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The map label for this gene is proA

Identifier: 158317012

GI number: 158317012

Start: 6318619

End: 6319875

Strand: Reverse

Name: proA

Synonym: Franean1_5256

Alternate gene names: 158317012

Gene position: 6319875-6318619 (Counterclockwise)

Preceding gene: 158317013

Following gene: 158317011

Centisome position: 70.36

GC content: 73.91

Gene sequence:

>1257_bases
ATGAACACCTCTGCGGAGGACGTCCGCGCCAGCGCGGTCCGAGCCCGGCAGGCCGCCGGGCAGCTCGCCCCGCTGTCGCG
GGCGGCGAAGGACGCCGCGCTGCTGGGCATGGCCGCGGCGCTGCTCGACCGGTCCGCCGAGATCCTCGCCGCGAACGCCC
TGGACACCGCCGCCGCGCGGGCCGCCGGCACGTCCGCCGCGCTGGTCGACCGGCTGACCCTCACCCCGGAGCGGATCGAG
GCGATGGCCGACGGCCTGCGCCAGGTCGCGGCGCTCGAGGACCCGGTCGGTGAGGTCGTCCGCGGGCGGGTGCTGCCCAA
CGGGCTGGAGCTGCGCCAGGTCCGGGTGCCGCTCGGCGTCATCGGGATCATCTACGAGGCCCGGCCCAACGTCACGGTGG
ACGCGGCGGGCCTGTGCATCAAGAGCGGCAACGCGGTGCTGCTGCGGGGCAGCGCCTCGGCGCTGAACTCCAACCGGGTG
CTGGTGGACGTCCTGCGGGAGGCGGCGGTGGCCGCGGGGCTGCCGGCCGACGGCGTGCAGCTCGTCCCGGGGGCGGACCA
CGACTCGGTGAAGCACCTCATGCGGCTGCGCGGCCTGGTGGACGTCCTCATCCCGCGCGGCGGGGCCGGCCTGATCCGCG
CGGTCGTCGAGGAGTCGACGGTTCCGGTCATCGAGACCGGCGTCGGTAACTGCCATGTGTACGTGGACGTCGACGCCGAC
GTCGACACCGCGCTGGCCATCACGCTGAACGCGAAGACGCAGAAGGTGTCGGTGTGCAACTCGGCCGAGACCCTGCTCGT
CCACGCCGGGATCGCCGCGGAGTTCCTGCCCCGGGTGCTGACGGCGCTGCGCGACGCGGGCGTGACCGTGCACGGTGACG
AGACGGTGCGCGCGGTCGACCCGTCCGCCGTGCCTGTCACCGACGAGGACTGGGCGACGGAGTACCTCTCGCTCGACATG
GCGGTGGGGGTCGTCGACTCGCTGGACCAGGCGCTCGACCACATCCGGCGCTGGAGCAGCGGCCACACCGAGGCGATCGT
GACCCGGTCGCTGGCGGCGAGTCGCCGGTTCGTCGCCTCCTGCGACAGCGCCGCGGTGATGGTGAACGCCTCGACCCGCT
TCACCGACGGCGAGCGGTTCGGGATGGGCGCCGAGATCGGCATCTCCACGCAGAAGCTGCACGCCCGCGGGCCGATGGGC
CTGCCCGAGCTGACCTCGACGACCTGGGTGGGCATCGGGGACGGCCACCTGGTGTGA

Upstream 100 bases:

>100_bases
CCGCCGCCGGTAGCCTCAGGGAACGGCGCACAGCGGCGCGCCGTCGACGCCGGGCCCGCGTCCGCGCCGGCCGTCGCGGA
CAGTCGGGAGGAATCCGGTC

Downstream 100 bases:

>100_bases
CCGGGCGGCGAGTGGGCGTTGCGGGTGGCCTTCCGGGAGGCCGGAACGGCCGTCTCGGGAGCACTCCGGAGCACTCCGGA
AGCCCGTCATCCCTCGTCAA

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase

Number of amino acids: Translated: 418; Mature: 418

Protein sequence:

>418_residues
MNTSAEDVRASAVRARQAAGQLAPLSRAAKDAALLGMAAALLDRSAEILAANALDTAAARAAGTSAALVDRLTLTPERIE
AMADGLRQVAALEDPVGEVVRGRVLPNGLELRQVRVPLGVIGIIYEARPNVTVDAAGLCIKSGNAVLLRGSASALNSNRV
LVDVLREAAVAAGLPADGVQLVPGADHDSVKHLMRLRGLVDVLIPRGGAGLIRAVVEESTVPVIETGVGNCHVYVDVDAD
VDTALAITLNAKTQKVSVCNSAETLLVHAGIAAEFLPRVLTALRDAGVTVHGDETVRAVDPSAVPVTDEDWATEYLSLDM
AVGVVDSLDQALDHIRRWSSGHTEAIVTRSLAASRRFVASCDSAAVMVNASTRFTDGERFGMGAEIGISTQKLHARGPMG
LPELTSTTWVGIGDGHLV

Sequences:

>Translated_418_residues
MNTSAEDVRASAVRARQAAGQLAPLSRAAKDAALLGMAAALLDRSAEILAANALDTAAARAAGTSAALVDRLTLTPERIE
AMADGLRQVAALEDPVGEVVRGRVLPNGLELRQVRVPLGVIGIIYEARPNVTVDAAGLCIKSGNAVLLRGSASALNSNRV
LVDVLREAAVAAGLPADGVQLVPGADHDSVKHLMRLRGLVDVLIPRGGAGLIRAVVEESTVPVIETGVGNCHVYVDVDAD
VDTALAITLNAKTQKVSVCNSAETLLVHAGIAAEFLPRVLTALRDAGVTVHGDETVRAVDPSAVPVTDEDWATEYLSLDM
AVGVVDSLDQALDHIRRWSSGHTEAIVTRSLAASRRFVASCDSAAVMVNASTRFTDGERFGMGAEIGISTQKLHARGPMG
LPELTSTTWVGIGDGHLV
>Mature_418_residues
MNTSAEDVRASAVRARQAAGQLAPLSRAAKDAALLGMAAALLDRSAEILAANALDTAAARAAGTSAALVDRLTLTPERIE
AMADGLRQVAALEDPVGEVVRGRVLPNGLELRQVRVPLGVIGIIYEARPNVTVDAAGLCIKSGNAVLLRGSASALNSNRV
LVDVLREAAVAAGLPADGVQLVPGADHDSVKHLMRLRGLVDVLIPRGGAGLIRAVVEESTVPVIETGVGNCHVYVDVDAD
VDTALAITLNAKTQKVSVCNSAETLLVHAGIAAEFLPRVLTALRDAGVTVHGDETVRAVDPSAVPVTDEDWATEYLSLDM
AVGVVDSLDQALDHIRRWSSGHTEAIVTRSLAASRRFVASCDSAAVMVNASTRFTDGERFGMGAEIGISTQKLHARGPMG
LPELTSTTWVGIGDGHLV

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family

Homologues:

Organism=Homo sapiens, GI21361368, Length=410, Percent_Identity=38.0487804878049, Blast_Score=257, Evalue=1e-68,
Organism=Homo sapiens, GI62912457, Length=410, Percent_Identity=38.0487804878049, Blast_Score=257, Evalue=2e-68,
Organism=Escherichia coli, GI1786438, Length=406, Percent_Identity=50.2463054187192, Blast_Score=389, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI17569967, Length=411, Percent_Identity=39.9026763990268, Blast_Score=285, Evalue=2e-77,
Organism=Caenorhabditis elegans, GI17569969, Length=411, Percent_Identity=39.9026763990268, Blast_Score=285, Evalue=2e-77,
Organism=Saccharomyces cerevisiae, GI6324899, Length=428, Percent_Identity=36.9158878504673, Blast_Score=261, Evalue=1e-70,
Organism=Drosophila melanogaster, GI21357643, Length=414, Percent_Identity=37.9227053140097, Blast_Score=268, Evalue=4e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PROA_FRASN (A8L1V4)

Other databases:

- EMBL:   CP000820
- RefSeq:   YP_001509520.1
- ProteinModelPortal:   A8L1V4
- SMR:   A8L1V4
- GeneID:   5673590
- GenomeReviews:   CP000820_GR
- KEGG:   fre:Franean1_5256
- HOGENOM:   HBG318080
- OMA:   QYPAACN
- ProtClustDB:   PRK00197
- BioCyc:   FSP1855:FRANEAN1_5256-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00412
- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134
- Gene3D:   G3DSA:3.40.309.10
- Gene3D:   G3DSA:3.40.605.10
- PANTHER:   PTHR11063:SF1
- PIRSF:   PIRSF000151
- TIGRFAMs:   TIGR00407

Pfam domain/function: PF00171 Aldedh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.2.1.41

Molecular weight: Translated: 43440; Mature: 43440

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTSAEDVRASAVRARQAAGQLAPLSRAAKDAALLGMAAALLDRSAEILAANALDTAAAR
CCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHH
AAGTSAALVDRLTLTPERIEAMADGLRQVAALEDPVGEVVRGRVLPNGLELRQVRVPLGV
HCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCHHHHHHHCCCCCCCCCEEEEECCCEE
IGIIYEARPNVTVDAAGLCIKSGNAVLLRGSASALNSNRVLVDVLREAAVAAGLPADGVQ
EEEEEECCCCEEEEECCEEEECCCEEEEECCHHHCCCCCHHHHHHHHHHHHCCCCCCCEE
LVPGADHDSVKHLMRLRGLVDVLIPRGGAGLIRAVVEESTVPVIETGVGNCHVYVDVDAD
ECCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCEEEECCCCEEEEEEECCC
VDTALAITLNAKTQKVSVCNSAETLLVHAGIAAEFLPRVLTALRDAGVTVHGDETVRAVD
CCEEEEEEEECCCEEEEECCCCCEEEEECCHHHHHHHHHHHHHHHCCCEEECCCEEEEEC
PSAVPVTDEDWATEYLSLDMAVGVVDSLDQALDHIRRWSSGHTEAIVTRSLAASRRFVAS
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHC
CDSAAVMVNASTRFTDGERFGMGAEIGISTQKLHARGPMGLPELTSTTWVGIGDGHLV
CCCCEEEEECCCCCCCCHHCCCCCEECCCHHHHCCCCCCCCCCCCCCEEEECCCCCCC
>Mature Secondary Structure
MNTSAEDVRASAVRARQAAGQLAPLSRAAKDAALLGMAAALLDRSAEILAANALDTAAAR
CCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHH
AAGTSAALVDRLTLTPERIEAMADGLRQVAALEDPVGEVVRGRVLPNGLELRQVRVPLGV
HCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCHHHHHHHCCCCCCCCCEEEEECCCEE
IGIIYEARPNVTVDAAGLCIKSGNAVLLRGSASALNSNRVLVDVLREAAVAAGLPADGVQ
EEEEEECCCCEEEEECCEEEECCCEEEEECCHHHCCCCCHHHHHHHHHHHHCCCCCCCEE
LVPGADHDSVKHLMRLRGLVDVLIPRGGAGLIRAVVEESTVPVIETGVGNCHVYVDVDAD
ECCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCEEEECCCCEEEEEEECCC
VDTALAITLNAKTQKVSVCNSAETLLVHAGIAAEFLPRVLTALRDAGVTVHGDETVRAVD
CCEEEEEEEECCCEEEEECCCCCEEEEECCHHHHHHHHHHHHHHHCCCEEECCCEEEEEC
PSAVPVTDEDWATEYLSLDMAVGVVDSLDQALDHIRRWSSGHTEAIVTRSLAASRRFVAS
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHC
CDSAAVMVNASTRFTDGERFGMGAEIGISTQKLHARGPMGLPELTSTTWVGIGDGHLV
CCCCEEEEECCCCCCCCHHCCCCCEECCCHHHHCCCCCCCCCCCCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA