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The map label for this gene is pdhA [H]

Identifier: 158314329

GI number: 158314329

Start: 2975412

End: 2976488

Strand: Direct

Name: pdhA [H]

Synonym: Franean1_2499

Alternate gene names: 158314329

Gene position: 2975412-2976488 (Clockwise)

Preceding gene: 158314327

Following gene: 158314330

Centisome position: 33.13

GC content: 72.42

Gene sequence:

>1077_bases
ATGACGTTGATGGCGGAACGCAGTGAGAACGGTGCGCCGTTCGACACGGGTGTTCGGCTGCTTGCGCCGGACGGCACTCT
CGTCGACGACCCGCGTTTCACTGTGCGTGCCGACTCCCGGCAGACGGAGTCGTTCTACCGGGAGATGGTGCGGGCGCGCC
GCCTCGACGAGGAGGCCACGGCGCTGCAACGCCAGGGCGAACTGGTCCTGTGGATTCCGCTGCGGGGCCAGGAGGCCGCC
CAGGTGGGCTCGGCGGCTGCCGCCGAGCCGGCGGACTTCCTCTTCCCCAGCTATCGCGAGCATGCCGTGGTCTGGCACCG
CGGCATCCCCCCGGTCGAGGCGCTGCGCCTGCTGCGGGGCGTCACGCACGGCGGCTGGGATCCCGAGGCGTACAACGTGG
CCAACTACGTGCTCGTGCTGGCGTCGCAGACCCTGCACGCGGTGGGCTACGGCCTGGGCGTCCGCCTCGACGGCGCAGCC
GGCCAGGTGGTGATGGTCTACCTCGGTGACGGCGCGATGAGCCAGGGCGACGCGAACGAGGCGTTCGTCTGGGCCGCGAG
CTTCGGCGCGCCGGTGGTGTTCTTCTGCCAGAACAACCAGTGGGCGATCTCCACACCCAGCGCGCGCCAGTCACCCGTGC
CGCTGGCACGCCGCGCGGCGGGCTTCGGCTTTCCGGGCGTGCGGGTGGACGGCAACGACGTGCTGGCGGTGCATGCGGTG
ACCACCTGGGCCCTGGAGCACGCCCGCTCGGGTCAGGGCCCCGTCCTGATCGAGGCGAACACCTACCGGATGGCGCCGCA
CACGACGTCCGACGACGCCAGCAGGTACCAGGAGGCCGCCGAGGTCGCGGCGTGGCGGGCGCGCGACCCGATCGACCGGG
TCGCGCTGCTGCTCGGCCACACGCACGACCCGGCCTGGTTCGAGGGTGTGCGGGCGGAGGCGGAGGAAGCCGCGGCCACG
CTGCGCCGGGAGTGCCTGGCCCTGCCCGACCCGGCCCCGCGGACCCTGGTGGATCATGTGCTGGTGGGTGGCTCCGCGCT
ACTTCGGGAGCAGCGGGGTGAGATCTGGGAGGGTTGA

Upstream 100 bases:

>100_bases
ACGACGGACGGCCCCCTGGGTCGGATGATGAGTACCCCTTGGGTGTCCCCTCCTCGCAGGCCTCGCAAACTGTGTCGTCG
ACCAGACAGGAATAATACGG

Downstream 100 bases:

>100_bases
CGCCGTGATAGACGTTGAGCTTCGCGGCGTGTCCGACCCCCGGCCCGCGGCCGGCGAGAGCCCCCAGCCCGACCAGCCAA
CCGCCGATCAGAGCACAGAG

Product: pyruvate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 358; Mature: 357

Protein sequence:

>358_residues
MTLMAERSENGAPFDTGVRLLAPDGTLVDDPRFTVRADSRQTESFYREMVRARRLDEEATALQRQGELVLWIPLRGQEAA
QVGSAAAAEPADFLFPSYREHAVVWHRGIPPVEALRLLRGVTHGGWDPEAYNVANYVLVLASQTLHAVGYGLGVRLDGAA
GQVVMVYLGDGAMSQGDANEAFVWAASFGAPVVFFCQNNQWAISTPSARQSPVPLARRAAGFGFPGVRVDGNDVLAVHAV
TTWALEHARSGQGPVLIEANTYRMAPHTTSDDASRYQEAAEVAAWRARDPIDRVALLLGHTHDPAWFEGVRAEAEEAAAT
LRRECLALPDPAPRTLVDHVLVGGSALLREQRGEIWEG

Sequences:

>Translated_358_residues
MTLMAERSENGAPFDTGVRLLAPDGTLVDDPRFTVRADSRQTESFYREMVRARRLDEEATALQRQGELVLWIPLRGQEAA
QVGSAAAAEPADFLFPSYREHAVVWHRGIPPVEALRLLRGVTHGGWDPEAYNVANYVLVLASQTLHAVGYGLGVRLDGAA
GQVVMVYLGDGAMSQGDANEAFVWAASFGAPVVFFCQNNQWAISTPSARQSPVPLARRAAGFGFPGVRVDGNDVLAVHAV
TTWALEHARSGQGPVLIEANTYRMAPHTTSDDASRYQEAAEVAAWRARDPIDRVALLLGHTHDPAWFEGVRAEAEEAAAT
LRRECLALPDPAPRTLVDHVLVGGSALLREQRGEIWEG
>Mature_357_residues
TLMAERSENGAPFDTGVRLLAPDGTLVDDPRFTVRADSRQTESFYREMVRARRLDEEATALQRQGELVLWIPLRGQEAAQ
VGSAAAAEPADFLFPSYREHAVVWHRGIPPVEALRLLRGVTHGGWDPEAYNVANYVLVLASQTLHAVGYGLGVRLDGAAG
QVVMVYLGDGAMSQGDANEAFVWAASFGAPVVFFCQNNQWAISTPSARQSPVPLARRAAGFGFPGVRVDGNDVLAVHAVT
TWALEHARSGQGPVLIEANTYRMAPHTTSDDASRYQEAAEVAAWRARDPIDRVALLLGHTHDPAWFEGVRAEAEEAAATL
RRECLALPDPAPRTLVDHVLVGGSALLREQRGEIWEG

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI258645172, Length=329, Percent_Identity=34.6504559270517, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI11386135, Length=330, Percent_Identity=34.8484848484849, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI4885543, Length=304, Percent_Identity=31.9078947368421, Blast_Score=138, Evalue=6e-33,
Organism=Homo sapiens, GI4505685, Length=257, Percent_Identity=32.295719844358, Blast_Score=126, Evalue=4e-29,
Organism=Homo sapiens, GI291084742, Length=257, Percent_Identity=32.295719844358, Blast_Score=125, Evalue=4e-29,
Organism=Homo sapiens, GI291084744, Length=267, Percent_Identity=31.8352059925094, Blast_Score=122, Evalue=7e-28,
Organism=Homo sapiens, GI291084757, Length=298, Percent_Identity=30.2013422818792, Blast_Score=108, Evalue=8e-24,
Organism=Caenorhabditis elegans, GI86563357, Length=288, Percent_Identity=35.4166666666667, Blast_Score=163, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI86563355, Length=288, Percent_Identity=35.4166666666667, Blast_Score=163, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI32564172, Length=307, Percent_Identity=32.2475570032573, Blast_Score=122, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17536047, Length=307, Percent_Identity=32.2475570032573, Blast_Score=122, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6321026, Length=338, Percent_Identity=28.1065088757396, Blast_Score=112, Evalue=1e-25,
Organism=Drosophila melanogaster, GI21355903, Length=359, Percent_Identity=31.7548746518106, Blast_Score=157, Evalue=1e-38,
Organism=Drosophila melanogaster, GI24639740, Length=308, Percent_Identity=32.1428571428571, Blast_Score=127, Evalue=9e-30,
Organism=Drosophila melanogaster, GI24639744, Length=308, Percent_Identity=32.1428571428571, Blast_Score=127, Evalue=9e-30,
Organism=Drosophila melanogaster, GI28571106, Length=308, Percent_Identity=32.1428571428571, Blast_Score=127, Evalue=9e-30,
Organism=Drosophila melanogaster, GI24639746, Length=252, Percent_Identity=33.7301587301587, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24639748, Length=274, Percent_Identity=30.6569343065693, Blast_Score=111, Evalue=7e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017596 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 38891; Mature: 38760

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLMAERSENGAPFDTGVRLLAPDGTLVDDPRFTVRADSRQTESFYREMVRARRLDEEAT
CCEECCCCCCCCCHHHCCEEECCCCCEECCCCEEEEECCHHHHHHHHHHHHHHHCCHHHH
ALQRQGELVLWIPLRGQEAAQVGSAAAAEPADFLFPSYREHAVVWHRGIPPVEALRLLRG
HHHHCCCEEEEEECCCCHHHHHCCCCCCCCHHHCCCCCCCCEEEEECCCCHHHHHHHHHH
VTHGGWDPEAYNVANYVLVLASQTLHAVGYGLGVRLDGAAGQVVMVYLGDGAMSQGDANE
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCEEEEEECCCCCCCCCCCC
AFVWAASFGAPVVFFCQNNQWAISTPSARQSPVPLARRAAGFGFPGVRVDGNDVLAVHAV
EEEEEECCCCCEEEEEECCEEEEECCCCCCCCCCHHHHHCCCCCCCEEECCCCEEEEEHH
TTWALEHARSGQGPVLIEANTYRMAPHTTSDDASRYQEAAEVAAWRARDPIDRVALLLGH
HHHHHHHHCCCCCCEEEEECCEEECCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCC
THDPAWFEGVRAEAEEAAATLRRECLALPDPAPRTLVDHVLVGGSALLREQRGEIWEG
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHCCCCCCC
>Mature Secondary Structure 
TLMAERSENGAPFDTGVRLLAPDGTLVDDPRFTVRADSRQTESFYREMVRARRLDEEAT
CEECCCCCCCCCHHHCCEEECCCCCEECCCCEEEEECCHHHHHHHHHHHHHHHCCHHHH
ALQRQGELVLWIPLRGQEAAQVGSAAAAEPADFLFPSYREHAVVWHRGIPPVEALRLLRG
HHHHCCCEEEEEECCCCHHHHHCCCCCCCCHHHCCCCCCCCEEEEECCCCHHHHHHHHHH
VTHGGWDPEAYNVANYVLVLASQTLHAVGYGLGVRLDGAAGQVVMVYLGDGAMSQGDANE
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCEEEEEECCCCCCCCCCCC
AFVWAASFGAPVVFFCQNNQWAISTPSARQSPVPLARRAAGFGFPGVRVDGNDVLAVHAV
EEEEEECCCCCEEEEEECCEEEEECCCCCCCCCCHHHHHCCCCCCCEEECCCCEEEEEHH
TTWALEHARSGQGPVLIEANTYRMAPHTTSDDASRYQEAAEVAAWRARDPIDRVALLLGH
HHHHHHHHCCCCCCEEEEECCEEECCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCC
THDPAWFEGVRAEAEEAAATLRRECLALPDPAPRTLVDHVLVGGSALLREQRGEIWEG
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2200674 [H]