Click here to switch to the map view.

The map label for this gene is mcl1 [H]

Identifier: 158318641

GI number: 158318641

Start: 8417690

End: 8418640

Strand: Direct

Name: mcl1 [H]

Synonym: Franean1_6909

Alternate gene names: 158318641

Gene position: 8417690-8418640 (Clockwise)

Preceding gene: 158318639

Following gene: 158318642

Centisome position: 93.72

GC content: 71.82

Gene sequence:

>951_bases
GTGCCCGGCAAAGCGGAAGAACCGAACGTCACCCGGCCGCGCGCCCGCCGCTCGGAACTGGCGACCCCGGCCAGCAGTGA
GCGGATGTGTGAGAAGGCCGCCGGTTCCGGAGCGGACCTCGTCTTCCTCGACCTGGAAGACGCGTGCGCGCCGTCGGCCA
AGGAGGCCGCCCGCGGCATCGCCGTCGCCGCGCTCACCGACCTGGACTGGGGACACACCGTCCGCGCCGTCCGGGTGAAC
GGCCTGGACACGCCCTGGTGCCACGACGACATCATCGAGGTCGTCACCGGGGCGGGCGCGTCGCTCGACGTGCTCATCGT
TCCCAAGGCCCGATCGGCGCGTGACGTCTGGTGGGTCGACGTGTTGCTGACCCAGCTCGAGACGAAGCTCGGACTGACCC
GGCGGATCGGGCTGGAAGTACTGATCGAGGAGGCGGAGGGCCTGTCCAACGCCGCCGAGATCGCCCGGTCCAGCAGCCGG
CTGGAGGCGATAATCTTCGGCGCCGGCGACCTCTCGGCGTCGCTGCGCGCCCGGGTGGACGGCAACTTCGACCCCGTCGG
GGAGTATCCGGGCGACTTCTGGCACTTCGCGCGTGTCCAGGTGCTGTCGGCGGCGCGCGGGGCGGGCATCGACGCGATCG
ACGCGCCGTACCCCGCCTACAAGGACGTCGACGGGTACCGCCGGTCGGCCACCCACGCGAGCCTGCTCGGCTTCGACGGA
AAATGGGCCATCCACCCGGCTCAGGTGCCCATCGCCAACGAGGTGTTCGCGCCGACCGAGCAGGAGGTGGCCGAGGCGCA
CGAGGCGATGAAGATCTACCGCGAGTCCGAGGCGGAGGGGGTCGGCGCGATCGGCCGCGACGGCCGGCTCGTCGACGCCG
CCCACATGCGTCTCGCCGAGAACGTCCTGCACAAGGCGGCCCTCGCCGGCGGAACCGCCCCGGCGACCTGA

Upstream 100 bases:

>100_bases
CGGCCGCCGGGAAGTCACCACCAGCGGCCGTGGGGCGACGGGCGGCACGCTTTTTACAGCGCACGACTGACAGCGAATTC
ACAAGACATAGGAGGCAGTT

Downstream 100 bases:

>100_bases
GCCGCCCCGCCCAGCTGAGCCGCCTCTGGCCGGCGGGCTACCTCACCGACGGTCGGCGCCGCCCTCACCCACGGTCGGCG
CCGCCCTCACCGGTGGGTGG

Product: citrate (pro-3S)-lyase

Products: NA

Alternate protein names: (3S)-malyl-CoA/beta-methylmalyl-CoA lyase; L-malyl-CoA/beta-methylmalyl-CoA lyase [H]

Number of amino acids: Translated: 316; Mature: 315

Protein sequence:

>316_residues
MPGKAEEPNVTRPRARRSELATPASSERMCEKAAGSGADLVFLDLEDACAPSAKEAARGIAVAALTDLDWGHTVRAVRVN
GLDTPWCHDDIIEVVTGAGASLDVLIVPKARSARDVWWVDVLLTQLETKLGLTRRIGLEVLIEEAEGLSNAAEIARSSSR
LEAIIFGAGDLSASLRARVDGNFDPVGEYPGDFWHFARVQVLSAARGAGIDAIDAPYPAYKDVDGYRRSATHASLLGFDG
KWAIHPAQVPIANEVFAPTEQEVAEAHEAMKIYRESEAEGVGAIGRDGRLVDAAHMRLAENVLHKAALAGGTAPAT

Sequences:

>Translated_316_residues
MPGKAEEPNVTRPRARRSELATPASSERMCEKAAGSGADLVFLDLEDACAPSAKEAARGIAVAALTDLDWGHTVRAVRVN
GLDTPWCHDDIIEVVTGAGASLDVLIVPKARSARDVWWVDVLLTQLETKLGLTRRIGLEVLIEEAEGLSNAAEIARSSSR
LEAIIFGAGDLSASLRARVDGNFDPVGEYPGDFWHFARVQVLSAARGAGIDAIDAPYPAYKDVDGYRRSATHASLLGFDG
KWAIHPAQVPIANEVFAPTEQEVAEAHEAMKIYRESEAEGVGAIGRDGRLVDAAHMRLAENVLHKAALAGGTAPAT
>Mature_315_residues
PGKAEEPNVTRPRARRSELATPASSERMCEKAAGSGADLVFLDLEDACAPSAKEAARGIAVAALTDLDWGHTVRAVRVNG
LDTPWCHDDIIEVVTGAGASLDVLIVPKARSARDVWWVDVLLTQLETKLGLTRRIGLEVLIEEAEGLSNAAEIARSSSRL
EAIIFGAGDLSASLRARVDGNFDPVGEYPGDFWHFARVQVLSAARGAGIDAIDAPYPAYKDVDGYRRSATHASLLGFDGK
WAIHPAQVPIANEVFAPTEQEVAEAHEAMKIYRESEAEGVGAIGRDGRLVDAAHMRLAENVLHKAALAGGTAPAT

Specific function: Catalyzes the reversible condensation of glyoxylate and acetyl-CoA to L-malyl-CoA and the reversible condensation of glyoxylate and propionyl-CoA to beta-methylmalyl-CoA [H]

COG id: COG2301

COG function: function code G; Citrate lyase beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HpcH/HpaI aldolase family [H]

Homologues:

Organism=Homo sapiens, GI45545437, Length=297, Percent_Identity=27.2727272727273, Blast_Score=121, Evalue=7e-28,
Organism=Escherichia coli, GI87081764, Length=300, Percent_Identity=33.6666666666667, Blast_Score=139, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI17557458, Length=303, Percent_Identity=30.6930693069307, Blast_Score=108, Evalue=4e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005000
- InterPro:   IPR011206
- InterPro:   IPR015813 [H]

Pfam domain/function: PF03328 HpcH_HpaI [H]

EC number: =4.1.3.24 [H]

Molecular weight: Translated: 33633; Mature: 33502

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPGKAEEPNVTRPRARRSELATPASSERMCEKAAGSGADLVFLDLEDACAPSAKEAARGI
CCCCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHCCCCCCEEEEECHHHCCCCHHHHHCCE
AVAALTDLDWGHTVRAVRVNGLDTPWCHDDIIEVVTGAGASLDVLIVPKARSARDVWWVD
EEEEEECCCCCCEEEEEEECCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHH
VLLTQLETKLGLTRRIGLEVLIEEAEGLSNAAEIARSSSRLEAIIFGAGDLSASLRARVD
HHHHHHHHHHCHHHHHHHHHHHHHHCCCHHHHHHHHCCCCEEEEEEECCCCCCCEEEEEC
GNFDPVGEYPGDFWHFARVQVLSAARGAGIDAIDAPYPAYKDVDGYRRSATHASLLGFDG
CCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHCCHHHHCCCCC
KWAIHPAQVPIANEVFAPTEQEVAEAHEAMKIYRESEAEGVGAIGRDGRLVDAAHMRLAE
CEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEHHHHHHHHH
NVLHKAALAGGTAPAT
HHHHHHHHCCCCCCCC
>Mature Secondary Structure 
PGKAEEPNVTRPRARRSELATPASSERMCEKAAGSGADLVFLDLEDACAPSAKEAARGI
CCCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHCCCCCCEEEEECHHHCCCCHHHHHCCE
AVAALTDLDWGHTVRAVRVNGLDTPWCHDDIIEVVTGAGASLDVLIVPKARSARDVWWVD
EEEEEECCCCCCEEEEEEECCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHH
VLLTQLETKLGLTRRIGLEVLIEEAEGLSNAAEIARSSSRLEAIIFGAGDLSASLRARVD
HHHHHHHHHHCHHHHHHHHHHHHHHCCCHHHHHHHHCCCCEEEEEEECCCCCCCEEEEEC
GNFDPVGEYPGDFWHFARVQVLSAARGAGIDAIDAPYPAYKDVDGYRRSATHASLLGFDG
CCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHCCHHHHCCCCC
KWAIHPAQVPIANEVFAPTEQEVAEAHEAMKIYRESEAEGVGAIGRDGRLVDAAHMRLAE
CEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEHHHHHHHHH
NVLHKAALAGGTAPAT
HHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA