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The map label for this gene is thrS

Identifier: 158313600

GI number: 158313600

Start: 2114770

End: 2116746

Strand: Direct

Name: thrS

Synonym: Franean1_1764

Alternate gene names: 158313600

Gene position: 2114770-2116746 (Clockwise)

Preceding gene: 158313599

Following gene: 158313602

Centisome position: 23.54

GC content: 70.21

Gene sequence:

>1977_bases
GTGTCCGACGTCCGCGTAACCGTCCAGCGAGGTCAGCAGGCCGAGGAGCGGGTGGTGCGGACGGGGACTACGGCCGCCGA
GCTCTTCGACGGGGAGCGGTCGGTGATCGCGGCCCGCGTGGGTGGTCTCCAGCGTGACCTCTCCCATCCGCTCGCCGCCG
GTGACGTCGTCGAGCCGATCACCGTCGACTCGCCGGACGGGCGGGCCATCGTCCGCCACTCCTGCGCCCACGTGGTGGCA
CAGGCGGTGCAGGACCTGTTCCCCAAGGCCCGGCTCGGCATCGGCCCGCCGATCCAGGACGGCTTCTACTACGACTTCGA
CGTCGAGCGCCCGTTCACCCCGGAGGACCTCAAGGCCGTCGAGAAGCGCGCCCAGGAGATCATCAAGGCCGGCCAGCGCT
TCGCCCGGCGGGTCGTCTCCGAGGACGAGGCGCGCGCCGAGCTCGCCGACGAGCCGTACAAGATCGAGCTGATCGGGCTG
AAGTCCAGCGCGGGCGACGACGCCGAGGCCGGGGTCGAGGTGGGCGAGGGCGAGCTCACCATCTACGACAACCTCGACCC
GAAGTCCGGCGAGCTGTGCTGGAAGGACCTGTGTCGCGGGCCGCACGTGCCCACCACCCGGCACATCCCCGCGTTCGCCG
TCCAGCGCTCGGCGGCGGCGTACTGGCGGGGCAGCGAGCGCAACCCGCAGCTGCAGCGCATCTACGGCACCGCCTGGGAG
TCCCGCGACGCGCTCAAGGCCTACCAGCACCGGCTGGCCGAGGCGGAGAAGCGCGACCACCGCCGGCTGGGCGCCGAGCT
CGACCTGTTCTCCTTCCCGACCGAGATCGGGCCCGGCCTGGCCGTGTTCCATCCCAAGGGCGGCGCGATCCGCACCGTGA
TGGAGGACTACTCGCGGCGCCGGCACATCGAGGCCGGGTACGAGTTCGTCAACACCCCGCACATCACCAAGTCGGATCTC
TACGAGATCTCCGGGCACCTCGACTGGTTCGCCGACGGCATGTACCCGCCCATGCAGCTCGACGGCGGGGCGGACTACTA
CCTCAAGCCGATGAACTGCCCGATGCACATCCTGATCTTCCGGTCGCGCGGCCGGTCGTACCGGGAGCTGCCGCTGCGGC
TGTTCGAGTTCGGCACCGTCTACCGGTACGAGAAGTCCGGGGTCGTGCACGGCCTGACCCGGGTCCGCGGCCTCACCCAG
GACGACGCGCACCTGTTCTGCGCCCGCGAGCAGCTGCCCACCGAGCTCGACACCGTCCTGAAGTTCGTGCTCGGCCTGCT
GCGCGACTACGGCCTCGAGGACTTCTACCTCGAGCTGTCGACCCGTCCGCCGGGCAAGGCGATCGGCAGCGACAAGGAGT
GGGAGGAGGCGACCGAGCTGCTGCGCGAGGCCGCCTCCAAGCAGGACCTCGAGCTCGTCATGGACGAGGGCGGCGGCGCG
TTCTACGGGCCGAAGATCTCCGTGCAGGCCCGGGACGCGATCGGGCGCACCTGGCAGCTGTCCACCATCCAGGTCGACTT
CCAGCTCCCGCAGCGCTTCGACATGACCTACCAGGCGGCGGACGGCACCCGCCAGCGCCCGTTCATGATCCACCGGGCGC
TGTTCGGGACGATCGAGCGGTTCTTCGCGATCCTGCTGGAGCACTACGCCGGCGCGCTGCCGCCGTGGCTGGCTCCCGTG
CAGGTGGTGGGCATCCCGATCACCGACGAGCACGTGCCGTATCTGACCGACGTGGCGGCGAAGCTGCGGCAGCGGGGCAT
CCGCGTCGAGGTCGACTCCTCCGACGACCGGATGCAGAAGAAGATCCGCACCGCCCAGAAGCAGAAGGTGCCCTTCATGC
TGCTCGCCGGTGACGAGGACGTCGCCAAGGGCGCGGTGTCCTTCCGCTTCCGGGACGGCACGCAGCGCAACGGCGTGCCG
GTGGACGAGGCCGTCGCGGAGATCCTCGACGCCGTCGAGCGTCGTATCCAGGTCTGA

Upstream 100 bases:

>100_bases
AGAACCCGAGATTCGCAGATCCCCGAGAACCAGCCGATCAGTGATCAGGGGCGGTCACAGGCACGCCCCGGTCGTTCGTC
CAACGCAGCAGGAGAAACCG

Downstream 100 bases:

>100_bases
GCCCGGCCCACCCCGCCCGCGGTCAGGCCGCCCGCGGTCAGGTCGCCCGCGGGCGGGGCCGCCCGGCGGTCAGCCCGCGG
AGTGGTCGCGCTCGCGCCAG

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS

Number of amino acids: Translated: 658; Mature: 657

Protein sequence:

>658_residues
MSDVRVTVQRGQQAEERVVRTGTTAAELFDGERSVIAARVGGLQRDLSHPLAAGDVVEPITVDSPDGRAIVRHSCAHVVA
QAVQDLFPKARLGIGPPIQDGFYYDFDVERPFTPEDLKAVEKRAQEIIKAGQRFARRVVSEDEARAELADEPYKIELIGL
KSSAGDDAEAGVEVGEGELTIYDNLDPKSGELCWKDLCRGPHVPTTRHIPAFAVQRSAAAYWRGSERNPQLQRIYGTAWE
SRDALKAYQHRLAEAEKRDHRRLGAELDLFSFPTEIGPGLAVFHPKGGAIRTVMEDYSRRRHIEAGYEFVNTPHITKSDL
YEISGHLDWFADGMYPPMQLDGGADYYLKPMNCPMHILIFRSRGRSYRELPLRLFEFGTVYRYEKSGVVHGLTRVRGLTQ
DDAHLFCAREQLPTELDTVLKFVLGLLRDYGLEDFYLELSTRPPGKAIGSDKEWEEATELLREAASKQDLELVMDEGGGA
FYGPKISVQARDAIGRTWQLSTIQVDFQLPQRFDMTYQAADGTRQRPFMIHRALFGTIERFFAILLEHYAGALPPWLAPV
QVVGIPITDEHVPYLTDVAAKLRQRGIRVEVDSSDDRMQKKIRTAQKQKVPFMLLAGDEDVAKGAVSFRFRDGTQRNGVP
VDEAVAEILDAVERRIQV

Sequences:

>Translated_658_residues
MSDVRVTVQRGQQAEERVVRTGTTAAELFDGERSVIAARVGGLQRDLSHPLAAGDVVEPITVDSPDGRAIVRHSCAHVVA
QAVQDLFPKARLGIGPPIQDGFYYDFDVERPFTPEDLKAVEKRAQEIIKAGQRFARRVVSEDEARAELADEPYKIELIGL
KSSAGDDAEAGVEVGEGELTIYDNLDPKSGELCWKDLCRGPHVPTTRHIPAFAVQRSAAAYWRGSERNPQLQRIYGTAWE
SRDALKAYQHRLAEAEKRDHRRLGAELDLFSFPTEIGPGLAVFHPKGGAIRTVMEDYSRRRHIEAGYEFVNTPHITKSDL
YEISGHLDWFADGMYPPMQLDGGADYYLKPMNCPMHILIFRSRGRSYRELPLRLFEFGTVYRYEKSGVVHGLTRVRGLTQ
DDAHLFCAREQLPTELDTVLKFVLGLLRDYGLEDFYLELSTRPPGKAIGSDKEWEEATELLREAASKQDLELVMDEGGGA
FYGPKISVQARDAIGRTWQLSTIQVDFQLPQRFDMTYQAADGTRQRPFMIHRALFGTIERFFAILLEHYAGALPPWLAPV
QVVGIPITDEHVPYLTDVAAKLRQRGIRVEVDSSDDRMQKKIRTAQKQKVPFMLLAGDEDVAKGAVSFRFRDGTQRNGVP
VDEAVAEILDAVERRIQV
>Mature_657_residues
SDVRVTVQRGQQAEERVVRTGTTAAELFDGERSVIAARVGGLQRDLSHPLAAGDVVEPITVDSPDGRAIVRHSCAHVVAQ
AVQDLFPKARLGIGPPIQDGFYYDFDVERPFTPEDLKAVEKRAQEIIKAGQRFARRVVSEDEARAELADEPYKIELIGLK
SSAGDDAEAGVEVGEGELTIYDNLDPKSGELCWKDLCRGPHVPTTRHIPAFAVQRSAAAYWRGSERNPQLQRIYGTAWES
RDALKAYQHRLAEAEKRDHRRLGAELDLFSFPTEIGPGLAVFHPKGGAIRTVMEDYSRRRHIEAGYEFVNTPHITKSDLY
EISGHLDWFADGMYPPMQLDGGADYYLKPMNCPMHILIFRSRGRSYRELPLRLFEFGTVYRYEKSGVVHGLTRVRGLTQD
DAHLFCAREQLPTELDTVLKFVLGLLRDYGLEDFYLELSTRPPGKAIGSDKEWEEATELLREAASKQDLELVMDEGGGAF
YGPKISVQARDAIGRTWQLSTIQVDFQLPQRFDMTYQAADGTRQRPFMIHRALFGTIERFFAILLEHYAGALPPWLAPVQ
VVGIPITDEHVPYLTDVAAKLRQRGIRVEVDSSDDRMQKKIRTAQKQKVPFMLLAGDEDVAKGAVSFRFRDGTQRNGVPV
DEAVAEILDAVERRIQV

