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The map label for this gene is hemA

Identifier: 158317873

GI number: 158317873

Start: 7460028

End: 7461458

Strand: Reverse

Name: hemA

Synonym: Franean1_6131

Alternate gene names: 158317873

Gene position: 7461458-7460028 (Counterclockwise)

Preceding gene: 158317874

Following gene: 158317872

Centisome position: 83.07

GC content: 74.7

Gene sequence:

>1431_bases
GTGAGCCTGCTCGCGGTGGGCCTGAACCACCGGACGGCCCCGACCTCGCTGCTCGAGCTCGCCGCGGTCTCCGCCGACGA
CGCGCCGAAGGTGCTGCACGACCTCGTCGGGGCGGATCATCTCAGCGAGGCGGTGCTGCTCTCCACCTGCAACCGCACCG
AGATCTACGCCGAGGTGGAGACCTTCCACGGCGGCCTGGCCGACATCTCCGACCAGCTGAGCCGGGTGTGCGGGGTACCG
CTGACCGATCTCGCCTCGCACCTGTACGTCCACCATGAGGCCCGCGCCGTCAGCCACCTCTTCTCGGTGGTCTGCGGCCT
CGACTCGATGCTGGTCGGCGAGACGCAGATCCTCGGCCAGGTCCGCGCCGCGTTCCGGCTGGCCCAGGCCGCCGAGGTGA
CCAGCGGCACGCTCGCCAACCTGTTCCAGACCGCGCTGCGGGTCGGCAAGCGGGCCCACACCGAGACCTCCATCGACGCC
GCGGGGGCCTCGATCGTCTCGGTCGGCGTCCGGATGGCCGCCTTCGACCTGCAGGCCCGCCGGCCGGACATGCTCGTCGC
GCCCGTCGCGTCCCCCGGATGCGACCCGGGTGACGCGGTGGAGGCGCTGCTGCGCCCCGAGCTGACGGCCCCGGTCGAGG
TGGCGGGCCCCGCCCCGCTCGCCGGGGCCCGGGTGCTGATCATCGGGGCCGGCGCGGTCGGTTCGCTGGCGGCCCAGACC
GTGCGCCGGGCCGGCGCCGGTGACGTCGTCGTCGCGAACCGGACGGCGGCCCGCGCGGCCCGGGTCGCCGATTTGCACGA
CGCCCGCGCGGTCGGGCTGGCCGAGATCGCCCACGAGGTCGGCCGCGCGGATCTCGTGATCTCGTCGACCGGAGCCTCCG
GGCTCGTCGTCGGCCACGACGCGGTACGCGCCTCGCTGGCGGGCCGCGGCGCCCGGCCGCTGGTCTTCCTCGACCTCGCG
CTGCCGCGCGACATCGACCCGGCGGTGCGCGAGCTCCCCGGGGTGACCCTGATCGACATCGAGGCCCTGCGGGTCGCCCT
GGACGGGGCGCAGGTGGCCCATGACGTGGAGGCCGTCCGGGCCCTCGTGACCACCGAGGTGGCCGGGTTCCTCGACCGGC
GGCGTGCCGAGCGGGTCGCCCCGACCGTGGTGGCGCTGCGGGCCCACGCGGCGGCGGTGGTGCGCGACGAGCTGGAGCGG
CTGCGCACCCGCCTGCCCGACCTTGACAACCGTGAGTGGGACATGGTCTCCGGCACTGTGCGGCGGGTCGTCGACAAGTT
GCTGCACGCGCCCACGGTGCGCGTCCAGCAGCTCGCCGAGGCGCCTGGCGGTGACTCCTACGCCGAGGCCCTGCGCGAGC
TCTTCGACCTGCCGCGTGACGTGCCGGCCATCGTCTCCGCCCCTGATCTGGATCTGGTGGAGAGAACGTGA

Upstream 100 bases:

>100_bases
AGTCGCGGGCGGCACAGGCGGCGCAGGCACCGGAGGCGGCACGGATGGCGCAGGCGCCGGAGGTGCCGATGCCGGCCGCC
ACTCACGGGGGTGAGGCGGA

Downstream 100 bases:

