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The map label for this gene is pyrC [H]

Identifier: 158313543

GI number: 158313543

Start: 2038535

End: 2039890

Strand: Direct

Name: pyrC [H]

Synonym: Franean1_1707

Alternate gene names: 158313543

Gene position: 2038535-2039890 (Clockwise)

Preceding gene: 158313542

Following gene: 158313544

Centisome position: 22.7

GC content: 74.19

Gene sequence:

>1356_bases
ATGACATCGGTGATCGTGGTGCGTGGCGTCCGTCCGCTGGGCGGTGACGCGCGGGATCTGGTGATCGCCGGCGGGACGAT
CGCCGCTGTCGCGCCGGCCGGGGGCGGCGAGCACACCGGCGTCGTGGCCGAGGCCACCGCGGGCTCCGCCGACGGCACCC
GCCCCGCCCCCCTGGTCGTCGACGCCACCGGGCTCGTGGCGCTGCCCGGGCTCGTTGACCTGCACACCCACCTGCGCGAG
CCTGGCCGGGAGGACGCCGAGACGGTCGACTCCGGTACCCGCGCGGCGGCGCTCGGCGGCTACACGACGGTGTTCGCGAT
GGCCAACACCGACCCCGTCGCCGACACCGCCGGGGTGGTCGAGCAGGTGTGGCGGCTCGGCCAGGACGCCGGGCACTGCG
ACGTGCGCCCGGTCGGCGCGGTGACCAGGGGGCTCGCCGGCGAGCGGCTCGCCGAGCTGGGCGCCATGGCCTCCTCCGCG
GCGGCGGTCCGGATGTTCTCCGACGACGGTCACTGTGTGTCCGACGCGTTGCTCATGCGCCGCGCGCTCGAGTACGTCAA
GGCCTTCGACGGCGTGATCGCGCAGCACGCGGAGGAGCCGAGGCTGACCGCCGGGGCGCAGATGAACGAGGGCGCCATGG
CCGCGCGGCTGGGCCTGCCCGGCTGGCCGGCCGTCGCAGAGGAGGCGATCATCGCCCGGGACGCCCTGCTGACCGGGCAC
GTCGGGTCGCGCCTGCACATCTGCCACGTGTCCACGGCGGGCTCGGTCGAGCTCATCCGGTGGGCCAAGGCGAAGGGCTG
GCGGGTGACCGCGGAGGTCACCCCGCACCACCTGCTGCTCACCGAGGAGCTCGTCGCCTCGTACGACCCGGTGTACAAGG
TCAATCCGCCGTTGCGCACCGCGGCCGACACAGAGGCACTGCGAGCCGGTCTCGCGGACGGCACGATCGACTGTGTGGCC
ACCGATCACGCCCCGCACGCCTCCGAGGACAAGGAGACGGAGTGGGCCGCCGCCCGGCCCGGGATGCTCGGCCTCGAGAC
AGCGCTGTCCATCGTGATCCAGACCATGGTCGAAACCGGCCGGCTCGACTGGGCCGGTGTCGCCGACCGGATGGCGCTGG
CGCCGGCCCGGATCGGCGCCGTCGCCGACACGCCGCGTGACCCGGCGAGCTTCGCCCAGGTGGGCGCGCCCGCCACCCTG
ACCCTGCTCGACCCGGAGGCGCGACGGGTGATCGATCCACTCGCCGTCGCCAGCCGGAGCAGCAACACTCCGTACGGTGG
CCGCACGCTGCCCGGTGCCATTCGGGCGACGTTCCTGCGAGGCCGGCCCACCGTGCTCGACGGGAAGATCATATGA

Upstream 100 bases:

>100_bases
CGCGCTCGACGGTGGTCGAGCAGGTCGCGAACGGCGTGAGCGTCCGCATGGCCGTCCTCTACCTGCTGCTCGGCGGCAGC
GGCGCCGAACGGGAGTCCTC

Downstream 100 bases:

>100_bases
CCTCCGCCTCACGATCCACATCCCTGCCGGGGATTACCCCGTTCGCGCTGGCCGGCCCCGTGCTGGCCGCCGGTGGCAAG
GATCAGACGGGCCTGCACCT

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 451; Mature: 450

Protein sequence:

>451_residues
MTSVIVVRGVRPLGGDARDLVIAGGTIAAVAPAGGGEHTGVVAEATAGSADGTRPAPLVVDATGLVALPGLVDLHTHLRE
PGREDAETVDSGTRAAALGGYTTVFAMANTDPVADTAGVVEQVWRLGQDAGHCDVRPVGAVTRGLAGERLAELGAMASSA
AAVRMFSDDGHCVSDALLMRRALEYVKAFDGVIAQHAEEPRLTAGAQMNEGAMAARLGLPGWPAVAEEAIIARDALLTGH
VGSRLHICHVSTAGSVELIRWAKAKGWRVTAEVTPHHLLLTEELVASYDPVYKVNPPLRTAADTEALRAGLADGTIDCVA
TDHAPHASEDKETEWAAARPGMLGLETALSIVIQTMVETGRLDWAGVADRMALAPARIGAVADTPRDPASFAQVGAPATL
TLLDPEARRVIDPLAVASRSSNTPYGGRTLPGAIRATFLRGRPTVLDGKII

Sequences:

>Translated_451_residues
MTSVIVVRGVRPLGGDARDLVIAGGTIAAVAPAGGGEHTGVVAEATAGSADGTRPAPLVVDATGLVALPGLVDLHTHLRE
PGREDAETVDSGTRAAALGGYTTVFAMANTDPVADTAGVVEQVWRLGQDAGHCDVRPVGAVTRGLAGERLAELGAMASSA
AAVRMFSDDGHCVSDALLMRRALEYVKAFDGVIAQHAEEPRLTAGAQMNEGAMAARLGLPGWPAVAEEAIIARDALLTGH
VGSRLHICHVSTAGSVELIRWAKAKGWRVTAEVTPHHLLLTEELVASYDPVYKVNPPLRTAADTEALRAGLADGTIDCVA
TDHAPHASEDKETEWAAARPGMLGLETALSIVIQTMVETGRLDWAGVADRMALAPARIGAVADTPRDPASFAQVGAPATL
TLLDPEARRVIDPLAVASRSSNTPYGGRTLPGAIRATFLRGRPTVLDGKII
>Mature_450_residues
TSVIVVRGVRPLGGDARDLVIAGGTIAAVAPAGGGEHTGVVAEATAGSADGTRPAPLVVDATGLVALPGLVDLHTHLREP
GREDAETVDSGTRAAALGGYTTVFAMANTDPVADTAGVVEQVWRLGQDAGHCDVRPVGAVTRGLAGERLAELGAMASSAA
AVRMFSDDGHCVSDALLMRRALEYVKAFDGVIAQHAEEPRLTAGAQMNEGAMAARLGLPGWPAVAEEAIIARDALLTGHV
GSRLHICHVSTAGSVELIRWAKAKGWRVTAEVTPHHLLLTEELVASYDPVYKVNPPLRTAADTEALRAGLADGTIDCVAT
DHAPHASEDKETEWAAARPGMLGLETALSIVIQTMVETGRLDWAGVADRMALAPARIGAVADTPRDPASFAQVGAPATLT
LLDPEARRVIDPLAVASRSSNTPYGGRTLPGAIRATFLRGRPTVLDGKII

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=396, Percent_Identity=31.0606060606061, Blast_Score=152, Evalue=8e-37,
Organism=Homo sapiens, GI4503051, Length=414, Percent_Identity=23.1884057971014, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI62422571, Length=414, Percent_Identity=23.1884057971014, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI190194363, Length=417, Percent_Identity=24.7002398081535, Blast_Score=65, Evalue=9e-11,
Organism=Escherichia coli, GI1786722, Length=451, Percent_Identity=27.7161862527716, Blast_Score=141, Evalue=1e-34,
Organism=Escherichia coli, GI87082175, Length=405, Percent_Identity=25.4320987654321, Blast_Score=96, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI193204318, Length=394, Percent_Identity=29.9492385786802, Blast_Score=145, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI86575075, Length=475, Percent_Identity=24, Blast_Score=65, Evalue=8e-11,
Organism=Drosophila melanogaster, GI24642586, Length=392, Percent_Identity=29.5918367346939, Blast_Score=145, Evalue=7e-35,
Organism=Drosophila melanogaster, GI18859883, Length=415, Percent_Identity=26.0240963855422, Blast_Score=80, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 46660; Mature: 46529

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSVIVVRGVRPLGGDARDLVIAGGTIAAVAPAGGGEHTGVVAEATAGSADGTRPAPLVV
CCCEEEEECCCCCCCCCCEEEEECCEEEEEECCCCCCCCCEEEECCCCCCCCCCCCCEEE
DATGLVALPGLVDLHTHLREPGREDAETVDSGTRAAALGGYTTVFAMANTDPVADTAGVV
ECCCCCCCCCHHHHHHHHCCCCCCHHHHHCCCCCEEECCCCEEEEEECCCCCCHHHHHHH
EQVWRLGQDAGHCDVRPVGAVTRGLAGERLAELGAMASSAAAVRMFSDDGHCVSDALLMR
HHHHHHCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHH
RALEYVKAFDGVIAQHAEEPRLTAGAQMNEGAMAARLGLPGWPAVAEEAIIARDALLTGH
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHEECC
VGSRLHICHVSTAGSVELIRWAKAKGWRVTAEVTPHHLLLTEELVASYDPVYKVNPPLRT
CCCEEEEEEECCCCCEEEEEECCCCCCEEEEECCCCEEEEHHHHHHCCCCCEECCCCCCC
AADTEALRAGLADGTIDCVATDHAPHASEDKETEWAAARPGMLGLETALSIVIQTMVETG
CCCHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHC
RLDWAGVADRMALAPARIGAVADTPRDPASFAQVGAPATLTLLDPEARRVIDPLAVASRS
CCCHHHHHHHHHHCHHHHCCCCCCCCCCHHHHHCCCCEEEEEECCHHHHHHHHHHHHCCC
SNTPYGGRTLPGAIRATFLRGRPTVLDGKII
CCCCCCCCCCCHHHHHHEECCCCCEECCCCC
>Mature Secondary Structure 
TSVIVVRGVRPLGGDARDLVIAGGTIAAVAPAGGGEHTGVVAEATAGSADGTRPAPLVV
CCEEEEECCCCCCCCCCEEEEECCEEEEEECCCCCCCCCEEEECCCCCCCCCCCCCEEE
DATGLVALPGLVDLHTHLREPGREDAETVDSGTRAAALGGYTTVFAMANTDPVADTAGVV
ECCCCCCCCCHHHHHHHHCCCCCCHHHHHCCCCCEEECCCCEEEEEECCCCCCHHHHHHH
EQVWRLGQDAGHCDVRPVGAVTRGLAGERLAELGAMASSAAAVRMFSDDGHCVSDALLMR
HHHHHHCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHH
RALEYVKAFDGVIAQHAEEPRLTAGAQMNEGAMAARLGLPGWPAVAEEAIIARDALLTGH
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHEECC
VGSRLHICHVSTAGSVELIRWAKAKGWRVTAEVTPHHLLLTEELVASYDPVYKVNPPLRT
CCCEEEEEEECCCCCEEEEEECCCCCCEEEEECCCCEEEEHHHHHHCCCCCEECCCCCCC
AADTEALRAGLADGTIDCVATDHAPHASEDKETEWAAARPGMLGLETALSIVIQTMVETG
CCCHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHC
RLDWAGVADRMALAPARIGAVADTPRDPASFAQVGAPATLTLLDPEARRVIDPLAVASRS
CCCHHHHHHHHHHCHHHHCCCCCCCCCCHHHHHCCCCEEEEEECCHHHHHHHHHHHHCCC
SNTPYGGRTLPGAIRATFLRGRPTVLDGKII
CCCCCCCCCCCHHHHHHEECCCCCEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]