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The map label for this gene is echA8 [H]

Identifier: 158314743

GI number: 158314743

Start: 3441417

End: 3442226

Strand: Direct

Name: echA8 [H]

Synonym: Franean1_2924

Alternate gene names: 158314743

Gene position: 3441417-3442226 (Clockwise)

Preceding gene: 158314742

Following gene: 158314744

Centisome position: 38.31

GC content: 62.72

Gene sequence:

>810_bases
ATGGACTACGAACACGTCGAGTACGAAGTTGAGGAACAGATCGGCGTCATTACGCTGAACCGACCGCAGTCGGCCAACGC
CCAGAGCGCGAAGGTGCTGCGCGAACTCGATGACGCCTGGCGGACCGCTGACAAGGATGCGCAAGTCAAAGTCATCCTTC
TGAAGTCAAACGGCAGGCATTTCTCCGCCGGCCACGACATGTCCAGAACAGACGATGAAAGCGAGCGACGCCCAGACTGG
ACACCCGACAGCGGCTACGACTGGGAGACTCGGCACTACCTGCACTACGCAAAGACGTGGCGTAACATCCCCAAGCCTTC
GATCGCCGCCGTCCAGGGCAAGTGCATCGCAGGAGGCCTCATGCTGTGCTGGCCCTGCGATCTCATCATCGCCGCCGACA
ACGCCGAGTTCTCCGACCCCGTCCTGTTCATGGGCCTCGCTGGCGTCGAGTACCATGCTCACACTTGGGAATTGGGTCCG
CGCAGGGCCAAGGAGCTGCTGTTCACCGGCGACCCAGTCCTCGCTGAAGAAGCTCTCGGACTCGGCATGGTCAACAAGGT
CGTACCCCTCGATGACCTCGTGACGGCCGCCATGGCGATGGCCCGACGCATAGCGCGGCAGGACACCTTCGCGCTGCGCA
TGGCCAAGCACGCCGTAAACCACACGCTCGACGTGCAGGGCTTCACCACCTCCGTCGACGCCGTCTTCGACATGCACCAC
CTCGGGCATGCCCGCGCCGCACTCCTCAACAGCGGTATCCCCTCCCTAGCCGGACTTTCTTCCATGAAGGGCCGCAGCCA
GGCCACATGA

Upstream 100 bases:

>100_bases
TCTCGCTGGACAGAACCGACGCGCACGGGAACGGGCGAGATTGTCTTACAACCGCTGGACCGATCGCAAGAGGCGCCCAC
CTCATGGACGAAGGAGACCG

Downstream 100 bases:

>100_bases
CCAGGTCAGCCGTCGGGGCTGACTCTCATGTGTTGGCAGGCGGCCGAAGCTACCCCAAGGGCAGGAGCCGGGGGCTTACC
ACCCTTGACAGAGCCTCCCA

Product: enoyl-CoA hydratase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 269; Mature: 269

Protein sequence:

>269_residues
MDYEHVEYEVEEQIGVITLNRPQSANAQSAKVLRELDDAWRTADKDAQVKVILLKSNGRHFSAGHDMSRTDDESERRPDW
TPDSGYDWETRHYLHYAKTWRNIPKPSIAAVQGKCIAGGLMLCWPCDLIIAADNAEFSDPVLFMGLAGVEYHAHTWELGP
RRAKELLFTGDPVLAEEALGLGMVNKVVPLDDLVTAAMAMARRIARQDTFALRMAKHAVNHTLDVQGFTTSVDAVFDMHH
LGHARAALLNSGIPSLAGLSSMKGRSQAT

Sequences:

>Translated_269_residues
MDYEHVEYEVEEQIGVITLNRPQSANAQSAKVLRELDDAWRTADKDAQVKVILLKSNGRHFSAGHDMSRTDDESERRPDW
TPDSGYDWETRHYLHYAKTWRNIPKPSIAAVQGKCIAGGLMLCWPCDLIIAADNAEFSDPVLFMGLAGVEYHAHTWELGP
RRAKELLFTGDPVLAEEALGLGMVNKVVPLDDLVTAAMAMARRIARQDTFALRMAKHAVNHTLDVQGFTTSVDAVFDMHH
LGHARAALLNSGIPSLAGLSSMKGRSQAT
>Mature_269_residues
MDYEHVEYEVEEQIGVITLNRPQSANAQSAKVLRELDDAWRTADKDAQVKVILLKSNGRHFSAGHDMSRTDDESERRPDW
TPDSGYDWETRHYLHYAKTWRNIPKPSIAAVQGKCIAGGLMLCWPCDLIIAADNAEFSDPVLFMGLAGVEYHAHTWELGP
RRAKELLFTGDPVLAEEALGLGMVNKVVPLDDLVTAAMAMARRIARQDTFALRMAKHAVNHTLDVQGFTTSVDAVFDMHH
LGHARAALLNSGIPSLAGLSSMKGRSQAT

Specific function: Could possibly oxidize fatty acids using specific components [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=230, Percent_Identity=30.4347826086957, Blast_Score=109, Evalue=2e-24,
Organism=Homo sapiens, GI31542718, Length=194, Percent_Identity=34.020618556701, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI70995211, Length=184, Percent_Identity=32.0652173913043, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI45643119, Length=223, Percent_Identity=25.1121076233184, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI260275230, Length=223, Percent_Identity=25.1121076233184, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI260274832, Length=223, Percent_Identity=25.1121076233184, Blast_Score=79, Evalue=4e-15,
Organism=Escherichia coli, GI1788597, Length=230, Percent_Identity=34.7826086956522, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1787659, Length=219, Percent_Identity=28.310502283105, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI87082183, Length=276, Percent_Identity=27.536231884058, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1787660, Length=234, Percent_Identity=32.4786324786325, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI221142681, Length=211, Percent_Identity=31.7535545023697, Blast_Score=81, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17554946, Length=220, Percent_Identity=30.4545454545455, Blast_Score=106, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI25145438, Length=234, Percent_Identity=29.9145299145299, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17540306, Length=186, Percent_Identity=28.494623655914, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17534483, Length=220, Percent_Identity=24.0909090909091, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17535521, Length=181, Percent_Identity=25.414364640884, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17540714, Length=219, Percent_Identity=26.027397260274, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17560910, Length=216, Percent_Identity=25.9259259259259, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI20129971, Length=228, Percent_Identity=30.7017543859649, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24653477, Length=228, Percent_Identity=30.7017543859649, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI21357171, Length=238, Percent_Identity=28.5714285714286, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24653139, Length=223, Percent_Identity=30.0448430493274, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24650670, Length=216, Percent_Identity=28.7037037037037, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI19920382, Length=227, Percent_Identity=26.8722466960352, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI19922422, Length=187, Percent_Identity=26.7379679144385, Blast_Score=71, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.17 [H]

Molecular weight: Translated: 29789; Mature: 29789

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYEHVEYEVEEQIGVITLNRPQSANAQSAKVLRELDDAWRTADKDAQVKVILLKSNGRH
CCCCCCCEECCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCE
FSAGHDMSRTDDESERRPDWTPDSGYDWETRHYLHYAKTWRNIPKPSIAAVQGKCIAGGL
ECCCCCCCCCCCCHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHCCCHHCCCE
MLCWPCDLIIAADNAEFSDPVLFMGLAGVEYHAHTWELGPRRAKELLFTGDPVLAEEALG
EEEECCEEEEEECCCCCCCCEEEEEECCCEEECEEECCCHHHHHHHEECCCCHHHHHHHC
LGMVNKVVPLDDLVTAAMAMARRIARQDTFALRMAKHAVNHTLDVQGFTTSVDAVFDMHH
CHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCHHHHHHHHHH
LGHARAALLNSGIPSLAGLSSMKGRSQAT
HHHHHHHHHHCCCCHHHHHHHCCCCCCCC
>Mature Secondary Structure
MDYEHVEYEVEEQIGVITLNRPQSANAQSAKVLRELDDAWRTADKDAQVKVILLKSNGRH
CCCCCCCEECCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCE
FSAGHDMSRTDDESERRPDWTPDSGYDWETRHYLHYAKTWRNIPKPSIAAVQGKCIAGGL
ECCCCCCCCCCCCHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHCCCHHCCCE
MLCWPCDLIIAADNAEFSDPVLFMGLAGVEYHAHTWELGPRRAKELLFTGDPVLAEEALG
EEEECCEEEEEECCCCCCCCEEEEEECCCEEECEEECCCHHHHHHHEECCCCHHHHHHHC
LGMVNKVVPLDDLVTAAMAMARRIARQDTFALRMAKHAVNHTLDVQGFTTSVDAVFDMHH
CHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCHHHHHHHHHH
LGHARAALLNSGIPSLAGLSSMKGRSQAT
HHHHHHHHHHCCCCHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]