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The map label for this gene is patB [H]

Identifier: 158318068

GI number: 158318068

Start: 7685652

End: 7686845

Strand: Direct

Name: patB [H]

Synonym: Franean1_6328

Alternate gene names: 158318068

Gene position: 7685652-7686845 (Clockwise)

Preceding gene: 158318067

Following gene: 158318069

Centisome position: 85.57

GC content: 73.37

Gene sequence:

>1194_bases
ATGCCCACGTTCCACCAGAGGGAGCACTCCTTGTCCGCCCGGGAGACCGCTCCGGGGGCGCTGGCCCTGTGGCTGGCGGA
GATGGAGTATCCGCCGCCCGACTGCGTCAGCGAGATGGTCACGCGCTACCTGGCCGGTGGGCATCTCGGCTATTCGGCAG
GCTTCGACTTCGCCACCGAGAGCCTCCGGCACTGGGCTCGGCGCCGCTACGGCTGGGCCACCGGGGAGCTGAGCTGTGGC
TGGTACTCCGGCGTGCTGCATGCCGCCGCGGCCGCCGTCCTGACCCTGACCGAGCCCGGCGACGCGGTGGTGGTGCTGAC
CCCGACCTATCCGCCGATGCTGCGCGCGGTGAGCCAGCTGGGACGGCGGGCGGTGCGCTGGCCGCTGCTCGACGAGGAGA
ACGGCTACCGCTTCGACCTGGCCGCGCTCGCGGCCGTGCTGGCCCGGGAACGACCGACGTTGCTGATCCTGAACACGCCG
CACAACCCGACCGGACGGGTGTTCACCGCGCCGGAGCTCCGTGCGCTGGCCGACCAGCTCCGCGACAGTCCTGTCCAGGT
GCTCTCGGACGAGATCTTCGCCGACATCGTCTACCCCGGCGCTCGGCACGTTCCGTTCATGCTCGCGGCCGGGGAGGAGG
TGGGCGAACGGACGGTGACGGTCCTTTCGGCGAGCAAGGCGTTCAACCTGGCGGGACTGCGCTGCGCCGCGGCCATCGCC
GGCTCGGACACGCTCGCGTGTCGGCTCGCGCGGCTGCCGGCGGCGCTCACCGGCACCACCACGGTCGTGGGTGCCGTGGC
CAGCGCCGCCGCCTGGGACCACGGAGAGACATGGCTCGACACGGTGGTCGACGTGCTGGCCGCAAACCGGGACCTGCTGT
TCAGCCAGCTGCCCCGGCGCATCCCGATGCTGTCCGGACGGCCCCCGGAGGGCACCTACCTCGGCTGGCTGCGAGCGCAC
GGCGCTCTCGCTGACTCGGGCGACGTGCGGGCCGAGCTCCTGCGCGCCGGAGTCGACCTGGCCGACGGAACGCCCTTCGG
GGACGAGTCGGGCCGGCGGGTGCGGCTGTCGTTTGCCTGCCCGCCCGACGTCCTGGCCCAGGCGCTGGACGCGATCGCCG
TGACCTGCCAGGCCCTGGCCGACCAGCCGTCCTCGCGGTCGCCCGGACGGGCGCCTGAGGGCCGGCCCGGATGA

Upstream 100 bases:

>100_bases
TCACCGCCGAGGAGATCGCGCGACTGGACAAGGTGTCGGAACCTGACTGGGGCTATCCGGAGTCCTTCATCGCGCGCTTC
GAGCCGTGGTGACCCGTCGT

Downstream 100 bases:

>100_bases
CATCGACATCCCGTCGCGGAGGAGGCACAGATGCCGGTACAGACGATGGACTTCGCCGCTCCGTCCTTCCGGACGGATCC
GTTCCCGGCCTGGTCCGACC

Product: class I and II aminotransferase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 397; Mature: 396

Protein sequence:

>397_residues
MPTFHQREHSLSARETAPGALALWLAEMEYPPPDCVSEMVTRYLAGGHLGYSAGFDFATESLRHWARRRYGWATGELSCG
WYSGVLHAAAAAVLTLTEPGDAVVVLTPTYPPMLRAVSQLGRRAVRWPLLDEENGYRFDLAALAAVLARERPTLLILNTP
HNPTGRVFTAPELRALADQLRDSPVQVLSDEIFADIVYPGARHVPFMLAAGEEVGERTVTVLSASKAFNLAGLRCAAAIA
GSDTLACRLARLPAALTGTTTVVGAVASAAAWDHGETWLDTVVDVLAANRDLLFSQLPRRIPMLSGRPPEGTYLGWLRAH
GALADSGDVRAELLRAGVDLADGTPFGDESGRRVRLSFACPPDVLAQALDAIAVTCQALADQPSSRSPGRAPEGRPG

Sequences:

>Translated_397_residues
MPTFHQREHSLSARETAPGALALWLAEMEYPPPDCVSEMVTRYLAGGHLGYSAGFDFATESLRHWARRRYGWATGELSCG
WYSGVLHAAAAAVLTLTEPGDAVVVLTPTYPPMLRAVSQLGRRAVRWPLLDEENGYRFDLAALAAVLARERPTLLILNTP
HNPTGRVFTAPELRALADQLRDSPVQVLSDEIFADIVYPGARHVPFMLAAGEEVGERTVTVLSASKAFNLAGLRCAAAIA
GSDTLACRLARLPAALTGTTTVVGAVASAAAWDHGETWLDTVVDVLAANRDLLFSQLPRRIPMLSGRPPEGTYLGWLRAH
GALADSGDVRAELLRAGVDLADGTPFGDESGRRVRLSFACPPDVLAQALDAIAVTCQALADQPSSRSPGRAPEGRPG
>Mature_396_residues
PTFHQREHSLSARETAPGALALWLAEMEYPPPDCVSEMVTRYLAGGHLGYSAGFDFATESLRHWARRRYGWATGELSCGW
YSGVLHAAAAAVLTLTEPGDAVVVLTPTYPPMLRAVSQLGRRAVRWPLLDEENGYRFDLAALAAVLARERPTLLILNTPH
NPTGRVFTAPELRALADQLRDSPVQVLSDEIFADIVYPGARHVPFMLAAGEEVGERTVTVLSASKAFNLAGLRCAAAIAG
SDTLACRLARLPAALTGTTTVVGAVASAAAWDHGETWLDTVVDVLAANRDLLFSQLPRRIPMLSGRPPEGTYLGWLRAHG
ALADSGDVRAELLRAGVDLADGTPFGDESGRRVRLSFACPPDVLAQALDAIAVTCQALADQPSSRSPGRAPEGRPG

Specific function: Catalyzes the transformation of cystathionine to homocysteine. Also exhibits cysteine desulfhydrase activity in vitro, producing sulfide from cysteine [H]

COG id: COG1168

COG function: function code E; Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. MalY/PatB cystathionine beta-lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI56713256, Length=349, Percent_Identity=23.4957020057307, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI56713254, Length=317, Percent_Identity=25.2365930599369, Blast_Score=73, Evalue=6e-13,
Organism=Homo sapiens, GI95147551, Length=239, Percent_Identity=25.5230125523013, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI169881279, Length=239, Percent_Identity=25.5230125523013, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1787909, Length=352, Percent_Identity=27.8409090909091, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1786816, Length=308, Percent_Identity=25.6493506493506, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1788722, Length=364, Percent_Identity=24.1758241758242, Blast_Score=72, Evalue=5e-14,
Organism=Drosophila melanogaster, GI28573069, Length=165, Percent_Identity=29.6969696969697, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24646114, Length=165, Percent_Identity=29.6969696969697, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI28573067, Length=165, Percent_Identity=29.6969696969697, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI28573065, Length=165, Percent_Identity=29.6969696969697, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 42431; Mature: 42299

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTFHQREHSLSARETAPGALALWLAEMEYPPPDCVSEMVTRYLAGGHLGYSAGFDFATE
CCCCCCHHHCCCHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHH
SLRHWARRRYGWATGELSCGWYSGVLHAAAAAVLTLTEPGDAVVVLTPTYPPMLRAVSQL
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHEEEEECCCCEEEEECCCCCHHHHHHHHH
GRRAVRWPLLDEENGYRFDLAALAAVLARERPTLLILNTPHNPTGRVFTAPELRALADQL
HHHHHCCCCCCCCCCCEEEHHHHHHHHHCCCCEEEEEECCCCCCCCEEECHHHHHHHHHH
RDSPVQVLSDEIFADIVYPGARHVPFMLAAGEEVGERTVTVLSASKAFNLAGLRCAAAIA
CCCHHHHHHHHHHHHHHCCCCCCCCEEEECCHHHCCCEEEEEECCCCCCCHHHHHHHHHC
GSDTLACRLARLPAALTGTTTVVGAVASAAAWDHGETWLDTVVDVLAANRDLLFSQLPRR
CCCHHHHHHHHCCCHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHH
IPMLSGRPPEGTYLGWLRAHGALADSGDVRAELLRAGVDLADGTPFGDESGRRVRLSFAC
CCCCCCCCCCCCEEEHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECC
PPDVLAQALDAIAVTCQALADQPSSRSPGRAPEGRPG
CHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PTFHQREHSLSARETAPGALALWLAEMEYPPPDCVSEMVTRYLAGGHLGYSAGFDFATE
CCCCCHHHCCCHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHH
SLRHWARRRYGWATGELSCGWYSGVLHAAAAAVLTLTEPGDAVVVLTPTYPPMLRAVSQL
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHEEEEECCCCEEEEECCCCCHHHHHHHHH
GRRAVRWPLLDEENGYRFDLAALAAVLARERPTLLILNTPHNPTGRVFTAPELRALADQL
HHHHHCCCCCCCCCCCEEEHHHHHHHHHCCCCEEEEEECCCCCCCCEEECHHHHHHHHHH
RDSPVQVLSDEIFADIVYPGARHVPFMLAAGEEVGERTVTVLSASKAFNLAGLRCAAAIA
CCCHHHHHHHHHHHHHHCCCCCCCCEEEECCHHHCCCEEEEEECCCCCCCHHHHHHHHHC
GSDTLACRLARLPAALTGTTTVVGAVASAAAWDHGETWLDTVVDVLAANRDLLFSQLPRR
CCCHHHHHHHHCCCHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHH
IPMLSGRPPEGTYLGWLRAHGALADSGDVRAELLRAGVDLADGTPFGDESGRRVRLSFAC
CCCCCCCCCCCCEEEHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECC
PPDVLAQALDAIAVTCQALADQPSSRSPGRAPEGRPG
CHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8497199; 9274030; 9384377 [H]