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The map label for this gene is adhC [C]

Identifier: 158314744

GI number: 158314744

Start: 3442412

End: 3443497

Strand: Direct

Name: adhC [C]

Synonym: Franean1_2925

Alternate gene names: 158314744

Gene position: 3442412-3443497 (Clockwise)

Preceding gene: 158314743

Following gene: 158314745

Centisome position: 38.33

GC content: 66.3

Gene sequence:

>1086_bases
GTGAGCCGTCAGGTCAAGGGCATCGTGTCGGTTAGGAAGGGAGCTCAGGTAGAGCTGCGCACGATTACCGTGCCAGACCC
GGGCGCCGGTGAGGTCACGGTGGACATCCTGGCTTGCGGGGTCTGCCATACCGACTTGCACTATCGCGAGGGCGGCATCA
GCGACGACTTCCCGTTTCTGCTCGGGCATGAGGCCGCGGGGACTGTCGCCCAGGTTGGCCCAGGGGTTACCCATGTGGCG
CCTGGTGATTATGTGATCCTGAACTGGCGGGCGGTCTGTGGGCGGTGCAGGGCCTGCGAACGCGGCAGGCCTTGGTACTG
CTTCGACACCGCGAACGCCACGCAGAAGATGACCCTGGAGGACGGCACCGAGCTGTCCCCGGCGCTTGGCATCGGAGCGT
TCGCGGAGGCCACGCTCGTTGCCGCCGGCCAGTGCACCAAGATCGATGCTAGCGCCCCGCCAGAGGTCGCGGGCCTGCTC
GGATGTGGCGTGATGGCTGGCATCGGGGCAGCGATCAACACTGGTGAGGTGACGCGCGGCGACAGCGTCGCGGTGATCGG
CTGCGGCGGTGTCGGCGCCGCGGCCGTCGCCGGCTCCCTGCTTGCCGGCGCGACAAAGATTATTGCGGTCGACCTCGACG
ACCGCAAGCTCGCCGTCGCGAAGACGCTGGGAGCGACCCACACGATCAACTCGCGGGAGGCTGATCCGGTCGCCGCGGTG
CAGGGGCTCACCGGCGGGTTTGGCGTCGACGTCGTCATCGATGCGGTCGGTCGGGCAGAGACCTGGAAGCAGGCATTTTA
CGCCCGTGACCTCGCCGGTACCGTTGTGCTCGTTGGCGTGCCCACCCCAGAGATAATGCTGGAGGTGCCGCTGCTGGACG
TGTTCGGTCGCGGTGGGCGGCTGAAGTCGTCCTGGTATGGCGACTGCCTGCCCGAGCGGGATTTCCCCATGCTGATCAAC
TTGTACCTGCAGGGTCGGCTGCCGCTGGACAGGTTCGTCTCCGAAAAGATCGGCCTAGAAGACGTCGAAGCAGCCTTTGA
CGCGATGAGTCGTGGCGACGTCCTGCGTTCGGTCGTGATGCTGTGA

Upstream 100 bases:

>100_bases
TGACAGAGCCTCCCAGTCAAAGTCCGGTGTGGTCTTCGGTCCTCCAGTTCCTGATCCGTCGCAGACGGGTCCCTGTCCCA
AACCAAAGGAGAAGACTGTT

Downstream 100 bases:

>100_bases
CAGACGAGGTGAGTTCTTCGACGAGCCGGGCCACGGGGGCCGGGTTGGCATCGACCACATCGTCACTTCGGGTACATTCT
CGCTTGACGGTGGCTGCTGG

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: NAD/mycothiol-dependent formaldehyde dehydrogenase; MD-FALDH [H]

Number of amino acids: Translated: 361; Mature: 360

Protein sequence:

>361_residues
MSRQVKGIVSVRKGAQVELRTITVPDPGAGEVTVDILACGVCHTDLHYREGGISDDFPFLLGHEAAGTVAQVGPGVTHVA
PGDYVILNWRAVCGRCRACERGRPWYCFDTANATQKMTLEDGTELSPALGIGAFAEATLVAAGQCTKIDASAPPEVAGLL
GCGVMAGIGAAINTGEVTRGDSVAVIGCGGVGAAAVAGSLLAGATKIIAVDLDDRKLAVAKTLGATHTINSREADPVAAV
QGLTGGFGVDVVIDAVGRAETWKQAFYARDLAGTVVLVGVPTPEIMLEVPLLDVFGRGGRLKSSWYGDCLPERDFPMLIN
LYLQGRLPLDRFVSEKIGLEDVEAAFDAMSRGDVLRSVVML

Sequences:

>Translated_361_residues
MSRQVKGIVSVRKGAQVELRTITVPDPGAGEVTVDILACGVCHTDLHYREGGISDDFPFLLGHEAAGTVAQVGPGVTHVA
PGDYVILNWRAVCGRCRACERGRPWYCFDTANATQKMTLEDGTELSPALGIGAFAEATLVAAGQCTKIDASAPPEVAGLL
GCGVMAGIGAAINTGEVTRGDSVAVIGCGGVGAAAVAGSLLAGATKIIAVDLDDRKLAVAKTLGATHTINSREADPVAAV
QGLTGGFGVDVVIDAVGRAETWKQAFYARDLAGTVVLVGVPTPEIMLEVPLLDVFGRGGRLKSSWYGDCLPERDFPMLIN
LYLQGRLPLDRFVSEKIGLEDVEAAFDAMSRGDVLRSVVML
>Mature_360_residues
SRQVKGIVSVRKGAQVELRTITVPDPGAGEVTVDILACGVCHTDLHYREGGISDDFPFLLGHEAAGTVAQVGPGVTHVAP
GDYVILNWRAVCGRCRACERGRPWYCFDTANATQKMTLEDGTELSPALGIGAFAEATLVAAGQCTKIDASAPPEVAGLLG
CGVMAGIGAAINTGEVTRGDSVAVIGCGGVGAAAVAGSLLAGATKIIAVDLDDRKLAVAKTLGATHTINSREADPVAAVQ
GLTGGFGVDVVIDAVGRAETWKQAFYARDLAGTVVLVGVPTPEIMLEVPLLDVFGRGGRLKSSWYGDCLPERDFPMLINL
YLQGRLPLDRFVSEKIGLEDVEAAFDAMSRGDVLRSVVML

Specific function: Has High Formaldehyde Dehydrogenase Activity In The Presence Of Glutathione And Catalyzes The Oxidation Of Normal Alcohols In A Reaction That Is Not Gsh-Dependent. In Addition, Hemithiolacetals Other Than Those Formed From Gsh, Including Omega-Thiol Fatty

COG id: COG1062

COG function: function code C; Zn-dependent alcohol dehydrogenases, class III

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI34577061, Length=363, Percent_Identity=36.6391184573003, Blast_Score=210, Evalue=2e-54,
Organism=Homo sapiens, GI4501929, Length=359, Percent_Identity=35.933147632312, Blast_Score=202, Evalue=4e-52,
Organism=Homo sapiens, GI4501933, Length=355, Percent_Identity=34.9295774647887, Blast_Score=200, Evalue=1e-51,
Organism=Homo sapiens, GI71743840, Length=354, Percent_Identity=33.0508474576271, Blast_Score=183, Evalue=2e-46,
Organism=Homo sapiens, GI262073058, Length=354, Percent_Identity=33.0508474576271, Blast_Score=183, Evalue=2e-46,
Organism=Homo sapiens, GI71565152, Length=377, Percent_Identity=33.1564986737401, Blast_Score=179, Evalue=5e-45,
Organism=Homo sapiens, GI71565154, Length=370, Percent_Identity=32.972972972973, Blast_Score=176, Evalue=2e-44,
Organism=Homo sapiens, GI156523966, Length=361, Percent_Identity=31.8559556786704, Blast_Score=175, Evalue=6e-44,
Organism=Homo sapiens, GI4501939, Length=353, Percent_Identity=32.0113314447592, Blast_Score=169, Evalue=5e-42,
Organism=Homo sapiens, GI156627571, Length=342, Percent_Identity=27.4853801169591, Blast_Score=100, Evalue=1e-21,
Organism=Escherichia coli, GI1786552, Length=371, Percent_Identity=34.7708894878706, Blast_Score=168, Evalue=4e-43,
Organism=Escherichia coli, GI1788073, Length=357, Percent_Identity=27.7310924369748, Blast_Score=109, Evalue=4e-25,
Organism=Escherichia coli, GI87081918, Length=285, Percent_Identity=31.2280701754386, Blast_Score=108, Evalue=5e-25,
Organism=Escherichia coli, GI87082125, Length=357, Percent_Identity=28.2913165266106, Blast_Score=99, Evalue=6e-22,
Organism=Escherichia coli, GI1788075, Length=347, Percent_Identity=29.971181556196, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1790045, Length=356, Percent_Identity=24.1573033707865, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1787863, Length=348, Percent_Identity=25.2873563218391, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1786825, Length=252, Percent_Identity=30.5555555555556, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1786518, Length=364, Percent_Identity=26.6483516483516, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1790718, Length=302, Percent_Identity=26.8211920529801, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1788407, Length=339, Percent_Identity=23.598820058997, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI226510992, Length=346, Percent_Identity=23.121387283237, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI25146526, Length=374, Percent_Identity=33.1550802139037, Blast_Score=183, Evalue=9e-47,
Organism=Caenorhabditis elegans, GI71997431, Length=376, Percent_Identity=32.9787234042553, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17565904, Length=341, Percent_Identity=33.4310850439883, Blast_Score=169, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17562876, Length=354, Percent_Identity=26.271186440678, Blast_Score=112, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17562878, Length=351, Percent_Identity=26.4957264957265, Blast_Score=85, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17562582, Length=271, Percent_Identity=28.7822878228782, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17562584, Length=359, Percent_Identity=27.2980501392758, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71988145, Length=356, Percent_Identity=26.685393258427, Blast_Score=69, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6320033, Length=377, Percent_Identity=35.2785145888594, Blast_Score=184, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6319621, Length=371, Percent_Identity=30.7277628032345, Blast_Score=105, Evalue=9e-24,
Organism=Saccharomyces cerevisiae, GI6323729, Length=366, Percent_Identity=27.0491803278689, Blast_Score=100, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6322619, Length=361, Percent_Identity=29.9168975069252, Blast_Score=98, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6319955, Length=361, Percent_Identity=29.6398891966759, Blast_Score=96, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6324486, Length=282, Percent_Identity=29.0780141843972, Blast_Score=86, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6323961, Length=282, Percent_Identity=29.4326241134752, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6319257, Length=371, Percent_Identity=25.3369272237197, Blast_Score=84, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6319258, Length=272, Percent_Identity=27.2058823529412, Blast_Score=84, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6323099, Length=366, Percent_Identity=25.9562841530055, Blast_Score=82, Evalue=9e-17,
Organism=Drosophila melanogaster, GI17737895, Length=357, Percent_Identity=35.0140056022409, Blast_Score=181, Evalue=9e-46,
Organism=Drosophila melanogaster, GI17737897, Length=344, Percent_Identity=28.1976744186047, Blast_Score=99, Evalue=6e-21,
Organism=Drosophila melanogaster, GI17137530, Length=344, Percent_Identity=27.6162790697674, Blast_Score=98, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR017816
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.306 [H]

Molecular weight: Translated: 37549; Mature: 37417

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRQVKGIVSVRKGAQVELRTITVPDPGAGEVTVDILACGVCHTDLHYREGGISDDFPFL
CCCCHHHHHHHCCCCEEEEEEEECCCCCCCCEEEEEEEECCCCCCCEECCCCCCCCCCEE
LGHEAAGTVAQVGPGVTHVAPGDYVILNWRAVCGRCRACERGRPWYCFDTANATQKMTLE
ECCCCCCCHHHCCCCEEEECCCCEEEEEHHHHHHHHHHHCCCCCEEEEECCCCCEEEEEC
DGTELSPALGIGAFAEATLVAAGQCTKIDASAPPEVAGLLGCGVMAGIGAAINTGEVTRG
CCCCCCHHHCCCHHHHEEEEECCCCEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCC
DSVAVIGCGGVGAAAVAGSLLAGATKIIAVDLDDRKLAVAKTLGATHTINSREADPVAAV
CCEEEEECCCCCHHHHHHHHHHCCEEEEEEECCCCEEEEHHHCCCCCCCCCCCCCCHHHH
QGLTGGFGVDVVIDAVGRAETWKQAFYARDLAGTVVLVGVPTPEIMLEVPLLDVFGRGGR
HCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCEEEEEECCCCHHEEEECHHHHHCCCCC
LKSSWYGDCLPERDFPMLINLYLQGRLPLDRFVSEKIGLEDVEAAFDAMSRGDVLRSVVM
CCCCCCCCCCCCCCCCEEEEEEEECCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHC
L
C
>Mature Secondary Structure 
SRQVKGIVSVRKGAQVELRTITVPDPGAGEVTVDILACGVCHTDLHYREGGISDDFPFL
CCCHHHHHHHCCCCEEEEEEEECCCCCCCCEEEEEEEECCCCCCCEECCCCCCCCCCEE
LGHEAAGTVAQVGPGVTHVAPGDYVILNWRAVCGRCRACERGRPWYCFDTANATQKMTLE
ECCCCCCCHHHCCCCEEEECCCCEEEEEHHHHHHHHHHHCCCCCEEEEECCCCCEEEEEC
DGTELSPALGIGAFAEATLVAAGQCTKIDASAPPEVAGLLGCGVMAGIGAAINTGEVTRG
CCCCCCHHHCCCHHHHEEEEECCCCEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCC
DSVAVIGCGGVGAAAVAGSLLAGATKIIAVDLDDRKLAVAKTLGATHTINSREADPVAAV
CCEEEEECCCCCHHHHHHHHHHCCEEEEEEECCCCEEEEHHHCCCCCCCCCCCCCCHHHH
QGLTGGFGVDVVIDAVGRAETWKQAFYARDLAGTVVLVGVPTPEIMLEVPLLDVFGRGGR
HCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCEEEEEECCCCHHEEEECHHHHHCCCCC
LKSSWYGDCLPERDFPMLINLYLQGRLPLDRFVSEKIGLEDVEAAFDAMSRGDVLRSVVM
CCCCCCCCCCCCCCCCEEEEEEEECCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHC
L
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9346279; 1597190; 9202149 [H]