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The map label for this gene is guaB [H]

Identifier: 158317740

GI number: 158317740

Start: 7315857

End: 7317650

Strand: Reverse

Name: guaB [H]

Synonym: Franean1_5998

Alternate gene names: 158317740

Gene position: 7317650-7315857 (Counterclockwise)

Preceding gene: 158317743

Following gene: 158317739

Centisome position: 81.47

GC content: 71.96

Gene sequence:

>1794_bases
TTGCCGGGCCTCTACGATGGAGTATCACCGTCGCCCGACCGGCGGGCCGCGCGGAGCCCAGCATGCTTCACCCGCCTGCC
CGGGCAGACCGGCTCGCGCCGGTTCCCGGGCGCGGGACTCCCCAGACATCGCGGGGACGCTCCCGCCGGCGCCGGGCCGA
TGCGAACGGAAGGTGCCATGGACGGTTCCCCCGCCAACCCGACGACCTCGATCACGCGCGCGACCGGGGAACCCGACCTC
GACCAGTCGCCCGTCCGGCACGTCGCTGACAGCCTGGGCGCCGAGGGGCCGGCGCTCCCGCCGAAGCTCGCGATGCTCGG
CCTCACCTTCGACGACGTCCTGCTGCTGCCGGCGGCGTCCGAGGTGGCGCCGTCGGGCGTCGACACGACCACGCGGCTGT
CCCGCAACATCTCGCTGGCGGTCCCGCTGGTGTCCTCCGCGATGGACACCGTGACCGAGGCCCGGATGGCGATCGCGATG
GCCCGCCAGGGCGGCGTCGGCGTGCTGCACCGCAACCTGTCCGTCGACGACCAGGCACAGCAGGTCGACATGGTGAAGCG
GTCCGAGTCGGGGATGATCACCTCCCCGATCACCTGCGGGCCGGACGCCACCATCGAAGAGGCGAACGTGCTCATGGCGC
GTTACCGCATCTCCGGCGTCCCGGTGACCGAGCCGGACGGCCGCCTCGTCGGGATCGTGACCAACCGCGACATCCGCTTC
GAGCGGGACTACACCCGCCGCGTCCACGAAGTGATGACCCGCATGCCGCTGATCACGGCACCGGTCGGGGTCTCGGCGGA
CGACGCGCTCGCTCTGCTGCGGCACAACAAGGTCGAGAAGCTGCCCATCGTCGACGGGCACGACCGGCTGTGCGGACTGA
TCACGGTCAAGGACTTCACCAAGCGCGAGCAGTACCCGCGGGCGACCAAGGACGCGGACGGCCGCCTCGTGGTCGGCGCC
GCGGTCGGCGTCGGCGAGGACGCGCTGAAGCGCGCCCAGGTCCTCGTCGCCGCCGGGGTGGACTTCCTCGTCGTCGACAC
CGCGCACGGCCACCACCACGCCGTCCCCGACATGATCGCCCGGATCAAGGCCGAGATGCCCGCCGGGGTGGACGGCCGTC
CGCTCGACGTCATCGGTGGCAACATCGCCACCGCGGCCGGGGCCGCCGCGCTCATCGCGGCCGGCGCCGACGCCGTCAAG
GTCGGGGTCGGGCCGGGCTCGATCTGCACGACCCGGGTGGTCACCGGCGTGGGTGTTCCGCAGGTCACCGCGATCTACGA
GGCGGCGCGGGCGGCGCGGGCCGCCGGCGTGCCGGTCATCGGCGACGGCGGGCTGCAGTACTCCGGTGACATCGCCAAGG
CGATTGCCGTCGGCGCGGACACCGTGATGCTCGGCAGCCTGCTCGCCGGTGTCGACGAGAGCCCCGGTGAGCTCATCTTC
ATCAACGGCAAGCAGTACAAGTCCTACCGGGGGATGGGCTCGCTCGGCGCCATGCGCAGCCGCGGCGACACCCGCTCCTA
CTCCAAGGACCGCTACTTCCAGGACGACGTCCTCTCCGACGACAAGCTCGTCCCCCAGGGTGTCGAGGGCCAGGTGCCCT
ACCGCGGCTCGCTGGCCGGGATGGCCCACCAGCTGATCGGCGGCCTGCAGGCCGCGATGGGGTACACGGGTGCCGCGACC
ATCCGTGATCTCCAGGAGAACAGCCAGCTGGTGCGGATCACGTCGGCTGGCCTGACCGAGAGCCACGCGCACGACGTCCA
GATGACGGTCGAGGCGCCGAACTACACCCGGTGA

Upstream 100 bases:

>100_bases
TTGTTTGGGCGGGGTGCCCACGGACGGGTGCGCCCCCGACCCCGGCGCCCGTCCTGTGGCATGCGTGGTGCTCTCGGTCA
CGCCGGGGAGTTCGGAGCCG

Downstream 100 bases:

>100_bases
GTCGCGGCCGGTGGTCGGGAGGTCTCTCTCCGCCGCCGGCCGCCAGCCGTTCCAGCGGCCGCGCGGCGCTCGTCGTTCCG
TATCCCCGCCGCCGGACGCC

Product: inosine-5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 597; Mature: 596

Protein sequence:

>597_residues
MPGLYDGVSPSPDRRAARSPACFTRLPGQTGSRRFPGAGLPRHRGDAPAGAGPMRTEGAMDGSPANPTTSITRATGEPDL
DQSPVRHVADSLGAEGPALPPKLAMLGLTFDDVLLLPAASEVAPSGVDTTTRLSRNISLAVPLVSSAMDTVTEARMAIAM
ARQGGVGVLHRNLSVDDQAQQVDMVKRSESGMITSPITCGPDATIEEANVLMARYRISGVPVTEPDGRLVGIVTNRDIRF
ERDYTRRVHEVMTRMPLITAPVGVSADDALALLRHNKVEKLPIVDGHDRLCGLITVKDFTKREQYPRATKDADGRLVVGA
AVGVGEDALKRAQVLVAAGVDFLVVDTAHGHHHAVPDMIARIKAEMPAGVDGRPLDVIGGNIATAAGAAALIAAGADAVK
VGVGPGSICTTRVVTGVGVPQVTAIYEAARAARAAGVPVIGDGGLQYSGDIAKAIAVGADTVMLGSLLAGVDESPGELIF
INGKQYKSYRGMGSLGAMRSRGDTRSYSKDRYFQDDVLSDDKLVPQGVEGQVPYRGSLAGMAHQLIGGLQAAMGYTGAAT
IRDLQENSQLVRITSAGLTESHAHDVQMTVEAPNYTR

Sequences:

>Translated_597_residues
MPGLYDGVSPSPDRRAARSPACFTRLPGQTGSRRFPGAGLPRHRGDAPAGAGPMRTEGAMDGSPANPTTSITRATGEPDL
DQSPVRHVADSLGAEGPALPPKLAMLGLTFDDVLLLPAASEVAPSGVDTTTRLSRNISLAVPLVSSAMDTVTEARMAIAM
ARQGGVGVLHRNLSVDDQAQQVDMVKRSESGMITSPITCGPDATIEEANVLMARYRISGVPVTEPDGRLVGIVTNRDIRF
ERDYTRRVHEVMTRMPLITAPVGVSADDALALLRHNKVEKLPIVDGHDRLCGLITVKDFTKREQYPRATKDADGRLVVGA
AVGVGEDALKRAQVLVAAGVDFLVVDTAHGHHHAVPDMIARIKAEMPAGVDGRPLDVIGGNIATAAGAAALIAAGADAVK
VGVGPGSICTTRVVTGVGVPQVTAIYEAARAARAAGVPVIGDGGLQYSGDIAKAIAVGADTVMLGSLLAGVDESPGELIF
INGKQYKSYRGMGSLGAMRSRGDTRSYSKDRYFQDDVLSDDKLVPQGVEGQVPYRGSLAGMAHQLIGGLQAAMGYTGAAT
IRDLQENSQLVRITSAGLTESHAHDVQMTVEAPNYTR
>Mature_596_residues
PGLYDGVSPSPDRRAARSPACFTRLPGQTGSRRFPGAGLPRHRGDAPAGAGPMRTEGAMDGSPANPTTSITRATGEPDLD
QSPVRHVADSLGAEGPALPPKLAMLGLTFDDVLLLPAASEVAPSGVDTTTRLSRNISLAVPLVSSAMDTVTEARMAIAMA
RQGGVGVLHRNLSVDDQAQQVDMVKRSESGMITSPITCGPDATIEEANVLMARYRISGVPVTEPDGRLVGIVTNRDIRFE
RDYTRRVHEVMTRMPLITAPVGVSADDALALLRHNKVEKLPIVDGHDRLCGLITVKDFTKREQYPRATKDADGRLVVGAA
VGVGEDALKRAQVLVAAGVDFLVVDTAHGHHHAVPDMIARIKAEMPAGVDGRPLDVIGGNIATAAGAAALIAAGADAVKV
GVGPGSICTTRVVTGVGVPQVTAIYEAARAARAAGVPVIGDGGLQYSGDIAKAIAVGADTVMLGSLLAGVDESPGELIFI
NGKQYKSYRGMGSLGAMRSRGDTRSYSKDRYFQDDVLSDDKLVPQGVEGQVPYRGSLAGMAHQLIGGLQAAMGYTGAATI
RDLQENSQLVRITSAGLTESHAHDVQMTVEAPNYTR

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI34328928, Length=465, Percent_Identity=44.3010752688172, Blast_Score=353, Evalue=2e-97,
Organism=Homo sapiens, GI34328930, Length=465, Percent_Identity=44.3010752688172, Blast_Score=353, Evalue=3e-97,
Organism=Homo sapiens, GI217035146, Length=465, Percent_Identity=44.3010752688172, Blast_Score=353, Evalue=3e-97,
Organism=Homo sapiens, GI156616279, Length=465, Percent_Identity=44.3010752688172, Blast_Score=353, Evalue=4e-97,
Organism=Homo sapiens, GI66933016, Length=461, Percent_Identity=44.2516268980477, Blast_Score=352, Evalue=7e-97,
Organism=Homo sapiens, GI217035152, Length=460, Percent_Identity=44.1304347826087, Blast_Score=345, Evalue=7e-95,
Organism=Homo sapiens, GI217035148, Length=465, Percent_Identity=43.6559139784946, Blast_Score=343, Evalue=2e-94,
Organism=Homo sapiens, GI217035150, Length=465, Percent_Identity=42.1505376344086, Blast_Score=319, Evalue=4e-87,
Organism=Homo sapiens, GI50541956, Length=340, Percent_Identity=30.5882352941176, Blast_Score=153, Evalue=5e-37,
Organism=Homo sapiens, GI50541954, Length=340, Percent_Identity=30.5882352941176, Blast_Score=152, Evalue=6e-37,
Organism=Homo sapiens, GI50541952, Length=340, Percent_Identity=30.5882352941176, Blast_Score=152, Evalue=6e-37,
Organism=Homo sapiens, GI50541948, Length=340, Percent_Identity=30.5882352941176, Blast_Score=152, Evalue=6e-37,
Organism=Homo sapiens, GI156104880, Length=260, Percent_Identity=33.4615384615385, Blast_Score=150, Evalue=4e-36,
Organism=Escherichia coli, GI1788855, Length=495, Percent_Identity=51.9191919191919, Blast_Score=445, Evalue=1e-126,
Organism=Escherichia coli, GI1786293, Length=351, Percent_Identity=30.7692307692308, Blast_Score=150, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI71994385, Length=485, Percent_Identity=37.319587628866, Blast_Score=271, Evalue=6e-73,
Organism=Caenorhabditis elegans, GI71994389, Length=436, Percent_Identity=37.6146788990826, Blast_Score=252, Evalue=5e-67,
Organism=Caenorhabditis elegans, GI17560440, Length=255, Percent_Identity=34.9019607843137, Blast_Score=157, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6323585, Length=467, Percent_Identity=42.6124197002141, Blast_Score=355, Evalue=1e-98,
Organism=Saccharomyces cerevisiae, GI6322012, Length=467, Percent_Identity=40.6852248394004, Blast_Score=345, Evalue=8e-96,
Organism=Saccharomyces cerevisiae, GI6323464, Length=505, Percent_Identity=40.990099009901, Blast_Score=342, Evalue=1e-94,
Organism=Saccharomyces cerevisiae, GI6319352, Length=344, Percent_Identity=39.5348837209302, Blast_Score=252, Evalue=1e-67,
Organism=Saccharomyces cerevisiae, GI6319353, Length=119, Percent_Identity=44.5378151260504, Blast_Score=95, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24641071, Length=488, Percent_Identity=41.5983606557377, Blast_Score=335, Evalue=7e-92,
Organism=Drosophila melanogaster, GI24641073, Length=488, Percent_Identity=41.5983606557377, Blast_Score=335, Evalue=7e-92,
Organism=Drosophila melanogaster, GI28571163, Length=447, Percent_Identity=41.834451901566, Blast_Score=301, Evalue=9e-82,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 62355; Mature: 62224

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPGLYDGVSPSPDRRAARSPACFTRLPGQTGSRRFPGAGLPRHRGDAPAGAGPMRTEGAM
CCCCCCCCCCCCCHHHCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
DGSPANPTTSITRATGEPDLDQSPVRHVADSLGAEGPALPPKLAMLGLTFDDVLLLPAAS
CCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHCCCCCCCCHHHEEEECCHHHEEEECCCH
EVAPSGVDTTTRLSRNISLAVPLVSSAMDTVTEARMAIAMARQGGVGVLHRNLSVDDQAQ
HCCCCCCCHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHH
QVDMVKRSESGMITSPITCGPDATIEEANVLMARYRISGVPVTEPDGRLVGIVTNRDIRF
HHHHHHHCCCCCEECCCCCCCCCCHHHHHEEEEEEEECCCCCCCCCCCEEEEEECCCEEE
ERDYTRRVHEVMTRMPLITAPVGVSADDALALLRHNKVEKLPIVDGHDRLCGLITVKDFT
CHHHHHHHHHHHHHCCEEECCCCCCCHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEHHHH
KREQYPRATKDADGRLVVGAAVGVGEDALKRAQVLVAAGVDFLVVDTAHGHHHAVPDMIA
HHHHCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHEECCCCEEEEECCCCCCCHHHHHHH
RIKAEMPAGVDGRPLDVIGGNIATAAGAAALIAAGADAVKVGVGPGSICTTRVVTGVGVP
HHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHCCCCC
QVTAIYEAARAARAAGVPVIGDGGLQYSGDIAKAIAVGADTVMLGSLLAGVDESPGELIF
HHHHHHHHHHHHHHCCCCEEECCCCEECCHHHHHHHHCCHHHHHHHHHHCCCCCCCCEEE
INGKQYKSYRGMGSLGAMRSRGDTRSYSKDRYFQDDVLSDDKLVPQGVEGQVPYRGSLAG
EECCCCHHHCCCCCHHHHHCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCHHH
MAHQLIGGLQAAMGYTGAATIRDLQENSQLVRITSAGLTESHAHDVQMTVEAPNYTR
HHHHHHHHHHHHHCCCCHHHHHHHHCCCCEEEEEECCCCCCCCCCEEEEEECCCCCC
>Mature Secondary Structure 
PGLYDGVSPSPDRRAARSPACFTRLPGQTGSRRFPGAGLPRHRGDAPAGAGPMRTEGAM
CCCCCCCCCCCCHHHCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
DGSPANPTTSITRATGEPDLDQSPVRHVADSLGAEGPALPPKLAMLGLTFDDVLLLPAAS
CCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHCCCCCCCCHHHEEEECCHHHEEEECCCH
EVAPSGVDTTTRLSRNISLAVPLVSSAMDTVTEARMAIAMARQGGVGVLHRNLSVDDQAQ
HCCCCCCCHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHH
QVDMVKRSESGMITSPITCGPDATIEEANVLMARYRISGVPVTEPDGRLVGIVTNRDIRF
HHHHHHHCCCCCEECCCCCCCCCCHHHHHEEEEEEEECCCCCCCCCCCEEEEEECCCEEE
ERDYTRRVHEVMTRMPLITAPVGVSADDALALLRHNKVEKLPIVDGHDRLCGLITVKDFT
CHHHHHHHHHHHHHCCEEECCCCCCCHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEHHHH
KREQYPRATKDADGRLVVGAAVGVGEDALKRAQVLVAAGVDFLVVDTAHGHHHAVPDMIA
HHHHCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHEECCCCEEEEECCCCCCCHHHHHHH
RIKAEMPAGVDGRPLDVIGGNIATAAGAAALIAAGADAVKVGVGPGSICTTRVVTGVGVP
HHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHCCCCC
QVTAIYEAARAARAAGVPVIGDGGLQYSGDIAKAIAVGADTVMLGSLLAGVDESPGELIF
HHHHHHHHHHHHHHCCCCEEECCCCEECCHHHHHHHHCCHHHHHHHHHHCCCCCCCCEEE
INGKQYKSYRGMGSLGAMRSRGDTRSYSKDRYFQDDVLSDDKLVPQGVEGQVPYRGSLAG
EECCCCHHHCCCCCHHHHHCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCHHH
MAHQLIGGLQAAMGYTGAATIRDLQENSQLVRITSAGLTESHAHDVQMTVEAPNYTR
HHHHHHHHHHHHHCCCCHHHHHHHHCCCCEEEEEECCCCCCCCCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]