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The map label for this gene is prcB

Identifier: 158316642

GI number: 158316642

Start: 5852699

End: 5853523

Strand: Reverse

Name: prcB

Synonym: Franean1_4879

Alternate gene names: 158316642

Gene position: 5853523-5852699 (Counterclockwise)

Preceding gene: 158316643

Following gene: 158316641

Centisome position: 65.17

GC content: 68.61

Gene sequence:

>825_bases
GTGCCCGATCCAACGGGTGTCGCCGGGCGTCTACCGGCTGTGTTCATGACACCGGGAACGTCGTCGTTCACCGATTTCCT
GTCCGTCGCGGCTCCGGACCTGCTTCCGGGCGCCCGGGGCCCGCTGCCCGCTCCGGTGACCGATGCGGCTCACGGCACCA
CCATCGTGGCCGTGGCGTTCCCCGGTGGCGTGATCATGGCCGGCGACCGCCGCGCGACGCAGGGGCACATGATCGCCCAG
CGTGACGTCGAGAAGGTCCACCACGCGGACGAGTTCTCCTGCGTCGGCTACGCCGGCACGGCCGGTGTGGGCGCCGAGCT
GATCCGTCTGTTCCAGGTCGAGCTCGAGCACTACGAGAAGATCGAGGGCTCCACGCTGAGCCTGGACGCGAAGGCCAACC
GGCTCGCGTTCATGGTCAAGGGGAACCTGGGCATGGCGATGCAGGGCCTTGCGGTCATCCCGCTGTTCGCCGGCTTCGAC
ACCGAGACCGGCGAGGGACGGATCTTCTCCTACGACATCGCCGCGGCGAAGTCCGAGGAGCGCACCTACGAGTCGATCGG
GTCGGGCTCGGTCTTCGCCCGCGGCTCGCTGAAGAAGCGCTATCGGGCCAACCACAGCCAGGACGACGCGATCCGGATCA
GCGTCGAGGCTCTCTACGACGCCGCCGACGACGACTCGGCGACCGGTGGGCCGGACCTCATCCGCAAGCTGTACCCGATC
GTCGCCTCGGTGACCGTCGACGGATACCGTCGCCTCACCGATGACGAGGTCGGCCCGGTGGTCGACTCGATCATCGCCGA
CCGCGCGCAGAACTCAGGAGGCTGA

Upstream 100 bases:

>100_bases
CCGGCACGTGGCATGTTGTGCATCACCCGGAGCCTTGGGCTGGGCCGCCTCGGACCATCCTGGGCCGCCGGCTCACGATC
GACTATCTGAAGGGGGATGC

Downstream 100 bases:

>100_bases
CGTGACCATGCCGTTCGGCTACGCAAGTCCCGAACAGCAGGTCCGGGACAAGTCCGAGTACGCGCGCAAGGGCATCGCGC
GCGGCCGGAGCGTGGTCGTC

Product: 20S proteasome subunits A and B

Products: NA

Alternate protein names: 20S proteasome beta subunit; Proteasome core protein PrcB

Number of amino acids: Translated: 274; Mature: 273

Protein sequence:

>274_residues
MPDPTGVAGRLPAVFMTPGTSSFTDFLSVAAPDLLPGARGPLPAPVTDAAHGTTIVAVAFPGGVIMAGDRRATQGHMIAQ
RDVEKVHHADEFSCVGYAGTAGVGAELIRLFQVELEHYEKIEGSTLSLDAKANRLAFMVKGNLGMAMQGLAVIPLFAGFD
TETGEGRIFSYDIAAAKSEERTYESIGSGSVFARGSLKKRYRANHSQDDAIRISVEALYDAADDDSATGGPDLIRKLYPI
VASVTVDGYRRLTDDEVGPVVDSIIADRAQNSGG

Sequences:

>Translated_274_residues
MPDPTGVAGRLPAVFMTPGTSSFTDFLSVAAPDLLPGARGPLPAPVTDAAHGTTIVAVAFPGGVIMAGDRRATQGHMIAQ
RDVEKVHHADEFSCVGYAGTAGVGAELIRLFQVELEHYEKIEGSTLSLDAKANRLAFMVKGNLGMAMQGLAVIPLFAGFD
TETGEGRIFSYDIAAAKSEERTYESIGSGSVFARGSLKKRYRANHSQDDAIRISVEALYDAADDDSATGGPDLIRKLYPI
VASVTVDGYRRLTDDEVGPVVDSIIADRAQNSGG
>Mature_273_residues
PDPTGVAGRLPAVFMTPGTSSFTDFLSVAAPDLLPGARGPLPAPVTDAAHGTTIVAVAFPGGVIMAGDRRATQGHMIAQR
DVEKVHHADEFSCVGYAGTAGVGAELIRLFQVELEHYEKIEGSTLSLDAKANRLAFMVKGNLGMAMQGLAVIPLFAGFDT
ETGEGRIFSYDIAAAKSEERTYESIGSGSVFARGSLKKRYRANHSQDDAIRISVEALYDAADDDSATGGPDLIRKLYPIV
ASVTVDGYRRLTDDEVGPVVDSIIADRAQNSGG

Specific function: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation

COG id: COG0638

COG function: function code O; 20S proteasome, alpha and beta subunits

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase T1B family

Homologues:

Organism=Homo sapiens, GI4506201, Length=252, Percent_Identity=32.1428571428571, Blast_Score=84, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6325360, Length=215, Percent_Identity=29.3023255813954, Blast_Score=66, Evalue=7e-12,
Organism=Drosophila melanogaster, GI20130281, Length=253, Percent_Identity=27.2727272727273, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI21355573, Length=207, Percent_Identity=27.536231884058, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24652553, Length=207, Percent_Identity=27.536231884058, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PSB_FRASN (A8LH54)

Other databases:

- EMBL:   CP000820
- RefSeq:   YP_001509150.1
- ProteinModelPortal:   A8LH54
- SMR:   A8LH54
- MEROPS:   T01.005
- GeneID:   5673219
- GenomeReviews:   CP000820_GR
- KEGG:   fre:Franean1_4879
- HOGENOM:   HBG322409
- OMA:   FQVELEH
- ProtClustDB:   CLSK2775874
- GO:   GO:0005737
- HAMAP:   MF_02113_B
- InterPro:   IPR022483
- InterPro:   IPR001353
- TIGRFAMs:   TIGR03690

Pfam domain/function: PF00227 Proteasome

EC number: =3.4.25.1

Molecular weight: Translated: 28876; Mature: 28745

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: PS00854 PROTEASOME_B_1; PS51476 PROTEASOME_B_2

Important sites: ACT_SITE 53-53

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDPTGVAGRLPAVFMTPGTSSFTDFLSVAAPDLLPGARGPLPAPVTDAAHGTTIVAVAF
CCCCCCCCCCCCEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEEC
PGGVIMAGDRRATQGHMIAQRDVEKVHHADEFSCVGYAGTAGVGAELIRLFQVELEHYEK
CCCEEEECCCCCCCCCHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHH
IEGSTLSLDAKANRLAFMVKGNLGMAMQGLAVIPLFAGFDTETGEGRIFSYDIAAAKSEE
CCCCEEEEECCCCEEEEEEECCCCCHHCCCEEEEEEECCCCCCCCCEEEEEEEHHCCCHH
RTYESIGSGSVFARGSLKKRYRANHSQDDAIRISVEALYDAADDDSATGGPDLIRKLYPI
HHHHHCCCCCEEECCCHHHHHHCCCCCCCEEEEEHHHHHCCCCCCCCCCCHHHHHHHHHH
VASVTVDGYRRLTDDEVGPVVDSIIADRAQNSGG
HHHEECCCHHHCCCCHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
PDPTGVAGRLPAVFMTPGTSSFTDFLSVAAPDLLPGARGPLPAPVTDAAHGTTIVAVAF
CCCCCCCCCCCEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEEC
PGGVIMAGDRRATQGHMIAQRDVEKVHHADEFSCVGYAGTAGVGAELIRLFQVELEHYEK
CCCEEEECCCCCCCCCHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHH
IEGSTLSLDAKANRLAFMVKGNLGMAMQGLAVIPLFAGFDTETGEGRIFSYDIAAAKSEE
CCCCEEEEECCCCEEEEEEECCCCCHHCCCEEEEEEECCCCCCCCCEEEEEEEHHCCCHH
RTYESIGSGSVFARGSLKKRYRANHSQDDAIRISVEALYDAADDDSATGGPDLIRKLYPI
HHHHHCCCCCEEECCCHHHHHHCCCCCCCEEEEEHHHHHCCCCCCCCCCCHHHHHHHHHH
VASVTVDGYRRLTDDEVGPVVDSIIADRAQNSGG
HHHEECCCHHHCCCCHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA