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The map label for this gene is hemD [H]

Identifier: 158317871

GI number: 158317871

Start: 7457150

End: 7458964

Strand: Reverse

Name: hemD [H]

Synonym: Franean1_6129

Alternate gene names: 158317871

Gene position: 7458964-7457150 (Counterclockwise)

Preceding gene: 158317872

Following gene: 158317870

Centisome position: 83.04

GC content: 74.71

Gene sequence:

>1815_bases
ATGGCCACCCGACGTACCAAGAAGCCCGTGTCCCCGGTCGCGCTTGTGGGCGCCGGTCCCCGTGATCCGGGGCTGCTCAC
GGTCCTCGCCGTGGAGACTCTCACCGCTGCCGACGTGGTGGTCGCCGACCCGGACGTACCGTCCGAGGTGGTCGAGTCGC
TGTCGGCCGAGGTGCTGCGGATCGGTGACCTCGACGCCCCGAAGCCGGTGCGGGACGCGGAGGCCGCGACCGCCGCGGTC
GTCAGCCGGGCACGGGCCGGGGACAAGGTCGTCCGGCTCTACGCCTCGGACCCGTGGCTGACCCGGATCGGCGCGGCGGA
CGCGCAGTCGCTGGCCAAGGCCAAGATCCCCTACCGGGTGGTTCCCGGTATCTCGACCTCCGCCGCGGTCGCGACCTACG
CCGGTGTCGCGCCGGGCAGCCCGGTCACCTTCGCCAGCACGTCGGGTGTCTTCTCGTCCTCGGGCTCGGTCGCCTCGGCC
TCACCGTTCGGCGTCGGTGACCCGGTCGGCCCGCTCACCCCGCCCCCCTTCGGGACGTCCCGCCTCGGCGGCCGGTCGAT
GCCGAGCCTCGGCGGCGGCCCGCTGGGCGTGGGCGGCGGCTTCGGCGCGCCCCTCGGCCTGGGCACCCCTACCGGCTTCG
GTGGTCTCGGCGTGCCCACCACGCCGGGCGACGTCGACTGGGGCGCGCTCGCGCAGGCCCCCGGCACGCTGATCGTCACC
GCCGGCCCCACCGAGATCGGCAAGGTGGCGACCGCGCTGGTCGAGCACGGCCGCGCCGGTGACACCCCCGTCGCGGTCAC
CGTCGACGGCACGACCACCGACCAGCGCACCGTCACCTCGACCCTCGACCGGATCGAGGCCGACGTCGCGCCGATGCTCA
ACGCCACCGCGAACCCGCCGAACGAGGTCATCATCTCCGTCGGCCCGGTCGTCGCGACCCGGGCGAAGCTGTCCTGGTGG
GAGACCCGCGCCCTGTTCGGCTGGACGGTGCTGGTGCCCCGGACGAAGGAACAGGCGGCGATCCTCTCCGACTCGCTGCG
CGCCCACGGGGCGAGTCCGCTGGAGGTGCCGACGATCGCCGTCGAGCCGCCGCGGACGGCCGCGCCGATGGAGCGCGCCA
TCACCGGGCTGGTCTCCGGCCGCTACCAGTGGGTCGCCTTCACCTCGGTGAACGCCGTCAAGGCGGTGCAGGAGAAGGTC
GAGGAGCGCAGCCTGGACGCCCGCGCCTTCGCCGGTGTCAAGGTCGCCGCGATCGGCGAGGCCACCGCGGACGCGCTGCG
CGCCTTCGGTATCCGCCCCGACCTGGTGCCCGCCGGCCAGCAGTCCAGCGAGGGCCTGCTCGAGGACTGGCCCGAGTTCG
ACGAGTCGCTTGACCTGCTCGACCGGGTTCTCCTGCCGCGCGCCGACATCGCCACCGACACTCTCGTCGCCGGCGTCAAG
GACCGCGGCTGGCAGGTGGACGACGTCACCGCCTACCGGACGGTGCGCGCCGCGCCGCCGCCCGCGCCGATCCGCGAGGC
CCTCAAGGGCGGCCGGGTCGACGCGGTGGTCTTCACCTCCTCCTCCACGGTGCGCAACCTGGTCGGAATCGCCGGCAAGC
CGCACGAGACCACCGTCATCGCGGTGATCGGCCCGGCGACGGCCGCGACCGCCCAGGAGCTCGGCCTGCGGGTGGACGTC
CAGGCGACCGAGGCGTCGATCCCGTCGCTCGTCGCGTCGCTGGCGGAGTTCGCCGCCGAGCACCGCGAGGAGCTCGGCAA
GGTCGGCCCGCTCGCCGCCAGGCTGCCCAAGCCGCGCCGGGGTTCCCGGCGATGA

Upstream 100 bases:

>100_bases
AGCTCACCGGTTCTGCCGTCGACCCGGAGGCGCTCGGGCAGCGCCTCGCGGACGAGCTGTTGTCCGCCGGAGCACACACG
CTGATGGGAACAAGCTGAGC

Downstream 100 bases:

>100_bases
TCGCGGGGCCCGGGCGGTCGGCCGTCGGTTTCCCCGTGGCGCGCCCGCGGCGGCTGCGCCGCGGGGCCGCGCTGCGGCGG
ATGGTGGCCGACGTCCGGCT

Product: uroporphyrinogen III synthase HEM4

Products: NA

Alternate protein names: Uroporphyrinogen-III C-methyltransferase; Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM; Uroporphyrinogen-III synthase; UROS; Hydroxymethylbilane hydrolyase [cyclizing]; Uroporphyrinogen-III cosynthase [H]

Number of amino acids: Translated: 604; Mature: 603

Protein sequence:

>604_residues
MATRRTKKPVSPVALVGAGPRDPGLLTVLAVETLTAADVVVADPDVPSEVVESLSAEVLRIGDLDAPKPVRDAEAATAAV
VSRARAGDKVVRLYASDPWLTRIGAADAQSLAKAKIPYRVVPGISTSAAVATYAGVAPGSPVTFASTSGVFSSSGSVASA
SPFGVGDPVGPLTPPPFGTSRLGGRSMPSLGGGPLGVGGGFGAPLGLGTPTGFGGLGVPTTPGDVDWGALAQAPGTLIVT
AGPTEIGKVATALVEHGRAGDTPVAVTVDGTTTDQRTVTSTLDRIEADVAPMLNATANPPNEVIISVGPVVATRAKLSWW
ETRALFGWTVLVPRTKEQAAILSDSLRAHGASPLEVPTIAVEPPRTAAPMERAITGLVSGRYQWVAFTSVNAVKAVQEKV
EERSLDARAFAGVKVAAIGEATADALRAFGIRPDLVPAGQQSSEGLLEDWPEFDESLDLLDRVLLPRADIATDTLVAGVK
DRGWQVDDVTAYRTVRAAPPPAPIREALKGGRVDAVVFTSSSTVRNLVGIAGKPHETTVIAVIGPATAATAQELGLRVDV
QATEASIPSLVASLAEFAAEHREELGKVGPLAARLPKPRRGSRR

Sequences:

>Translated_604_residues
MATRRTKKPVSPVALVGAGPRDPGLLTVLAVETLTAADVVVADPDVPSEVVESLSAEVLRIGDLDAPKPVRDAEAATAAV
VSRARAGDKVVRLYASDPWLTRIGAADAQSLAKAKIPYRVVPGISTSAAVATYAGVAPGSPVTFASTSGVFSSSGSVASA
SPFGVGDPVGPLTPPPFGTSRLGGRSMPSLGGGPLGVGGGFGAPLGLGTPTGFGGLGVPTTPGDVDWGALAQAPGTLIVT
AGPTEIGKVATALVEHGRAGDTPVAVTVDGTTTDQRTVTSTLDRIEADVAPMLNATANPPNEVIISVGPVVATRAKLSWW
ETRALFGWTVLVPRTKEQAAILSDSLRAHGASPLEVPTIAVEPPRTAAPMERAITGLVSGRYQWVAFTSVNAVKAVQEKV
EERSLDARAFAGVKVAAIGEATADALRAFGIRPDLVPAGQQSSEGLLEDWPEFDESLDLLDRVLLPRADIATDTLVAGVK
DRGWQVDDVTAYRTVRAAPPPAPIREALKGGRVDAVVFTSSSTVRNLVGIAGKPHETTVIAVIGPATAATAQELGLRVDV
QATEASIPSLVASLAEFAAEHREELGKVGPLAARLPKPRRGSRR
>Mature_603_residues
ATRRTKKPVSPVALVGAGPRDPGLLTVLAVETLTAADVVVADPDVPSEVVESLSAEVLRIGDLDAPKPVRDAEAATAAVV
SRARAGDKVVRLYASDPWLTRIGAADAQSLAKAKIPYRVVPGISTSAAVATYAGVAPGSPVTFASTSGVFSSSGSVASAS
PFGVGDPVGPLTPPPFGTSRLGGRSMPSLGGGPLGVGGGFGAPLGLGTPTGFGGLGVPTTPGDVDWGALAQAPGTLIVTA
GPTEIGKVATALVEHGRAGDTPVAVTVDGTTTDQRTVTSTLDRIEADVAPMLNATANPPNEVIISVGPVVATRAKLSWWE
TRALFGWTVLVPRTKEQAAILSDSLRAHGASPLEVPTIAVEPPRTAAPMERAITGLVSGRYQWVAFTSVNAVKAVQEKVE
ERSLDARAFAGVKVAAIGEATADALRAFGIRPDLVPAGQQSSEGLLEDWPEFDESLDLLDRVLLPRADIATDTLVAGVKD
RGWQVDDVTAYRTVRAAPPPAPIREALKGGRVDAVVFTSSSTVRNLVGIAGKPHETTVIAVIGPATAATAQELGLRVDVQ
ATEASIPSLVASLAEFAAEHREELGKVGPLAARLPKPRRGSRR

Specific function: May catalyze sequential reactions to synthesize uroporphyrinogen III from hydroxymethylbilane (HMB) and then precorrin-2, which are intermediate compounds in both vitamin B12 and siroheme biosyntheses [H]

COG id: COG1587

COG function: function code H; Uroporphyrinogen-III synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=317, Percent_Identity=26.813880126183, Blast_Score=103, Evalue=4e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR003754
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR003043 [H]

Pfam domain/function: PF02602 HEM4; PF00590 TP_methylase [H]

EC number: =2.1.1.107; =4.2.1.75 [H]

Molecular weight: Translated: 61913; Mature: 61782

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
0.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATRRTKKPVSPVALVGAGPRDPGLLTVLAVETLTAADVVVADPDVPSEVVESLSAEVLR
CCCCCCCCCCCCEEEEECCCCCCCEEEEEEHHHHHHCCEEEECCCCHHHHHHHHHHHEEE
IGDLDAPKPVRDAEAATAAVVSRARAGDKVVRLYASDPWLTRIGAADAQSLAKAKIPYRV
ECCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHCCCCCHHHHHHHCCCEEE
VPGISTSAAVATYAGVAPGSPVTFASTSGVFSSSGSVASASPFGVGDPVGPLTPPPFGTS
ECCCCCHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
RLGGRSMPSLGGGPLGVGGGFGAPLGLGTPTGFGGLGVPTTPGDVDWGALAQAPGTLIVT
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCEEEEE
AGPTEIGKVATALVEHGRAGDTPVAVTVDGTTTDQRTVTSTLDRIEADVAPMLNATANPP
CCCHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
NEVIISVGPVVATRAKLSWWETRALFGWTVLVPRTKEQAAILSDSLRAHGASPLEVPTIA
CCEEEEECCHHHHHHHHHHHHHHHEEEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCEEE
VEPPRTAAPMERAITGLVSGRYQWVAFTSVNAVKAVQEKVEERSLDARAFAGVKVAAIGE
ECCCCCCCHHHHHHHHHHCCCEEEEEEECHHHHHHHHHHHHHHCCCHHHHCCEEEEECCH
ATADALRAFGIRPDLVPAGQQSSEGLLEDWPEFDESLDLLDRVLLPRADIATDTLVAGVK
HHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCC
DRGWQVDDVTAYRTVRAAPPPAPIREALKGGRVDAVVFTSSSTVRNLVGIAGKPHETTVI
CCCCCCCCHHHHEEEECCCCCHHHHHHHCCCCEEEEEEECCHHHHHHHHCCCCCCCEEEE
AVIGPATAATAQELGLRVDVQATEASIPSLVASLAEFAAEHREELGKVGPLAARLPKPRR
EEECCCCHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCC
GSRR
CCCC
>Mature Secondary Structure 
ATRRTKKPVSPVALVGAGPRDPGLLTVLAVETLTAADVVVADPDVPSEVVESLSAEVLR
CCCCCCCCCCCEEEEECCCCCCCEEEEEEHHHHHHCCEEEECCCCHHHHHHHHHHHEEE
IGDLDAPKPVRDAEAATAAVVSRARAGDKVVRLYASDPWLTRIGAADAQSLAKAKIPYRV
ECCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHCCCCCHHHHHHHCCCEEE
VPGISTSAAVATYAGVAPGSPVTFASTSGVFSSSGSVASASPFGVGDPVGPLTPPPFGTS
ECCCCCHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
RLGGRSMPSLGGGPLGVGGGFGAPLGLGTPTGFGGLGVPTTPGDVDWGALAQAPGTLIVT
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCEEEEE
AGPTEIGKVATALVEHGRAGDTPVAVTVDGTTTDQRTVTSTLDRIEADVAPMLNATANPP
CCCHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
NEVIISVGPVVATRAKLSWWETRALFGWTVLVPRTKEQAAILSDSLRAHGASPLEVPTIA
CCEEEEECCHHHHHHHHHHHHHHHEEEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCEEE
VEPPRTAAPMERAITGLVSGRYQWVAFTSVNAVKAVQEKVEERSLDARAFAGVKVAAIGE
ECCCCCCCHHHHHHHHHHCCCEEEEEEECHHHHHHHHHHHHHHCCCHHHHCCEEEEECCH
ATADALRAFGIRPDLVPAGQQSSEGLLEDWPEFDESLDLLDRVLLPRADIATDTLVAGVK
HHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCC
DRGWQVDDVTAYRTVRAAPPPAPIREALKGGRVDAVVFTSSSTVRNLVGIAGKPHETTVI
CCCCCCCCHHHHEEEECCCCCHHHHHHHCCCCEEEEEEECCHHHHHHHHCCCCCCCEEEE
AVIGPATAATAQELGLRVDVQATEASIPSLVASLAEFAAEHREELGKVGPLAARLPKPRR
EEECCCCHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCC
GSRR
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7665501 [H]