>100_bases
CAGTGACCCGAGGGCCCGAGGCACGAGCACACGCGCTCCTGGCGCGGCGGCCGCTGCGACTGGGCACCCGGCGTTCCGCG
CTGGCGCGGGCTCAGTCCGA

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR

Number of amino acids: Translated: 476; Mature: 475

Protein sequence:

>476_residues
MSLLAVGLNHRTAPTSLLELAAVSADDAPKVLHDLVGADHLSEAVLLSTCNRTEIYAEVETFHGGLADISDQLSRVCGVP
LTDLASHLYVHHEARAVSHLFSVVCGLDSMLVGETQILGQVRAAFRLAQAAEVTSGTLANLFQTALRVGKRAHTETSIDA
AGASIVSVGVRMAAFDLQARRPDMLVAPVASPGCDPGDAVEALLRPELTAPVEVAGPAPLAGARVLIIGAGAVGSLAAQT
VRRAGAGDVVVANRTAARAARVADLHDARAVGLAEIAHEVGRADLVISSTGASGLVVGHDAVRASLAGRGARPLVFLDLA
LPRDIDPAVRELPGVTLIDIEALRVALDGAQVAHDVEAVRALVTTEVAGFLDRRRAERVAPTVVALRAHAAAVVRDELER
LRTRLPDLDNREWDMVSGTVRRVVDKLLHAPTVRVQQLAEAPGGDSYAEALRELFDLPRDVPAIVSAPDLDLVERT

Sequences:

>Translated_476_residues
MSLLAVGLNHRTAPTSLLELAAVSADDAPKVLHDLVGADHLSEAVLLSTCNRTEIYAEVETFHGGLADISDQLSRVCGVP
LTDLASHLYVHHEARAVSHLFSVVCGLDSMLVGETQILGQVRAAFRLAQAAEVTSGTLANLFQTALRVGKRAHTETSIDA
AGASIVSVGVRMAAFDLQARRPDMLVAPVASPGCDPGDAVEALLRPELTAPVEVAGPAPLAGARVLIIGAGAVGSLAAQT
VRRAGAGDVVVANRTAARAARVADLHDARAVGLAEIAHEVGRADLVISSTGASGLVVGHDAVRASLAGRGARPLVFLDLA
LPRDIDPAVRELPGVTLIDIEALRVALDGAQVAHDVEAVRALVTTEVAGFLDRRRAERVAPTVVALRAHAAAVVRDELER
LRTRLPDLDNREWDMVSGTVRRVVDKLLHAPTVRVQQLAEAPGGDSYAEALRELFDLPRDVPAIVSAPDLDLVERT
>Mature_475_residues
SLLAVGLNHRTAPTSLLELAAVSADDAPKVLHDLVGADHLSEAVLLSTCNRTEIYAEVETFHGGLADISDQLSRVCGVPL
TDLASHLYVHHEARAVSHLFSVVCGLDSMLVGETQILGQVRAAFRLAQAAEVTSGTLANLFQTALRVGKRAHTETSIDAA
GASIVSVGVRMAAFDLQARRPDMLVAPVASPGCDPGDAVEALLRPELTAPVEVAGPAPLAGARVLIIGAGAVGSLAAQTV
RRAGAGDVVVANRTAARAARVADLHDARAVGLAEIAHEVGRADLVISSTGASGLVVGHDAVRASLAGRGARPLVFLDLAL
PRDIDPAVRELPGVTLIDIEALRVALDGAQVAHDVEAVRALVTTEVAGFLDRRRAERVAPTVVALRAHAAAVVRDELERL
RTRLPDLDNREWDMVSGTVRRVVDKLLHAPTVRVQQLAEAPGGDSYAEALRELFDLPRDVPAIVSAPDLDLVERT

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family

Homologues:

Organism=Escherichia coli, GI1787461, Length=441, Percent_Identity=30.3854875283447, Blast_Score=183, Evalue=2e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM1_FRASN (A8LDG7)

Other databases:

- EMBL:   CP000820
- RefSeq:   YP_001510381.1
- ProteinModelPortal:   A8LDG7
- SMR:   A8LDG7
- GeneID:   5674452
- GenomeReviews:   CP000820_GR
- KEGG:   fre:Franean1_6131
- HOGENOM:   HBG732626
- OMA:   GPILNRL
- ProtClustDB:   PRK00045
- BioCyc:   FSP1855:FRANEAN1_6131-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00087
- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR018214
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF000445
- TIGRFAMs:   TIGR01035

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH; SSF69075 4pyrrol_synth_GluRdtase_C; SSF69742 GlutR

EC number: =1.2.1.70

Molecular weight: Translated: 49894; Mature: 49762

Theoretical pI: Translated: 5.57; Mature: 5.57

Prosite motif: PS00747 GLUTR

Important sites: ACT_SITE 50-50 BINDING 109-109 BINDING 120-120

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLLAVGLNHRTAPTSLLELAAVSADDAPKVLHDLVGADHLSEAVLLSTCNRTEIYAEVE
CCEEEECCCCCCCHHHHHHHHHCCCCCHHHHHHHHHCHHHHHHHHHHHCCCCHHHEEEHH
TFHGGLADISDQLSRVCGVPLTDLASHLYVHHEARAVSHLFSVVCGLDSMLVGETQILGQ
HHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
VRAAFRLAQAAEVTSGTLANLFQTALRVGKRAHTETSIDAAGASIVSVGVRMAAFDLQAR
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCHHHCCHHHHHHHHHHHHHHHHCC
RPDMLVAPVASPGCDPGDAVEALLRPELTAPVEVAGPAPLAGARVLIIGAGAVGSLAAQT
CCCEEEEECCCCCCCHHHHHHHHHCCCCCCCEEECCCCCCCCCEEEEEECCCHHHHHHHH
VRRAGAGDVVVANRTAARAARVADLHDARAVGLAEIAHEVGRADLVISSTGASGLVVGHD
HHHCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCEEEEHH
AVRASLAGRGARPLVFLDLALPRDIDPAVRELPGVTLIDIEALRVALDGAQVAHDVEAVR
HHHHHHCCCCCCCEEEEEECCCCCCCHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHH
ALVTTEVAGFLDRRRAERVAPTVVALRAHAAAVVRDELERLRTRLPDLDNREWDMVSGTV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
RRVVDKLLHAPTVRVQQLAEAPGGDSYAEALRELFDLPRDVPAIVSAPDLDLVERT
HHHHHHHHCCCCHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCHHCCCCCCHHCCCC
>Mature Secondary Structure 
SLLAVGLNHRTAPTSLLELAAVSADDAPKVLHDLVGADHLSEAVLLSTCNRTEIYAEVE
CEEEECCCCCCCHHHHHHHHHCCCCCHHHHHHHHHCHHHHHHHHHHHCCCCHHHEEEHH
TFHGGLADISDQLSRVCGVPLTDLASHLYVHHEARAVSHLFSVVCGLDSMLVGETQILGQ
HHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
VRAAFRLAQAAEVTSGTLANLFQTALRVGKRAHTETSIDAAGASIVSVGVRMAAFDLQAR
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCHHHCCHHHHHHHHHHHHHHHHCC
RPDMLVAPVASPGCDPGDAVEALLRPELTAPVEVAGPAPLAGARVLIIGAGAVGSLAAQT
CCCEEEEECCCCCCCHHHHHHHHHCCCCCCCEEECCCCCCCCCEEEEEECCCHHHHHHHH
VRRAGAGDVVVANRTAARAARVADLHDARAVGLAEIAHEVGRADLVISSTGASGLVVGHD
HHHCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCEEEEHH
AVRASLAGRGARPLVFLDLALPRDIDPAVRELPGVTLIDIEALRVALDGAQVAHDVEAVR
HHHHHHCCCCCCCEEEEEECCCCCCCHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHH
ALVTTEVAGFLDRRRAERVAPTVVALRAHAAAVVRDELERLRTRLPDLDNREWDMVSGTV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
RRVVDKLLHAPTVRVQQLAEAPGGDSYAEALRELFDLPRDVPAIVSAPDLDLVERT
HHHHHHHHCCCCHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCHHCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA