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The map label for this gene is hemB [H]

Identifier: 158317870

GI number: 158317870

Start: 7456137

End: 7457153

Strand: Reverse

Name: hemB [H]

Synonym: Franean1_6128

Alternate gene names: 158317870

Gene position: 7457153-7456137 (Counterclockwise)

Preceding gene: 158317871

Following gene: 158317865

Centisome position: 83.02

GC content: 74.14

Gene sequence:

>1017_bases
ATGATCGCGGGGCCCGGGCGGTCGGCCGTCGGTTTCCCCGTGGCGCGCCCGCGGCGGCTGCGCCGCGGGGCCGCGCTGCG
GCGGATGGTGGCCGACGTCCGGCTGCACCCCGCCGACCTCATCCTGCCGATGTTCGTCCGGGAGGGTGTGACCGAGCCGG
TCCCGATCTCCTCGATGCCCGGCGTCGTGCAGCACACCCGTTCCTCGCTGCGCAAGGCGGCGGCTGAGGCGGCCGCGGCC
GGCGTCGGCGGCATCATCCTGTTCGGCGTGCCCGAGCACAAGGACGCCCGCGGCTCGTCCGCCGACGACCCGGCCGGCAT
CGTCCAGCTCGCCATCGCCGACCTCGTGTCCGAGGTCGGCGGCGACACGGTGATCATGGCCGACCTCTGCCTGGACGAGT
ACACCGACCACGGTCACTGCGGCCTGCTCACGGCCACGGGCGAGGTCGACAACGACGCGACCCTCGTCCGCTACGGCGAG
ATCGCGCTGGCCCAGGCCGCCGCCGGCGTCGAGATGATCGCCCCCAGCGGCATGATGGACGGCCAGGTCGCAGCGATCCG
CACCGCGCTGGACGGCGGTGGCCACACCGACATCCCGATCATGGCCTACTCGGCGAAGTACGCCTCGGCCTTCTACGGCC
CGTTCCGGGAGGCCGCCCTGTGCGCCCCCCAGTTCGGCGACCGGGCCGGCTACCAGCAGGATCCAGCCCGCTCGGCCGGT
GAGGCGCTGCGCGAGGTGGCGCTGGACCTGGCCGAGGGCGCGGACGCCGTGATGGTGAAGCCCGCCCTGGCCTACCTGGA
CGTCCTGCGCGCGGTCGCCGACTCCGTGGACGTCCCGGTCGCCGCCTACCAGGTCTCCGGCGAGTACGCGATGGTCGAGG
CCGCCGCGGCCAACGGGTGGCTCGACCGCGACCGGGTCATCATGGAGACGCTTACCGCCATCCACCGGGCGGGCGCCGAC
ATCATCCTCACCTACTGGGCGGCCGAGGTCGCGGAGCGGCTGGCCTCCCGCCGCTAG

Upstream 100 bases:

>100_bases
TCGCGTCGCTGGCGGAGTTCGCCGCCGAGCACCGCGAGGAGCTCGGCAAGGTCGGCCCGCTCGCCGCCAGGCTGCCCAAG
CCGCGCCGGGGTTCCCGGCG

Downstream 100 bases:

>100_bases
CCTCCCCGCCACCAGCCTCCGGCCGCCGCCAGGTTCGGGCCGCGGCCGGGGGCGTTGGTCAGAGGCGGCCGGTCAGGGTG
TAGCCGGCCTCCTCGACGGC

Product: delta-aminolevulinic acid dehydratase

Products: NA

Alternate protein names: ALAD; ALADH; Porphobilinogen synthase [H]

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MIAGPGRSAVGFPVARPRRLRRGAALRRMVADVRLHPADLILPMFVREGVTEPVPISSMPGVVQHTRSSLRKAAAEAAAA
GVGGIILFGVPEHKDARGSSADDPAGIVQLAIADLVSEVGGDTVIMADLCLDEYTDHGHCGLLTATGEVDNDATLVRYGE
IALAQAAAGVEMIAPSGMMDGQVAAIRTALDGGGHTDIPIMAYSAKYASAFYGPFREAALCAPQFGDRAGYQQDPARSAG
EALREVALDLAEGADAVMVKPALAYLDVLRAVADSVDVPVAAYQVSGEYAMVEAAAANGWLDRDRVIMETLTAIHRAGAD
IILTYWAAEVAERLASRR

Sequences:

>Translated_338_residues
MIAGPGRSAVGFPVARPRRLRRGAALRRMVADVRLHPADLILPMFVREGVTEPVPISSMPGVVQHTRSSLRKAAAEAAAA
GVGGIILFGVPEHKDARGSSADDPAGIVQLAIADLVSEVGGDTVIMADLCLDEYTDHGHCGLLTATGEVDNDATLVRYGE
IALAQAAAGVEMIAPSGMMDGQVAAIRTALDGGGHTDIPIMAYSAKYASAFYGPFREAALCAPQFGDRAGYQQDPARSAG
EALREVALDLAEGADAVMVKPALAYLDVLRAVADSVDVPVAAYQVSGEYAMVEAAAANGWLDRDRVIMETLTAIHRAGAD
IILTYWAAEVAERLASRR
>Mature_338_residues
MIAGPGRSAVGFPVARPRRLRRGAALRRMVADVRLHPADLILPMFVREGVTEPVPISSMPGVVQHTRSSLRKAAAEAAAA
GVGGIILFGVPEHKDARGSSADDPAGIVQLAIADLVSEVGGDTVIMADLCLDEYTDHGHCGLLTATGEVDNDATLVRYGE
IALAQAAAGVEMIAPSGMMDGQVAAIRTALDGGGHTDIPIMAYSAKYASAFYGPFREAALCAPQFGDRAGYQQDPARSAG
EALREVALDLAEGADAVMVKPALAYLDVLRAVADSVDVPVAAYQVSGEYAMVEAAAANGWLDRDRVIMETLTAIHRAGAD
IILTYWAAEVAERLASRR

Specific function: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen [H]

COG id: COG0113

COG function: function code H; Delta-aminolevulinic acid dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ALADH family [H]

Homologues:

Organism=Homo sapiens, GI189083849, Length=309, Percent_Identity=42.7184466019417, Blast_Score=232, Evalue=4e-61,
Organism=Escherichia coli, GI87081728, Length=320, Percent_Identity=46.875, Blast_Score=278, Evalue=3e-76,
Organism=Saccharomyces cerevisiae, GI6321398, Length=315, Percent_Identity=38.0952380952381, Blast_Score=207, Evalue=2e-54,
Organism=Drosophila melanogaster, GI21358291, Length=316, Percent_Identity=42.0886075949367, Blast_Score=231, Evalue=5e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001731
- InterPro:   IPR013785 [H]

Pfam domain/function: PF00490 ALAD [H]

EC number: =4.2.1.24 [H]

Molecular weight: Translated: 35375; Mature: 35375

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS00169 D_ALA_DEHYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIAGPGRSAVGFPVARPRRLRRGAALRRMVADVRLHPADLILPMFVREGVTEPVPISSMP
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCC
GVVQHTRSSLRKAAAEAAAAGVGGIILFGVPEHKDARGSSADDPAGIVQLAIADLVSEVG
HHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHC
GDTVIMADLCLDEYTDHGHCGLLTATGEVDNDATLVRYGEIALAQAAAGVEMIAPSGMMD
CCEEEEHHHHHHHCCCCCCEEEEEECCCCCCCCEEEEECHHHHHHHHCCHHEECCCCCCC
GQVAAIRTALDGGGHTDIPIMAYSAKYASAFYGPFREAALCAPQFGDRAGYQQDPARSAG
CHHHHHHHHHCCCCCCCCEEEEECHHHHHHHHCHHHHHHHCCCCCCCCCCCCCCHHHHHH
EALREVALDLAEGADAVMVKPALAYLDVLRAVADSVDVPVAAYQVSGEYAMVEAAAANGW
HHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHCCCCCCEEEEEECCCEEEEEEHHHCCC
LDRDRVIMETLTAIHRAGADIILTYWAAEVAERLASRR
CCHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIAGPGRSAVGFPVARPRRLRRGAALRRMVADVRLHPADLILPMFVREGVTEPVPISSMP
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCC
GVVQHTRSSLRKAAAEAAAAGVGGIILFGVPEHKDARGSSADDPAGIVQLAIADLVSEVG
HHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHC
GDTVIMADLCLDEYTDHGHCGLLTATGEVDNDATLVRYGEIALAQAAAGVEMIAPSGMMD
CCEEEEHHHHHHHCCCCCCEEEEEECCCCCCCCEEEEECHHHHHHHHCCHHEECCCCCCC
GQVAAIRTALDGGGHTDIPIMAYSAKYASAFYGPFREAALCAPQFGDRAGYQQDPARSAG
CHHHHHHHHHCCCCCCCCEEEEECHHHHHHHHCHHHHHHHCCCCCCCCCCCCCCHHHHHH
EALREVALDLAEGADAVMVKPALAYLDVLRAVADSVDVPVAAYQVSGEYAMVEAAAANGW
HHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHCCCCCCEEEEEECCCEEEEEEHHHCCC
LDRDRVIMETLTAIHRAGADIILTYWAAEVAERLASRR
CCHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]