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The map label for this gene is hemC1 [H]

Identifier: 158317872

GI number: 158317872

Start: 7458967

End: 7460031

Strand: Reverse

Name: hemC1 [H]

Synonym: Franean1_6130

Alternate gene names: 158317872

Gene position: 7460031-7458967 (Counterclockwise)

Preceding gene: 158317873

Following gene: 158317871

Centisome position: 83.05

GC content: 73.8

Gene sequence:

>1065_bases
GTGACAGTGACCCGAGGGCCCGAGGCACGAGCACACGCGCTCCTGGCGCGGCGGCCGCTGCGACTGGGCACCCGGCGTTC
CGCGCTGGCGCGGGCTCAGTCCGAGAAAGTGGCCGAGACGCTGCGGACCCGGCTGAGCCGACCCGTGGAGCTCGTTCCGA
TCGTCACCGCGGGTGACCAGTCGCAGGTGGCGATCAGCCAGATCGGTGGAACGGGCGTCTTTGTCAGCGCGCTGCGTGAC
GCCCTGCTCGCCGGTGAGATCGACCTCGCCGTCCACTCGCTCAAGGACCTGCCGACGGCCACCCCGGACGGGCTCGTCCT
GGCCGCCGTCCCGCGCCGGGCCGACACCCGGGACGTCCTCGTCTCGCCCAGCGGCCGGCGCCTGAGCGAGCTGGGGCCGG
GCGCGCGGGTCGGGACGGGGTCGCCGCGGCGGGCCGCCCAGCTGCTCGCGCTCGGCCACGGCTTCGAGGTCGTCCCGATC
CGCGGCAACGTCGACACCCGGATCAAGAAGGCCATCGACGGCGAGGTGGACGCGGTGGTGCTCGCGCACGCCGGCCTCGA
CCGCCTCGACCGCCTCGACGCGGTCACCGAGATCATCTCACCCGAGGTGATGCTGCCCGCTCCCGGGCAGGGCGCGCTGG
CGATCGAGTGCGTGCGCACCCCGGCCGGCGGCGGACCAGCCCACGACCAGACCGGACCAGAAGCGGGCCGGGGCTTCGAT
GAGGGACTCGCGGAGCTGCTACGGTTTGTGCTCGACGACGCAACGTCCTCCGTCGCGGTCCGAGCCGAGCGTGCCTTCCT
GGCGGGCATCGAGGCCGGTTGTACCGCTCCGGTGGGTGCTCTGGCCCACGTGCTTCCGGGTACCGACGCACGCCTGGTCG
CGGGCGGTGACGATGCGCCCGCCGTGGGTGAGATCCGCCTGCGGGCGGTGGTCGCCGCGCCGGATGGAGGCAGGGTCCTG
CGGCGCGAGCTCACCGGTTCTGCCGTCGACCCGGAGGCGCTCGGGCAGCGCCTCGCGGACGAGCTGTTGTCCGCCGGAGC
ACACACGCTGATGGGAACAAGCTGA

Upstream 100 bases:

>100_bases
GCGGTGACTCCTACGCCGAGGCCCTGCGCGAGCTCTTCGACCTGCCGCGTGACGTGCCGGCCATCGTCTCCGCCCCTGAT
CTGGATCTGGTGGAGAGAAC

Downstream 100 bases:

>100_bases
GCATGGCCACCCGACGTACCAAGAAGCCCGTGTCCCCGGTCGCGCTTGTGGGCGCCGGTCCCCGTGATCCGGGGCTGCTC
ACGGTCCTCGCCGTGGAGAC

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG 1; Hydroxymethylbilane synthase 1; HMBS 1; Pre-uroporphyrinogen synthase 1 [H]

Number of amino acids: Translated: 354; Mature: 353

Protein sequence:

>354_residues
MTVTRGPEARAHALLARRPLRLGTRRSALARAQSEKVAETLRTRLSRPVELVPIVTAGDQSQVAISQIGGTGVFVSALRD
ALLAGEIDLAVHSLKDLPTATPDGLVLAAVPRRADTRDVLVSPSGRRLSELGPGARVGTGSPRRAAQLLALGHGFEVVPI
RGNVDTRIKKAIDGEVDAVVLAHAGLDRLDRLDAVTEIISPEVMLPAPGQGALAIECVRTPAGGGPAHDQTGPEAGRGFD
EGLAELLRFVLDDATSSVAVRAERAFLAGIEAGCTAPVGALAHVLPGTDARLVAGGDDAPAVGEIRLRAVVAAPDGGRVL
RRELTGSAVDPEALGQRLADELLSAGAHTLMGTS

Sequences:

>Translated_354_residues
MTVTRGPEARAHALLARRPLRLGTRRSALARAQSEKVAETLRTRLSRPVELVPIVTAGDQSQVAISQIGGTGVFVSALRD
ALLAGEIDLAVHSLKDLPTATPDGLVLAAVPRRADTRDVLVSPSGRRLSELGPGARVGTGSPRRAAQLLALGHGFEVVPI
RGNVDTRIKKAIDGEVDAVVLAHAGLDRLDRLDAVTEIISPEVMLPAPGQGALAIECVRTPAGGGPAHDQTGPEAGRGFD
EGLAELLRFVLDDATSSVAVRAERAFLAGIEAGCTAPVGALAHVLPGTDARLVAGGDDAPAVGEIRLRAVVAAPDGGRVL
RRELTGSAVDPEALGQRLADELLSAGAHTLMGTS
>Mature_353_residues
TVTRGPEARAHALLARRPLRLGTRRSALARAQSEKVAETLRTRLSRPVELVPIVTAGDQSQVAISQIGGTGVFVSALRDA
LLAGEIDLAVHSLKDLPTATPDGLVLAAVPRRADTRDVLVSPSGRRLSELGPGARVGTGSPRRAAQLLALGHGFEVVPIR
GNVDTRIKKAIDGEVDAVVLAHAGLDRLDRLDAVTEIISPEVMLPAPGQGALAIECVRTPAGGGPAHDQTGPEAGRGFDE
GLAELLRFVLDDATSSVAVRAERAFLAGIEAGCTAPVGALAHVLPGTDARLVAGGDDAPAVGEIRLRAVVAAPDGGRVLR
RELTGSAVDPEALGQRLADELLSAGAHTLMGTS

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI66933009, Length=358, Percent_Identity=34.6368715083799, Blast_Score=148, Evalue=8e-36,
Organism=Homo sapiens, GI20149500, Length=358, Percent_Identity=34.6368715083799, Blast_Score=148, Evalue=8e-36,
Organism=Escherichia coli, GI48994974, Length=336, Percent_Identity=37.797619047619, Blast_Score=181, Evalue=5e-47,
Organism=Saccharomyces cerevisiae, GI6319996, Length=347, Percent_Identity=28.5302593659942, Blast_Score=125, Evalue=1e-29,
Organism=Drosophila melanogaster, GI20130425, Length=272, Percent_Identity=35.6617647058824, Blast_Score=144, Evalue=1e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 36457; Mature: 36326

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVTRGPEARAHALLARRPLRLGTRRSALARAQSEKVAETLRTRLSRPVELVPIVTAGDQ
CCCCCCCCHHHHHHHHHCCHHCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCC
SQVAISQIGGTGVFVSALRDALLAGEIDLAVHSLKDLPTATPDGLVLAAVPRRADTRDVL
CCEEHHHCCCCHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCEE
VSPSGRRLSELGPGARVGTGSPRRAAQLLALGHGFEVVPIRGNVDTRIKKAIDGEVDAVV
ECCCCCHHHHCCCCCCCCCCCHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHCCCCCEEE
LAHAGLDRLDRLDAVTEIISPEVMLPAPGQGALAIECVRTPAGGGPAHDQTGPEAGRGFD
EECCCHHHHHHHHHHHHHHCCCEEECCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCHH
EGLAELLRFVLDDATSSVAVRAERAFLAGIEAGCTAPVGALAHVLPGTDARLVAGGDDAP
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCEEEECCCCCC
AVGEIRLRAVVAAPDGGRVLRRELTGSAVDPEALGQRLADELLSAGAHTLMGTS
CCCCEEEEEEEECCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHCCCC
>Mature Secondary Structure 
TVTRGPEARAHALLARRPLRLGTRRSALARAQSEKVAETLRTRLSRPVELVPIVTAGDQ
CCCCCCCHHHHHHHHHCCHHCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCC
SQVAISQIGGTGVFVSALRDALLAGEIDLAVHSLKDLPTATPDGLVLAAVPRRADTRDVL
CCEEHHHCCCCHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCEE
VSPSGRRLSELGPGARVGTGSPRRAAQLLALGHGFEVVPIRGNVDTRIKKAIDGEVDAVV
ECCCCCHHHHCCCCCCCCCCCHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHCCCCCEEE
LAHAGLDRLDRLDAVTEIISPEVMLPAPGQGALAIECVRTPAGGGPAHDQTGPEAGRGFD
EECCCHHHHHHHHHHHHHHCCCEEECCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCHH
EGLAELLRFVLDDATSSVAVRAERAFLAGIEAGCTAPVGALAHVLPGTDARLVAGGDDAP
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCEEEECCCCCC
AVGEIRLRAVVAAPDGGRVLRRELTGSAVDPEALGQRLADELLSAGAHTLMGTS
CCCCEEEEEEEECCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]