
VAVIGNVVNLHPLLAESRPKVIPRQ
>Mature_264_residues
TTDFPQPPATCFGKVYLVGAGPGDPGLLTLKGKTLLECADVVIYDALVSPEILAMIGDQAEKIHAGKRRGQHSLLQAETT
QLLIDKAQTHAVVVRLKGGDPFVFGRGGEEMEDLIQAGVSVEIIPGITAGIAAPAYAGIPVTHRNYSSSVTFVTGHEPID
KYRPRVNWRAMAEASETLVIYMGVHNLSHILSELDAAGKDPDTPIALVRWGTRPDQEELVGTLATILSQMEAAQFEAPAV
AVIGNVVNLHPLLAESRPKVIPRQ

Specific function: Catalyzes both methylations at C-2 and C-7 of uroporphyrinogen III leading to precorrin-1 and precorrin-2; their oxidative esterification gives respectively factor I octamethyl ester and sirohydrochlorin [H]

COG id: COG0007

COG function: function code H; Uroporphyrinogen-III methylase

Gene ontology:
GO:0006779: Uroporphyrin-III C-methyltransferase
GO:0008152: Uroporphyrin-III C-methyltransferase
GO:0008168: Uroporphyrin-III C-methyltransferase
GO:0016740: Uroporphyrin-III C-methyltransferase
GO:0032259: Uroporphyrin-III C-methyltransferase
GO:0043115: Uroporphyrin-III C-methyltransferase
GO:0055114: Uroporphyrin-III C-methyltransferase

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=253, Percent_Identity=44.6640316205534, Blast_Score=205, Evalue=2e-54,
Organism=Saccharomyces cerevisiae, GI6322922, Length=237, Percent_Identity=32.0675105485232, Blast_Score=108, Evalue=7e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR003043 [H]

Pfam domain/function: PF00590 TP_methylase [H]

EC number: =2.1.1.107 [H]

Molecular weight: Translated: 28368; Mature: 28237

Theoretical pI: Translated: 5.57; Mature: 5.57

Prosite motif: PS00839 SUMT_1 ; PS00840 SUMT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTDFPQPPATCFGKVYLVGAGPGDPGLLTLKGKTLLECADVVIYDALVSPEILAMIGDQ
CCCCCCCCCHHHCCEEEEEECCCCCCCEEEECCCHHHHHHHHHHHHHHCCHHHHHHHCCH
AEKIHAGKRRGQHSLLQAETTQLLIDKAQTHAVVVRLKGGDPFVFGRGGEEMEDLIQAGV
HHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEECCCCHHHHHHHHCCC
SVEIIPGITAGIAAPAYAGIPVTHRNYSSSVTFVTGHEPIDKYRPRVNWRAMAEASETLV
CEEEECCCHHHHCCCCCCCCCEEECCCCCEEEEEECCCCHHHHCCCCCHHHHCCCCCEEE
IYMGVHNLSHILSELDAAGKDPDTPIALVRWGTRPDQEELVGTLATILSQMEAAQFEAPA
EEECHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCH
VAVIGNVVNLHPLLAESRPKVIPRQ
HHHHCCHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
TTDFPQPPATCFGKVYLVGAGPGDPGLLTLKGKTLLECADVVIYDALVSPEILAMIGDQ
CCCCCCCCHHHCCEEEEEECCCCCCCEEEECCCHHHHHHHHHHHHHHCCHHHHHHHCCH
AEKIHAGKRRGQHSLLQAETTQLLIDKAQTHAVVVRLKGGDPFVFGRGGEEMEDLIQAGV
HHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEECCCCHHHHHHHHCCC
SVEIIPGITAGIAAPAYAGIPVTHRNYSSSVTFVTGHEPIDKYRPRVNWRAMAEASETLV
CEEEECCCHHHHCCCCCCCCCEEECCCCCEEEEEECCCCHHHHCCCCCHHHHCCCCCEEE
IYMGVHNLSHILSELDAAGKDPDTPIALVRWGTRPDQEELVGTLATILSQMEAAQFEAPA
EEECHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCH
VAVIGNVVNLHPLLAESRPKVIPRQ
HHHHCCHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]