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI38570111, Length=658, Percent_Identity=35.258358662614, Blast_Score=397, Evalue=1e-110,
Organism=Homo sapiens, GI38202255, Length=661, Percent_Identity=34.947049924357, Blast_Score=386, Evalue=1e-107,
Organism=Homo sapiens, GI20070344, Length=641, Percent_Identity=35.8814352574103, Blast_Score=363, Evalue=1e-100,
Organism=Escherichia coli, GI1788013, Length=625, Percent_Identity=39.68, Blast_Score=479, Evalue=1e-136,
Organism=Caenorhabditis elegans, GI71984192, Length=651, Percent_Identity=34.5622119815668, Blast_Score=392, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI71984184, Length=651, Percent_Identity=34.5622119815668, Blast_Score=391, Evalue=1e-109,
Organism=Saccharomyces cerevisiae, GI6322112, Length=634, Percent_Identity=36.2776025236593, Blast_Score=404, Evalue=1e-113,
Organism=Saccharomyces cerevisiae, GI6322654, Length=386, Percent_Identity=35.7512953367876, Blast_Score=243, Evalue=8e-65,
Organism=Drosophila melanogaster, GI24583842, Length=659, Percent_Identity=35.0531107738998, Blast_Score=399, Evalue=1e-111,
Organism=Drosophila melanogaster, GI28574141, Length=659, Percent_Identity=35.0531107738998, Blast_Score=399, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24583839, Length=659, Percent_Identity=35.0531107738998, Blast_Score=399, Evalue=1e-111,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYT_FRASN (A8LE67)

Other databases:

- EMBL:   CP000820
- RefSeq:   YP_001506108.1
- ProteinModelPortal:   A8LE67
- SMR:   A8LE67
- GeneID:   5670166
- GenomeReviews:   CP000820_GR
- KEGG:   fre:Franean1_1764
- HOGENOM:   HBG352811
- OMA:   FHPKGMV
- ProtClustDB:   PRK00413
- BioCyc:   FSP1855:FRANEAN1_1764-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00184_B
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947
- Gene3D:   G3DSA:3.40.50.800
- PRINTS:   PR01047
- SMART:   SM00863
- TIGRFAMs:   TIGR00418

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD; SSF52954 Anticodon_bd; SSF55186 Thr/Ala-tRNA-synth_IIc_edit

EC number: =6.1.1.3

Molecular weight: Translated: 73977; Mature: 73845

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDVRVTVQRGQQAEERVVRTGTTAAELFDGERSVIAARVGGLQRDLSHPLAAGDVVEPI
CCCCEEEHHCCCHHHHHHHHCCCHHHHHHCCCHHHHHHHHCCHHHHHCCCCCCCCCCCCE
TVDSPDGRAIVRHSCAHVVAQAVQDLFPKARLGIGPPIQDGFYYDFDVERPFTPEDLKAV
ECCCCCCCHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCEEEEEECCCCCCHHHHHHH
EKRAQEIIKAGQRFARRVVSEDEARAELADEPYKIELIGLKSSAGDDAEAGVEVGEGELT
HHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCEECCCCEE
IYDNLDPKSGELCWKDLCRGPHVPTTRHIPAFAVQRSAAAYWRGSERNPQLQRIYGTAWE
EEECCCCCCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHCCCC
SRDALKAYQHRLAEAEKRDHRRLGAELDLFSFPTEIGPGLAVFHPKGGAIRTVMEDYSRR
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCEEEEECCCCHHHHHHHHHHHH
RHIEAGYEFVNTPHITKSDLYEISGHLDWFADGMYPPMQLDGGADYYLKPMNCPMHILIF
HHHHHCHHCCCCCCCCHHHHHHHCCCCHHHHCCCCCCCEECCCCCEEEECCCCCEEEEEE
RSRGRSYRELPLRLFEFGTVYRYEKSGVVHGLTRVRGLTQDDAHLFCAREQLPTELDTVL
ECCCCCHHHHHHHHHHHCCEEEECCCCHHHHHHHHCCCCCCCCCEEEEHHHCCHHHHHHH
KFVLGLLRDYGLEDFYLELSTRPPGKAIGSDKEWEEATELLREAASKQDLELVMDEGGGA
HHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCE
FYGPKISVQARDAIGRTWQLSTIQVDFQLPQRFDMTYQAADGTRQRPFMIHRALFGTIER
EECCEEEEEEHHHCCCEEEEEEEEEEEECCCHHCCEEEECCCCCCCHHHHHHHHHHHHHH
FFAILLEHYAGALPPWLAPVQVVGIPITDEHVPYLTDVAAKLRQRGIRVEVDSSDDRMQK
HHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCEEEECCCHHHHHH
KIRTAQKQKVPFMLLAGDEDVAKGAVSFRFRDGTQRNGVPVDEAVAEILDAVERRIQV
HHHHHHHHCCCEEEEECCCHHHCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SDVRVTVQRGQQAEERVVRTGTTAAELFDGERSVIAARVGGLQRDLSHPLAAGDVVEPI
CCCEEEHHCCCHHHHHHHHCCCHHHHHHCCCHHHHHHHHCCHHHHHCCCCCCCCCCCCE
TVDSPDGRAIVRHSCAHVVAQAVQDLFPKARLGIGPPIQDGFYYDFDVERPFTPEDLKAV
ECCCCCCCHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCEEEEEECCCCCCHHHHHHH
EKRAQEIIKAGQRFARRVVSEDEARAELADEPYKIELIGLKSSAGDDAEAGVEVGEGELT
HHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCEECCCCEE
IYDNLDPKSGELCWKDLCRGPHVPTTRHIPAFAVQRSAAAYWRGSERNPQLQRIYGTAWE
EEECCCCCCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHCCCC
SRDALKAYQHRLAEAEKRDHRRLGAELDLFSFPTEIGPGLAVFHPKGGAIRTVMEDYSRR
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCEEEEECCCCHHHHHHHHHHHH
RHIEAGYEFVNTPHITKSDLYEISGHLDWFADGMYPPMQLDGGADYYLKPMNCPMHILIF
HHHHHCHHCCCCCCCCHHHHHHHCCCCHHHHCCCCCCCEECCCCCEEEECCCCCEEEEEE
RSRGRSYRELPLRLFEFGTVYRYEKSGVVHGLTRVRGLTQDDAHLFCAREQLPTELDTVL
ECCCCCHHHHHHHHHHHCCEEEECCCCHHHHHHHHCCCCCCCCCEEEEHHHCCHHHHHHH
KFVLGLLRDYGLEDFYLELSTRPPGKAIGSDKEWEEATELLREAASKQDLELVMDEGGGA
HHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCE
FYGPKISVQARDAIGRTWQLSTIQVDFQLPQRFDMTYQAADGTRQRPFMIHRALFGTIER
EECCEEEEEEHHHCCCEEEEEEEEEEEECCCHHCCEEEECCCCCCCHHHHHHHHHHHHHH
FFAILLEHYAGALPPWLAPVQVVGIPITDEHVPYLTDVAAKLRQRGIRVEVDSSDDRMQK
HHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCEEEECCCHHHHHH
KIRTAQKQKVPFMLLAGDEDVAKGAVSFRFRDGTQRNGVPVDEAVAEILDAVERRIQV
HHHHHHHHCCCEEEEECCCHHHCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA