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The map label for this gene is nhaA2 [H]

Identifier: 158318660

GI number: 158318660

Start: 8439083

End: 8440423

Strand: Reverse

Name: nhaA2 [H]

Synonym: Franean1_6928

Alternate gene names: 158318660

Gene position: 8440423-8439083 (Counterclockwise)

Preceding gene: 158318664

Following gene: 158318659

Centisome position: 93.97

GC content: 72.48

Gene sequence:

>1341_bases
ATGCCGAGCGTTCCCCCAGCCCCCACGCCCGGCCCTGCCTCGGGCTCCGGCTCGTCGGTGTCCCGGCCGCGGCTGCTGGC
CCGGCCGACCTGGCCGCAGGCACGGTACGTCGCCGGGATCCTGCGCAGTGAGACGGTCGGCGGCCTGCTGTTGCTCGCGG
GCGCCGTGGTGGCGCTGGTCTGGGCGAACTCACCGTGGCGGGACGCCTATGCCACCGTCGTCCACACCGGCGTGGGCCCC
GCGTCCCTGCGCCTGCATCTGGACCTGGAGCACTGGGCCGCCGACGGGCTGCTTGCGATCTTCTTCTTCGTGGTGGGCCT
CGAGCTCAAACGCGAGTTCGTCCTCGGCGATCTGAGATCACCGAGCCGCGCGGCGCTGCCCATCGTGGCCGCCCTCGGCG
GGATGCTCGTGCCCGCGCTCATCTACACGCTGGTCAACGGCCTGGCCGTGGACGGCTCCCCCGAGGGCTGGGCGGTGCCG
ACGGCCACCGACATCGCCTTCGCGGTCGCGGTGCTGGCGATCATCACGACGCATCTGCCGGCGGCGCTGCGGTCGTTCCT
GCTGACGCTGGCGGTGGTCGACGACCTGCTCGCGATCGTGATCATCGCCGTGTTCTTCACCGACCGGCTCAGCCCCGCGC
CGCTGGCGGGCTCCCTCGCGGTCATCGCGGTGTTCGCGTTGCTGGTGAACCGCGGCGTCACCCGCTGGTGGCTGCTCATC
CCGCTCGCGCTCGTTGCCTGGGCCCTCATGCACGCCTCGGGGGTGCACGCGACCATCGCCGGGGTACTGCTGGGGTTCGC
CGTGCCGGCCCGCCCTCGCTCCGGCGAGCACGCCGGGATGTCCGAGCGGTTCGAACACGCCTGGCGTCCTGTCTCGGCGG
GCGTCGCGGTTCCGTTGTTCGCGTTGATGGCCGCCGGGGTCTCGCTCGCGGGCGGCGGCGTCAGCGCCGCGCTGGCCGAT
CCGGCCGGCCTGGGTGTGGCGATGGGCCTGCTGCTGGGCAAGCCAATCGGGGTGATGGGTGCCACCGGCCTGCTCGCCCG
GTTAACCCGGGCCGAACTGGACCCCGACCTGTCCTGGTGGGACGTCGCCGGCGTCGCCGTGCTCGCCGGAGTCGGGTTCA
CTGTCTCCCTGCTCATCGGCGAGCTGGCCTTCGGCGCCGGCACAGCGGAGAACGATCACGTCAAGGCCGCCATCCTGATC
GGCTCGCTGGCCTCGGCACTGCTCGCCTCGATCGTGCTGCGGGCGCGTAACCGGGTGTATCGCCGGATCGAGGAGCGGGA
GACCGTCGACCTCGACGCCGACGGCATCCCCGACGTCTTCCAGGAACCGACCGTCGGCTGA

Upstream 100 bases:

>100_bases
GCGTTGCGCCCTCACAGCCAGGGACGACCGGTTCAGGATGGTCACCCGTCGTGAGGTCGGGGCGGCGCCGCGCGACCGCG
CCGACCGAGGAGACCAGCCG

Downstream 100 bases:

>100_bases
GGTCGTCGAGATGGCCAACACCAAGGTGCGGCTGTTCCGTGCCGGCTGATCTCCGTGCCGGGTTCGACCACGAGGGCGTC
CAGCACCCGTGGGGGAGATC

Product: Na+/H+ antiporter NhaA

Products: Na (I) [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: Sodium/proton antiporter nhaA 2 [H]

Number of amino acids: Translated: 446; Mature: 445

Protein sequence:

>446_residues
MPSVPPAPTPGPASGSGSSVSRPRLLARPTWPQARYVAGILRSETVGGLLLLAGAVVALVWANSPWRDAYATVVHTGVGP
ASLRLHLDLEHWAADGLLAIFFFVVGLELKREFVLGDLRSPSRAALPIVAALGGMLVPALIYTLVNGLAVDGSPEGWAVP
TATDIAFAVAVLAIITTHLPAALRSFLLTLAVVDDLLAIVIIAVFFTDRLSPAPLAGSLAVIAVFALLVNRGVTRWWLLI
PLALVAWALMHASGVHATIAGVLLGFAVPARPRSGEHAGMSERFEHAWRPVSAGVAVPLFALMAAGVSLAGGGVSAALAD
PAGLGVAMGLLLGKPIGVMGATGLLARLTRAELDPDLSWWDVAGVAVLAGVGFTVSLLIGELAFGAGTAENDHVKAAILI
GSLASALLASIVLRARNRVYRRIEERETVDLDADGIPDVFQEPTVG

Sequences:

>Translated_446_residues
MPSVPPAPTPGPASGSGSSVSRPRLLARPTWPQARYVAGILRSETVGGLLLLAGAVVALVWANSPWRDAYATVVHTGVGP
ASLRLHLDLEHWAADGLLAIFFFVVGLELKREFVLGDLRSPSRAALPIVAALGGMLVPALIYTLVNGLAVDGSPEGWAVP
TATDIAFAVAVLAIITTHLPAALRSFLLTLAVVDDLLAIVIIAVFFTDRLSPAPLAGSLAVIAVFALLVNRGVTRWWLLI
PLALVAWALMHASGVHATIAGVLLGFAVPARPRSGEHAGMSERFEHAWRPVSAGVAVPLFALMAAGVSLAGGGVSAALAD
PAGLGVAMGLLLGKPIGVMGATGLLARLTRAELDPDLSWWDVAGVAVLAGVGFTVSLLIGELAFGAGTAENDHVKAAILI
GSLASALLASIVLRARNRVYRRIEERETVDLDADGIPDVFQEPTVG
>Mature_445_residues
PSVPPAPTPGPASGSGSSVSRPRLLARPTWPQARYVAGILRSETVGGLLLLAGAVVALVWANSPWRDAYATVVHTGVGPA
SLRLHLDLEHWAADGLLAIFFFVVGLELKREFVLGDLRSPSRAALPIVAALGGMLVPALIYTLVNGLAVDGSPEGWAVPT
ATDIAFAVAVLAIITTHLPAALRSFLLTLAVVDDLLAIVIIAVFFTDRLSPAPLAGSLAVIAVFALLVNRGVTRWWLLIP
LALVAWALMHASGVHATIAGVLLGFAVPARPRSGEHAGMSERFEHAWRPVSAGVAVPLFALMAAGVSLAGGGVSAALADP
AGLGVAMGLLLGKPIGVMGATGLLARLTRAELDPDLSWWDVAGVAVLAGVGFTVSLLIGELAFGAGTAENDHVKAAILIG
SLASALLASIVLRARNRVYRRIEERETVDLDADGIPDVFQEPTVG

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons [H]

COG id: COG3004

COG function: function code P; Na+/H+ antiporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaA Na(+)/H(+) (TC 2.A.33) antiporter family [H]

Homologues:

Organism=Escherichia coli, GI1786201, Length=359, Percent_Identity=42.8969359331476, Blast_Score=226, Evalue=3e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023171
- InterPro:   IPR004670 [H]

Pfam domain/function: PF06965 Na_H_antiport_1 [H]

EC number: NA

Molecular weight: Translated: 46091; Mature: 45960

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSVPPAPTPGPASGSGSSVSRPRLLARPTWPQARYVAGILRSETVGGLLLLAGAVVALV
CCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WANSPWRDAYATVVHTGVGPASLRLHLDLEHWAADGLLAIFFFVVGLELKREFVLGDLRS
HCCCCCHHHHHHHHHCCCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PSRAALPIVAALGGMLVPALIYTLVNGLAVDGSPEGWAVPTATDIAFAVAVLAIITTHLP
CCHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
AALRSFLLTLAVVDDLLAIVIIAVFFTDRLSPAPLAGSLAVIAVFALLVNRGVTRWWLLI
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHH
PLALVAWALMHASGVHATIAGVLLGFAVPARPRSGEHAGMSERFEHAWRPVSAGVAVPLF
HHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCCCHHHHHH
ALMAAGVSLAGGGVSAALADPAGLGVAMGLLLGKPIGVMGATGLLARLTRAELDPDLSWW
HHHHCCCCCCCCCCHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHH
DVAGVAVLAGVGFTVSLLIGELAFGAGTAENDHVKAAILIGSLASALLASIVLRARNRVY
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RRIEERETVDLDADGIPDVFQEPTVG
HHHHHHCCCCCCCCCCCHHHCCCCCC
>Mature Secondary Structure 
PSVPPAPTPGPASGSGSSVSRPRLLARPTWPQARYVAGILRSETVGGLLLLAGAVVALV
CCCCCCCCCCCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WANSPWRDAYATVVHTGVGPASLRLHLDLEHWAADGLLAIFFFVVGLELKREFVLGDLRS
HCCCCCHHHHHHHHHCCCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PSRAALPIVAALGGMLVPALIYTLVNGLAVDGSPEGWAVPTATDIAFAVAVLAIITTHLP
CCHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
AALRSFLLTLAVVDDLLAIVIIAVFFTDRLSPAPLAGSLAVIAVFALLVNRGVTRWWLLI
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHH
PLALVAWALMHASGVHATIAGVLLGFAVPARPRSGEHAGMSERFEHAWRPVSAGVAVPLF
HHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCCCHHHHHH
ALMAAGVSLAGGGVSAALADPAGLGVAMGLLLGKPIGVMGATGLLARLTRAELDPDLSWW
HHHHCCCCCCCCCCHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHH
DVAGVAVLAGVGFTVSLLIGELAFGAGTAENDHVKAAILIGSLASALLASIVLRARNRVY
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RRIEERETVDLDADGIPDVFQEPTVG
HHHHHHCCCCCCCCCCCHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: Na (I) [Cytoplasm] + 2 Proton [Periplasm] = Na (I) [Periplasm] + 2 Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA