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The map label for this gene is serS [H]

Identifier: 158316889

GI number: 158316889

Start: 6148975

End: 6150237

Strand: Reverse

Name: serS [H]

Synonym: Franean1_5133

Alternate gene names: 158316889

Gene position: 6150237-6148975 (Counterclockwise)

Preceding gene: 158316891

Following gene: 158316883

Centisome position: 68.47

GC content: 70.23

Gene sequence:

>1263_bases
ATGCTCGACAAGCGCTTCATCCGGGAAAATCCCGACGCCGTGAAGGAGGCTGTCCGCCTCAAGGGCGTCGACCTCGACGT
CGACGAACTGCTCCAGCTCGACCAGGAGAACCGCAAGCTGCAGTTCGAGGTCGACGAGGCCCAGGCCCGGCGCAAGTCCT
TCGCCAAGCAGTTCGCCAAGGCTGACGAGGCGCGCCGCGCCGAGCTGCGTGCCGAGCACGCCGAGTTCGACCGGCAGCTC
CGTGACCTGCGCGAGCAGCTCACCCGGACGAGCACGCGGATGTCCGAGCTGATGCTGCTCACCCCGGGCATCCCCTGGGA
GGGCGCCCCGGTCGGCCCGGACGAGTCCGCGAACGTGGTGGTCCGCACCGTGGGCACCCGCCCGGAGTTCGACTTCACCC
CGATCGACCACACCGAGCTCGCCGAGAAGCGCGGCTGGGCCGAGTTCGCCCGGGCCCGCAGGGTCGCCGGTGAGCGGGCG
TACGCCCTGGTCGGCGACATGGTCATGCTCGAGCGGGCGGTCCACTCCTACGCCCTCGACCTGCTGCGCGAGCGGGACTT
CACCCCGGTGTCGGTCCCCGCGCTGGTCAAGGAGGGCCCGCTCGTCGGCACGGGCATGCTCCCGAAGGCCCGCGAGGAGA
TCTACGAGATCCCCGCCGACGACGCGTTCCTCGCCGGGACGGCGGAGGTGGCCCTGGTCGGCCTGCATGCCGGGGAGATC
CTCGACGCCAGGCGTCTGCCGATCCGCTACGCCGGCATCTCGCCGTGCTTCCGGCGAGAGATCGGCAGCGCCAGCCGGGA
CGTCCGCGGGCTACTGCGGGTACACCAGTTCGAGAAGGTCGAGCAGTTCGTCCTGTGCGTGAACGACCCGGCGGAGTCAG
CCCGTTGGCACGCGGAGCTGCTGGCTACGGCCGAGCACATCCTGGCCGACCTGGGTCTGCACTACGAGGTCGTCGAGTGC
TCGACCGGGGACATGGGCCTGGGCAAGTTCCGGATGAACGACATCAACACGTGGTTCCCCACCCTCGACCTGTTCCGGGA
GACCCACAGCTGCTCGACGCTGCACGACTGGCAGGCCCGCCGGGCGAACCTGCGCTACCGCGACGCGGACGGCAACGTAC
GTTTCGCGCACACCCTCAACAACACCGCGGTGGCCACGCCGCGCCTGCTGGCCGCGATCCTGGAGAACTTCCAGACCGCC
GACCACCAGGTCAGGGTGCCCGAGGTGCTGCGCCCCTACCTCGGCGGCCGCGACCTGCTCTGA

Upstream 100 bases:

>100_bases
TGCCGAGCCGGGCGCCGGCGGGCCCTTACGGCAGGGGGTCCGGGGAGGCGACTGATAGCGTCTGCGCACAGGGAACCGAT
ACGAAGGCTGACACGAATTC

Downstream 100 bases:

>100_bases
GTCACGACCCGCTCTGAGCCGTGATGTGGGGGCTGGTGGGGCGGCTTAGTTCGTCGAGGGATGGCGGCGGGAGCGGGTGG
CGCGGATCAGGGCCGGGGTC

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase [H]

Number of amino acids: Translated: 420; Mature: 420

Protein sequence:

>420_residues
MLDKRFIRENPDAVKEAVRLKGVDLDVDELLQLDQENRKLQFEVDEAQARRKSFAKQFAKADEARRAELRAEHAEFDRQL
RDLREQLTRTSTRMSELMLLTPGIPWEGAPVGPDESANVVVRTVGTRPEFDFTPIDHTELAEKRGWAEFARARRVAGERA
YALVGDMVMLERAVHSYALDLLRERDFTPVSVPALVKEGPLVGTGMLPKAREEIYEIPADDAFLAGTAEVALVGLHAGEI
LDARRLPIRYAGISPCFRREIGSASRDVRGLLRVHQFEKVEQFVLCVNDPAESARWHAELLATAEHILADLGLHYEVVEC
STGDMGLGKFRMNDINTWFPTLDLFRETHSCSTLHDWQARRANLRYRDADGNVRFAHTLNNTAVATPRLLAAILENFQTA
DHQVRVPEVLRPYLGGRDLL

Sequences:

>Translated_420_residues
MLDKRFIRENPDAVKEAVRLKGVDLDVDELLQLDQENRKLQFEVDEAQARRKSFAKQFAKADEARRAELRAEHAEFDRQL
RDLREQLTRTSTRMSELMLLTPGIPWEGAPVGPDESANVVVRTVGTRPEFDFTPIDHTELAEKRGWAEFARARRVAGERA
YALVGDMVMLERAVHSYALDLLRERDFTPVSVPALVKEGPLVGTGMLPKAREEIYEIPADDAFLAGTAEVALVGLHAGEI
LDARRLPIRYAGISPCFRREIGSASRDVRGLLRVHQFEKVEQFVLCVNDPAESARWHAELLATAEHILADLGLHYEVVEC
STGDMGLGKFRMNDINTWFPTLDLFRETHSCSTLHDWQARRANLRYRDADGNVRFAHTLNNTAVATPRLLAAILENFQTA
DHQVRVPEVLRPYLGGRDLL
>Mature_420_residues
MLDKRFIRENPDAVKEAVRLKGVDLDVDELLQLDQENRKLQFEVDEAQARRKSFAKQFAKADEARRAELRAEHAEFDRQL
RDLREQLTRTSTRMSELMLLTPGIPWEGAPVGPDESANVVVRTVGTRPEFDFTPIDHTELAEKRGWAEFARARRVAGERA
YALVGDMVMLERAVHSYALDLLRERDFTPVSVPALVKEGPLVGTGMLPKAREEIYEIPADDAFLAGTAEVALVGLHAGEI
LDARRLPIRYAGISPCFRREIGSASRDVRGLLRVHQFEKVEQFVLCVNDPAESARWHAELLATAEHILADLGLHYEVVEC
STGDMGLGKFRMNDINTWFPTLDLFRETHSCSTLHDWQARRANLRYRDADGNVRFAHTLNNTAVATPRLLAAILENFQTA
DHQVRVPEVLRPYLGGRDLL

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) [H]

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily [H]

Homologues:

Organism=Homo sapiens, GI8923421, Length=429, Percent_Identity=34.4988344988345, Blast_Score=208, Evalue=8e-54,
Organism=Homo sapiens, GI225579074, Length=310, Percent_Identity=39.6774193548387, Blast_Score=204, Evalue=9e-53,
Organism=Homo sapiens, GI16306548, Length=336, Percent_Identity=35.7142857142857, Blast_Score=194, Evalue=9e-50,
Organism=Escherichia coli, GI1787120, Length=428, Percent_Identity=38.3177570093458, Blast_Score=274, Evalue=8e-75,
Organism=Caenorhabditis elegans, GI17539260, Length=455, Percent_Identity=30.5494505494506, Blast_Score=203, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI17542084, Length=319, Percent_Identity=31.3479623824451, Blast_Score=160, Evalue=9e-40,
Organism=Saccharomyces cerevisiae, GI6320226, Length=442, Percent_Identity=29.6380090497738, Blast_Score=192, Evalue=6e-50,
Organism=Saccharomyces cerevisiae, GI6321799, Length=413, Percent_Identity=29.0556900726392, Blast_Score=172, Evalue=9e-44,
Organism=Drosophila melanogaster, GI24581334, Length=330, Percent_Identity=35.1515151515151, Blast_Score=189, Evalue=4e-48,
Organism=Drosophila melanogaster, GI17737985, Length=286, Percent_Identity=33.5664335664336, Blast_Score=169, Evalue=3e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.11 [H]

Molecular weight: Translated: 47524; Mature: 47524

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDKRFIRENPDAVKEAVRLKGVDLDVDELLQLDQENRKLQFEVDEAQARRKSFAKQFAK
CCCCHHHHCCHHHHHHHHHHCCCCCCHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHH
ADEARRAELRAEHAEFDRQLRDLREQLTRTSTRMSELMLLTPGIPWEGAPVGPDESANVV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCCCCEE
VRTVGTRPEFDFTPIDHTELAEKRGWAEFARARRVAGERAYALVGDMVMLERAVHSYALD
EEEECCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLRERDFTPVSVPALVKEGPLVGTGMLPKAREEIYEIPADDAFLAGTAEVALVGLHAGEI
HHHHCCCCCCCCHHHHHCCCEECCCCCCHHHHHHHCCCCCCCEECCCCEEEEEEECHHHH
LDARRLPIRYAGISPCFRREIGSASRDVRGLLRVHQFEKVEQFVLCVNDPAESARWHAEL
HHCCCCCEEECCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHEEEECCCHHHHHHHHHH
LATAEHILADLGLHYEVVECSTGDMGLGKFRMNDINTWFPTLDLFRETHSCSTLHDWQAR
HHHHHHHHHHHCCCEEEEEECCCCCCCCCEEECCCCHHHHHHHHHHHHCCCCHHHHHHHH
RANLRYRDADGNVRFAHTLNNTAVATPRLLAAILENFQTADHQVRVPEVLRPYLGGRDLL
HCCCEEECCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEECHHHHHHHCCCCCCC
>Mature Secondary Structure
MLDKRFIRENPDAVKEAVRLKGVDLDVDELLQLDQENRKLQFEVDEAQARRKSFAKQFAK
CCCCHHHHCCHHHHHHHHHHCCCCCCHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHH
ADEARRAELRAEHAEFDRQLRDLREQLTRTSTRMSELMLLTPGIPWEGAPVGPDESANVV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCCCCEE
VRTVGTRPEFDFTPIDHTELAEKRGWAEFARARRVAGERAYALVGDMVMLERAVHSYALD
EEEECCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLRERDFTPVSVPALVKEGPLVGTGMLPKAREEIYEIPADDAFLAGTAEVALVGLHAGEI
HHHHCCCCCCCCHHHHHCCCEECCCCCCHHHHHHHCCCCCCCEECCCCEEEEEEECHHHH
LDARRLPIRYAGISPCFRREIGSASRDVRGLLRVHQFEKVEQFVLCVNDPAESARWHAEL
HHCCCCCEEECCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHEEEECCCHHHHHHHHHH
LATAEHILADLGLHYEVVECSTGDMGLGKFRMNDINTWFPTLDLFRETHSCSTLHDWQAR
HHHHHHHHHHHCCCEEEEEECCCCCCCCCEEECCCCHHHHHHHHHHHHCCCCHHHHHHHH
RANLRYRDADGNVRFAHTLNNTAVATPRLLAAILENFQTADHQVRVPEVLRPYLGGRDLL
HCCCEEECCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEECHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA