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The map label for this gene is trx [C]

Identifier: 158335711

GI number: 158335711

Start: 2596862

End: 2597179

Strand: Reverse

Name: trx [C]

Synonym: AM1_2561

Alternate gene names: 158335711

Gene position: 2597179-2596862 (Counterclockwise)

Preceding gene: 158335712

Following gene: 158335708

Centisome position: 39.93

GC content: 47.48

Gene sequence:

>318_bases
ATGGCCACAAAAAAGCAATACAAAAATTTTGCCGAACTTTTAGCTGGATCTGATAAACCTGTCCTAGTCGATTTCTATGC
AATTTGGTGTGGGCCTTGTCGGATGTTGGTCCCCATCCTGGAGCAGGTCAGCACCTTGTTGAAAGATAAGGTCCAAGTGG
TCAAAATTGATACCGAGCGTTACCCAGAGCTGGCAACGGAATACCATATCCATGCCTTGCCGACCCTCGTGTTATTTAAG
GATGGTCAACCCGTGGAACGGATTGAAGGGGTCTTACCGCCGGAAGATATTGTCAGTCGCGTACAGCCTTTACTCTAG

Upstream 100 bases:

>100_bases
ATCTTAGGGTTACACCTAAACCTGAAATGAATAACGACATCCCTGCCAATGCCTAAATTCTGGGTCTAGGATTGAAAAGA
TTCCTACCTAGACTCTCCCT

Downstream 100 bases:

>100_bases
TCATTTGCGGCGTTTAGAGATCCTTGAGGAGCGAGAAAAAGTCGGTCGCTACAGTCTGTTGTTCAAGTTCTTGGCTACCG
AGAAGCTTGAGGACAATGTT

Product: thioredoxin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 105; Mature: 104

Protein sequence:

>105_residues
MATKKQYKNFAELLAGSDKPVLVDFYAIWCGPCRMLVPILEQVSTLLKDKVQVVKIDTERYPELATEYHIHALPTLVLFK
DGQPVERIEGVLPPEDIVSRVQPLL

Sequences:

>Translated_105_residues
MATKKQYKNFAELLAGSDKPVLVDFYAIWCGPCRMLVPILEQVSTLLKDKVQVVKIDTERYPELATEYHIHALPTLVLFK
DGQPVERIEGVLPPEDIVSRVQPLL
>Mature_104_residues
ATKKQYKNFAELLAGSDKPVLVDFYAIWCGPCRMLVPILEQVSTLLKDKVQVVKIDTERYPELATEYHIHALPTLVLFKD
GQPVERIEGVLPPEDIVSRVQPLL

Specific function: Efficient Electron Donor For The Essential Enzyme Ribonucleotide Reductase. Is Also Able To Reduce The Interchain Disulfide Bridges Of Insulin. [C]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=83, Percent_Identity=38.5542168674699, Blast_Score=75, Evalue=1e-14,
Organism=Homo sapiens, GI4758304, Length=97, Percent_Identity=38.1443298969072, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1788936, Length=76, Percent_Identity=44.7368421052632, Blast_Score=83, Evalue=3e-18,
Organism=Escherichia coli, GI87082331, Length=76, Percent_Identity=40.7894736842105, Blast_Score=76, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI212646193, Length=98, Percent_Identity=37.7551020408163, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71998175, Length=80, Percent_Identity=36.25, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71980562, Length=78, Percent_Identity=32.0512820512821, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71980565, Length=78, Percent_Identity=32.0512820512821, Blast_Score=65, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17509965, Length=73, Percent_Identity=35.6164383561644, Blast_Score=65, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17569137, Length=81, Percent_Identity=35.8024691358025, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI32566189, Length=81, Percent_Identity=35.8024691358025, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI193209454, Length=81, Percent_Identity=35.8024691358025, Blast_Score=62, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6321648, Length=89, Percent_Identity=34.8314606741573, Blast_Score=75, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6323072, Length=90, Percent_Identity=37.7777777777778, Blast_Score=74, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6319925, Length=84, Percent_Identity=42.8571428571429, Blast_Score=72, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17648013, Length=80, Percent_Identity=42.5, Blast_Score=81, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24583090, Length=80, Percent_Identity=42.5, Blast_Score=81, Evalue=2e-16,
Organism=Drosophila melanogaster, GI28573567, Length=88, Percent_Identity=37.5, Blast_Score=80, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24639826, Length=79, Percent_Identity=35.4430379746835, Blast_Score=73, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24664269, Length=96, Percent_Identity=37.5, Blast_Score=73, Evalue=4e-14,
Organism=Drosophila melanogaster, GI17530795, Length=77, Percent_Identity=31.1688311688312, Blast_Score=65, Evalue=7e-12,
Organism=Drosophila melanogaster, GI21358065, Length=89, Percent_Identity=35.9550561797753, Blast_Score=64, Evalue=1e-11,
Organism=Drosophila melanogaster, GI17647799, Length=81, Percent_Identity=39.5061728395062, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: 1.8.1.8 [C]

Molecular weight: Translated: 11918; Mature: 11787

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATKKQYKNFAELLAGSDKPVLVDFYAIWCGPCRMLVPILEQVSTLLKDKVQVVKIDTER
CCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEEECCHH
YPELATEYHIHALPTLVLFKDGQPVERIEGVLPPEDIVSRVQPLL
CHHHHHHHHHHHHCEEEEECCCCCHHHHCCCCCHHHHHHHHHCCC
>Mature Secondary Structure 
ATKKQYKNFAELLAGSDKPVLVDFYAIWCGPCRMLVPILEQVSTLLKDKVQVVKIDTER
CCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEEECCHH
YPELATEYHIHALPTLVLFKDGQPVERIEGVLPPEDIVSRVQPLL
CHHHHHHHHHHHHCEEEEECCCCCHHHHCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]