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The map label for this gene is guaB [C]

Identifier: 158317739

GI number: 158317739

Start: 7314567

End: 7315697

Strand: Reverse

Name: guaB [C]

Synonym: Franean1_5997

Alternate gene names: 158317739

Gene position: 7315697-7314567 (Counterclockwise)

Preceding gene: 158317740

Following gene: 158317738

Centisome position: 81.45

GC content: 72.5

Gene sequence:

>1131_bases
GTGGCAGACGTCGAAATCGGTATCGGGAAGAACGCGCGAGTGGGCTACGGCCTTGACGCCGTGGGCATCGTTCCCTCGCG
GCGCACCCGGGACCCAGCCGACGTGTCACTCGCCTGGGAGATCGACGCCTATCACTTCGATCTGCCGATCGTCGCGGCGC
CGGCCGACGCGGTGACCTCGCCGGAGTCCGCGATCGCCGTCGGGCGCCAGGGTGGGCTCGGCGTGCTGCACCTCGAGGGG
CTGTGGACCAGGCACGAGGACCCCGAGCCGCTGCTCGAGGAGGTCGCGGAGCTGGGCGCGCGTTCCGGCGCGGTGGCGGC
GACCCGGCGCCTGCGTGAGTTCTACGCGGCGCCGGTGCAGCCCGAGCTCATCGGGGCGCGGCTGGCGCGGATGCGGGAGG
CCGGCGTGGTCACCGCCGCCGCGCTGCGCCCGCAGAAGGTCCGGGCACTGTGCCCGCACGTGCTGGCCGCGGGCGTGGAC
CTCCTCGTCATCCATGGCACGGCGGTGTCGGCCGAGCACCAGTCCAGGCGCACTGAGCCGCTGAATCTCAAGCAGTTCAT
AGGACAGCTCGACATCCCGGTGATCGTCGGTGGCTGCGCATCCTTCTCCACGGCACTGCATCTCATGCGGACGGGCGCGG
CCGGCGTGATCGTCGGAGTCGGTGCCGGCCTCGGCGACGACACGGCCGAGACCCTCGGAATTGGTGTTCCGCTGGCGACT
GCGATCGCCGACGCGGCCGGCGCCCGGATGCGGTACCTCGACGAGTCCGGCGGCCGGTACGTCCACGTCATCGCGCATGG
CGACCTGCGCACCGGCGGGGACGCGGCGAAGGCCGTGGCCTGCGGAGCCGACGCCGTGATGGTGGATTCGCCGCTCGCGC
AGGCGGTGGACGCCCCTGGGCGGGGCTCGGTCTGGTCGATGGAGATCCTGCACTCGGACCTGCCGCGCGGGCGGTGGGCG
CCGGTCGAGACGTCACGTACCGTCGCCGAGATCCTCACCGGGGGCGAGGTCGCGGCCGAGGACGGTGTGGCGAACATCGC
CGGGGCCCTGCGGGCGGCGATGGCCACAACGGGCTACGCGACGTTGAAGGAGTTCCAGAAGGCGGAGATCATGATCGCCG
CCGGGCGCTAG

Upstream 100 bases:

>100_bases
CGCGCGGCGCTCGTCGTTCCGTATCCCCGCCGCCGGACGCCGACGCACCAGGCAGGATGGTCGGCGGGACCAAACGGGCT
GACCAGGAGGCCGGGACACG

Downstream 100 bases:

>100_bases
CGGAACGGGCCCGGAGAGCCAGCGGTGTGCGTCGGTCGTGCTGCCGACCCGGACGCCTTGGGTGTAAGTCCGCCGTGGCA
CCCTTGGAGCCGTCCGTCTC

Product: inosine 5-monophosphate dehydrogenase

Products: xanthosine 5'-phosphate; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 376; Mature: 375

Protein sequence:

>376_residues
MADVEIGIGKNARVGYGLDAVGIVPSRRTRDPADVSLAWEIDAYHFDLPIVAAPADAVTSPESAIAVGRQGGLGVLHLEG
LWTRHEDPEPLLEEVAELGARSGAVAATRRLREFYAAPVQPELIGARLARMREAGVVTAAALRPQKVRALCPHVLAAGVD
LLVIHGTAVSAEHQSRRTEPLNLKQFIGQLDIPVIVGGCASFSTALHLMRTGAAGVIVGVGAGLGDDTAETLGIGVPLAT
AIADAAGARMRYLDESGGRYVHVIAHGDLRTGGDAAKAVACGADAVMVDSPLAQAVDAPGRGSVWSMEILHSDLPRGRWA
PVETSRTVAEILTGGEVAAEDGVANIAGALRAAMATTGYATLKEFQKAEIMIAAGR

Sequences:

>Translated_376_residues
MADVEIGIGKNARVGYGLDAVGIVPSRRTRDPADVSLAWEIDAYHFDLPIVAAPADAVTSPESAIAVGRQGGLGVLHLEG
LWTRHEDPEPLLEEVAELGARSGAVAATRRLREFYAAPVQPELIGARLARMREAGVVTAAALRPQKVRALCPHVLAAGVD
LLVIHGTAVSAEHQSRRTEPLNLKQFIGQLDIPVIVGGCASFSTALHLMRTGAAGVIVGVGAGLGDDTAETLGIGVPLAT
AIADAAGARMRYLDESGGRYVHVIAHGDLRTGGDAAKAVACGADAVMVDSPLAQAVDAPGRGSVWSMEILHSDLPRGRWA
PVETSRTVAEILTGGEVAAEDGVANIAGALRAAMATTGYATLKEFQKAEIMIAAGR
>Mature_375_residues
ADVEIGIGKNARVGYGLDAVGIVPSRRTRDPADVSLAWEIDAYHFDLPIVAAPADAVTSPESAIAVGRQGGLGVLHLEGL
WTRHEDPEPLLEEVAELGARSGAVAATRRLREFYAAPVQPELIGARLARMREAGVVTAAALRPQKVRALCPHVLAAGVDL
LVIHGTAVSAEHQSRRTEPLNLKQFIGQLDIPVIVGGCASFSTALHLMRTGAAGVIVGVGAGLGDDTAETLGIGVPLATA
IADAAGARMRYLDESGGRYVHVIAHGDLRTGGDAAKAVACGADAVMVDSPLAQAVDAPGRGSVWSMEILHSDLPRGRWAP
VETSRTVAEILTGGEVAAEDGVANIAGALRAAMATTGYATLKEFQKAEIMIAAGR

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the IMPDH/GMPR family [H]

Homologues:

None

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR001093
- InterPro:   IPR005992 [H]

Pfam domain/function: PF00478 IMPDH [H]

EC number: 1.1.1.205

Molecular weight: Translated: 38904; Mature: 38773

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADVEIGIGKNARVGYGLDAVGIVPSRRTRDPADVSLAWEIDAYHFDLPIVAAPADAVTS
CCCEEECCCCCCCCCCCCCEEECCCCCCCCCCCCEEEEEEEEEEEECCCEEECCCHHCCC
PESAIAVGRQGGLGVLHLEGLWTRHEDPEPLLEEVAELGARSGAVAATRRLREFYAAPVQ
CCHHEEECCCCCEEEEEECCEECCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCC
PELIGARLARMREAGVVTAAALRPQKVRALCPHVLAAGVDLLVIHGTAVSAEHQSRRTEP
HHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHCCCEEEEEECCEECCHHHHCCCCC
LNLKQFIGQLDIPVIVGGCASFSTALHLMRTGAAGVIVGVGAGLGDDTAETLGIGVPLAT
CCHHHHHCCCCCCEEEECHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHCCCCHHHH
AIADAAGARMRYLDESGGRYVHVIAHGDLRTGGDAAKAVACGADAVMVDSPLAQAVDAPG
HHHHHCCCCEEEEECCCCCEEEEEEECCCCCCCCHHHHHHCCCCEEEECCHHHHHHCCCC
RGSVWSMEILHSDLPRGRWAPVETSRTVAEILTGGEVAAEDGVANIAGALRAAMATTGYA
CCCEEEHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCHHHHCCHHHHHHHHHHHHHHCCHH
TLKEFQKAEIMIAAGR
HHHHHCCCEEEEEECC
>Mature Secondary Structure 
ADVEIGIGKNARVGYGLDAVGIVPSRRTRDPADVSLAWEIDAYHFDLPIVAAPADAVTS
CCEEECCCCCCCCCCCCCEEECCCCCCCCCCCCEEEEEEEEEEEECCCEEECCCHHCCC
PESAIAVGRQGGLGVLHLEGLWTRHEDPEPLLEEVAELGARSGAVAATRRLREFYAAPVQ
CCHHEEECCCCCEEEEEECCEECCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCC
PELIGARLARMREAGVVTAAALRPQKVRALCPHVLAAGVDLLVIHGTAVSAEHQSRRTEP
HHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHCCCEEEEEECCEECCHHHHCCCCC
LNLKQFIGQLDIPVIVGGCASFSTALHLMRTGAAGVIVGVGAGLGDDTAETLGIGVPLAT
CCHHHHHCCCCCCEEEECHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHCCCCHHHH
AIADAAGARMRYLDESGGRYVHVIAHGDLRTGGDAAKAVACGADAVMVDSPLAQAVDAPG
HHHHHCCCCEEEEECCCCCEEEEEEECCCCCCCCHHHHHHCCCCEEEECCHHHHHHCCCC
RGSVWSMEILHSDLPRGRWAPVETSRTVAEILTGGEVAAEDGVANIAGALRAAMATTGYA
CCCEEEHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCHHHHCCHHHHHHHHHHHHHHCCHH
TLKEFQKAEIMIAAGR
HHHHHCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NAD+ [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: inosine 5'-phosphate; NAD+; H2O

Specific reaction: inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA