| Definition | Frankia sp. EAN1pec chromosome, complete genome. |
|---|---|
| Accession | NC_009921 |
| Length | 8,982,042 |
Click here to switch to the map view.
The map label for this gene is hdhA [C]
Identifier: 158316342
GI number: 158316342
Start: 5453973
End: 5454758
Strand: Reverse
Name: hdhA [C]
Synonym: Franean1_4571
Alternate gene names: 158316342
Gene position: 5454758-5453973 (Counterclockwise)
Preceding gene: 158316343
Following gene: 158316341
Centisome position: 60.73
GC content: 72.77
Gene sequence:
>786_bases ATGCCCGACGAGACGCTGGTCAACGAGACGCCGGCCAAGGAGCACGCTGGCAAGGTCGCGCTGATAACAGGGGGCGGCCG CGGCTTCGGCAAGGCGTTCGGCGCCGCGCTGACCGAGCGCGGGGCGCACGTCGTGCTGGCCGACATCGACGGTGACGTCG CCTCGGCCGCCGCGGCCGAGCTCACCGCGCTCGGCGGCAGCGCGACCGGGGTCACCTGCGACGTGACGGACGAGGCCCGC GTCGGTGAGGTGGTGGCCGACATCGTCCGCGCGCACGGCGGGCTCGACATTCTGGTCAACAACGCGGGGCTGCACTCGGC CGCCTTCAACAAGCCGACCGCCGAGCTCGGCGCCGGCCAGATCCGCCGGCTGTTCGAGGTCAACGTGATGGGTGTCGTCA TATGCACGTTGGCCGCGAAGGACGCTATGAGCGGGCGGGCGGGCGCCGCCGTCGTCAACATCTCCTCCTCGGCGGCCTAC GCCAACCGGACCGCCTACGGCGTCTCCAAGCTGGCGGTGCGCGGCTTCACCGCGCAGTTCGCCCGCGAGCTGGCCGCGGT CGGCGTCCGGGTCAACGCGATCGCCCCCGGGCTGATCCTCACCGACACCGTGCGGGCCGAGCTGCCCGCGACCGAGGTCG CGCGCGTCCTCGCGCAGCAGGTCCTGGCGCGCGAGGGCGAGGAGCGGGACGTGGTGAACGCGCTGCTCTACCTGGTCTCG GACGCAGCCGCCTTCATCACCGGGGAGACGCTGCGGGTCACCGGTGGGTTCGCGCTCTCGGTCTAG
Upstream 100 bases:
>100_bases CGGGTGTGATCGCTTAGAGCTCCGGCGGCGGTGGCGCCGCCCGCGACCGTTCCAGCCGCGGACCCGCCGGCCGCCGCACG ACGACGATCGAAGGAGATCC
Downstream 100 bases:
>100_bases CCCGACCCGAGCTGAGGAAATGAGACACGCATGGCAGATCACCAGGCCGGCACGGCTCACCCGGCTGACGTCGCCCGCCA GGCCGACGTCGCTCACCCGG
Product: short-chain dehydrogenase/reductase SDR
Products: 3-oxoacyl-[acyl-carrier protein]; NADPH; H+
Alternate protein names: NA
Number of amino acids: Translated: 261; Mature: 260
Protein sequence:
>261_residues MPDETLVNETPAKEHAGKVALITGGGRGFGKAFGAALTERGAHVVLADIDGDVASAAAAELTALGGSATGVTCDVTDEAR VGEVVADIVRAHGGLDILVNNAGLHSAAFNKPTAELGAGQIRRLFEVNVMGVVICTLAAKDAMSGRAGAAVVNISSSAAY ANRTAYGVSKLAVRGFTAQFARELAAVGVRVNAIAPGLILTDTVRAELPATEVARVLAQQVLAREGEERDVVNALLYLVS DAAAFITGETLRVTGGFALSV
Sequences:
>Translated_261_residues MPDETLVNETPAKEHAGKVALITGGGRGFGKAFGAALTERGAHVVLADIDGDVASAAAAELTALGGSATGVTCDVTDEAR VGEVVADIVRAHGGLDILVNNAGLHSAAFNKPTAELGAGQIRRLFEVNVMGVVICTLAAKDAMSGRAGAAVVNISSSAAY ANRTAYGVSKLAVRGFTAQFARELAAVGVRVNAIAPGLILTDTVRAELPATEVARVLAQQVLAREGEERDVVNALLYLVS DAAAFITGETLRVTGGFALSV >Mature_260_residues PDETLVNETPAKEHAGKVALITGGGRGFGKAFGAALTERGAHVVLADIDGDVASAAAAELTALGGSATGVTCDVTDEARV GEVVADIVRAHGGLDILVNNAGLHSAAFNKPTAELGAGQIRRLFEVNVMGVVICTLAAKDAMSGRAGAAVVNISSSAAYA NRTAYGVSKLAVRGFTAQFARELAAVGVRVNAIAPGLILTDTVRAELPATEVARVLAQQVLAREGEERDVVNALLYLVSD AAAFITGETLRVTGGFALSV
Specific function: 7-Alpha-Dehydroxylation Of Cholic Acid, Yielding Deoxycholic Acid And Lithocholic Acid, Respectively. Highest Affinity With Taurochenodeoxycholic Acid. [C]
COG id: NA
COG function: NA
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI32483357, Length=245, Percent_Identity=35.5102040816327, Blast_Score=117, Evalue=1e-26, Organism=Homo sapiens, GI19923817, Length=259, Percent_Identity=28.5714285714286, Blast_Score=97, Evalue=1e-20, Organism=Homo sapiens, GI31542939, Length=260, Percent_Identity=31.1538461538462, Blast_Score=93, Evalue=2e-19, Organism=Homo sapiens, GI7705925, Length=252, Percent_Identity=31.3492063492063, Blast_Score=92, Evalue=4e-19, Organism=Homo sapiens, GI59889578, Length=233, Percent_Identity=35.1931330472103, Blast_Score=91, Evalue=7e-19, Organism=Homo sapiens, GI5031737, Length=246, Percent_Identity=31.3008130081301, Blast_Score=91, Evalue=9e-19, Organism=Homo sapiens, GI126723750, Length=246, Percent_Identity=30.8943089430894, Blast_Score=89, Evalue=4e-18, Organism=Homo sapiens, GI40254992, Length=246, Percent_Identity=28.4552845528455, Blast_Score=87, Evalue=2e-17, Organism=Homo sapiens, GI4758504, Length=256, Percent_Identity=31.640625, Blast_Score=83, Evalue=2e-16, Organism=Homo sapiens, GI15277342, Length=257, Percent_Identity=28.7937743190661, Blast_Score=80, Evalue=1e-15, Organism=Homo sapiens, GI33667109, Length=247, Percent_Identity=31.1740890688259, Blast_Score=79, Evalue=3e-15, Organism=Homo sapiens, GI209862901, Length=212, Percent_Identity=30.6603773584906, Blast_Score=79, Evalue=4e-15, Organism=Homo sapiens, GI19923983, Length=212, Percent_Identity=30.6603773584906, Blast_Score=79, Evalue=4e-15, Organism=Homo sapiens, GI126723191, Length=181, Percent_Identity=33.7016574585635, Blast_Score=78, Evalue=9e-15, Organism=Homo sapiens, GI4503301, Length=256, Percent_Identity=28.90625, Blast_Score=77, Evalue=2e-14, Organism=Homo sapiens, GI224922801, Length=169, Percent_Identity=33.7278106508876, Blast_Score=76, Evalue=3e-14, Organism=Homo sapiens, GI109715829, Length=248, Percent_Identity=28.2258064516129, Blast_Score=76, Evalue=4e-14, Organism=Homo sapiens, GI142976729, Length=249, Percent_Identity=27.3092369477912, Blast_Score=75, Evalue=7e-14, Organism=Homo sapiens, GI66933014, Length=254, Percent_Identity=27.1653543307087, Blast_Score=72, Evalue=3e-13, Organism=Homo sapiens, GI10190704, Length=250, Percent_Identity=28, Blast_Score=72, Evalue=4e-13, Organism=Homo sapiens, GI225579078, Length=207, Percent_Identity=29.951690821256, Blast_Score=72, Evalue=7e-13, Organism=Homo sapiens, GI210032110, Length=218, Percent_Identity=26.605504587156, Blast_Score=72, Evalue=7e-13, Organism=Homo sapiens, GI40254986, Length=200, Percent_Identity=30, Blast_Score=69, Evalue=4e-12, Organism=Homo sapiens, GI40548397, Length=220, Percent_Identity=30.4545454545455, Blast_Score=69, Evalue=5e-12, Organism=Homo sapiens, GI214010158, Length=220, Percent_Identity=30.4545454545455, Blast_Score=69, Evalue=5e-12, Organism=Homo sapiens, GI214010156, Length=220, Percent_Identity=30.4545454545455, Blast_Score=69, Evalue=5e-12, Organism=Homo sapiens, GI22758144, Length=220, Percent_Identity=30.4545454545455, Blast_Score=69, Evalue=5e-12, Organism=Homo sapiens, GI20149619, Length=193, Percent_Identity=30.5699481865285, Blast_Score=68, Evalue=7e-12, Organism=Homo sapiens, GI4504505, Length=206, Percent_Identity=31.5533980582524, Blast_Score=67, Evalue=2e-11, Organism=Homo sapiens, GI193804850, Length=234, Percent_Identity=26.9230769230769, Blast_Score=66, Evalue=4e-11, Organism=Homo sapiens, GI83715985, Length=256, Percent_Identity=28.515625, Blast_Score=65, Evalue=6e-11, Organism=Homo sapiens, GI50726952, Length=193, Percent_Identity=32.1243523316062, Blast_Score=65, Evalue=6e-11, Organism=Homo sapiens, GI32455239, Length=192, Percent_Identity=28.125, Blast_Score=65, Evalue=8e-11, Organism=Homo sapiens, GI5031765, Length=192, Percent_Identity=28.125, Blast_Score=65, Evalue=8e-11, Organism=Escherichia coli, GI1787905, Length=244, Percent_Identity=34.8360655737705, Blast_Score=125, Evalue=3e-30, Organism=Escherichia coli, GI1787335, Length=248, Percent_Identity=34.6774193548387, Blast_Score=118, Evalue=4e-28, Organism=Escherichia coli, GI2367175, Length=248, Percent_Identity=32.6612903225806, Blast_Score=103, Evalue=1e-23, Organism=Escherichia coli, GI1790717, Length=250, Percent_Identity=30.8, Blast_Score=103, Evalue=2e-23, Organism=Escherichia coli, GI87082160, Length=250, Percent_Identity=30.4, Blast_Score=100, Evalue=1e-22, Organism=Escherichia coli, GI87082100, Length=260, Percent_Identity=32.3076923076923, Blast_Score=93, Evalue=2e-20, Organism=Escherichia coli, GI1789057, Length=260, Percent_Identity=28.4615384615385, Blast_Score=88, Evalue=5e-19, Organism=Escherichia coli, GI2367365, Length=245, Percent_Identity=31.8367346938775, Blast_Score=86, Evalue=3e-18, Organism=Escherichia coli, GI1788459, Length=249, Percent_Identity=28.5140562248996, Blast_Score=85, Evalue=4e-18, Organism=Escherichia coli, GI1789378, Length=248, Percent_Identity=27.4193548387097, Blast_Score=83, Evalue=2e-17, Organism=Escherichia coli, GI1786812, Length=258, Percent_Identity=30.6201550387597, Blast_Score=81, Evalue=8e-17, Organism=Escherichia coli, GI1789208, Length=247, Percent_Identity=29.1497975708502, Blast_Score=80, Evalue=1e-16, Organism=Escherichia coli, GI1787820, Length=184, Percent_Identity=29.3478260869565, Blast_Score=68, Evalue=8e-13, Organism=Caenorhabditis elegans, GI25147288, Length=249, Percent_Identity=34.5381526104418, Blast_Score=117, Evalue=4e-27, Organism=Caenorhabditis elegans, GI17555706, Length=248, Percent_Identity=31.8548387096774, Blast_Score=114, Evalue=7e-26, Organism=Caenorhabditis elegans, GI115534694, Length=255, Percent_Identity=33.3333333333333, Blast_Score=107, Evalue=6e-24, Organism=Caenorhabditis elegans, GI17562906, Length=264, Percent_Identity=29.1666666666667, Blast_Score=89, Evalue=3e-18, Organism=Caenorhabditis elegans, GI71994600, Length=255, Percent_Identity=32.9411764705882, Blast_Score=88, Evalue=3e-18, Organism=Caenorhabditis elegans, GI17560676, Length=246, Percent_Identity=30.8943089430894, Blast_Score=88, Evalue=4e-18, Organism=Caenorhabditis elegans, GI71994604, Length=255, Percent_Identity=31.7647058823529, Blast_Score=88, Evalue=4e-18, Organism=Caenorhabditis elegans, GI17561402, Length=256, Percent_Identity=30.46875, Blast_Score=87, Evalue=1e-17, Organism=Caenorhabditis elegans, GI17562910, Length=262, Percent_Identity=27.0992366412214, Blast_Score=86, Evalue=3e-17, Organism=Caenorhabditis elegans, GI17538182, Length=260, Percent_Identity=32.3076923076923, Blast_Score=85, Evalue=4e-17, Organism=Caenorhabditis elegans, GI17560220, Length=265, Percent_Identity=29.811320754717, Blast_Score=81, Evalue=6e-16, Organism=Caenorhabditis elegans, GI17559104, Length=264, Percent_Identity=29.1666666666667, Blast_Score=80, Evalue=1e-15, Organism=Caenorhabditis elegans, GI17536025, Length=252, Percent_Identity=30.1587301587302, Blast_Score=80, Evalue=1e-15, Organism=Caenorhabditis elegans, GI17544670, Length=270, Percent_Identity=28.8888888888889, Blast_Score=80, Evalue=1e-15, Organism=Caenorhabditis elegans, GI17562908, Length=197, Percent_Identity=33.502538071066, Blast_Score=80, Evalue=1e-15, Organism=Caenorhabditis elegans, GI193204405, Length=197, Percent_Identity=30.9644670050761, Blast_Score=76, Evalue=1e-14, Organism=Caenorhabditis elegans, GI17536651, Length=250, Percent_Identity=27.2, Blast_Score=75, Evalue=3e-14, Organism=Caenorhabditis elegans, GI17531453, Length=264, Percent_Identity=28.4090909090909, Blast_Score=73, Evalue=2e-13, Organism=Caenorhabditis elegans, GI71982365, Length=193, Percent_Identity=30.5699481865285, Blast_Score=72, Evalue=2e-13, Organism=Caenorhabditis elegans, GI72000259, Length=263, Percent_Identity=25.0950570342205, Blast_Score=70, Evalue=1e-12, Organism=Caenorhabditis elegans, GI17560150, Length=264, Percent_Identity=25.7575757575758, Blast_Score=70, Evalue=1e-12, Organism=Caenorhabditis elegans, GI17508895, Length=213, Percent_Identity=27.2300469483568, Blast_Score=70, Evalue=1e-12, Organism=Caenorhabditis elegans, GI17560332, Length=263, Percent_Identity=27.7566539923954, Blast_Score=69, Evalue=2e-12, Organism=Caenorhabditis elegans, GI17568967, Length=207, Percent_Identity=32.3671497584541, Blast_Score=69, Evalue=2e-12, Organism=Caenorhabditis elegans, GI17562904, Length=261, Percent_Identity=24.1379310344828, Blast_Score=69, Evalue=3e-12, Organism=Caenorhabditis elegans, GI17555612, Length=206, Percent_Identity=31.5533980582524, Blast_Score=68, Evalue=5e-12, Organism=Caenorhabditis elegans, GI17567345, Length=205, Percent_Identity=25.8536585365854, Blast_Score=68, Evalue=5e-12, Organism=Caenorhabditis elegans, GI17563726, Length=261, Percent_Identity=26.4367816091954, Blast_Score=67, Evalue=1e-11, Organism=Caenorhabditis elegans, GI17538480, Length=262, Percent_Identity=25.5725190839695, Blast_Score=65, Evalue=3e-11, Organism=Caenorhabditis elegans, GI17562990, Length=263, Percent_Identity=27.3764258555133, Blast_Score=65, Evalue=4e-11, Organism=Saccharomyces cerevisiae, GI6322861, Length=253, Percent_Identity=26.4822134387352, Blast_Score=71, Evalue=1e-13, Organism=Saccharomyces cerevisiae, GI6322227, Length=195, Percent_Identity=29.2307692307692, Blast_Score=70, Evalue=2e-13, Organism=Saccharomyces cerevisiae, GI6323882, Length=207, Percent_Identity=28.0193236714976, Blast_Score=62, Evalue=6e-11, Organism=Drosophila melanogaster, GI28571526, Length=249, Percent_Identity=34.9397590361446, Blast_Score=107, Evalue=6e-24, Organism=Drosophila melanogaster, GI21355319, Length=250, Percent_Identity=32, Blast_Score=99, Evalue=2e-21, Organism=Drosophila melanogaster, GI24644339, Length=250, Percent_Identity=32.4, Blast_Score=99, Evalue=3e-21, Organism=Drosophila melanogaster, GI21357041, Length=251, Percent_Identity=33.4661354581673, Blast_Score=96, Evalue=2e-20, Organism=Drosophila melanogaster, GI24640492, Length=209, Percent_Identity=29.6650717703349, Blast_Score=93, Evalue=2e-19, Organism=Drosophila melanogaster, GI23397609, Length=249, Percent_Identity=32.1285140562249, Blast_Score=91, Evalue=6e-19, Organism=Drosophila melanogaster, GI24643142, Length=251, Percent_Identity=31.4741035856574, Blast_Score=85, Evalue=5e-17, Organism=Drosophila melanogaster, GI24644337, Length=256, Percent_Identity=31.25, Blast_Score=83, Evalue=2e-16, Organism=Drosophila melanogaster, GI17737361, Length=257, Percent_Identity=31.5175097276265, Blast_Score=82, Evalue=3e-16, Organism=Drosophila melanogaster, GI24639444, Length=248, Percent_Identity=30.241935483871, Blast_Score=82, Evalue=3e-16, Organism=Drosophila melanogaster, GI281364892, Length=246, Percent_Identity=27.2357723577236, Blast_Score=72, Evalue=5e-13, Organism=Drosophila melanogaster, GI24641232, Length=202, Percent_Identity=28.7128712871287, Blast_Score=70, Evalue=1e-12, Organism=Drosophila melanogaster, GI18859837, Length=223, Percent_Identity=32.2869955156951, Blast_Score=70, Evalue=2e-12, Organism=Drosophila melanogaster, GI116007236, Length=239, Percent_Identity=28.0334728033473, Blast_Score=65, Evalue=4e-11, Organism=Drosophila melanogaster, GI21357673, Length=198, Percent_Identity=28.7878787878788, Blast_Score=65, Evalue=7e-11, Organism=Drosophila melanogaster, GI161076371, Length=213, Percent_Identity=29.5774647887324, Blast_Score=64, Evalue=7e-11,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 - InterPro: IPR020904 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: 1.1.1.100
Molecular weight: Translated: 26492; Mature: 26361
Theoretical pI: Translated: 5.11; Mature: 5.11
Prosite motif: PS00061 ADH_SHORT
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.8 %Cys (Translated Protein) 1.1 %Met (Translated Protein) 1.9 %Cys+Met (Translated Protein) 0.8 %Cys (Mature Protein) 0.8 %Met (Mature Protein) 1.5 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MPDETLVNETPAKEHAGKVALITGGGRGFGKAFGAALTERGAHVVLADIDGDVASAAAAE CCCCCCCCCCCCHHHCCEEEEEECCCCCHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHH LTALGGSATGVTCDVTDEARVGEVVADIVRAHGGLDILVNNAGLHSAAFNKPTAELGAGQ HHHCCCCCCCEEEECCCCHHHHHHHHHHHHHCCCEEEEEECCCCCHHHCCCCHHHHCHHH IRRLFEVNVMGVVICTLAAKDAMSGRAGAAVVNISSSAAYANRTAYGVSKLAVRGFTAQF HHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHCHHHHHHHHHHHHHHHHHH ARELAAVGVRVNAIAPGLILTDTVRAELPATEVARVLAQQVLAREGEERDVVNALLYLVS HHHHHHHCEEEEEECCCEEEECCHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH DAAAFITGETLRVTGGFALSV HHHHHEECCEEEEECCEEECC >Mature Secondary Structure PDETLVNETPAKEHAGKVALITGGGRGFGKAFGAALTERGAHVVLADIDGDVASAAAAE CCCCCCCCCCCHHHCCEEEEEECCCCCHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHH LTALGGSATGVTCDVTDEARVGEVVADIVRAHGGLDILVNNAGLHSAAFNKPTAELGAGQ HHHCCCCCCCEEEECCCCHHHHHHHHHHHHHCCCEEEEEECCCCCHHHCCCCHHHHCHHH IRRLFEVNVMGVVICTLAAKDAMSGRAGAAVVNISSSAAYANRTAYGVSKLAVRGFTAQF HHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHCHHHHHHHHHHHHHHHHHH ARELAAVGVRVNAIAPGLILTDTVRAELPATEVARVLAQQVLAREGEERDVVNALLYLVS HHHHHHHCEEEEEECCCEEEECCHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH DAAAFITGETLRVTGGFALSV HHHHHEECCEEEEECCEEECC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: (3R)-3-hydroxyacyl-[acyl-carrier protein]; NADP+
Specific reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 9655913; 12597275 [H]